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Efficacy of imatinib dose escalation in Chinese gastrointestinal stromal tumor patients

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World Journal of Gastroenterology 2012年第7期18卷 698-703页

作者： jian li ji-fang Gong jie li jing Gao Nai-Ping Sun lin Shen Laboratory of Carcinogenesis and Translational Researchfor the Ministry of National Education Department of GI Oncol-ogy Peking University School of Oncology Beijing Cancer Hos-pital and Institute Beijing 100142 China

AIM： To investigate the efficacy and safety of imatinib dose escalation in Chinese patients with advanced gas- trointestinal stromal tumor （GIST）.

关键词： Gene mutation Gastrointestinal stromal tu-mor Imatinib Increased dose

Transcriptome analysis of the endangered Notopterygium incisum: Coldtolerance gene discovery and identification of EST-SSR and SNP markers

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Plant Diversity 2019年第1期41卷 1-6页

作者： Yun jia ji-Qing Bai Mi-li liu Zhen-fang jiang Yan Wu Min-Feng fang Zhong-Hu li Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of Education College of Life Sciences Northwest University Shaanxi University of Chinese Medicine

Notopterygium incisum C. C. Ting ex H. T. Chang(Apiaceae) is an endangered perennial herb in China. The lack of transcriptomic and genomic resources for N. incisum greatly hinders studies of its population genetics and conservation. In this study, we employed RNA-seq technology to characterize transcriptomes for the flowers, leaves, and stems of this endangered herb. A total of 56 million clean reads were assembled into 120,716 unigenes with an N50 length of 850 bp. Among these unigenes, 70,245(58.19%) were successfully annotated and 65,965(54.64%) were identified as coding sequences based on their similarities with sequences in public databases. We identified 21 unigenes that had significant relationships with cold tolerance in N. incisum according to gene ontology(GO) annotation analysis. In addition, 13,149 simple sequence repeats(SSRs) and 85,681 single nucleotide polymorphisms were detected as potential molecular genetic markers. Ninety-six primer pairs of SSRs were randomly selected to validate their amplification efficiency and polymorphism. Nineteen SSR loci exhibited polymorphism in three natural populations of N. incisum. These results provide valuable resources to facilitate future functional genomics and conservation genetics studies of N. incisum.

关键词： Endangered species EST-SSR marker Notopterygium incisum Single nucleotide polymorphism Transcriptome

Implementation of the parallel mean shift-based imagesegmentation algorithm on a GPU cluster

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International Journal of Digital Earth 2019年第3期12卷 328-353页

作者： fang Huang Yinjie Chen li li ji Zhou jian Tao Xicheng Tan Guangsong Fana School of Resources&Environment University of Electronic Science and Technology of ChinaChengduPeople’s Republic of China Institute of Remote Sensing Big Data Big Data Research CenterUniversity of Electronic Science and Technology of ChinaChengduPeople’s Republic of China School of Construction&Management Engineering Xihua UniversityChengduPeople’s Republic of China Texas A&M Engineering Experiment Station and High Performance Research Computing Texas A&M UniversityCollege StationTXUSA International School of Software Wuhan UniversityWuhanPeople’s Republic of China

The mean shift image segmentation algorithm is very computationintensive. To address the need to deal with a large number of remotesensing (RS) image segmentations in real-world applications, this studyhas investigated the parallelization of the mean shift algorithm on asingle graphics processing unit (GPU) and a task-scheduling methodwith message passing interface (MPI)+OpenCL programming model on aGPU cluster platform. This paper presents the test results of the parallelmean shift image segmentation algorithm on Shelob, a GPU clusterplatform at Louisiana State University, with different datasets andparameters. The experimental results show that the proposed parallelalgorithm can achieve good speedups with different configurations andRS data and can provide an effective solution for RS image processingon a GPU cluster.

关键词： Mean shift algorithm GPU cluster task scheduling MPI OpenCL

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脓毒症辨治探析

上海中医药杂志 2009年第3期43卷 45-46页

作者：杨荣源方志坚李际强广州中医药大学第二附属医院急诊科广东广州510120

探讨脓毒症的病因病机及治疗方法。认为热毒内蕴、内陷营血、腑气不通是脓毒症的主要病理基础,瘀血阻络贯穿脓毒症始终;治疗当以通腑活血法,方选桃核承气汤化裁。

关键词：脓毒症通腑活血法桃核承气汤

Effect of Cooling Water Flow Path on the Flow and Heat Transfer in a 660 MW Power Plant Condenser

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Journal of Thermal Science 2019年第2期28卷 262-270页

作者： ZHONG Dawen MENG ji'an QIN Peng QIU Xiaolong jiANG Ping li Zhixin YUAN fang Beijing Key Laboratory of Passive Safety Technology for Nuclear Energy North China Electric Power University Key Laboratory of Thermal Science and Power Engineering of Ministry of Education School of Aerospace Engineering Tsinghua University Central Southern China Electric Power Design Institute CO.LTD Shanxi Zhaozhuang Xinguang Power Generation CO.LTD School of Energy and Power Engineering Huazhong University of Science and Technology

The effect of the cooling water flow path on the flow and heat transfer in a double tube-pass condenser for a 660 MW power plant unit was numerically investigated based on a porous medium model. The results were used to analyze the streamline, velocity, air mass fraction and heat transfer coefficient distributions. The simulations indicate that the cooling water flow path is important in large condensers. For the original tube arrangement, the heat transfer with the lower-upper cooling water flow path is better than that with the upper-lower cooling water flow path. The reason is that the steam cannot flow into the internal of upper tube bundle and the air fractions are higher in the upper tube bundle with the upper-lower cooling water flow path. An improvement tube arrangement was developed for the upper-lower cooling water flow path which reduced the back pressure by 0.47 kPa compared to the original scheme. Thus, the results show that the tube arrangements should differ for different cooling water flow paths and the condenser heat transfer can be improved for the upper-lower cooling water flow path by modifying the tube arrangement.

关键词： steam surface condenser porous media cooling water flow path condensation computational fluid dynamics

Synthesis and Biological Activities of Novel 1,2,4-Triazole Derivatives Containing 1,2,3-Thiadiazole Ring

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Chemical Research in Chinese Universities 2014年第3期30卷 390-395页

作者： li Yuedong MAO Wutao FAN Zhijin li Juanjuan fang Zhen ji Xiaotian ZONG Guangning li Fengyun State Key Laboratory of Elemento-organic Chemistry Nankai University Tianjin 300071 P. R. China College of Chemistry and Pharmacy Engineering Nanyang Normal University Nanyang 473061 P R. China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Nankai University Tianjin 300071 P. R. China

A series of novel 1,2,4-triazole derivatives containing 1,2,3-thiadiazole ring was designed and synthesized. Their structures were confirmed by IR, 1^H NMR, high resolution mass spectrometer（HRMS） and electrospray ionization-mass spectromcter（ESI-MS） combined with melting points and elemental analysis. Preliminary bioassays indi- cate that these compounds exhibit good insecticidal activity against Aphis laburni at 100 μg/mL, especially compound 6b shows mortality of no less than 95%. Most of the compounds show good activities against tobacco mosaic virus（TMV） with different modes in vivo at 100 μg/mL. Compound 6d standed out, showing a good insecticidal activity and very high induction effects against TMV in vivo. Collectively, our data demonstrate a new strategy for insect and virus control.

关键词： 1,2,3-Thiadiazole 1,2,4-Triazole Insecticidal activity Anti-tobacco mosaic virus(TMV) activity

Distinct roles of pH and organic ligands in the dissolution of goethite by cysteine

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Journal of Environmental Sciences 2022年第3期34卷 260-268页

作者： ji li Chenlu Shi Wenbin Zeng Yaru Wang Zebin Hong Yibing Ma liping fang Faculty of Material Sciences and Chemistry China University of GeosciencesWuhan 430074China Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management Institute of Eco-environmental and Soil SciencesGuangdong Academy of SciencesGuangzhou 510650China National-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China Guangzhou 520650China Macao Environmental Research Institute Macao University of Science and TechnologyTaipa 999078MachaoChina

Electron shuttles such cysteine play an important role in Fe cycle and its availability in soils,while the roles of pH and organic ligands in this process are poorly ***,the reductive dissolution process of goethite by cysteine were explored in the presence of organic *** results showed that cysteine exhibited a strong reactivity towards goethite-a typical iron minerals in paddy soils with a rate constant ranging from 0.01 to0.1 hr^(-1).However,a large portion of Fe(Ⅱ) appeared to be "structural species" retained on the *** decline of pH was favorable to generate more Fe(Ⅱ) ions and enhancing tendency of Fe(Ⅱ) release to *** decline of generation of Fe(Ⅱ) by increasing pH was likely to be caused by a lower redox potential and the nature of cysteine pH-dependent adsorption towards ***,the co-existence of oxalate and citrate ligands also enhanced the rate constant of Fe(Ⅱ) release from 0.09 to 0.15 hr-1;nevertheless,they negligibly affected the overall generation of Fe(Ⅱ) in opposition to the pH *** spectroscopic evidence demonstrated that two molecules of cysteine could form disulfide bonds(S-S) to generate cystine through oxidative dehydration,and subsequently,inducing electron transfer from cysteine to the structural Fe(Ⅲ) on goethite;meanwhile,those organic ligands act as Fe(Ⅱ) "strippers".The findings of this work provide new insights into the understanding of the different roles of pH and organic ligands on the generation and release of Fe induced by electron shuttles in soils.

关键词： Electron transfer Reductive dissolution Iron cycling Organic ligands

Authentication and Access Control in RFID Based Logistics-customs Clearance Service Platform

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International Journal of Automation and computing 2010年第2期7卷 180-189页

作者： Hui-fang Deng Wen Deng Han li Hong-ji Yang School of Computer Science and Engineering South China University of Technology Guangzhou 510006 PRC School of Software Engineering South China University of Technology Guangzhou 510006 PRC School of Computer Science and Technology Dalian University of Technology Dalian 116023 PRC School of Computing De Montfort University Leicester LE1 9BH UK

The content security requirements of a radio frequency identification （RFID） based logistics-customs clearance service platform （LCCSP） are analysed in this paper. Then, both the unified identity authentication and the access control modules are designed according to those analyses. Finally, the unified identity authentication and the access control on the business level are implemented separately. In the unified identity authentication module, based on an improved Kerberos-based authentication approach, a new control transfer method is proposed to solve the sharing problem of tickets among different servers of different departments. In the access control module, the functions of access controls are divided into different granularities to make the access control management more flexible. Moreover, the access control module has significant reference value for user management in similar systems.

关键词： Content security unified identity authentication control transfer access control logistics-customs clearance service platform (LCCSP).

Molecular Dynamics Simulation of Diffusion Coefficients of Oxygen, Nitrogen and Sodium Chloride in Supercritical Water

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Chinese Physics Letters 2001年第7期18卷 847-849页

作者： XIAO ji LU jiu-fang CHEN jian li Yi-Gui Department of Chemical Engineering Tsinghua UniversityBeijing 100084

Molecular dynamics simulation has been performed to determine the infinite-dilution diffusion coefficients of oxygen and nitrogen, and the diffusion coefficients of NaCl in supercritical water from 703.2-763.2 K and 30-45 MPa. The results obtained show that the diffusion coefficients in supercritical water increase with temperature, while decrease with pressure. Nevertheless, the diffusion coefficients in supercritical water are much larger than those in normal water.

关键词： diffusion Molecular Oxygen