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Recent Advances of Research on Tomato Late Blight, Bacterial Wilt and Begomovirus at AVRDC-The World Vegetable Center

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Recent Advances of Research on Tomato Late Blight, Bacterial...

A Blockchain-Based Proxy Re-Encryption Scheme with Conditional Privacy Protection and Auditability

中国植物病理学会2008年学术年会

作者： Tien-Cheng Wang Chien-Hua Chen Jaw-Fen Wang fang-i ho Peter Hanson Jen-Tzu Chen Wen-Shi Tsai Sylvia K.Green AVRDC-The World Vegetable Center

Late blight, caused by Phytophthora infestans, is one of the most destructive tomato diseases in Taiwan. To monitor change in the pathogen’s development, 706 isolates of P. infestans, including 40 isolates from potato, were collected in Taiwan from 1991 to 2007. These isolates were analyzed by phenotype and genotype characterization. A dramatic genetic shift occurred in the population of P infestans during Taiwan’s 1997-1998 cool growing season. Most isolates obtained after 1998 were non host-specific. Metalaxyl sensitivity of the isolates changed from sensitive/intermediate before 1997 to resistant after 1998. isolates obtained before 1997 were all US-1 clonal lineage. During the 1997-1998 cool growing season, the US-11 clonal lineage appeared, possibly introduced on table potatoes imported from the USA. The new lineage spread rapidly and since 1999 has almost completely displaced the old population in Taiwan. All isolates were of the A1 mating type by pairing with P. parasitica. Ten tomato physiological races were identified. A total of 74 sources resistant to race T1,2 were identified from 1783 wild tomato accessions. Among them, accessions L3683, L3684, L3707 and L3708 were confirmed to have durable resistance in multilocation tests. inheritance studies on CLN657 BCF-274-0-15-4×L3708 and Moneymaker×L3684 indicated the resistance is partially dominant and is inherited as a monogenic trait in both L3708 and L3684. L3708 was used as the donor parent and resistance was introgressed into tomato by backcrossing and selection with a race T1,2 isolate. Six BC3F6 inbred lines, SRE-2037B, C, E, G, H, i and five F populations (FMTT791-795) were selected carrying the Ph-3 gene and exhibited high resistance to race T1,2 with good horticultural traits. Bacterial wilt caused by Ralstonia solanacearum is a devastating disease of tomato production in warm and humid regions worldwide. R. solanacearum is a species complex. All the 158 strains isolated from various host plants in T

关键词： Solanum lycopercicum resistance breeding physiological race quantitative trait loci tomato-infecting begomoviruses

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China Communications 2024年第7期21卷 267-277页

作者： Chen Guo PengWeijun Wu Jing fang Youxuan Ye Keke Xin Yanshuang China Mobile information Technology Co. LtdBeijing 100037China China Mobile information Technology Co. LtdShenzhen 518048China

With the development of internet of Things technology,intelligent door lock devices are widely used in the field of house *** the traditional housing leasing scenario,problems of door lock information disclosure,tenant privacy disclosure and rental contract disputes frequently occur,and the security,fairness and auditability of the housing leasing transaction cannot be *** solve the above problems,a blockchain-based proxy re-encryption scheme with conditional privacy protection and auditability is *** scheme implements fine-grained access control of door lock data based on attribute encryption technology with policy hiding,and uses proxy re-encryption technology to achieve auditable supervision of door lock information *** encryption technology and zero-knowledge proof technology are introduced to ensure the confidentiality of housing rent information and the fairness of rent *** construct a decentralized housing lease transaction architecture,the scheme realizes the efficient collaboration between the door lock data ciphertext stored under the chain and the key information ciphertext on the chain based on the blockchain and interPlanetary File ***,the security proof and computing performance analysis of the proposed scheme are carried *** results show that the scheme can resist the chosen plaintext attack and has low computational cost.

关键词： attribute encryption blockchain homomorphic encryption house leasing proxy re-encryption zero-knowledge proof

Lactiplantibacillus plantarum AR113 alleviates microbiota dysbiosis of tongue coating and cerebral ischemia/reperfusion injury in rat

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Food Science and Human Wellness 2024年第4期13卷 2132-2140页

作者： Zhiqiang Xiong Gang Liu Ling fang Xiuming Li Yongjun Xia Guangqiang Wang Xin Song Lianzhong Ai Shanghai Engineering Research Center of Food Microbiology School of Health Science and EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China Department of Rehabilitation Huashan HospitalFudan UniversityShanghai 200040China Department of Rehabilitation Medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Stroke is one of the leading causes of death and disability ***,information on stroke-related tongue coating microbiome(TCM)is limited,and whether TCM modulation could benefit for stroke prevention and rehabilitation is ***,TCM from stroke patients(SP)was characterized using molecular *** occurrence of stroke resulted in TCM dysbiosis with significantly reduced species richness and *** abundance of Prevotella,Leptotrichia,Actinomyces,Alloprevotella,Haemophilus,and TM7_[G-1]were greatly reduced,but common infection Streptococcus and Pseudomonas were remarkably ***,an antioxidative probiotic Lactiplantibacillus plantarum AR113 was used for TCM intervention in stroke rats with cerebral ischemia/reperfusion(i/R).AR113 partly restored i/R induced change of TCM and gut microbiota with significantly improved neurological deficit,relieved histopathologic change,increased activities of antioxidant enzymes,and decreased contents of oxidative stress ***,the gene expression of antioxidant-related proteins and apoptosis-related factors heme oxygenase-1(ho-1),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),nuclear factor erythroid 2-related factor 2(Nrf2),NAD(P)H:quinone oxidoreductase-1(NQO-1),and Bcl-2 was significantly increased,but cytochrome C,cleaved caspase-3,and Bax were markedly decreased in the brain by AR113 *** results suggested that AR113 could ameliorate cerebral i/R injury through antioxidation and anti-apoptosis pathways,and AR113 intervention of TCM may have the application potential for stroke prevention and control.

关键词： Stroke Cerebral ischemia/reperfusion Tongue coating Lactiplantibacillus plantarum AR113 Probiotic intervention

Etomidate protects retinal ganglion cells from hydrogen peroxide-induced injury via Nrf2/ho-1 pathway

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international Journal of Ophthalmology(English edition) 2024年第9期17卷 1606-1613页

作者： Xuan Zhao De-Gang Fan Xin-Chao Zhang Si-Wei You fang Kuang Ming-Mei Wu Department of Histology and Embryology School of Basic Medical SciencesXi’an Medical UniversityXi’an 710021Shaanxi ProvinceChina Department of Neurobiology the Basic Medical Science Academythe Fourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Spinal Surgery Honghui HospitalXi’an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina College of Life Sciences Northwestern UniversityXi’an 710069Shaanxi ProvinceChina

AiM:To determine whether etomidate(ET)has a protective effect on retinal ganglion cells(RGCs)injured with hydrogen peroxide(H_(2)O_(2))and to explore the potential mechanism underlying the antioxidative stress effect of ***:Cultured RGCs were identified by double immunofluorescent labeling of microtubule-associated protein 2 and *** injury model of H_(2)O_(2)-induced RGCs oxidative stress was established in *** were pretreated with different concentrations of ET(1,5,and 10μmol/L)for 4h,followed by further exposure to H_(2)O_(2)at 1000μmol/*** counting kit 8 and Annexin V/propidium iodide assays were applied to detect the viabilities and apoptosis rates of the RGCs at 12,24,and 48h after H_(2)O_(2)*** levels of nitric oxide,malondialdehyde,and glutathione in culture media were measured at these time *** reverse transcription polymerase chain reaction(qRT-PCR)and Western blot were performed to observe the effects of ET on the messenger RNA and protein expression of inducible nitric oxide synthase(iNOS),nuclear factor erythroid 2-related factor 2(Nrf2),heme oxygenase 1(ho-1),glutathione peroxidase 1 and the level of conjugated acrolein in RGCs at 12,24,and 48h after H_(2)O_(2)stimulation and in the retina at 12h after optic nerve transection(ONT).RESULTS:The applications of 5 and 10μmol/L of ET significantly increased the viability of *** from qRT-PCR indicated a decrease in the expression of iNOS and an increase in the expressions of Nrf2 and ho-1 in ETpretreated RGCs at 12,24 and 48h after H_(2)O_(2)stimulation,as well as in ET-treated retinas at 12h after *** blot analysis revealed a decrease in the expression of iNOS and levels of conjugated acrolein,along with an increase in the expressions of Nrf2 and ho-1 in ET-pretreated RGCs in vitro and ET-treated retinas in ***:ET is a neuroprotective agent in primary cultured RGCs injured by H_(2)O_(2).The effect of ET is dosedependent with the

关键词： etomidate retinal ganglion cell neuroprotection hydrogen peroxide-induced injury nuclear factor erythroid 2-related factor 2 heme oxygenase 1

Mesenchymal stem cells-extracellular vesicles alleviate pulmonary fibrosis by regulating immunomodulators

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World Journal of Stem Cells 2024年第6期16卷 670-689页

作者： Ying Gao Mei-fang Liu Yang Li Xi Liu Yu-Jie Cao Qian-Fa Long Jun Yu Jian-Ying Li Department of Respiratory and Critical Care Medicine Shaanxi Provincial Rehabilitation HospitalXi’an 710000Shaanxi ProvinceChina Department of Respiratory and Critical Care Medicine Second Affiliated Hospital of Ningxia Medical University(The First People’s Hospital of Yinchuan)Yinchuan 750001Ningxia Hui Autonomous RegionChina School of Clinical Medicine Xi’an Medical UniversityXi’an 710021Shaanxi ProvinceChina Department of Respiratory and Critical Care Medicine Xi’an Central HospitalXi’an 710000Shaanxi ProvinceChina Department of Neurosurgery Xi’an Central HospitalXi’an 710000Shaanxi ProvinceChina Department of Emergency Xi’an Central HospitalXi’an 710000Shaanxi ProvinceChina

BACKGROUND Pulmonary fibrosis(PF)is a chronic interstitial lung disease characterized by fibroblast proliferation and extracellular matrix formation,causing structural damage and lung *** cell therapy and mesenchymal stem cells-extracellular vesicles(MSC-EVs)offer new hope for PF *** To investigate the therapeutic potential of MSC-EVs in alleviating fibrosis,oxidative stress,and immune inflammation in A549 cells and bleomycin(BLM)-induced mouse *** The effect of MSC-EVs on A549 cells was assessed by fibrosis markers[collagen i andα-smooth muscle actin(α-SMA),oxidative stress regulators[nuclear factor E2-related factor 2(Nrf2)and heme oxygenase-1(ho-1),and inflammatory regu-lators[nuclear factor-kappaB(NF-κB)p65,interleukin(iL)-1β,and iL-2].Similarly,they were assessed in the lungs of mice where PF was induced by BLM after MSC-EV ***-EVs ion PF mice were detected by pathological staining and western ***-cell RNA sequencing was performed to investigate the effects of the MSC-EVs on gene expression profiles of macrophages after modeling in *** Transforming growth factor(TGF)-β1 enhanced fibrosis in A549 cells,significantly increasing collagen i andα-SMA ***,treatment with MSC-EVs demonstrated a remarkable alleviation of these ***,the expression of oxidative stress regulators,such as Nrf2 and ho-1,along with inflammatory regulators,including NF-κB p65 and iL-1β,were mitigated by MSC-EV ***,in a parallel manner,MSC-EVs exhibited a downregulatory impact on collagen deposition,oxidative stress injuries,and inflammatory-related cytokines in the lungs of mice with ***,the mRNA sequencing results suggested that BLM may induce PF in mice by upregulating pulmonary collagen fiber deposition and triggering an immune inflammatory *** findings collectively highlight the potential therapeutic efficacy of MSC-EVs in ameliorating fibrotic processes,oxidative stres

关键词： Mesenchymal stem cells Extracellular vesicles Pulmonary fibrosis Oxidative stress response Epithelial-mesenchymal transition

Duodenal-jejunal bypass improves hypothalamic oxidative stress and inflammation in diabetic rats via glucagon-like peptide 1-mediated Nrf2/ho-1 signaling

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World Journal of Diabetes 2024年第2期15卷 287-304页

作者： Huai-Jie Wang Li-Bin Zhang Si-Peng Sun Qing-Tao Yan Zhi-Qin Gao fang-Ming Fu Mei-Hua Qu Translational Medical Center Weifang Second People's HospitalWeifang 261041Shandong ProvinceChina Department of Endocrinology Weifang Second People's HospitalWeifang 261041Shandong ProvinceChina Department of Pediatric Surgery Weifang People’s HospitalWeifang 261041Shandong ProvinceChina School of Bioscience and Technology Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Endocrinology Jinan Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND Type 2 diabetes mellitus(T2DM)is often accompanied by impaired glucose utilization in the brain,leading to oxidative stress,neuronal cell injury and *** studies have shown that duodenal jejunal bypass(DJB)surgery significantly improves brain glucose metabolism in T2DM rats,the role and the metabolism of DJB in improving brain oxidative stress and inflammation condition in T2DM rats remain *** To investigate the role and metabolism of DJB in improving hypothalamic oxidative stress and inflammation condition in T2DM *** A T2DM rat model was induced via a high-glucose and high-fat diet,combined with a low-dose streptozotocin injection.T2DM rats were divided into DJB operation and Sham operation *** surgical intervention was carried out on T2DM *** differential expression of hypothalamic proteins was analyzed using quantitative proteomics *** related to oxidative stress,inflammation,and neuronal injury in the hypothalamus of T2DM rats were analyzed by flow cytometry,quantitative real-time PCR,Western blotting,and *** Quantitative proteomics analysis showed significant differences in proteins related to oxidative stress,inflammation,and neuronal injury in the hypothalamus of rats with T2DM-DJB after DJB surgery,compared to the T2DM-Sham groups of *** stress-related proteins(glucagon-like peptide 1 receptor,Nrf2,and ho-1)were significantly increased(Pin the hypothalamus of rats with T2DM after DJB *** surgery significantly reduced(Pic inflammation in T2DM rats by inhibiting the activation of NF-κB and decreasing the expression of interleukin(iL)-1βand *** surgery significantly reduced(Pion of factors related to neuronal injury(glial fibrillary acidic protein and Caspase-3)in the hypothalamus of T2DM rats and upregulated(Pion of neuroprotective factors(C-fos,Ki67,Bcl-2,and BDNF),thereby reducing hypot

关键词： Duodenal jejunal bypass surgery Type 2 diabetes mellitus Neuron apoptosis inflammatory Oxidative stress Hypothalamic injury

Large circuit models: opportunities and challenges

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Science China(information Sciences) 2024年第10期67卷 25-66页

作者： Lei CHEN Yiqi CHEN Zhufei CHU Wenji fang Tsung-Yi ho Ru HUANG Yu HUANG Sadaf KHAN Min Li Xingquan Li Yu Li Yun LiANG Jinwei LiU Yi LiU Yibo LiN Guojie LUO hongyang PAN Zhengyuan SHi Guangyu SUN Dimitrios TSARAS Runsheng WANG Ziyi WANG Xinming WEi Zhiyao XiE Qiang XU Chenhao XUE Junchi YAN Jun YANG Bei YU Mingxuan YUAN Evangeline F.Y.YOUNG Xuan ZENG Haoyi ZHANG Zuodong ZHANG Yuxiang ZHAO Hui-Ling ZHEN Ziyang ZHENG Binwu ZHU Keren ZHU Sunan ZOU Huawei Noah’s Ark Lab School of integrated Circuits Peking University Faculty of Electrical Engineering and Computer Science Ningbo University Department of Electronic and Computer Engineering Hong Kong University of Science and Technology Department of Computer Science and Engineering The Chinese University of Hong Kong School of integrated Circuits Southeast University Huawei HiSilicon Peng Cheng Laboratory School of Computer Science Peking University School of Microelectronics State Key Laboratory of Integrated Chips and System Fudan University School of Artificial intelligence Shanghai Jiao Tong University

Within the electronic design automation(EDA) domain, artificial intelligence(Ai)-driven solutions have emerged as formidable tools, yet they typically augment rather than redefine existing methodologies. These solutions often repurpose deep learning models from other domains, such as vision, text, and graph analytics, applying them to circuit design without tailoring to the unique complexities of electronic circuits. Such an “Ai4EDA” approach falls short of achieving a holistic design synthesis and understanding,overlooking the intricate interplay of electrical, logical, and physical facets of circuit data. This study argues for a paradigm shift from Ai4EDA towards Ai-rooted EDA from the ground up, integrating Ai at the core of the design process. Pivotal to this vision is the development of a multimodal circuit representation learning technique, poised to provide a comprehensive understanding by harmonizing and extracting insights from varied data sources, such as functional specifications, register-transfer level(RTL) designs, circuit netlists,and physical layouts. We champion the creation of large circuit models(LCMs) that are inherently multimodal, crafted to decode and express the rich semantics and structures of circuit data, thus fostering more resilient, efficient, and inventive design methodologies. Embracing this Ai-rooted philosophy, we foresee a trajectory that transcends the current innovation plateau in EDA, igniting a profound “shift-left” in electronic design methodology. The envisioned advancements herald not just an evolution of existing EDA tools but a revolution, giving rise to novel instruments of design-tools that promise to radically enhance design productivity and inaugurate a new epoch where the optimization of circuit performance, power, and area(PPA) is achieved not incrementally, but through leaps that redefine the benchmarks of electronic systems' capabilities.

关键词： Ai-rooted EDA large circuit models (LCMs) multimodal circuit representation learning circuit optimization

Characteristic investigation of permanent magnet actuator for vacuum contactors operating with an intrinsically safe low voltage

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Science China(Technological Sciences) 2012年第6期55卷 1688-1694页

作者： fang ShuHua LiN HeYun ho SiuLau WANG XianBing JiN Ping School of Electrical Engineering Southeast UniversityNanjing 210096China Department of Electrical Engineering Hong Kong Polytechnic UniversityKowloonHong KongChina

This paper reports a new application of permanent magnet actuator for vacuum contactors.A novel permanent magnet(PM) actuator to drive a vacuum contactor with intrinsically safe and low supply voltage is *** is mounted on the static iron of the contactor to enhance its holding force and *** only one coil is used to break the vacuum contactor,two series coils are deployed to yield a high magnetomotive force to realize the making *** electrical circuit equation,mechanical equation and magnetic field are all coupled in the simulation.A prototype is manufactured and tested to validate and showcase the performance of the contactor which is equipped with the proposed PM actuator.

关键词： low voltage control permanent magnet actuator intrinsic safety vacuum contactor

勒哲多糖粗提物体外抑制H_(2)O_(2)诱导HepG2细胞氧化损伤的作用及机制研究

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中国新药杂志 2024年第8期33卷 810-817页

作者：樊慧芳李国峰陈海芳张武岗江西中医药大学中药固体制剂制造技术国家工程研究中心南昌330004 江西中医药大学现代中药制剂教育部重点实验室南昌330004

目的:基于体外活性氧(reactive oxygen species,ROS)清除体系和H_(2)O_(2)诱导HepG2细胞氧化损伤模型探讨勒哲多糖粗提物(LZC)的体外抗氧化作用和机制。方法:测定LZC对羟基自由基、超氧阴离子、DPPH自由基、亚硝酸根离子的清除作用;试... 详细信息

目的:基于体外活性氧(reactive oxygen species,ROS)清除体系和H_(2)O_(2)诱导HepG2细胞氧化损伤模型探讨勒哲多糖粗提物(LZC)的体外抗氧化作用和机制。方法:测定LZC对羟基自由基、超氧阴离子、DPPH自由基、亚硝酸根离子的清除作用;试剂盒检测H_(2)O_(2)诱导HepG2细胞氧化损伤模型中细胞中丙二醛(malondialdehyde,MDA)和谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)水平,2’,7’-二氯荧光黄双乙酸盐(2’,7’-dichlorofluorescein diacetate,DCFH2-DA)荧光探针检测细胞内ROS水平和Annexin V-FiTC/Pi双染法检测细胞凋亡情况,Western blot检测核因子E2相关因子2/血红素氧合酶-1(nuclear factor erythroid-2-related factor 2/heme oxygenase 1,Nrf2/ho-1)、肿瘤蛋白53(p53)、Bcl-2相关X蛋白(Bax)和半胱氨酸天冬氨酸蛋白水解酶-3(Caspase-3)的蛋白表达。结果:LZC表现出强ROS清除活性,显著提升H_(2)O_(2)诱导HepG2细胞氧化损伤模型中细胞的GSH-Px活性,抑制MDA水平、ROS释放和细胞凋亡。Western blot结果表明LZC能上调Nrf2和ho-1的蛋白表达,下调p53,Bax和Caspase-3表达。结论:LZC具有较强的体外抗氧化作用,其作用与激活Nrf2/ho-1信号通路进而抑制细胞凋亡有关。

关键词：勒哲多糖粗提物抗氧化核因子E2相关因子2/血红素氧合酶-1信号通路细胞凋亡