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Inspection-replacement policy of system under predictive maintenance

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第3期8卷 495-500页

作者： LIU Bao-you fang You-tong WEI Jin-xiang WANG Yong-liang Department of Mathematics and Physics Shijiazhuang Railway Institute Shijiazhuang 050043 China College of Electrical Engineering Zhejiang University Hangzhou 310027 China Extrahigh Tension Transmittal and Transformation Company Branch Hebei Electric Power Company Shijiazhuang 050051 China

In general, every system is in one of the three states： normal, abnormal, or failure state. When the system is diagnosed as abnormal state, it needs predictive maintenance, lfthe system fails, an identical new one will replace it. The predictive maintenance cannot make the system ＂as good as new＂. Under these assumptions, the reliability index and the inspection-replacement policy of a system were studied. The explicit expression of the reliability index and the average income rate （i.e., the long-run average income per unit time） are derived by using probability analysis and vector Markov process method. The criterion of feasibility for the optimal inspection-replacement policy under the maximum average income rate is obtained. The numerical example shows the optimal inspection-replacement policy can raise the average income rate when the optimal inspection-replacement policy is feasible.

关键词： lnspection-replacement policy. Inspection and diagnosis. Monotone stochastic process. Reliability index Vector Markov process method

Clinical Analysis of 29 Cases with Primary Malignant Lymphoma of the Prostate

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Chinese Journal of Clinical Oncology 2007年第2期4卷 129-132页

作者： tong fang Beijing Shijitan Hospital Department of Radiation Oncology Beijing 100038 China

OBJECTIVE To summarize the clinical characteristics, pathology, treatment and prognosis of malignant lymphoma of the prostate. METHODS Clinical data from 29 patients with primary malignant lymphoma of the prostate were reviewed retrospectively. The median age was 66 years. Clinical signs and symptoms were due to lower urinary tract obstruction resulting from a diffusely enlarged prostate. Prostate biopsies revealed diffuse large B-cell non-Hodgkin＇s lymphoma. The therapeutic modalities included prostatectomy, radiotherapy and chemotherapy. RESULTS Extraprostatic involvement at various sites became evident in 19 of the 29 patients after diagnosis. Ten patients died from lymphoma with a median survival of 23 months （range, 2-30 months）. Seven patients were alive up to 60 months. CONCLUSION Malignant lymphoma involving the prostate was rare and has a rather poor prognosis. Prognosis related to the patient age, histologic type, and treatment or clinical stage of the disease at presentation.

关键词： malignant lymphoma non-Hodgkin's prostate

基于实时无标记细胞分析技术时间维度特征的体外抗肿瘤活性评价新策略

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中国药理学通报 2024年第3期40卷 592-598页

作者：刘芳彤邢淑雁刘孝云叶冬雪杨佳张国英容蓉杨勇山东中医药大学中医药创新研究院山东济南250355 山东中医药大学药学院山东济南250355 山东中医药大学实验中心山东济南250355 山东中医药大学中医药经典理论教育部重点实验室山东济南250355 山东中医药大学中医药基础研究山东省重点实验室山东济南250355 山东中医药大学山东省中医药抗病毒工程研究中心山东济南250355

目的基于实时无标记细胞分析(real time cellular analysis,RTCA)技术,以黄芩苷、黄芪甲苷、橙皮苷和顺铂为例进行抗A549、H1299肺腺癌活性分析,建立一种反映时间维度变化特征的EC_(50)评价新策略。方法应用RTCA Software Pro数据分析及... 详细信息

目的基于实时无标记细胞分析(real time cellular analysis,RTCA)技术,以黄芩苷、黄芪甲苷、橙皮苷和顺铂为例进行抗A549、H1299肺腺癌活性分析,建立一种反映时间维度变化特征的EC_(50)评价新策略。方法应用RTCA Software Pro数据分析及GraphPad Prism、Origin Pro做图,分别采用终点法和时间维度表征黄芩苷、黄芪甲苷、橙皮苷、顺铂受试液/药的体外抗A549、H1299肺腺癌活性。结果①受试液/药对A549及H1299细胞在24 h、48 h终点法中的EC_(50)值有的存在较大差异。②采用四参数方程拟合曲线的相关系数>0.9,EC_(50)动态变化相对稳定期(相邻4点EC_(50)线性拟合|斜率|≤1)计算此时间维度内的EC_(50)值。黄芩苷、黄芪甲苷、橙皮苷和顺铂对A549细胞的EC_(50)分别为52.97±1.75μmol·L^(-1)(16~48 h)、62.88±2.91μmol·L^(-1)(32.25~48 h)、78.84±0.33μmol·L^(-1)(21.5~29.75 h)、13.57±1.54μmol·L^(-1)(27.5~48 h);黄芩苷、黄芪甲苷、橙皮苷和顺铂对H1299细胞的EC_(50)分别为43.71±1.26μmol·L^(-1)(19.5~48 h)、47.23±1.19μmol·L^(-1)(14~48 h)、39.45±0.24μmol·L^(-1)(12.75~46.25 h)、25.97±4.76μmol·L^(-1)(10.25~48 h)。显示受试液/药抗肿瘤起效的时间窗口期不同。结论基于RTCA技术,选用拟合度好、稳定并带有时间维度特征的EC_(50)数据用于抗肿瘤活性评价将更加精确和合理。此外,这种区分开不同有效时间的抗肿瘤药物方法可为临床联合用药的给药时机提供参考,本思路也将为其他体外相关研究提供借鉴。

关键词： RTCA技术时间维度特征抗肿瘤活性 EC_(50) 肺腺癌新策略

CALCULATING RESPONSE SPECTRAL MOMENTS BY COMPLEX MODAL ANALYSIS

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Acta Mechanica Sinica 1989年第2期5卷 159-166页

作者： fang tong Zhang Tianshu (Northwestern Polytechnical University) Northwestern Polytechnical University China

Response spectral moments are useful for system reliability ***,spectral mo- ments are calculated by the frequency domain *** on the time domain modal analysis of random vibrations,the authors present a new method for calculating response spectral moments through response correlation *** method can be applied to both classical and non-classical damping cases and to three kinds of random excitations,i.e.,white noise,band-limited white noise, and filtered white noise.

关键词： spectral moment random response reliability analysis modal analysis

Trehalose-6-phosphate phosphatases are involved in trehalose synthesis and metamorphosis in Bactrocera minax

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Insect Science 2022年第6期29卷 1643-1658页

作者： Jia Wang Huan Fan Ying Li tong-fang Zhang Ying-Hong Liu College of Plant Protection Southwest UniversityChongqingChina College of Food Science Southwest UniversityChongqingChina

Trehalose is the principal sugar circulating in the hemolymph of insects,and trehalose synthesis is catalyzed by trehalose-6-phosphate synthase(TPS)and trehalose-6-phosphate phosphatase(TPP).Insect TPS is a fused enzyme containing both TPS do-main and TPP ***,many insects do not possess TPP genes as TPSs have re-placed the function of ***,TPPs are widely distributed across the dipteran insects,while the roles they play remain largely *** this study,3 TPP genes from notorious dipteran pest Bactrocera minax(BmiTPPB,BmiTPPCl,and BmiTPPC2)were identified and *** different temporal-spatial expression patterns of 3 BmiTPPs implied that they exert different functions in *** BmiTPPs were heterologously expressed in yeast cells,and all purified proteins exhibited enzy-matic activities,despite the remarkable disparity in performance between BmiTPPB and *** interference revealed that all BmiTPPs were successfully downregulated after double-stranded RNA injection,leading to decreased trehalose content and increased glucose ***,suppression of BmiTPPs significantly affected expression of down-stream genes and increased the mortality and malformation ***,these results indicated that all 3 BmiTPPs in *** are involved in trehalose synthesis and ***,these genes could be evaluated as insecticidal targets for managing ***,andevenforotherdipteranpests.

关键词： Bactrocera minax heterologous expression metamorphosis trehalose trehalose-6-phosphate phosphatase RNA interference

前置胎盘住院患者发生创伤后应激障碍的相关影响因素分析

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沈阳医学院学报 2024年第1期26卷 63-67页

作者：李亭亭彭凌云方铜江西省景德镇市乐平市妇幼保健院妇产科江西景德镇333300

目的:探讨前置胎盘住院患者发生创伤后应激障碍(PTSD)的相关影响因素。方法:选取2019年10月至2023年1月我院收治的110例前置胎盘住院患者,采用创伤后应激障碍量表平民版(PCL-C)评估患者住院期间PTSD的发生情况,并收集相关资料,采用多因... 详细信息

目的:探讨前置胎盘住院患者发生创伤后应激障碍(PTSD)的相关影响因素。方法:选取2019年10月至2023年1月我院收治的110例前置胎盘住院患者,采用创伤后应激障碍量表平民版(PCL-C)评估患者住院期间PTSD的发生情况,并收集相关资料,采用多因素Logistic回归分析影响该类患者发生PTSD的因素。结果:110例患者中有41例发生PTSD,发生率为37.27%。单因素分析显示孕妇类型(初产妇)、乐观倾向水平、家庭支持度、心理弹性、人格特征与前置胎盘住院患者发生PTSD有关(P0.05)。经多因素Logistic回归分析显示,初产妇、人格特征为内向是前置胎盘住院患者发生PTSD的危险因素(OR>1,P<0.05),乐观倾向水平较高、家庭支持度较高、心理弹性较高为前置胎盘住院患者发生PTSD的保护因素(OR<1,P<0.05)。结论:前置胎盘住院患者PTSD发生率较高,初产妇、乐观倾向水平较低、家庭支持度较低、心理弹性较低、人格特征为内向是该类患者发生PTSD的危险因素。

关键词：前置胎盘创伤后应激障碍乐观倾向家庭支持度心理弹性

超声波辅助酶法处理对百香果出汁率及品质的影响

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食品安全质量检测学报 2024年第10期15卷 234-242页

作者：方晓彤王前菊穆波王宇贵州省农业科学院果树科学研究所贵阳550006 贵州省分析测试研究院贵阳550013

目的探究超声波辅助酶法处理对百香果出汁率及品质的影响。方法以台农1号百香果为原料,利用超声波辅助复合酶法,通过研究超声温度、超声时间、酶解时间、酶解温度、复合酶配比和加酶量等因素对百香果果汁的影响,在单因素的基础上进行正... 详细信息

目的探究超声波辅助酶法处理对百香果出汁率及品质的影响。方法以台农1号百香果为原料,利用超声波辅助复合酶法,通过研究超声温度、超声时间、酶解时间、酶解温度、复合酶配比和加酶量等因素对百香果果汁的影响,在单因素的基础上进行正交试验,以出汁率和感官评价结果为依据,得出最佳加工工艺,并对运用该工艺提取的百香果果汁进行品质分析。结果最佳工艺为超声温度20℃、超声时间30 min、酶解时间60 min、酶解温度20℃、果胶酶与纤维素酶的质量比为1:1、加酶量为总质量的0.24%;与物理压榨果肉相比出汁率提高23.29%,杀菌后维生素C含量损失率降低了20.88%,可溶性糖含量提升了42.41%、总抗氧化能力、2,2’-联氮-二(3-乙基-苯并噻唑啉-6-磺酸)二铵盐自由基清除能力和1,1-二苯基-2-三硝基苯肼自由基清除能力和总酚含量分别提升了55.23%、7.73%、73.18%和37.61%,对氨基酸含量的影响差异不显著。结论采用超声波辅助酶法处理百香果可以显著提升百香果出汁率及品质,为百香果高效加工开发技术提供理论基础,提升产业附加值。

关键词：果汁百香果超声波辅助酶工艺优化抗氧化性

Design and analysis of the hybrid excitation rail eddy brake system of high-speed trains

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第12期12卷 936-944页

作者： Ji-en MA Bin ZHANG Xiao-yan HUANG You-tong fang Wen-ping CAO College of Electrical Engineering Zhejiang University Hangzhou 310027 China The Key State Lab of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China Newcastle University Newcastle upon Type NE1 7RU UK

Compared to the current eddy braking patterns using a single magnetic source,hybrid excitation rail eddy brakes have many advantages,such as controllability,energy saving,and various operating *** the large braking power consumption of the high-speed train,a hybrid excitation rail eddy brake system,which is based on the principle of electromagnetic field,is proposed to fulfill the needs of safety and *** the working processes of the mechanical lifting system and electromagnetic system are *** the electromagnetic system analyzed using the finite element method,the factors such as speed,air gap,and exciting current have influences on the braking force and attractive *** last,the structure optimization of the brake system is discussed.

关键词： High-speed train Hybrid excitation Eddy brake Finite element method

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电力语音精准识别系统构建模型研究

电力设备管理 2024年第6期 137-139页

作者：林鑫佟芳马国雷张容福杨承李心国网青海省电力公司信息通信公司国网青海省电力公司科大讯飞股份有限公司

对电网大数据系统的可用算力资源进行重新优化整合,将电网大数据系统的显示功能整合为独立服务的电网电力大数据语音三维场景可视化系统,构建管理模型并形成新调度语音桌面控制系统,其对所有处于工作状态下的电力调度人员的工作效率提... 详细信息

对电网大数据系统的可用算力资源进行重新优化整合,将电网大数据系统的显示功能整合为独立服务的电网电力大数据语音三维场景可视化系统,构建管理模型并形成新调度语音桌面控制系统,其对所有处于工作状态下的电力调度人员的工作效率提高均具备一定程度的作用,使电网电力调度语音工作的可靠性得到有效提升。

关键词：电力大数据三维可视化语音调度桌面系统管理模型调度效率