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Cuproptosis mediates copper-induced testicular spermatogenic cell death

Asian Journal of Andrology 2024年第3期26卷 295-301页

作者： Jing-Yi Zhang Xu-Jun Yu Jun-Jun Li Yao Xiao Guang-Sen Li fang yang Liang Dong Chengdu University of Traditional Chinese Medicine Chengdu 611137China Chengdu Fifth People’s Hospital The Fifth People’s Hospital of Chengdu University of Traditional Chinese MedicineChengdu 611130China TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072China Department of Surgery The Reproductive and Women-Children HospitalChengdu University of Traditional Chinese MedicineChengdu 610041China

Cuproptosis,a novel mechanism of programmed cell death,has not been fully explored in the context of spermatogenic *** investigated the potential involvement of cuproptosis in spermatogenic cell death using a mouse model of copper *** male Institute of Cancer Research(ICR)mice were randomly divided into four groups that received daily oral gavage withsodium chloride(control)or copper sulfate(CuSO_(4))at 50 mg kg^(−1),100 mg kg^(−1),or 200 mg kg^(−1),for 42 consecutive *** to copper overload exhibited a disruption in copper ***,significant upregulated expression of keycuproptosis factors was accompanied by a significant rise in the rates of testicular tissue cell *** revealed the presence of ferredoxin 1(Fdx1)in Sertoli cells,Leydig cells,and spermatogenic cells at various stages oftesticular development,and the Fdx1-positive staining area was significantly increased in copper-overloaded *** and decreased adenosine triphosphate levels were also observed,further implicating mitochondrial damage *** analyses revealed pathological lesions and blood−testis barrier destruction in the testicular tissue,accompaniedby decreased sperm concentration and motility,in copper-overloaded *** summary,our results indicate that copper-overloadedmice exhibit copper homeostasis disorder in the testicular tissue and that cuproptosis participates in spermatogenic cell *** findings provide novel insights into the pathogenic mechanisms underlying spermatogenic cell death and provide initialexperimental evidence for the occurrence of cuproptosis in the testis.

关键词： blood−testis barrier cuproptosis ferredoxin 1 spermatogenic cell death

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Global dust density in two-dimensional complex plasma

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Chinese Physics B 2024年第6期33卷 445-450页

作者：赵逸真刘松芬孔伟杨芳 School of Physics Nankai UniversityTianjin 300071China College of Science Civil Aviation University of ChinaTianjin 300300China

The driven-dissipative Langevin dynamics simulation is used to produce a two-dimensional(2D) dense cloud, which is composed of charged dust particles trapped in a quadratic potential. A 2D mesh grid is built to analyze the center-to-wall dust density. It is found that the local dust density in the outer region relative to that of the inner region is more nonuniform,being consistent with the feature of quadratic potential. The dependences of the global dust density on equilibrium temperature, particle size, confinement strength, and confinement shape are investigated. It is found that the particle size, the confinement strength, and the confinement shape strongly affect the global dust density, while the equilibrium temperature plays a minor effect on it. In the direction where there is a stronger confinement, the dust density gradient is bigger.

关键词： dust particles quadratic potential two-dimensional mesh grid

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Risk stratification in gastric cancer lung metastasis: Utilizing an overall survival nomogram and comparing it with previous staging

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 357-381页

作者： Zhi-Ren Chen Mei-fang yang Zhi-Yuan Xie Pei-An Wang Liang Zhang Ze-Hua Huang Yao Luo Department of Science and Education Xuzhou Medical UniversityXuzhou Clinical CollegeXuzhou 221000Jiangsu ProvinceChina Department of Neurology Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Neurology Clinical LaboratoryGastrointestinal SurgeryCentral Hospital of XuzhouCentral Hospital of XuzhouXuzhou 221000Jiangsu ProvinceChina Department of Public Health Xuzhou Central HospitalXuzhou 221000Jiangsu ProvinceChina Department of Gastroenterology Xuzhou Centre HospitalXuzhou 221000Jiangsu ProvinceChina Department of Public Health Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)is prevalent and aggressive,especially when patients have distant lung metastases,which often places patients into advanced *** identifying prognostic variables for lung metastasis in GC patients,it may be po-ssible to construct a good prediction model for both overall survival(OS)and the cumulative incidence prediction(CIP)plot of the *** To investigate the predictors of GC with lung metastasis(GCLM)to produce nomograms for OS and generate CIP by using cancer-specific survival(CSS)*** Data from January 2000 to December 2020 involving 1652 patients with GCLM were obtained from the Surveillance,epidemiology,and end results program *** major observational endpoint was OS;hence,patients were se-parated into training and validation *** analysis determined va-rious *** and multivariate Cox analyses validated the independent predictive *** distinction and calibration were performed with the time-dependent area under the curve(AUC)and calibration *** evaluate the accuracy and clinical usefulness of the nomograms,decision curve analysis(DCA)was *** clinical utility of the novel prognostic model was compared to that of the 7th edition of the American Joint Committee on Cancer(AJCC)staging system by utilizing Net Reclassification Improvement(NRI)and Integrated Discrimination Improvement(IDI).Finally,the OS prognostic model and Cox-AJCC risk stratification model modified for the AJCC system were *** For the purpose of creating the OS nomogram,a CIP plot based on CSS was *** multivariate regression analysis identified eleven significant prognostic factors(P0),time-de-pendent ROC curve(training/v

关键词： Gastric cancer Lung metastasis Nomograms Surveillance Epidemiology Surveillance epidemiology and end results program database Overall survival Prognosis

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Probability Distribution of Arithmetic Average of China Aviation Network Edge Vertices Nearest Neighbor Average Degree Value and Its Evolutionary Trace Based on Complex Network

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Journal of Traffic and Transportation Engineering 2024年第4期12卷 163-174页

作者： Cheng Xiangjun yang fang Xiong Zhihua School of Traffic and Transportation Beijing Jiaotong UniversityBeijing 100044China

In order to reveal the complex network characteristics and evolution principle of China aviation network,the probability distribution and evolution trace of arithmetic average of edge vertices nearest neighbor average degree values of China aviation network were studied based on the statistics data of China civil aviation network in 1988,1994,2001,2008 and *** to the theory and method of complex network,the network system was constructed with the city where the airport was located as the network node and the route between cities as the edge of the *** on the statistical data,the arithmetic averages of edge vertices nearest neighbor average degree values of China aviation network in 1988,1994,2001,2008 and 2015 were *** the probability statistical analysis method,it was found that the arithmetic average of edge vertices nearest neighbor average degree values had the probability distribution of normal function and the position parameters and scale parameters of the probability distribution had linear evolution trace.

关键词： Complex network China aviation network arithmetic average of edge vertices nearest neighbor average degree value linear evolution trace

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Flood Forecasting Experiment Based on EC and WRF in the Bailian River Basin

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Meteorological and Environmental Research 2024年第3期15卷 53-59页

作者： Zhiyuan YIN fang yang Xiaohua LI China Meteorological Administration Basin Heavy Rainfall Key Laboratory/Hubei Key Laboratory for Heavy Rain Monitoring and Warning Research Institute of Heavy RainChina Meteorological AdministrationWuhan 430205China Huanggang Meteorological Bureau of Hubei Province Huanggang 438020China Hubei Province Meteorological Information and Support Centre Wuhan 430074China

In order to extend the forecasting period of flood and improve the accuracy of flood forecasting,this paper took Bailian River Reservoir which located in Huanggang City of Hubei Province as an example and carried out basin flood simulation and forecasting by coupling the quantitative precipitation forecasting products of numerical forecast operation model of Institute of Heavy Rain in Wuhan(WRF)and the European Center for Medium-range Weather Forecasts(ECMWF)with the three water sources Xin an River *** experimental results showed that the spatiotemporal distribution of rainfall predicted by EC is closer to the actual situation compared to WRF;the efficiency coefficient and peak time difference of EC used for flood forecasting are comparable to WRF,but the average relative error of flood peaks is about 14%smaller than ***,the precipitation forecasting products of the two numerical models can be used for flood forecasting in the Bailian River *** forecasting indicators have certain reference value,and there is still significant room for improvement in the forecasting effects of the two models.

关键词： Hydrometeor EC WRF Xin an River model Bailian River

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Probability Distribution of Ratio of China Aviation Network Edge Vertices Degree and Its Evolutionary Trace Based on Complex Network

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Journal of Traffic and Transportation Engineering 2024年第3期12卷 119-129页

作者： Cheng Xiangjun yang fang Wei Liying School of Traffic and Transportation Beijing Jiaotong UniversityBeijing100044China

In order to reveal the complex network characteristics and evolution principle of China aviation network, the probability distribution and evolution trace of ratio of China aviation network edge vertices degree were studied based on the statistics data of China civil aviation network in 1988, 1994, 2001, 2008 and 2015. According to the theory and method of complex network, the network system was constructed with the city where the airport was located as the network node and the route between cities as the edge of the network. Based on the statistical data, the ratio of edge vertices degree in China aviation network in 1988, 1994, 2001, 2008 and 2015 were calculated. Using the probability statistical analysis method and regression analysis approach, it was found that the ratio of edge vertices degree had linear probability distribution and the two parameters of the probability distribution had linear evolution trace.

关键词： Complex network China aviation network ratio of edge vertices degree linear probability distribution linear evolution trace.

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宋朝粮食安全政策及其实践

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西北师大学报（社会科学版） 2024年第5期61卷 135-144页

作者：杨芳西北师范大学历史文化学院甘肃兰州730070

两宋时期,自然灾害多发,战争频繁,人口增长,人地矛盾突出,土地兼并严重,粮食安全形势严峻。宋朝政府大力垦田,发展农业,提高耕作技术,增加粮食产量;鼓励粮食贸易,促进粮食流通,稳定粮食价格;加强仓储建设,完善仓储管理,确保灾荒与突发... 详细信息

两宋时期,自然灾害多发,战争频繁,人口增长,人地矛盾突出,土地兼并严重,粮食安全形势严峻。宋朝政府大力垦田,发展农业,提高耕作技术,增加粮食产量;鼓励粮食贸易,促进粮食流通,稳定粮食价格;加强仓储建设,完善仓储管理,确保灾荒与突发情况下的粮食供给。宋朝通过一系列政策措施,有力促进了农业的发展,为社会经济的发展奠定了基础,也对粮食安全起到了重要保障作用。但宋朝粮食安全政策也存在不足与缺陷,许多好的政策、措施不能一以贯之,加之自然灾害频发、财政危机、吏治腐败,粮食危机亦日趋严重,进一步削弱了国家保障粮食安全的能力。

关键词：宋朝粮食安全政策粮食安全

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伪蛋白生物材料的分类、合成及其应用

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化工进展 2024年第4期43卷 2001-2016页

作者：薛云娇张璇刘洋陈玉焕房静杨芳河北工业大学化工学院天津300130 天津生物工程职业技术学院天津300462

伪蛋白是一种新型合成生物可降解材料,以氨基酸为基本结构单元,它与蛋白质不同的是除了含有肽键外,还含有其他连接基团,这种结构使其既具有蛋白质的优良特性,又具有良好的力学性能、热性能、可调节的物理化学性能以及优异的细胞相容性... 详细信息

伪蛋白是一种新型合成生物可降解材料,以氨基酸为基本结构单元,它与蛋白质不同的是除了含有肽键外,还含有其他连接基团,这种结构使其既具有蛋白质的优良特性,又具有良好的力学性能、热性能、可调节的物理化学性能以及优异的细胞相容性和3D微孔结构等性质,因此伪蛋白能够有效应用于载体、伤口愈合、组织工程等生物医药领域。本文首先综述了目前所研究的伪蛋白的类型,包括非功能性和功能性伪蛋白两类;之后详细阐述了缩聚合成伪蛋白的方法,包括溶液缩聚、界面聚合、熔融缩聚、开环聚合四种方法;接着归纳了伪蛋白生物材料在药物载体、基因载体、组织工程、创面敷料等方面的应用;最后,对伪蛋白生物材料在合成路线及应用方面未来的发展进行了探讨和展望。

关键词：伪蛋白合成聚合物载体组织工程

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Cardiotoxicity induced by fluoropyrimidine drugs in the treatment of gastrointestinal tumors

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 251-254页

作者： Mo-Wei Kong Feng-Di Sun Zhen-Ying Pei Li Xu Ze-Bi Wang Yan Chen Shu-Qing Tang Ting-fang yang Guo-Xiang He Department of Cardiology Guiqian International General HospitalGuiyang 550018Guizhou ProvinceChina Department of Oncology Guiqian International General HospitalGuiyang 550018Guizhou ProvinceChina

In this editorial,we review the article published in World J Gastrointest Oncol 2019,11:*** specifically focus on the occurrence,clinical characteristics,and risk factors of fluoropyrimidine drug-related cardiotoxicity in patients with gastrointestinal *** significant advancements in diagnostic and therapeutic techniques that have reduced mortality rates associated with digestive system tumors,the incidence and mortality rates of treatment-related car-diotoxicity have been increasing,severely impacting the survival and prognosis of cancer *** drugs are widely used as antimetabolites in the treatment of malignant tumors,including gastrointestinal tumors,and they represent the second largest class of drugs associated with ***,there is often a lack of awareness or understanding regarding their cardiotoxic effects and associated risks.

关键词： Cardiotoxicity Gastrointestinal tumors Risk factors Fluoropyrimidine Chest pain

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伯仲胺基团修饰Fe_(3)O_(4)磁性材料的制备和性能表征

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复合材料学报 2024年第4期41卷 1977-1986页

作者：周书威傅红杨方福州海关技术中心福州350001 福州大学生物科学与工程学院福州350108

食品中的有机酸等内源性物质会干扰其中痕量残留物的检测,为消除此影响,以N-β-(氨乙基)-γ-氨丙基三甲氧基硅烷(KH792)为氨基化试剂,直接修饰酸化后的Fe_(3)O_(4)得到磁性吸附材料。经响应面试验优化得到KH792对酸化Fe_(3)O_(4)的最佳... 详细信息

食品中的有机酸等内源性物质会干扰其中痕量残留物的检测,为消除此影响,以N-β-(氨乙基)-γ-氨丙基三甲氧基硅烷(KH792)为氨基化试剂,直接修饰酸化后的Fe_(3)O_(4)得到磁性吸附材料。经响应面试验优化得到KH792对酸化Fe_(3)O_(4)的最佳修饰条件为温度82.5℃、pH=4.9,KH792添加量1.8 mL,在最佳条件下,KH792直接修饰的酸化Fe_(3)O_(4)对没食子酸吸附量为22.8 mg/g,比市售Fe_(3)O_(4)提高了188%,且具备快速固液分离的能力、良好的稳定性及分散性。通过BET、Zeta电位、FTIR和XPS对直接修饰的产物性能进行了表征,结果表明,KH792与Fe_(3)O_(4)表面羟基通过Fe−O−Si键结合,酸化提高了Fe_(3)O_(4)表面羟基含量,因此也增强了KH792对Fe_(3)O_(4)的修饰效果,本文制备的磁性产物可用于净化复杂样品基质中的有机酸。

关键词： N-β-(氨乙基)-γ-氨丙基三甲氧基硅烷酸化Fe_(3)O_(4) 直接修饰法磁性吸附材料修饰机制

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