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生物化学与生物物理进展 2008年第6期35卷 620-624页

作者：郑君芳贺俊崎首都医科大学生物化学与分子生物学系北京100069

磷酸化蛋白50(ERM-binding phosphoprotein-50,EBP50)是由358个氨基酸组成的多功能连接蛋白.EBP50通过其PDZ-Ⅰ、PDZ-Ⅱ和ERM结合结构域与多种蛋白质结合,对PI3K/Akt、PLCβ等生长信号途径及对细胞迁移进行调控.目前有很多证据提示,ebp5... 详细信息

磷酸化蛋白50(ERM-binding phosphoprotein-50,EBP50)是由358个氨基酸组成的多功能连接蛋白.EBP50通过其PDZ-Ⅰ、PDZ-Ⅱ和ERM结合结构域与多种蛋白质结合,对PI3K/Akt、PLCβ等生长信号途径及对细胞迁移进行调控.目前有很多证据提示,ebp50是一种新的抑癌基因.在乳腺癌病人临床标本和细胞系中可检测到ebp50基因的杂合性丢失(LOH)和突变,其抑癌作用可能是通过它与多种抑癌蛋白(如抑癌蛋白PTEN、MERLIN和SYK)的相互作用并增强它们的稳定性,并与致癌蛋白结合从而抑制其致癌功能来达到的.通过对其分子结构、调控的信号途径及其与乳腺癌发生、发展的关系进行综述,为乳腺癌的防治提供新线索.

关键词：磷酸化蛋白50(EBP50)/钠氢交换子调节因子1(NHERF1) 抑癌蛋白杂合性丢失(LOH) 基因突变信号转异迁移

Sulfur dioxide acts as a novel endogenous gaseous signaling molecule in the cardiovascular system

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Chinese Medical Journal 2011年第12期124卷 1901-1905页

作者： CHEN Shan-shan TANG Chao-shu JIN Hong-fang DU jun-bao Department of Pediatrics Peking University First Hospital Beijing100034 China Key Laboratory of Molecular Cardiology Ministry of EducationBeijing 100191 China

Objective Sulfur dioxide was considered to be toxic and detrimental to human health. However, this review highlights recent advances that suggest sulfur dioxide might be a novel endogenous gaseous signaling molecule involved in the regulation of cardiovascular functions. Data sources The data used in this review were mainly from the studies reported in Medline and PubMed published from 1986 to 2010. Study selection Original articles and critical reviews selected were relevant to exogenous and endogenous sulfur dioxide. Results The sulfur dioxide/aspartate amino transferase pathway is endogenously generated in the cardiovascular system, and sulfur dioxide shows broad bioactive effects, such as antihypertension, vasodilation, and amelioration of vascular remodeling. A disturbed sulfur dioxide/aspartate amino transferase pathway is known to be involved in the pathogenesis of many cardiovascular diseases, such as ischemia-reperfusion injury, monocrotaline-induced pulmonary hypertension, athrosclerosis, spontaneous hypertension and hypoxic pulmonary hypertension. Furthermore, in experimental studies the prognosis of these cardiovascular diseases can be improved by targeting endogenous sulfur dioxide. Conclusion The findings suggest that sulfur dioxide is a novel endogenous gaseous signaling molecule involved in the regulation of cardiovascular functions.

关键词： cardiovascular diseases endogenous exogenous sulfur dioxide

Study on the Transition of Teachers’ Ecological Role in College English Teaching in New Media Age

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海外英语 2019年第13期 264-265页

作者：卢俊荆楚理工学院

As the emergence of new information and communication technologies and new social communication practices has driven the transformation of educational ecosystem in China,College English teaching in China becomes deeply intertwined with information *** changes accordingly in China have put forward new requirements for teachers’ecological role to adjust to the new College English teaching paradigm and maintain the balance of this ecosystem in *** in Education of Ecology,combined with currently common issues posed in College English classroom in China,this paper aims to illuminate teachers’ecological role of this new ecosystem in College English teaching in the new media age in China.

关键词： transition Education of Ecology teachers’role

Reconstruction of Educational Ecology in College English Teaching in Information Age

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海外英语 2020年第9期 273-274页

作者：卢俊荆楚理工学院湖北荆门448000

With the burgeoning of new information and communication technology,the technology-driven information foreign language teaching has come into being,which is reconstructing the educational ecology,especially in colleges and ***,in order to set foreign language teaching literally adapting to the new ecology of information age,the previous ecology of foreign language teaching should be *** paper tries to analyze this new ecological environment in foreign language teaching from the perspective of educational ecology,and strains up to explore the educational ecology in this information context.

关键词： educational ecology reconstruction college English teaching

Grey matter volume abnormalities in patients with bipolar I depressive disorder and unipolar depressive disorder:a voxelbased morphometry study

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Neuroscience Bulletin 2015年第1期31卷 4-12页

作者： Yi Cai jun Liu Li Zhang Mei Liao Yan Zhang Lifeng Wang Hongjun Peng Zhong He Zexuan Li Weihui Li Shaojia lu Yuqiang Ding Lingjiang Li Mental Health Institute of the Second Xiangya Hospital National Technology Institute of Psychiatry Key Laboratory of Psychiatry and Mental Health of Hunan ProvinceCentral South University Department of Mental Health and Psychiatry Brain Hospital of Hunan Province Hunan University of Chinese Medicine Clinical Medical College Department of Radiology the Second Xiangya Hospital of Central South University Guangzhou Psychiatric Hospital Affiliated Hospital of Guangzhou Medical College Key Laboratory of Arrhythmias Ministry of EducationEast HospitalTongji University School of Medicine Shenzhen Kangning Hospital of Guangdong Province

Bipolar disorder and unipolar depressive disorder（UD） may be different in brain structure. In the present study,we performed voxel-based morphometry（VBM） to quantify the grey matter volumes in 23 patients with bipolar I depressive disorder（BP1） and 23 patients with UD,and 23 age-,gender-,and educationmatched healthy controls（HCs） using magnetic resonance imaging. We found that compared with the HC and UD groups,the BP1 group showed reduced grey matter volumes in the right inferior frontal gyrus and middle cingulate gyrus,while the UD group showed reduced volume in the right inferior frontal gyrus compared to HCs. In addition,correlation analyses revealed that the grey matter volumes of these regions were negatively correlated with the Hamilton depression rating scores. Taken together,the results of our study suggest that decreased grey matter volume of the right inferior frontal gyrus is a common abnormality in BP1 and UD,and decreasedgrey matter volume in the right middle cingulate gyrus may be specifi c to BP1.

关键词： bipolar depressive disorder unipolar depressive disorder prefrontal cortex cingulate gyrus voxel-based morphometry

Inverted Internal Limiting Membrane Flap Technique for Repair of Large Macular Holes： A Short-term Follow-up of Anatomical and Functional Outcomes

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Chinese Medical Journal 2016年第5期129卷 511-517页

作者： Zhe Chen Chan Zhao jun-Jie Ye Xu-Qian Wang Rui-fang Sui Department of Ophthalmology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College geijing 100005 China

Background：Inverted internal limiting membrane （ILM） flap technique has recently been reported in a limited number of studies as an effective surgical technique for the management of large macular holes （MHs） with fair MH closure rates as well as gains in visual *** the current study,longitudinal changes in multi-focal electroretinogram （mfERG） responses,best-corrected visual acuity （BCVA） and spectral-domain optical coherence tomography （SD-OCT） were evaluated in eyes with large MHs managed by this ***：A prospective noncontrolled interventional study of eight patients （eight eyes） with large MHs （minimum diameter 〉400 μm） was *** MHs were treated with pars plana vitrectomy and indocyanine green-assisted inverted ILM flap ***-OCT images were used to assess the anatomical outcomes of surgery while BCVA and mfERG were used to evaluate the functional outcomes during a 3-month ***：All patients underwent successful intended manipulation and translocation of the ILM flap without flap dislocation and achieved complete anatomical *** microstructural reconstruction,demonstrated on SD-OCT as restoration of the external limiting membrane and the ellipsoid zone,was observed in all cases as early as 1 month after ***,as compared to baseline,all patients showed improvements in BCVA and all but one in mfERG response during ***,Pearson＇s test revealed no significant correlations between BCVA and mfERG responses of the fovea and of the macular area at each evaluation time ***：Inverted ILM flap technique appeares to be a safe and effective approach for the management of large idiopathic MHs with favorable short-term anatomical and functional *** reconstruction of the microstructure generally shows good consistency with improvements in both BCVA and mfERG response,of which the latter might be a supplement for the former in postoperative functional follow-up.

关键词： Inverted Internal Limiting Membrane Flap Technique Large Macular Hole Multi-focal Electroretinogram:Spectral-domain Optical Coherence Tomography

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信贷资产异质性对信贷组合损失的影响研究

系统工程理论与实践 2006年第12期26卷 55-61页

作者：曾健陈俊芳上海交通大学管理学院上海200030

在新巴塞尔协议的资本监管框架下,同一信用级别中的信贷资产被认为是同质的.本文结合Vasicek模型分析了资产异质性对信贷组合损失的影响,并比较了不同参数的异质性对损失的影响效果.分析结果显示,异质性对信用风险损失分布尤其是分布尾... 详细信息

在新巴塞尔协议的资本监管框架下,同一信用级别中的信贷资产被认为是同质的.本文结合Vasicek模型分析了资产异质性对信贷组合损失的影响,并比较了不同参数的异质性对损失的影响效果.分析结果显示,异质性对信用风险损失分布尤其是分布尾部有较大影响,忽略异质性一般会高估信用损失;较之资产的行业相关性,违约率和违约波动率的异质性影响可能更为显著;有关信贷组合分散化的探讨往往局限于正态假设,这将导致信用损失的低估.

关键词：信贷组合异质性信用风险损失

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骨桥蛋白在宫颈癌中的表达及临床意义

第二军医大学学报 2009年第6期30卷 734-735页

作者：方芳张俊洁第二军医大学长海医院妇产科上海200433

目的:探讨骨桥蛋白(OPN)在宫颈癌中的表达及其作为诊断和预后指标的临床意义。方法:采用免疫组化S-P法检测150例宫颈癌及癌前病变组织(宫颈上皮内瘤样变,CIN)和20例正常宫颈组织中OPN的表达;采用ELISA法检测25例宫颈癌及20例癌前病变(C... 详细信息

目的:探讨骨桥蛋白(OPN)在宫颈癌中的表达及其作为诊断和预后指标的临床意义。方法:采用免疫组化S-P法检测150例宫颈癌及癌前病变组织(宫颈上皮内瘤样变,CIN)和20例正常宫颈组织中OPN的表达;采用ELISA法检测25例宫颈癌及20例癌前病变(CIN)患者血浆及手术切除标本组织匀浆中OPN的含量,并以10例子宫良性病变(子宫肌瘤、子宫内膜异位症)患者为对照。结果:免疫组化法测得OPN在宫颈癌组织中表达阳性率[53.2%(50/94)]显著高于正常宫颈组织[10.0%(2/20)]及CIN[10.7%(6/56),P<0.05];临床Ⅱ、Ⅲ期宫颈癌组织OPN表达阳性率显著高于Ⅰ期者(P<0.05);宫颈癌有淋巴结转移者OPN表达阳性率显著高于无转移者(P<0.05)。正常宫颈组织、CIN、宫颈癌组织匀浆及相应患者血浆中OPN含量也呈类似的变化趋势。结论:OPN可能与宫颈癌的发生、发展和转移有关,定量检测其表达可作为判断宫颈癌的预后和术后复发的评估指标之一。

关键词：宫颈肿瘤骨桥蛋白免疫组织化学酶联免疫吸附测定

Coronary stenting versus bypass surgery in heart failure patients with preserved ejection fraction

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Chinese Medical Journal 2012年第6期125卷 1000-1004页

作者： XUE Zeng-ming LI Wei-ju MA Chang-sheng NIE Shao-ping DONG Jian-zeng LIU Xiao-hui KANG jun-ping lu Qiang DU Xin WANG Xiao CHiN fang ZHOU Yu-jie lu Shu-zheng HUANG fang-jiong GU Cheng-xiong WU Xue-si Department of Cardiology Beijing Anzhen Hospital Capital Medical university Beijing 100029 China Department of Cardiology Peking University Hospital Beijing 100873 China Department of Cardiac Surgery Beijing Anzhen Hospital Capital Medical university Beijing 100029 China

Background The optimal revascularization strategy in patients with heart failure with preserved ejection fraction （HFPEF） remains unclear. The aim of the present study was to compare the effects of percutaneous coronary intervention （PCI） and coronary artery bypass grafting （CABG） in patients with HFPEF. Methods From July 2003 through September 2005, a total of 920 patients with coronary artery disease （CAD） and HFPEF （ejection fraction 〉50%） underwent PCI （n=350） or CABG （n=570）. We compared the groups with respect to the primary outcome of mortality, and the secondary outcomes of main adverse cardiac and cerebral vascular events （MACCE）, including death, myocardial infarction, stroke and repeat revascularization, at a median follow-up of 543 days. Results In-hospital mortality was significantly lower in the PCI group than in the CABG group （0.3% vs. 2.5%, adjusted P=0.016）. During follow-up, there was no significant difference in the two groups with regard to mortality rates （2.3% vs. 3.5%, adjusted P=0.423）. Patients receiving PCI had higher MACCE rates as compared with patients receiving CABG （13.4% vs. 4.0%, adjusted P 〈0.001）, mainly due to higher rate of repeat revascularization （adjusted P 〈0.001）. Independent predictors of mortality were age, New York Heart Association （NYHA） class and chronic total occlusion. Conclusion Among patients with CAD and HFPEF, PCI was shown to be as good as CABG with respect to the mortality rate, although there was a higher rate of repeat revascularization in patients undergoing PCI.

关键词： revascularization coronary artery disease heart failure