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Functional hepatic flow in patients with liver cirrhosis

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World Journal of Gastroenterology 2004年第6期10卷 915-918页

作者： ZhengPan Xing-JiangWu Jie-ShouLi fang-NanLiu wei-SuLi Jian-MingHan ResearchInstituteofGeneralSurgery NanjingGeneralHospitalofNanjingCommand/ClinicalSchoolofMedicalCollegeofNanjingUniversityNanjing210002JiangsuProvinceChina

AIM:To evaluate hepatic reserve function by investigating the change of functional hepatic flow and total hepatic flow in cirrhotic patients with portal ***:HPLC method was employed for bhe determination of concentration of D-sorbitol in human plasma and *** functional hepatic flow (FHF) and total hepatic flow (THF) were determined by means of modified hepatic clearance of D-sorbitol combined with duplex doppler color sonography in 20 patients with cirrhosis and 10 healthy ***:FHF,evaluated by means of the D-sorbitol dearance,was significantly reduced in patients with drrhosis in comparison to controls (764.74±167.91 vs 1195.04±242.97mL/min,P<0.01). While THF was significantly increased in patients with cirrhosis in comparison to controls (1605.23±279.99 vs 1 256.12±198.34mL/min, P<0.01).Portal blood flow and hepatic artery flow all were increased in cirrhosis compared to controls (P<0.05 and P<0.01). D-sorbitol total clearance was significantly reduced in cirrhosis compared to control (P<0.01), while D-sorbitol renal clearance was significantly increased in cirrhosis (P<0.05). In controls FHF was similar to THF (1195.05±242.97 vs 1256.12±198.34mL/min, P=0.636),while FHF was significantly reduced compared with THF in drrhosis (764.74±167.91 vs 1605.23±279.99mL/min,P<0.01).CONCLUSION:Our method that combined modified hepatic clearance of D-sorbitol with duplex doppler color sonography is effective in the measurement of FHF and THE FHF can be used to estimate hepatic reserve function.

关键词：肝储备功能肝硬化肝动脉高压高效液相色谱法

The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers

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Virologica Sinica 2017年第5期32卷 357-368页

作者： Yuyan Wang Shuvomoy Banerjee Ling Ding Cankun Cai fang wei Qiliang Cai MOH & MOE Key Laboratory of Medical Molecular Virology School of Basic Medical SciencesShanghai Medical College of Fudan University Shanghai 200032 China Amity Institute of Virology and Immunology Block-J3 Sector-125 Amity University Uttar Pradesh201303 India Sheng Yushou Center of Cell Biology and Immunology School of Life Sciences and BiotechnologyShanghai Jiao Tong University Shanghai 200240 China

Activation of specific sets of protein kinases by intracellular signal molecules has become more and more apparent in the past decade. Phosphorylation, one of key posttranslational modification events, is activated by kinase or regulatory protein and is vital for controlling many physiological functions of eukaryotic cells such as cell proliferation, differentiation, malignant transformation,and signal transduction mediated by external stimuli. Moreovers, the reversible modification of phosphorylation and dephosphorylation can result in different features of the target substrate molecules including DNA binding, protein-protein interaction, subcellular location and enzymatic activity, and is often hijacked by viral infection. Epstein-Barr virus(EBV) and Kaposi's sarcomaassociated herpesvirus(KSHV), two human oncogenic gamma-herpesviruses, are shown to tightly associate with many malignancies. In this review, we summarize the recent progresses on understanding of molecular properties and regulatory modes of cellular and viral proteins phosphorylation influenced by these two tumor viruses, and highlight the potential therapeutic targets and strategies against their related cancers.

关键词： Epstein-Barr Virus(EBV) Kaposi’s sarcoma-associated herpesvirus(KSHV) phosphorylation

Determination of optimal grid opening width for herringbone water-sediment separation structures based on sediment separation efficiency

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Journal of Mountain Science 2019年第3期16卷 619-629页

作者： XIE Xiang-ping wei fang-qiang WANG Xiao-jun YANG Hong-juan Anyang Institute of Technology Chongqing Institutes of Green and Intelligent Technology Chinese Academy of Science Institute of Mountain Hazards and Environment Chinese Academy of Sciences

The herringbone water-sediment separation structure(HWSSS) was developed to prevent debris flows. This paper mainly focuses on evaluating the sediment separation efficiency of HWSSS in debris flow prevention and determining the grid opening width D, a crucial structure parameter for HWSSS design. Theoretical analysis on the total sediment separation rate Pt reveals that the efficiency of sediment separation is much related with sediment grain size distribution(GSD) and grid opening width. The lower limit of Pt is deduced from the perspective of safety consideration by transforming debris flow into sediment-laden flow. Hydraulic model tests were carried out. Based on the regression analysis of the experimental data, the quantitative relationships between Pt and D and GSD characteristic values were finally established. A procedure for determining optimal grid opening width is proposed based on these analyses. These results are of significance in evaluating sediment separation effect by HWSSS in debris flow prevention and contribute to a more explicit methodology for design of HWSSS.

关键词： Debris flow Water-sediment separation Structure design Sediment separation efficiency Grid opening width

Determination of the suspension competence of debris flows based on particle size analysis

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International Journal of Sediment Research 2014年第1期29卷 73-81页

作者： Hong-juan YANG fang-qiang wei Kai-heng HU Chuan-chang WANG Key Laboratory of Mountain Hazards and Earth Surface Process Chinese Academy of Sciences Institute of Mountain Hazards and Environment Chinese Academy of Sciences

The determination of the critical particle size between solid and fluid phases,i.e.,the suspension competence,is fundamental for debris flow.A method for determining suspension competence based on particle size analysis is presented in this *** competence of static experimental water-debris mixtures prepared with the sediment of Jiangjia Gully is-0.025 mm if the bulk density is less than 1,800 kg m;and it increases with bulk density of more concentrated *** competence of natural debris flows in Jiangjia Gully increases exponentially with the bulk *** two data sets are compared in order to understand the suspension *** is concluded that turbulence may play a leading role in particle suspension in non-viscous and sub-viscous debris flows,while in viscous debris flows both matrix strength and excess pore water pressure play important roles.

关键词： Debris flow Suspension competence Particle size analysis Critical particle size Particle suspension mechanism

Rh(Ⅱ) carbene S-H insertion into H_2S via the stepwise mechanism

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Chinese Chemical Letters 2007年第1期18卷 107-110页

作者： Zhen Feng Liu Xian fang Yue Qiang wei Ke Li Han State Key Laboratory of Molecular Reaction Dynamics~ Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China

The mechanism of Rh（Ⅱ） carbene S-H insertion into H2S in gas phase has been studied by B3LYP functional. Calculation results showed that the Rh（Ⅱ） carbene S-H insertion into H2S took only stepwise channels and n... 详细信息

关键词： Sulfonium ylides 1,2-Hydrogen shift Density functional calculations Dirhodium(Ⅱ) carbene

Novel Method for Indirect Determination of Iodine in Marine Products by Atomic Fluorescence Spectrometry

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Chemical Research in Chinese Universities 2013年第1期29卷 26-29页

作者： LU Jian-ping TAN fang-wei TANG Qiong JIANG Tian-cheng College of Chemistry and Chemical Engineering Guangxi University Nanning 530004 P. R. China" Guangxi Center of Analysis and Test Research Nanning 530022 P. R. China

A method for the determination of iodine based upon compound H2HgI4, formed between I- and Hg1＋ in nitric acid and extracted in methyl isobutyl ketone（MIBK）, was developed via atomic fluorescence spectrometry（AFS）. After the compound is reduced with potassium borohydrid（KBH4）, the resultant mercury vapor was injected into the instrument and iodine was, therefore, indirectly determined. Experimental parameters such as the conditions of extraction reagents, aqueous phase acidity, elemental mercury diffusion temperature in a vial and other factors were investigated and optimized. Under the optimum experimental conditions, this method shows a detection limit of 0.038μg/L iodine and a linear relationship between 0.04-20 p.g/L. The method was applied to determining the iodine content in marine duck eggs, kelps, laver and Ganoderma lucidum spirulina, showing a relative standard deviation（RSD） of 2.15% and the recoveries in the range of 98.1%-102.5%.

关键词： Methyl isobutyl ketone Gas injection Atomic fluorescence spectrometer(AFS) Indirect determination Iodine

Radiometric Calibration Chain Design Based on Uniform Collimated Laser Source

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Journal of Beijing Institute of Technology 2018年第3期27卷 385-390页

作者： Liwei Sun Xin Ye wei fang Zhenlei He Yupeng Wang Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of Sciences University of Chinese Academy of Sciences

A uniform collimated laser source,composed of the integrating sphere source and the off-axis parabolic,is *** calibration process is analyzed theoretically,and Monte Carlo ray tracing method is used to simulate and analyze the design *** results show that when the calibration source is composed of an 8 cm diameter integral sphere,10 mm diameter exit port,and 1 000 mm focal length,and an off-axis angle 60°parabolic mirror,the maximum divergence angle is 7.5 mrad and the uniformity of irradiance is 99.31%.Finally,the uncertainty of radiometric calibration process is analyzed,and the calibration accuracy of 0.335%for imaging spectrometer can be achieved by using the radiation calibration laser source.

关键词： transfer radiometer radiometric calibration laser source uniformity

Cadmium and copper uptake and accumulation by Sesbania rostrata seedling, a N-fixing annual plant: implications for the mechanism of heavy metal tolerance

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Frontiers in Biology 2009年第2期4卷 200-206页

作者： Fuhua CHEN wei fang Zhongyi YANG Jiangang YUAN School of Life Sciences Sun Yat-Sen UniversityGuangzhou 510275China Biology Department Long Island University-Brooklyn1 University PlazaBrooklynNY 11201USA

Sesbania rostrata,an annual tropical legume,has been found to be tolerant to heavy metals,with an unknown *** is a promising candidate species for revegetation at mine *** this study,sequential extractions with five buffers and strong acids were used to extract various chemical forms of cadmium and copper in ***,with or without Cd or Cu treatments,so that the mechanisms of tolerance and detoxification could be *** metals had low transition rates from roots to the aboveground of *** transition ratio of Cd(4.00%)was higher than that of Cu(1.46%).The proportion of NaCl extracted Cd(mostly in proteinbinding forms)increased drastically in Cd treated plants from being undetectable in untreated *** suggests that Cd induced biochemical processes producing proteinlike phytochelatins that served as a major mechanism for the high Cd tolerance of *** case for Cu was quite different,indicating that the mechanism for metal tolerance in *** is *** proportion of water-insoluble Cu(*** and phosphate)in roots increased significantly with Cu treatment,which partially explains the tolerance of *** to ***,how *** copes with the high biotic activity of inorganic salts of Cu,which increased in all parts of the plant under Cu stress,is a question for future *** rostrata is among the very few N-fixing plants tolerant to heavy *** study provides evidence for the detoxification mechanism of metals in Sesbania rostrata.

关键词： Sesbania rostrata phytoremediation heavy metal tolerance sequential extraction chemical forms

A New Method of Image Restoration Technology Based on WGAN

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Computer Systems Science & Engineering 2022年第5期41卷 689-698页

作者： wei fang Enming Gu weinan Yi weiqing Wang Victor S.Sheng School of Computer&Software Engineering Research Center of Digital ForensicsMininstry of EducationNanjing University of Information Science&TechnologyNanjing210044China Provincial Key Laboratory for Computer Information Processing Technology Soochow UniversitySuzhou215325China Texas Tech University USA

With the development of image restoration technology based on deep learning,more complex problems are being solved,especially in image semantic inpainting based on ***,image semantic inpainting techniques are becoming more ***,due to the limitations of memory,the instability of training,and the lack of sample diversity,the results of image restoration are still encountering difficult problems,such as repairing the content of glitches which cannot be well integrated with the original ***,we propose an image inpainting network based on Wasserstein generative adversarial network(WGAN)*** the corresponding technology having been adjusted and improved,we attempted to use the Adam algorithm to replace the traditional stochastic gradient descent,and another algorithm to optimize the training used in recent *** evaluated our algorithm on the ImageNet *** obtained high-quality restoration results,indicating that our algorithm improves the clarity and consistency of the image.

关键词： Image restoration WGAN DCGAN context semantic