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Design of Lattice Structures Using Local Relative Density Mapping Method

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Chinese Journal of Mechanical Engineering 2018年第5期31卷 110-118页

作者： Guo-Hua Song Shi-Kai Jing fang-lei zhao Ye-Dong Wang Hao Xing Long-Fei Qie Beijing Xinghang Mechanical-electrical Equipment Co.Ltd. Beijing 100074 China School of Mechanical Engineering Beijing Institute of Technology Beijing 100081 China

In order to solve the problem of substantial computational resources of lattice structure during optimization, a local relative density mapping(LRDM) method is proposed. The proposed method uses solid isotropic microstructures with penalization to optimize a model at the macroscopic scale. The local relative density information is obtained from the topology optimization result. The contour lines of an optimized model are extracted using a density contour approach, and the triangular mesh is generated using a mesh generator. A local mapping relationship between the elements’ relative density and the struts’ relative cross?sectional area is established to automatically determine the diameter of each individual strut in the lattice structures. The proposed LRDM method can be applied to local finite element meshes and local density elements, but it is also suitable for global ones. In addition, some cases are con?sidered in order to test the e ectiveness of the LRDM method. The results show that the solution time of the LRDM is lower than the RDM method by approximately 50%. The proposed method provides instructions for the design of more complex lattice structures.

关键词： Lattice structures Local relative density mapping Topology optimization Additive manufacturing

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一种改进的SAR影像边缘检测方法

测绘通报 2017年第9期 56-59页

作者：刘晓君韩芳赵磊山东农业大学山东泰安271018 山东理工大学山东淄博255000 山东能源集团有限公司山东菏泽274700

由于SAR影像具有乘性相干斑噪声,某些对光学影像有较好检测性能的边缘检测算子,对于SAR影像并不适用,因此本文提出了一种将改进后的Ratio算子与Canny算子相组合的新方法。首先采用多种客观评价指标,得出经典方法中的Lee滤波能有效去除噪... 详细信息

由于SAR影像具有乘性相干斑噪声,某些对光学影像有较好检测性能的边缘检测算子,对于SAR影像并不适用,因此本文提出了一种将改进后的Ratio算子与Canny算子相组合的新方法。首先采用多种客观评价指标,得出经典方法中的Lee滤波能有效去除噪声,且最大限度保留了梯度信息,适用于边缘检测;然后对边缘检测具有恒虚警特性的Ratio算子进行改进,改进后的算子更利于影像归一化处理;最后利用改进后的Ratio算子与Canny算子组合成新方法。试验结果证明,组合后的新方法显著提高了边缘检测正确率和定位精度,改善了边缘连续性,具有一定的有效性和实用性。

关键词： SAR影像边缘检测 Lee滤波改进Ratio算子 Canny算子

液相泡沫复合微波活化技术制备分级多孔泡沫碳及电化学性能

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材料工程 2018年第11期46卷 63-70页

作者：辛兆鹏方伟赵雷何漩陈辉李薇馨孙志敏武汉科技大学省部共建耐火材料与冶金国家重点实验室武汉430081

以液相泡沫为软模板、水溶性酚醛树脂为碳源、异氰酸酯作为固化剂,复合微波活化技术制备出具有分级多孔结构特征的泡沫碳,对其结构和电化学性能进行分析表征。结果表明:微波活化技术可促进泡沫液膜上H_2O分子的快速逸出,于泡沫碳孔壁上... 详细信息

以液相泡沫为软模板、水溶性酚醛树脂为碳源、异氰酸酯作为固化剂,复合微波活化技术制备出具有分级多孔结构特征的泡沫碳,对其结构和电化学性能进行分析表征。结果表明:微波活化技术可促进泡沫液膜上H_2O分子的快速逸出,于泡沫碳孔壁上形成大量纳米孔,提高比表面积,但未改变其平均孔径;活化后试样的比表面积为378.2m^2/g,其在1A/g电流密度下的比电容达到123.7F/g,相比于未活化试样提升了约94%,并且由于微波活化对试样孔结构的改善而使试样的内阻减小。

关键词：液相泡沫微波活化泡沫碳电化学性能

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun zhao De-En Xu Ming-lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng zhao Bin Dai lei Ye Tao Song Shuai Huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

Highly mass activity electrocatalysts with ultralow Pt loading on carbon black for hydrogen evolution reaction

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 182-190页

作者： Shaorou Ke Yajing zhao Xin Min Yanghong Li Ruiyu Mi Yangai Liu Xiaowen Wu Minghao fang zhaohui Huang Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastersNational Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of Geosciences(Beijing)Beijing 100083China

Pt-based nanocatalysts offer excellent prospects for various ***,the low loading of Pt with excellent performance for efficient and stable nanocatalysts still presents a considerable *** this study,nanocatalysts with ultralow Pt content,excellent performance,and carbon black as support were prepared through in-situ ***~2-nm particles uniformly and stably dispersed on carbon black because of the strong s-p-d orbital hybridizations between carbon black and Pt,which suppressed the agglomeration of Pt *** unique structure is beneficial for the hydrogen evolution *** catalysts exhibited remarkable catalytic activity for hydrogen evolution reaction,exhibiting a potential of 100 mV at 100 mA·cm^(-2),which is comparable to those of commercial Pt/C *** activity(1.61 A/mg)was four times that of a commercial Pt/C catalyst(0.37 A/mg).The ultralow Pt loading(6.84wt%)paves the way for the development of next-generation electrocatalysts.

关键词： hydrogen evolution reaction ultralow platinum in-situ synthesis ultrasound

A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua zhao lei Xi Zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

Correlations of the expression of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in colon cancer tissues

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 207-213页

作者： Rong-Gang Luan Ming-Da Liu Zi-Feng Deng Cong-Lan Lu Mei-Ling Yu Ming-Yu Zhang Rong Liu Ran An You-Liang Yao Dong-Bei Guo Yong-Xing Zhang lei zhao Department of Gastrointestinal Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamen 361102Fujian ProvinceChina Trauma Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina Department of Orthopaedics Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina

BACKGROUND Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ***,reduced expression results in a loss of this capacity to facilitate cyclin E *** ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein,with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical *** To investigate the correlation between expression of Cx43,SKP1/Cullin1/F-box(SCF)FBXW7,p-cyclin E1(ser73,thr77,thr395)and clinicopathological indexes in colon *** Expression levels of Cx43,SCFFBXW7,p-cyclin E1(ser73,thr77,thr395)in 38 clinical colon cancer samples were detected by immunohistochemistry and were analyzed by statistical methods to discuss their *** Positive rate of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in detected samples were 76.32%,76.32%,65.79%,5.26%and 55.26%*** expressions of these proteins were not related to the tissue type,degree of tissue differentiation or lymph node ***43 and SCFFBXW7(r=0.749),p-cyclin E1(Ser73)(r=0.667)and p-cyclin E1(Thr395)(r=0.457),SCFFBXW7 and p-cyclin E1(Ser73)(r=0.703)and p-cyclin E1(Thr395)(0.415)were correlated in colon cancer(P<0.05),and expressions of the above proteins were positively correlated in colon *** Cx43 may facilitate the phosphorylation of cyclin E1 at the Ser73 and Thr195 sites through its interaction with SCFFBXW7,thereby influencing the ubiquitination and degradation of cyclin E1.

关键词： Colon cancer Cx43 SCFFBXW7 Phosphorylation of cyclin E1 Sites of cyclin E1 Correlation analysis

Density Functional Studies on Isonicotinato Lead(II) Complex [Pb(C_5H_4NCOO)_2]

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Chinese Journal of Structural Chemistry 2006年第6期25卷 657-662页

作者： zhao Pu-Su JIAN fang-fang LI Chun-lei ZHENG Jian Department of Chemistry Huaiyin Teachers＇College Huaian Jiangsu 223001 China New Materials ＆ Function Coordination Chemistry Laboratory Qingdao University of Science and Technology Qingdao Shandong 266042 China

The title compound of isonicotinato lead（Ⅱ） [Pb（C5H4NCOO）2] has been optimized at B3LYP/LANL2DZ level of theory and calculated results show that the lead（Ⅱ） ion adopts 4-coordinate geometry. Atomic charge distributions indicate that during forming the title compound, each isonicotinic acid ion transfers -0.452 e to lead（Ⅱ） ion. The electronic spectra calculations show that there exist two absorption bands and the electronic transitions are mainly derived from the contribution of intraligand π→π^＊ transition and ligand-to-metal charge transfer （LMCT） transition. The thermodynamic properties of the title compound at different temperatures have been calculated and corresponding relations between property and temperature have also been obtained. The calculation of the second order optical nonlinearity was carried out, and the molecular hyperpolarizability was 3.62365^＊10^-30 esu.

关键词： isonicotinato lead(Ⅱ) complex density functional theory electronic spectra thermal property analysis the second order optical nonlinearity