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Coastal hypoxia response to the coupling of catastrophic flood,extreme marine heatwave and typhoon:a case study off the Changjiang River Estuary in summer 2020

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Acta Oceanologica Sinica 2024年第6期43卷 107-118页

作者： Xiao Ma Qicheng meng Dewang Li Yuanli Zhu Xiaobo Ni Dingyong Zeng Di Tian Ting huang Zhihao Jiang Haiyan Jin Feng Zhou State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Observation and Research Station of Yangtze River Delta Marine Ecosystems Ministry of Natural ResourcesZhoushan 316022China Key Laboratory of Marine Ecosystem Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China School of Oceanography Shanghai Jiao Tong UniversityShanghai 200240China College of Oceanography Zhejiang UniversityZhoushan 316021China

Massive bodies of low-oxygen bottom waters are found in coastal areas worldwide,which are detrimental to coastal *** summer 2020,the response of coastal hypoxia to extreme weather events,including a catastrophic flooding,an extreme marine heatwave,and Typhoon Bavi,is investigated based on multiple satellite,four cruises,and mooring *** extensive fan-shaped hypoxia zone presents significant northward extension during July-September 2020,and is estimated as large as 13 000 km^(2) with rather low oxygen minimum(0.42 mg/L) during its peak in 28-30 *** severe hypoxia is attributed to the persistent strong stratification,which is indicated by flood-induced larger amount of riverine freshwater input and subsequent marine heatwave off the Changjiang River ***,the Typhoon Bavi has limited effect on the marine heatwave and coastal hypoxia in summer 2020.

关键词： coastal hypoxia Changjiang River Estuary extreme weather events seasonal evolution

Single-cell transcriptome sequencing reveals the mechanism regulating rice plumule development

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The Crop Journal 2024年第3期12卷 688-697页

作者： Mingdong Zhu meng Zhang Kunyong huang Feifei Lu Hong Wang Shaolu Zhao Yinghong Yu Shaoqing Tang Haining Wu Peisong Hu Xiangjin Wei State Key Laboratory of Rice Biology and Breeding China National Center for Rice ImprovementChina National Rice Research InstituteHangzhou 310006ZhejiangChina b State Key Laboratory of Hybrid Rice Hunan Rice Research InstituteHunan Academy of Agricultural SciencesChangsha 410125HunanChina Hunan Provincial Key Laboratory of Plant Functional Genomics and Developmental Regulation College of BiologyHunan UniversityChangsha 410082HunanChina Hubei University Wuhan 430062HubeiChina

Seed plumules comprise multiple developing tissues and are key sites for above-ground plant organ ***,the spatial expression of genes in developing rice seed plumules was characterized by single-cell transcriptome sequencing in Zhongjiazao 17,a popular Chinese indica rice *** 15 cell clusters,13 were assigned to cell types using marker genes and cluster-specific *** genes of multiple cell types were expressed in several clusters,suggesting a complex developmental *** genes for signaling by phytohormones such as abscisic acid were highly expressed in specific *** cis-elements in the promoters of genes specifically expressed in cell clusters were calculated,and some key hormone-related motifs were frequent in certain *** expression patterns of genes involved in rapid seed germination,seedling growth,and development were *** findings enhanced our understanding of cellular diversity and specialization within plumules of rice,a monocotyledonous model crop.

关键词： Rice Plumule Single-cell sequencing Regulatory network

Loss of monopolar spindle-binding protein 3B expression promotes colorectal cancer malignant behaviors by activation of target of rapamycin kinase/autophagy signaling

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World Journal of Gastroenterology 2024年第26期30卷 3229-3246页

作者： Juan Sun Jin-Xiu Zhang meng-Shi Li meng-Bin Qin Ruo-Xi Cheng Qing-Ru Wu Qiu-Ling Chen Dan Yang Cun Liao Shi-Quan Liu Jie-An huang Department of Gastroenterology The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530007Guangxi Zhuang Autonomous RegionChina Department of Colorectal&Anal Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Monopolar spindle-binding protein 3B(MOB3B)functions as a signal transducer and altered MOB3B expression is associated with the development of human *** To investigate the role of MOB3B in colorectal cancer(CRC).METHODS This study collected 102 CRC tissue samples for immunohistochemical detection of MOB3B expression for association with CRC *** overexpression and knockdown of MOB3B expression were induced in CRC cell lines,changes in cell viability,migration,invasion,and gene expression were *** cell autophagy was detected using transmission electron microscopy,while nude mouse xenograft experiments were performed to confirm the in-vitro *** MOB3B expression was reduced in CRC vs normal tissues and loss of MOB3B expression was associated with poor CRC *** of MOB3B protein in vitro attenuated the cell viability as well as the migration and invasion capacities of CRC cells,whereas knockdown of MOB3B expression had the opposite effects in CRC *** the molecular level,microtubule-associated protein light chain 3 II/I expression was elevated,whereas the expression of matrix metalloproteinase(MMP)2,MMP9,sequestosome 1,and phosphorylated mechanistic target of rapamycin kinase(mTOR)was downregulated in MOB3B-overexpressing RKO *** contrast,the opposite results were observed in tumor cells with MOB3B *** nude mouse data confirmed these in-vitro findings,i.e.,MOB3B expression suppressed CRC cell xenograft growth,whereas knockdown of MOB3B expression promoted the growth of CRC cell *** Loss of MOB3B expression promotes CRC development and malignant behaviors,suggesting a potential tumor suppressive role of MOB3B in CRC by inhibition of mTOR/autophagy signaling.

关键词： Colorectal cancer Monopolar spindle-binding protein 3B Mechanistic target of rapamycin kinase Autophagy Prognosis

Photon counting technique as a potential tool in micro-defect detection of epoxy insulation pull rod in gas-insulated switchgears

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High Voltage 2024年第2期9卷 267-274页

作者： Xianhao Fan Shu Niu Hanhua Luo Jizhong Liang fang Liu Wenqiang Li Weidong Liu Wensheng Gao Yulong huang Chuanyang Li Jinliang He School of Electrical Engineering Tsinghua UniversityBeijingChina Electric Power Research Institute Shangxi Power Grid CorporationTaiyuanShanxiChina Shandong Taikai Electrical Insulation Co. Ltd.TaianShandongChina

The micro-defects in epoxy-based insulation materials generate a local high electric field which results in continuous degradation,seriously endangering the insulation system of gas-insulated switchgears.A highly sensitive detection technique is reported for micro-defects of insulation pull rods based on the photon counting(PC)*** re-sults demonstrated that for an epoxy-based insulation pull rod,the photons released during electroluminescence and ionisation at 2 kV,which is less than the partial discharge inception voltage,can be clearly *** findings presented a strong correlation between photon counts and defect *** has been conducted to elucidate the mechanism behind defect-induced PC,employing the amplification of ionising luminescence through electric field distortion induced by micro defects and the augmentation of electroluminescence through the aggregation of trap *** this regard,the authors verified that PC can serve as a potential tool in the detection of micro-insulation defects,which also has huge potential in online insulation condition monitoring.

关键词： technique. insulation defect

Synthesis and nitrogen content regulation of diamond in a high-pressure hydrogen-rich environment

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Chinese Physics B 2024年第6期33卷 541-546页

作者：黄国锋陈良超房超 Inner Mongolia Key Laboratory of High-pressure Phase Functional Materials Chifeng UniversityChifeng 024000China Key Laboratory of Material Physics of Ministry of Education School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China

The regulating nitrogen content of diamond in a hydrogen-rich high-temperature and high-pressure(HPHT) growth environment was systematically investigated in this work by developing three growth systems,namely, "FeNi+Ti", "FeNi+G_(3)N_(6)H_(6)",and "FeNi+Ti+C_(3)N_(6)H_(6)".Optical microscopy,infrared spectroscopy,and photoluminescence(PL)spectroscopy measurements were conducted to analyze the spectroscopic characteristics of diamonds grown in these three *** our analysis,it was demonstrated that the presence of hydrogen in the sp^(3) hybrid C-H does not directly affect the color of the diamond and facilitates the increase of the nitrogen-vacancy(NV) center concentration in a highnitrogen-content *** addition,titanium plays an important role in nitrogen removal,while its impact on hydrogen doping within the diamond lattice is *** importantly,by regulating the ratio of nitrogen impurities that coexist in the nitrogen and hydrogen HPHT environment,the production of hydrogenous Ⅱa-type diamond,hydrogenous Ib-type diamond,and hydrogenous high-nitrogen-type diamonds was achieved with a nitrogen content of less than 1 ppm to 1600 ppm.

关键词： diamond HPHT superhard material hydrogen-rich environment

Health benefits from the rapid reduction in ambient exposure to air pollutants after China's clean air actions:progress in efficacy and geographic equality

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National Science Review 2024年第2期11卷 103-113页

作者： Tao Xue Ruohan Wang meng Wang Yanying Wang Dan Tong Xia meng Conghong huang Siqi Ai fangzhou Li Jingyuan Cao Mingkun Tong Xueqiu Ni Hengyi Liu Jianyu Deng Hong Lu Wei Wan Jicheng Gong Shiqiu Zhang Tong Zhu Institute of Reproductive and Child Health National Health Commission Key Laboratory of Reproductive Health/Department of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Epidemiology of Major Diseases(PKU) School of Public Health Peking University Health Science Centre State Environmental Protection Key Laboratory of Atmospheric Exposure and Health Risk Management and Center for Environment and Health Peking University Advanced Institute of Information Technology Peking University Department of Epidemiology and Environmental Health School of Public Health and Health ProfessionsUniversity at Buffalo State Key Joint Laboratory of Environment Simulation and Pollution Control College of Environmental Sciences and EngineeringPeking University Department of Earth System Science Tsinghua University School of Public Health Key Laboratory of Public Health Safety of the Ministry of Education and Key Laboratory of Health Technology Assessment of the Ministry of HealthFudan University College of Land Management Nanjing Agricultural University National&Local Joint Engineering Research Center for Rural Land Resources Use and Consolidation Clean Air Asia

Clean air actions （CAAs） in China have been linked to considerable benefits in public ***,whether the beneficial effects of CAAs are equally distributed geographically is *** high-resolution maps of the distributions of major air pollutants (fine particulate matter[PM2.5]and ozone[O3]) and population,we aimed to track spatiotemporal changes in health impacts from,and geographic inequality embedded in,the reduced exposures to PM2.5and O3from 2013 to *** used a method established by the Global Burden of Diseases *** analyzing the changes in loss of life expectancy（LLE） attributable to PM2.5and O3,we calculated the gain of life expectancy （GLE） to quantify the health benefits of the air-quality ***,we assessed the geographic inequality embedded in the GLE using the Gini index （GI）.Based on risk assessments of PM2.5and O3,during the first stage of CAAs（2013 to 2017）,the mean GLE was 1.87 *** of the sum of the GLE was disproportionally distributed in about one quarter of the population exposed （GI 0.44）.During the second stage of CAAs（2017 to 2020）,the mean GLE increased to 3.94 months and geographic inequality decreased （GI 0.18）.According to our assessments,CAAs were enhanced,from the first to second stages,in terms of not only preventing premature mortality but also ameliorating health *** enhancements were related to increased sensitivity to the health effects of air pollution and synergic control of PM2.5and *** findings will contribute to optimizing future CAAs.

关键词： clean air action public health inequality fine particulate matter ozone

Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPβ-SCD activation in non-alcoholic fatty liver disease

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Zoological Research 2024年第1期45卷 79-94页

作者： Ya-Ling Zhu Lei-Lei meng Jin-Hu Ma Xin Yuan Shu-Wen Chen Xin-Rui Yi Xin-Yu Li Yi Wang Yun-Shu Tang Min Xue Mei-Zi Zhu Jin Peng Xue-Jin Lu Jian-Zhen huang Zi-Chen Song Chong Wu Ke-Zhong Zheng Qing-Qing Dai Fan huang Hao-Shu fang Department of Pathophysiology Anhui Medical UniversityHefeiAnhui 230032China Laboratory Animal Research Center School of Basic Medical SciencesAnhui Medical UniversityHefeiAnhui 230032China Department of Hepatobiliary Surgery First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China College of Animal Science and Technology Jiangxi Agricultural UniversityNanchangJiangxi 330045China

Non-alcoholic fatty liver disease(NAFLD)is associated with mutations in lipopolysaccharide-binding protein(LBP),but the underlying epigenetic mechanisms remain ***,LBP^(-/-)rats with NAFLD were established and used to conduct integrative targetingactive enhancer histone H3 lysine 27 acetylation(H3K27ac)chromatin immunoprecipitation coupled with high-throughput and transcriptomic sequencing analysis to explore the potential epigenetic pathomechanisms of active enhancers of NAFLD exacerbation upon LBP ***,LBP^(-/-)reduced the inflammatory response but markedly aggravated high-fat diet(HFD)-induced NAFLD in rats,with pronounced alterations in the histone acetylome and regulatory *** total,1128 differential enhancer-target genes significantly enriched in cholesterol and fatty acid metabolism were identified between wild-type(WT)and LBP^(-/-)NAFLD *** on integrative analysis,CCAAT/enhancer-binding proteinβ(C/EBPβ)was identified as a pivotal transcription factor(TF)and contributor to dysregulated histone acetylome H3K27ac,and the lipid metabolism gene SCD was identified as a downstream effector exacerbating *** study not only broadens our understanding of the essential role of LBP in the pathogenesis of NAFLD from an epigenetics perspective but also identifies key TF C/EBPβand functional gene SCD as potential regulators and therapeutic targets.

关键词： Non-alcoholic fatty liver disease C/EBPβ Lipopolysaccharide-binding protein H3K27ac Integrative analysis Enhancer

Asymmetric NiH-Catalyzed Regioselective Hydroalkynylation of Unactivated Alkenes

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CCS Chemistry 2024年第8期6卷 1929-1940页

作者： mengyuan Liu Haoran Shi Xiao meng Rui He Jie huang Jiaxin Wang Jun Lv Chao Wang Tianjin Key Laboratory of Structure and Performance for Functional Molecules College of ChemistryTianjin Normal UniversityTianjin 300387

Herein,we disclose a ligand-controlled,directing group-assisted strategy to facilitate NiH-catalyzed hydroalkynylation of allyl amides at remoteα-position adjacent to nitrogen and initial olefinic site in a predictable and switchable *** regiodivergent hydroalkynylation and asymmetric hydroalkynylation with a wide alkyne scope were achieved,producingα-and(enantioenriched)β-branched alkynyl-functionalized amine derivatives from the same raw *** formation of a carbonyl-ligated 5-or 6-membered nickelacycle intermediate via Ni migration or nonmigration was believed to be the key step in controlling the *** asymmetric protocol could be applied to synthesizing other value-added chiral aliphatic amines.

关键词： asymmetric catalysis hydroalkynylation regiodivergent chain-walking nickel catalysis

A preliminary site selection system for underground hydrogen storage in salt caverns and its application in Pingdingshan,China

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Deep Underground Science and Engineering 2024年第1期3卷 117-128页

作者： Liangchao huang Yanli fang Zhengmeng Hou Yachen Xie Lin Wu Jiashun Luo Qichen Wang Yilin Guo Wei Sun Sino‐German Research Institute of Carbon Neutralization and Green Development Zhengzhou UniversityZhengzhouChina Institute of Subsurface Energy Systems Clausthal University of TechnologyClausthal ZellerfeldGermany Research Centre of Energy Storage Technologies Clausthal University of TechnologyGoslarGermany Sino‐German Energy Research Center Sichuan UniversityChengduChina State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhanChina Faculty of Land and Resources Engineering Kunming University of Science and TechnologyKunmingChina

Large‐scale underground hydrogen storage(UHS)provides a promising method for increasing the role of hydrogen in the process of carbon neutrality and energy *** all the existing storage deposits,salt caverns are recognized as ideal sites for pure hydrogen *** and optimization of site selection for hydrogen storage facilities in salt caverns have become significant *** this article,the software CiteSpace is used to analyze and filter hot topics in published *** on a detailed classification and analysis,a“four‐factor”model for the site selection of salt cavern hydrogen storage is proposed,encompassing the dynamic demands of hydrogen energy,geological,hydrological,and ground factors of salt ***,20 basic indicators for comprehensive suitability grading of the target site were screened using the analytic hierarchy process and expert survey methods were adopted,which provided a preliminary site selection system for salt cavern hydrogen ***,the developed system was applied for the evaluation of salt cavern hydrogen storage sites in the salt mines of Pingdingshan City,Henan Province,thereby confirming its rationality and *** research provides a feasible method and theoretical basis for the site selection of UHS in salt caverns in China.

关键词： analytic hierarchy process(AHP) evaluation index hydrogen storage salt cavern site selection