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Application of radioactive iodine-125 microparticles in hepatocellular carcinoma with portal vein embolus

World Journal of Gastrointestinal Surgery 2024年第7期16卷 2023-2030页

作者： Peng meng Ji-Peng Ma Xiao-Fei huang Kang-Le Zhang The Fourth Department of Oncology Yantai Hospital of Traditional Chinese MedicineYantai 264001Shandong ProvinceChina Department of Medical Services Yantai Hospital of Traditional Chinese MedicineYantai 264001Shandong ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Sun Yatsen UniversityGuangzhou 510062Guangdong ProvinceChina The Third Department of Oncology Yantai Hospital of Traditional Chinese MedicineYantai 264001Shandong ProvinceChina

BACKGROUND Radioactive iodine-125(125I)microparticle therapy is a new type of internal radiation therapy that has shown unique advantages in the treatment of malignant tumors,especially hepatocellular *** with hepatocellular carcinoma frequently experience portal vein embolism,which exacerbates the difficulty and complexity of treatment.125I particles,used in local radiotherapy,can directly act on tumor tissue and reduce damage to surrounding healthy *** retrospective analysis,this study discussed the efficacy and safety of radioactive 125I particles in portal vein embolization patients with hepatocellular carcinoma in order to provide more powerful evidence supporting clinical *** To investigate the effect of transcatheter arterial chemoembolization combined with portal vein 125I particle implantation in the treatment of primary liver cancer patients with portal vein tumor thrombus and its influence on liver *** The clinical data of 96 patients with primary liver cancer combined with portal vein tumor thrombus admitted to our hospital between January 2020 and December 2023 were retrospectively ***-two patients received treatment with transcatheter arterial chemoembolization and implantation of 125I particles in the portal vein(combination group),while 44 patients received treatment with transcatheter arterial chemoembolization alone(control group).The therapeutic effects on tumor lesions,primary liver cancer,and portal vein tumor embolisms were compared between the two *** in relevant laboratory indexes before and after treatment were *** t test was used to compare the measurement data between the two groups,and the χ^(2) test was used to compare the counting data between *** The tumor lesion response rate in the combination group(59.62%vs 38.64%)and the response rate of patients with primary liver cancer complicated with portal vein tumor thrombus(80.77%vs 59.09%)were signi

关键词： Radioactive iodine-125 Hepatocellular carcinoma Transcatheter arterial chemoembolization Portal vein embolus Retrospective study

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Synthetic strategy of biomimetic sea urchin-like Co-NC@PANI modified MXene-based magnetic aerogels with enhanced electromagnetic wave absorption properties

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Nano Research 2024年第3期17卷 2025-2037页

作者： meng Yu Ying huang Xudong Liu Kaihang She Xiaoxiao Zhao Wanqing Fan Xiaofang Ma Junhui Zou Tiehu Li MOE Key Laboratory of Material Physics and Chemistry Under Extraordinary Conditions School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710129China NPU-NCP Joint International Research Center on Advanced Nanomaterials&Defects Engineering State Key Laboratory of Solidification ProcessingShaanxi Engineering Laboratory for Graphene New Carbon Materials and ApplicationsSchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China

The rational and effective combination of multicomponent materials and ingenious microstructure design for efficient electromagnetic wave(EMW)absorption are still *** this paper,MXene was used as the aerogel matrix,modified with sea urchin-like magnetic Co/N-doped carbon@polyaniline(Co-NC@PANI),gelatin was introduced as the reinforcement phase of the aerogel backbone,and a microwave absorber with high efficiency and excellent performance was successfully *** sea urchin-like Co-NC@PANI not only adjusted the impedance matching of the MXene but also introduced a magnetic loss mode into the *** multicomponent interfacial polarization,heterostructure,three-dimensional(3D)lightweight porous structure,and electromagnetic synergy strategy enabled the MXene-based aerogel modified by Co-NC@PANI(MCoP)to exhibit surprising EMW absorption *** maximum reflection loss(RL_(max))of the aerogel composite reached-62.4 dB,and the effective absorption bandwidth(EAB)reached 6.56 GHz when the loading was only 12%.In addition,through electromagnetic simulation experiments,the change in the electromagnetic field before and after EMW passed through the materials and the distribution of the volume loss density of EMW by the coaxial ring were *** coordinated electromagnetic balance strategy in the 3D network provides inspiration for the construction of materials and expands the research direction of lightweight and outstanding microwave absorbers.

关键词： MXene sea urchin-like Co/N-doped carbon@polyaniline(Co-NC@PANI) aerogel electromagnetic synergy strategy electromagnetic wave absorption

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Prediction and quantification of effective gas source rocks in a lacustrine basin: Western Depression in the Liaohe Subbasin, China

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Petroleum Science 2024年第4期21卷 2218-2239页

作者： Si-Bo Yang Mei-Jun Li Hong Xiao fang-Zheng Wang Guo-Gang Cai Shuang-Quan huang State Key Laboratory of Petroleum Resources and Prospecting College of Geosciences China University of Petroleum China University of Petroleum-Beijing at Karamay College of Petroleum Research Institute of Petroleum Exploration and Development Liaohe Oilfield Company PetroChina

Due to limited data on the geochemical properties of natural gas, estimations are needed for the effective gas source rock in evaluating gas potential. However, the pronounced heterogeneity of mudstones in lacustrine successions complicates the prediction of the presence and geochemical characteristics of gas source rocks. In this paper, the Liaohe Subbasin of Northeast China is used as an example to construct a practical methodology for locating effective gas source rocks in typical lacustrine basins. Three types of gas source rocks, microbial, oil-type, and coal-type, were distinguished according to the different genetic types of their natural gas. A practical three-dimensional geological model was developed, refined, and applied to determine the spatial distribution of the mudstones in the Western Depression of the Liaohe Subbasin and to describe the geochemical characteristics(the abundance, type, and maturation levels of the organic matter). Application of the model in the subbasin indicates that the sedimentary facies have led to heterogeneity in the mudstones, particularly with respect to organic matter types. The effective gas source rock model constructed for the Western Depression shows that the upper sequence(SQ2) of the Fourth member(Mbr 4) of the Eocene Shahejie Formation(Fm) and the lower and middle sequences(SQ3 and SQ4) of the Third member(Mbr 3) form the principal gas-generating interval. The total volume of effective gas source rocks is estimated to be 586 km3. The effective microbial, oil-type, and coal-type gas source rocks are primarily found in the shallow western slope, the central sags, and the eastern slope of the Western Depression, respectively. This study provides a practical approach for more accurately identifying the occurrence and geochemical characteristics of effective natural gas source rocks, enabling a precise quantitative estimation of natural gas reserves.

关键词： Effective gas source rock 3D geological modeling Spatial distribution Geochemical characteristics Lacustrine rift basin

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Clinical relevance of distolingual roots and periodontal status in mandibular first molars: a cross-sectional study employing CBCT analysis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第3期25卷 244-253页

作者： Feifei MAO meng WANG Shuai ZHOU Yan ZHAO Jiaping huang Fengying YIN Haiping YANG Pei-hui DING Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityHangzhou 310016China

Objectives:Distolingual root of the permanent mandibular first molar(PMFM-DLR)has been frequently reported,which may complicate the treatment of *** study aimed to assess the morphological features of PMFM-DLR and investigate the correlation between the morphological features of PMFM-DLR and periodontal status in patients with Eastern Chinese ethnic *** and methods:A total of 836 cone beam computed tomography(CBCT)images with 1497 mandibular first molars were analyzed to observe the prevalence of PMFM-DLR at the patients and tooth levels in Eastern *** them,complete periodontal charts were available for 69 Chinese patients with 103 *** and regression analyses were used to evaluate the correlation between the morphological features of DLR,bone loss,and periodontal clinical parameters,including clinical attachment loss(CAL),probing pocket depth(PPD),gingival recession(GR),and furcation involvement(FI).Results:The patient-level prevalence and tooth-level prevalence of DLR in mandibular first molars were 29.4%and 26.3%,*** linear regression analysis suggested that bone loss at the lingual site and CAL were negatively affected by the angle of separation between distolingual and mesial roots in the transverse section,while they were significantly influenced by age and the angle of separation between distobuccal and mesial roots in the coronal ***:The prevalence of PMFM-DLR in Eastern China was relatively high in our *** morphological features of DLR were correlated with the periodontal status of mandibular first *** study provides critical information on the morphological features of DLR for improved diagnosis and treatment options of mandibular molars with DLR.

关键词： Distolingual root Mandibular first molar Periodontal clinical parameter Clinical attachment loss Cone beam computed tomography(CBCT)

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Add-on perceptual learning on refractive amblyopia in children

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1850-1856页

作者： Heng-Chiao huang Wan-Hua Cho Po-Chiung fang Pei-Wen Lin Yi-Hao Chen Hsiu-Mei huang Department of Ophthalmology Chang Gung Memorial HospitalChiayi 613TaiwanChina Department of Ophthalmology Chi-Mei Medical CenterTainan 710TaiwanChina Department of Ophthalmology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung City 833TaiwanChina School of Medicine Chang Gung UniversityTaoyuan City 333TaiwanChina

AIM:To evaluate the visual outcomes of standard amblyopic treatment add-on training via perceptual learning in refractive amblyopic children and to identify the risk factors for treatment ***:Retrospective charts were reviewed in children with refractive amblyopia who received standard treatment and add-on Cambridge Visual Stimulator(CAM)*** add-on CAM group that was enrolled had worn full-corrected glasses for at least 2mo before training.A control group received only the standard *** success was defined as best-corrected visual acuity(BCVA)≥20/*** age,sex,initial BCVA,refractive errors,sessions and duration of training,and final BCVA were ***:A total of 209 children(129 children in add-on CAM group and 80 children in control group)were ***-six percent of unilateral and 87%of bilateral amblyopic children achieved treatment *** children with unilateral or bilateral moderate amblyopia,the duration to reach BCVA≥20/25 was significantly shorter in add-on CAM group than in control *** initial BCVA(P<0.001)and high astigmatism(P=0.007)were risk factors for treatment failure after add-on CAM ***,sex,and types of refractive error were not associated with treatment ***:Add-on CAM training is an effective strategy for visual improvement and can shorten the treatment course when the effect of standard treatment is limited in amblyopic children.

关键词： amblyopia amblyopic children add-on Cambridge Visual Stimulator training astigmatism

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Convenient room-temperature synthesis of sulfur and nitrogen co-doped NiCo-LDH coupled with CNTs on NiCo foam as battery-type electrode for high performance hybrid supercapacitor

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Rare Metals 2024年第9期43卷 4286-4301页

作者： Li Song Xiao-Hong Zhong fang-Lin Wang Zhi-Hui huang Zhe Hong Yun-fang Gao Hai-Dong Wang Jian-Wei Ren Sheng-Jie Peng Lei Li College of Biological Chemical Sciences and EngineeringJiaxing UniversityJiaxing 314001China College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Research and Development Department Jiangxi Ganfeng LiEnergy Technology Co.Ltd.Xinyu 338000China Department of Mechanical Engineering Science University of JohannesburgAuckland ParkJohannesburg 2092South Africa

The convenient synthesis of the composite electrode with high supercapacitance performance plays an important role in practical application but is ***,the carbon nanotubes(CNTs)coupled with lowcrystalline sulfur and nitrogen co-doped Ni Co-LDH(denoted as SN-Ni Co-LDH)nanosheets array are grown on Ni Co foam(NCF)substrate by two convenient steps of metal induced self-assembly and corrosion engineering,which present the advantages of operating at roomtemperature and low preparation *** from the S–N co-doping and low-crystallinity of Ni Co-LDH,the prepared SN-Ni Co-LDH@CNTs@NCF electrode presents a topping charge capacity of 2470 C·g^(-1)(4.94 C·cm^(-2))at 5 m A·cm^(-2).Furthermore,the fabricated asymmetry supercapacitor(ASC)achieves an extraordinary energy density of 77 Wh·kg^(-1)(0.617 m Wh·cm^(-2))at a power density of 438 W·kg^(-1)(3.5 m W·cm^(-2))and outstanding stability(91%capacity retention after 5000 cycles at20 m A·cm^(-2)).Impressively,the structure evolution of Ni Co-LDH during the charge/discharge processes has been thoroughly elucidated by in-situ Raman ***,this work verifies a powerful strategy and practical value for preparing composite electrodes with high supercapacitance performance,and also provides guidance for the rational design of the smart electrodes.

关键词： Supercapacitor NiCo-LDH Carbon nanotubes Sulfur and nitrogen co-doped Convenient synthesis

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我国经济型酒店投资风险与措施研究

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特区经济 2009年第1期240卷 245-246页

作者：张梦芳黄亮浙江工业大学建筑工程学院浙江杭州310032

我国经济的不断增长与旅游业的发展,为新酒店业态的经济型酒店发展提供了广阔的市场空间。本文对经济型酒店进行了界定,阐述了我国经济型酒店的发展现状和存在的主要问题。分析其竞争压力和投资风险,提出了我国经济型酒店防御投资风险... 详细信息

我国经济的不断增长与旅游业的发展,为新酒店业态的经济型酒店发展提供了广阔的市场空间。本文对经济型酒店进行了界定,阐述了我国经济型酒店的发展现状和存在的主要问题。分析其竞争压力和投资风险,提出了我国经济型酒店防御投资风险的措施和未来的发展策略。

关键词：经济型酒店投资风险发展策略

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Pien Tze huang Inhibits Proliferation of Colorectal Cancer Cells through Suppressing PNO1 Expression and Activating p53/p21 Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第6期30卷 515-524页

作者： CAO Liu-jing LIU Li-ya CHEN You-qin HAN Yu-ying WEI Li-hui YAO meng-ying fang Yi WU Mei-zhu CHENG Ying Thomas J.Sferra LIU Hui-xin LI Li PENG Jun SHEN A-ling Clinical Research Institute the Second Affiliated Hospital&Academy of Integrative MedicineFujian University of Traditional Chinese MedicineFuzhou350122China Fujian Key Laboratory of Integrative Medicine in Geriatrics Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Pediatrics Case Western Reserve University School of MedicineUH Rainbow Babies and Children’s HospitalClevelandOH44106USA Innovation and Transformation Center Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Health Management Fujian Provincial HospitalShengli Clinical College of Fujian Medical UniversityFuzhou000000China

ObjectiveTo explore the regulatory effect of Pien Tze huang (PZH) on targeting partner of NOB1 (PNO1) and it’s down-stream mediators in colorectal cancer (CRC) *** polymerase chain reaction was performed to determine mRNA levels of PNO1, TP53, and CDKN1A. Western blotting was performed to determine protein levels of PNO1, p53, and p21. HCT-8 cells were transduced with a lentivirus over-expressing PNO1. Colony formation assay was used to detect cell survival in PNO1 overexpression of HCT-8 cells after PZH treatment. Cell-cycle distribution, cell viability and cell apoptosis were performed to identify the effect of PNO1 overexpression on cell proliferation and apoptosis of HCT-8 cells after PZH treatment. Xenograft BALB/c nude mice bearing HCT116 cells transduced with sh-PNO1 or sh-Ctrl lentivirus were evaluated. Western blot assay was performed to detect PNO1, p53, p21 and PCNA expression in tumor sections. Terminal deoxynucleotidyl transferase dUTP nick end labling (TUNEL) assay was used to determine the apoptotic cells in *** treatment decreased cell viability, down-regulated PNO1 expression, and up-regulated p53 and p21 expressions in HCT-8 cells (P<0.05). PNO1 overexpression attenuated the effects of PZH treatment, including the expression of p53 and p21, cell growth, cell viability, cell cycle arrest and cell apoptosis in vitro (P<0.05). PNO1 knockdown eliminated the effects of PZH treatment on tumor growth, inhibiting cell proliferation inhibition and apoptosis induction in vivo (P<0.05). Similarly, PNO1 knockdown attenuated the effects of PZH treatment on the down-regulation of PNO1 and up-regulation of p53 and p21 in vivo (P<0.05).ConclusionThe mechanism by which PZH induces its CRC anti-proliferative effect is at least in part by regulating the expression of PNO1 and its downstream targets p53 and p21.

关键词： colorectal cancer Pien Tze huang Chinese medicine partner of NOB1 proliferation p53/p21 pathway

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Study on the mechanism of near-field underwater explosion on supported thin plates with prefabricated holes

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Acta Mechanica Sinica 2024年第8期40卷 32-44页

作者： Si Chen Jian Qin Xiangyao meng Zhichao Lai Yanbo Wen Ruiyuan huang School of Mechatronical Engineering Beijing Institute of TechnologyBeijing100081China Naval Academy Beijing100161China College of Civil Engineering Fuzhou UniversityFuzhou350116China

In this study,underwater explosion tests with 2.5 g trinitrotoluene explosive under different fixed plates with prefabricated holes were *** experimental results showed that the air inflow from the prefabricated hole caused the bubble to collapse earlier with an increase in the hole *** addition,the deformation mode of the thin plate transitioned from“convex”to“concave”(up to down).Next,the coupled Eulerian-Lagrangian method was used to perform the corresponding numerical *** accuracy of the numerical simulation method was verified through a comparison with the experimental *** addition,a series of numerical simulations were conducted with different prefabricated-hole diameters,blast distances,and prefabricated-hole *** results showed that the bubble-pulsating water jet substantially influenced the deformation of the thin plate when the diameter of the prefabricated hole was within the theoretical maximum bubble *** the blast distance was within the theoretical maximum bubble radius,the thin plate was subjected to only a single bubble pulsation owing to the air inflow from the prefabricated hole.

关键词： Underwater explosion Hole High-speed camera Bubble pulsation Fixed plate

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Photocatalytic oxidation of methane to methanol over zinc titanate supported silver catalysts

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Journal of Rare Earths 2024年第5期42卷 899-906,I0004页

作者： Yuyan Gan Jinbi huang Qian Lv Yanru Li Lizhi Wu YU Tang Yuanxing fang Pengfei Zhu Li Tan Institute of Molecule Catalysis and In-Situ/Operando Studies State Key Laboratory of Photocatalysis on Energy and EnvironmentCollege of ChemistryFuzhou UniversityFuzhou350108China School of Environmental Science and Engineering Shaanxi University of Science and TechnologyXi'an 70021China

The direct activation of methane under mild condition to achieve highly selective of oxygenates is a challenging *** this study,a well dispersed silver supported ZnTiO_(3) catalyst was prepared to achieve selective preparation of methanol from methane and water under mild condition.X-ray diffraction,transmission electron microscopy and X-ray photoelectron spectroscopy characterizations demonstrate that silver species are uniformly dispersed on ZnTiO_(3) surface in the form of metallic silver *** photoelectric characterizations reveal that the addition of silver species enhances light absorption and promotes charge separation of the *** the reaction conditions of 50℃and 3 MPa,the methanol is obtained as the only liquid product over the designed Ag/ZnTiO_(3) catalyst under light *** this photocatalytic process,the holes generated by ZnTiO_(3) activate water to produce intermediate·OH,which further reacts with methane to synthesize *** silver species as co-catalysts extend the light absorption range of ZnTiO_(3) as well as promote charge separation.

关键词： Photocatalytic Methane oxidation Zinc titanate Silver Methanol

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