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Morphology evolution and crystallographic feature of Nb nanowire in an in-situ NiTi-Nb nanocomposite

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Rare Metals 2014年第5期33卷 563-567页

作者： Zhen-Yang Liu fang-min guo Zhong-Qiang Wang Li-Shan Cui Department of Materials Science and Engineering China University of Petroleum

In–situ NiTi shape memory alloy–Nb nanowire nanocomposite was revealed to exhibit exceptional mechanical properties. The properties of high strength and ultra-large elastic strains are closely related with the high performance of in situ-formed Nb nanowire reinforcements. In this study, the morphology evolution and crystallographic feature of Nb nanowires in NiTi shape memory alloy matrix during cold drawing were investigated by means of transmission electron microscopy（TEM）. It is revealed that, as a result of the severe work hardening and amorphization of NiTi matrix, the cold work reduction of nanowire reinforcements can exceed that of the entire composite. The irregular-shaped Nb nanowires are reshaped to straight and smooth nanowires during cold drawing process. By means of TEM nanobeam diffraction,it is revealed that the in situ-formed Nb nanowire in such top-down processed NiTi–Nb composite keeps single crystalline over 1,000 nm at length direction. As a consequence, the aspect ratio of nanowire reinforcements in NiTi matrix exceeds 25：1.

关键词： Deep drawing Nanowire Metal matrix composite TEM

Fight or flee,a vital choice for Clostridioides difficile

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mLife 2024年第1期3卷 14-20页

作者： Ji Zeng Sshuying fang Jinquan guo min Dong guo-Bao Tian Liang Tao School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhouChina Department of Brest Surgery Panyu Central Hospital.GuangzhouChina Department of Microbiology Harvard Medical SchoolBostonMassachusettsUSA Department of Urology Boston Children's HospitalHarvard Medical SchoolBostonMassachusettsUSA Department of Microbiology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouChina Advanced Medical Technology Center The First Affiliated HospitalZhongshan School of MedicineSun Yat-sen UniversityGuangzhouChina Key Laboratory of Tropical Diseases Control(Sun Yat-sen University) Ministry of EducationGuangzhouChina School of Medicine Xizang Minzu UniversityXianyangChina Center for Infectious Disease Research Westlake Laboratory of Life Sciences and BiomedicineWestlake UniversityHangzhouChina Research Center for Industries of the Future School of Life SciencesWestlake UniversityHangzhouChina

Clostridioides difficile is a leading cause of healthcare-associated infections,causing billions of economic losses every *** symptoms range from mild diarrhea to life-threatening damage to the *** and recurrence of *** infection(CDl)are mediated by the metabolically dormant spores,while the virulence of *** is mainly due to the two large clostridial toxins,TcdA and *** toxins or forming spores are two different strategies for *** to cope with harsh environmental *** is of great significance to understand the molecular mechanisms for *** to skew to either of the cellular ***,we summarize the current understanding of the regulation and connections between toxin production and sporulation in *** and further discuss the potential solutions for yet-to-be-answered questions.

关键词： C.difficile sporulation TcdA TcdB toxin production

Association between luteinizing hormone level decrease on the triggering day and pregnancy outcome for in vitro fertilization/intracytoplasmic sperm injection patients following gonadotropin-releasing hormone antagonist protocol: a retrospective cohor

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生殖与发育医学(英文) 2024年第1期08卷 8-17页

作者： Li Qing-fang Tang min-Yue Wang Gui-Quan Chen Xi-Jing Feng guo-fang Zhu Yi-min Women’s Hospital School of Medicine 3. Zhejiang University 4. 1 Xueshi Road 5. Hangzhou 310006 6. China

Objective: Optimal luteinizing hormone (LH) levels forin vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) patients following the gonadotropin-releasing hormone (GnRH) antagonist protocol remain controversial. This study aimed to estimate the association between serum LH levels on the triggering day (LHLOT) and clinical pregnancy outcomes in IVF/ICSI patients following the GnRH antagonist ***: We enrolled 4743 IVF/ICSI cycles using flexible or fixed GnRH antagonist protocols between January 2017 and June 2021. The patients were stratified into four groups according to the LHLOT quartiles (Q1–Q4). Each group was further divided into two subgroups according to the median basal LH/LHLOT. The main outcomes were clinical pregnancy, birth, and miscarriage rates. Secondary outcomes were oocyte yield, number of MII, fertilized oocytes (2PN), and high-quality ***: Serum LHLOT levels were negatively correlated with oocyte yield and the numbers of MII, 2PN, and high-quality embryos. Reproductive outcomes were compared among the different quartiles and subgroups. The absolute difference in the clinical pregnancy rates between the Q4 and Q1 groups was 6.4% (47.2%vs. 40.8%,P 3.04 and ≤3.04 were 32.7% and 48.6% (P 2.14 and ≤2.14 were 50.2% and 41.9%, respectively (P <0.05). The greater the decrease in LH levels, the lower the oocyte maturation rate across all ***: According to the LHLOT quartiles, the Q1 of serum LHLOT <1.43 IU/L may result in a higher number of oocytes but reduced oocyte maturation and lower clinical pregnancy rates. A decrease in LH levels by approximately 2.14 to 3.04 times compared to basal LH levels may lead to higher clinical pregnancy rates in IVF/ICSI patients following the GnRH antagonist protocol.

关键词： GnRH antagonist IVF/ICSI Luteinizing hormone Ovarian stimulation Reproductive outcomes

Rational design of superior catalysts from topological semimetals with nontrivial energy window

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Rare Metals 2024年第5期43卷 1956-1964页

作者： min Zhao Li-Rong Wang Wei Liu ming-Hang Li Ying Liu Xue-fang Dai guo-Dong Liu Xiao-ming Zhang Key Laboratory of Reliability and Intelligence of Electrical Equipment School of Materials Science and Engineering ManufacturingHebei University of TechnologyTianjin 300130China

Materials featuring topological energy bands and nontrivial surface states hold significant promise in unlocking unprecedented opportunities for innovating electrocatalytic ***,it remains a challenge to realize superior topological catalysts which can carry both high catalytic activity and excellent catalytic ***,we propose that a family of Ni-based binary materials hosting fantasying topological conjunct-nodalpoint state and a large nontrivial energy window(NEWD)represents an ideal choice for such superior topological catalysts in hydrogen evolution *** presence of conjunct-nodal-points ensures long Fermi arcs on the surface,thereby enabling an extremely high catalytic *** NEWD plays a crucial role in stabilizing the high catalytic activity against external perturbations,such as strain and electron/hole *** roles for conjunctnodal-points and NEWD are substantiated by the observable weakening of catalytic performance during topological phase transitions,which result in the removal of the conjunct-nodal-points,NEWD and their corresponding long Fermi *** work unveils a hidden mechanism and opens a feasible route for developing superior quantum catalysts from novel topology point of view.

关键词： First-principles modeling Topological semimetal Nontrivial surface states Hydrogen evolution reaction

Vibration Control of A Flexible Marine Riser System Subject to Input Dead Zone and Extraneous Disturbances

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China Ocean Engineering 2024年第2期38卷 271-284页

作者： ZHOU Li WANG guo-rong WAN min School of Mechatronic Engineering Southwest Petroleum UniversityChengdu 610500China Energy Equipment Institute Southwest Petroleum UniversityChengdu 610500China National Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China

An observer-based adaptive backstepping boundary control is proposed for vibration control of flexible offshore riser systems with unknown nonlinear input dead zone and uncertain environmental *** control algorithm can update the control law online through real-time data to make the controller adapt to the environment and improve the control ***,based on the adaptive backstepping framework,virtual control laws and Lyapunov functions are designed for each *** direction interference observers are designed to track the timevarying boundary *** this basis,the inverse of the dead zone and linear state transformation are used to compensate for the original system and eliminate the adverse effects of the dead *** addition,the stability of the closed-loop system is proven by Lyapunov stability *** the system states are bounded,and the vibration offset of the riser converges to a small area of the initial ***,four examples of flexible marine risers are simulated in MATLAB to verify the effectiveness of the proposed controller.

关键词： adaptive backstepping control disturbance observer flexible marine riser input dead zone vibration control

Rheum palmatum L. and Salvia miltiorrhiza Bge. Alleviates Acute Pancreatitis by Regulating Th17 Cell Differentiation: An Integrated Network Pharmacology Analysis, Molecular Dynamics Simulation and Experimental Validation

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Chinese Journal of Integrative Medicine 2024年第5期30卷 408-420页

作者： FENG min-chao LUO fang HUANG Liang-jiang LI Kai CHEN Zu-min LI Hui YAO Chun QIN Bai-jun CHEN guo-zhong The First Clinical Medical College Guangxi University of Traditional Chinese MedicineNanning 530000China Guangxi Key Laboratory of Molecular Biology of Traditional Chinese Medicine and Preventive Medicine Nanning 530000China Graduate School Guangxi University of Traditional Chinese MedicineNanning 530000China Department of Gastroenterology the First Affiliated Hospital of Guangxi University of Traditional Chinese MedicineNanning 530023China

Objective: To identify the core targets of Rheum palmatum L. and Salvia miltiorrhiza Bge.,(Dahuang-Danshen, DH-DS) and the mechanism underlying its therapeutic efficacy in acute pancreatitis(AP)using a network pharmacology approach and validate the findings in animal experiments. Methods: Network pharmacology analysis was used to elucidate the mechanisms underlying the therapeutic effects of DH-DS in AP. The reliability of the results was verified by molecular docking simulation and molecular dynamics ***, the results of network pharmacology enrichment analysis were verified by immunohistochemistry,Western blot analysis and real-time quantitative PCR, respectively. Results: Sixty-seven common targets of DH-DS in AP were identified and mitogen-activated protein kinase 3(MAPK3), Janus kinase 2(JAK2), signal transducer and activator of transcription 3(STAT3), protein c-Fos(FOS) were identified as core targets in the protein interaction(PPI) network analysis. Gene ontology analysis showed that cellular response to organic substance was the main functions of DH-DS in AP, and Kyoto Encyclopedia of Genes and Genomes analysis showed that the main pathway included Th17 cell differentiation. Molecular docking simulation confirmed that DH-DS binds with strong affinity to MAPK3, STAT3 and FOS. Molecular dynamics simulation revealed that FOS-isotanshinone Ⅱ and STAT3-dan-shexinkum d had good binding capacity. Animal experiments indicated that compared with the AP model group, DH-DS treatment effectively alleviated AP by inhibiting the expression of interleukin-1β, interleukin-6 and tumor necrosis factor-α, and blocking the activation of Th17 cell differentiation(P<0.01). Conclusion: DH-DS could inhibit the expression of inflammatory factors and protect pancreatic tissues,which would be functioned by regulating Th17 cell differentiation-related m RNA and protein expressions.

关键词： Rheum palmatum L. Salvia miltiorrhiza Bge. molecular docking simulation network pharmacology acute pancreatitis Th17 cell differentiation

Tuina alleviates neuropathic pain through regulate the activation of microglia and the secretion of inflammatory cytokine in spinal cord

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Journal of Traditional Chinese Medicine 2024年第4期44卷 762-769页

作者： WU Zhiwei ZHU Qingguang KONG Lingjun SONG Pengfei ZHOU Xin guo Guangxin ZHANG Shuaipan HE Tianxiang CHENG Yanbin fang min Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese MedicineShanghai 200437China Institute of Tuina Shanghai Institute of Traditional Chinese MedicineShanghai 200437China Shuguang Hospital Shanghai University of Traditional Chinese MedicineShanghai 200021China Department of Acupuncture and Tuina Shanghai University of Traditional Chinese MedicineShanghai 201203China

OBJECTIVE:To observe the analgesic effects of Tuina on neuropathic pain(NPP)and the underlying ***:Forty-eight Sprague-Dawley(SD)rats were assigned by random into three treatment groups:sham,chronic constriction injury(CCI),and *** group contained sixteen *** model was generated by ligating the right sciatic *** changes of CCI were assessed by the paw withdrawal threshold(PWT)and paw withdrawal latency(PWL).In addition,biochemical techniques such as immunofluorescence staining,enzyme-linked immunosorbent assay(ELISA)and Western blotting were used to profile levels of microglia activation and inflammatory factors in the spinal dorsal horn(SDH)of ***(clockwise pressing and rubbing)was performed at Chengshan(BL57)to observe the analgesic effects on CCI rats and the underlying ***:Rats with CCI experienced significant reduction in the PWT and PWL of the right hind paw relative to CCI group at day *** treatment rescued this situation significantly on days 10 and ***,Iba-1,microglia M1 receptor CD68,tumor necrosis factor-α(TNF-α),and interleukin-1β(IL-1β)were higher in the right SDH for CCI group compared to the sham group on day *** expected,Tuina partially downregulated the CCI-induced overexpressed Iba-1,CD68,TNF-α,and IL-1βin the SDH of CCI ***:Tuina induces a time-dependent cumulative analgesic effect in CCI rats by inhibiting the activation of microglia and the secretion of IL-1βand TNF-αin SDH.

关键词： Tuina neuralgia microglia inflammatory cytokine spinal cord

Intestinal glucagon-like peptide-1:A new player associated with impaired counterregulatory responses to hypoglycaemia in type 1 diabetic mice

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World Journal of Diabetes 2024年第8期15卷 1764-1777页

作者： fang-Xin Jin Yan Wang min-Ne Li Ru-Jiang Li Jun-Tang guo Department of Histology and Embryology Key Laboratory of Universities in Shandong ProvinceShandong Second Medical UniversityWeifang 261053Shandong ProvinceChina Department of Pathological Physiology Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina

BACKGROUND Impaired hypoglycaemic counterregulation has emerged as a critical concern for diabetic patients who may be hesitant to medically lower their blood glucose levels due to the fear of potential hypoglycaemic ***,the pathogenesis of hypoglycaemic counterregulation is still ***-like peptide-1(GLP-1)and its analogues have been used as adjunctive therapies for type 1 diabetes mellitus(T1DM).The role of GLP-1 in counterregulatory dysfunction during hypoglycaemia in patients with T1DM has not been *** To explore the impact of intestinal GLP-1 on impaired hypoglycaemic counterregulation in type 1 diabetic *** T1DM was induced in C57BL/6J mice using streptozotocin,followed by intraperitoneal insulin injections to create T1DM models with either a single episode of hypoglycaemia or recurrent episodes of hypoglycaemia(DH5).Immunofluorescence,Western blot,and enzyme-linked immunosorbent assay were employed to evaluate the influence of intestinal GLP-1 on the sympathetic-adrenal reflex and glucagon(GCG)*** GLP-1 receptor agonist GLP-1(7-36)or the antagonist exendin(9-39)were infused into the terminal ileum or injected intraperitoneally to further investigate the role of intestinal GLP-1 in hypoglycaemic counterregulation in the model *** The expression levels of intestinal GLP-1 and its receptor(GLP-1R)were significantly increased in DH5 *** instances of excess of intestinal GLP-1 weakens the sympathetic-adrenal reflex,leading to dysfunction of adrenal counterregulation during ***5 mice showed increased pancreaticδ-cell mass,cAMP levels inδcells,and plasma somatostatin concentrations,while cAMP levels in pancreaticαcells and plasma GCG levels ***,GLP-1R expression in islet cells and plasma active GLP-1 levels were significantly increased in the DH5 *** experiments involving terminal ileal infusion and intraperitoneal injection in the model mice demonstra

关键词： Glucagon-like peptide-1 Impaired hypoglycaemic counterregulation Type 1 diabetes Intestine Pancreas

Structure and 2p decay mechanism of^(18)Mg

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Nuclear Science and Techniques 2024年第6期35卷 145-154页

作者： Long Zhou De-Qing fang Si-min Wang Hui Hua Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan UniversityShanghai 200438China School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China

The recently discovered,extremely proton-rich nuclide 18 Mg exhibits ground-state decay via two sequential two-proton(2p)emissions through the intermediate nucleus,*** study investigates the structure and the initial 2p decay mechanism of^(18)Mgby examining the density and correlations of the valence protons using a three-body Gamow coupled-channel *** results show that the ground state of^(18)Mgis significantly influenced by the continuum,resulting in a significant s-wave ***,based on the current framework,this does not lead to a significant deviation in mirror symmetry in either the structure or spectroscopy of the 18Mg-18C ***,the time evolution analysis of the^(18)Mgground state suggests a simultaneous 2p emission during the first step of *** observed nucleon-nucleon correlations align with those of the light-mass 2p emitters,indicating a consistent decay behavior within this nuclear region.

关键词： Structure of^(18)Mg Two-proton decay Proton-proton correlation