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World Journal of Clinical Cases 2021年第23期9卷 6879-6885页

作者： Ying-Ming Xiao Sheng-Ke Yang Ying Wang Dun Mao fang-lei Duan Shu-Kui Zhou Department of Urology Sichuan Cancer Hospital and InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610041Sichuan ProvinceChina Department of Urology Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai 200233China Department of Pathology Sichuan Cancer Hospital and InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610041Sichuan ProvinceChina

BACKGROUND The majority of renal cell carcinomas are single lesions;unilateral synchronous multifocal renal carcinoma(USMRC)is rarely reported and poses a treatment challenge for urological *** SUMMARY A 56-year-old man was hospitalized for pain and discomfort in the right kidney area for 6 ***-enhanced computed tomography demonstrated cT1a renal tumors at the lower pole of the right kidney and a cT1b renal tumor at the middle dorsal portion of the right *** patient underwent retroperitoneal laparoscopic partial nephrectomy(RLPN).There were no complications *** revealed a low-grade,pathologic stage T1a(pT1a),clear cell renal cell carcinoma at the lower pole of the right kidney and a pT1b,chromophobe renal cell carcinoma at the middle dorsal portion of the right *** tumor bed recurrence or metastasis was observed on imaging and his renal function remained stable during the 12-mo follow-up *** RLPN is a safe,effective,and feasible for the management of USMRC,which can obtain equivalent oncological results with optimal renal function preservation.

关键词： Kidney neoplasm Multifocal Retroperitoneal laparoscopic operation Partial nephrectomy Case report

Targeted Degradation of DNA/RNA Binding Proteins via Covalent Hydrophobic Tagging

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CCS Chemistry 2023年第10期5卷 2207-2214页

作者： Yan Wang Jingzi Zhang Jiafang Deng Chengzhi Wang lei fang Yan Zhang Jinbo Li State Key Laboratory of Analytical Chemistry for Life Sciences Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringChemistry and Biomedicine Innovation Center(ChemBIC)Nanjing UniversityNanjing 210023 Jiangsu Key Laboratory of Molecular Medicine Chemistry and Biomedicine Innovation Center(ChemBIC)Medical School of Nanjing UniversityNanjing 210093

Targeted protein degradation(TPD)holds great promise for biological inquiry and therapeutic ***,it still remains elusive to destruct DNA/RNA binding proteins(DBPs/RBPs)previously deemed ***,we report ligandassisted covalent hydrophobic tagging(LACHT)as a modular strategy for TPD of these difficult-totarget *** by a noncovalent protein ligand,LACHT leverages a reactive N-acyl-N-alkyl sulfonamide group to covalently label the protein target with a hydrophobic adamantane,which further engages the cellular quality control mechanism to induce proteolytic *** a smallmolecule ligand,we demonstrated that LACHT allowed TPD of a DBP,bromodomain-containing protein 4,in human leukemia cells with high *** studies revealed that LACHT-mediated TPD dependent on ligand-directed irreversible tagging and the covalently labeled proteins underwent polyubiquitination before removal through both the proteasome and the ***,when an RNA ligand was employed,we showed that LACHT also enabled TPD of an RBP,Lin28a,leading to upregulation of its downstream let-7 *** study thus provides a generalizable platform to expand the TPD toolbox for biomedical applications.

关键词： targeted protein degradation covalent labeling hydrophobic tagging DNA/RNA binding proteins miRNA

Hydrothermal synthesis of uniform CdWO4:Eu^3+microrods as single component for UV-based WLEDs

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Journal of Rare Earths 2016年第12期34卷 1179-1187页

作者：雷芳殷录桥施鹰谢建军章蕾范灵聪 School of Materials Science and Enggineering Shanghai UniversityShanghai 200444China Key Laboratory of Advanced Display and System Applications Ministry of EducationShanghai UniversityShanghai 200072China

A series of single-composition emission-tunable CdWO4：Eu^3＋ uniform size nanorods were synthesized by polyvinylpyrrolidone（PVP） assisted hydrothermal process. The products were measured by powder X-ray diffraction（PXRD）, scanning electron microscopy（SEM）, transmission electron microscopy（TEM）, photoluminescence, and fluorescent decay test. The results showed that reaction time, temperature, p H values and Eu^3＋ doped concentration played important roles in determining the morphologies and photoluminescent properties. And we also investigated its use in Ga N LED, warm-white-light could be obtained by the combination of the bright blue light originated from the charge transfer transition in the tungstate groups and the near UV light from LED chip with the red emission from 4f-4f transition of Eu^3＋, respectively. By properly tuning the doping concentration of Eu^3＋, chromaticity coordinates（0.30 0.22） could be achieved under the 380 nm excitation and its color rendering index was 80.6. So it has potential application in warm-WLED and replacing the commercial YAG：Ce phosphor which absence of red band emission.

关键词： CdWO4:Eu3+ hydrothermal synthesis WLED photoluminescence single-component rare earths

Oxygen-vacancy-rich phenanthroline/TiO_(2) nanocomposites: An integrated adsorption, detection and photocatalytic material for complex pollutants remediation

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Chinese Chemical Letters 2022年第2期33卷 907-911页

作者： Pinghua Chen Huitao Zheng Hualin Jiang Jun Liu Xinman Tu Weibo Zhang Bailey Phillips lei fang Jian-Ping Zou Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063China Department of Applied Chemistry College of Environmental and Chemical EngineeringNanchang Hangkong UniversityNanchang 330063China Department of Chemistry Texas A&M UniversityCollege StationTexas 77843United States School of Resources Environmental and Chemical EngineeringNanchang UniversityNanchang 330031China

To address the challenge of treating complex pollutants containing heavy metals and organic compounds,a phenanthroline/TiO_(2)nanocomposite with rich oxygen vacancy defects was synthesized to integrate the functions of pollutant detection, adsorption, and photocatalytic degradation. The results showed that the nanocomposite could adsorb Cr^(3+)and the process could be transduced into a colorimetric signal for qualitative and quantitative detection. The adsorbed heavy metal also exhibited a synergistically enhanced photocatalytic degradation of a model organic pollutant under visible light. The simultaneous adsorption, detection, and photocatalysis could reduce the multifarious operations and high cost of traditional environmental remediation methods, indicating a strong application potential for the nanocomposite.

关键词： Heavy metals Organic contaminants Adsorption Detection Photocatalytic degradation Oxygen vacancy

梯度人工骨修复支架调控骨骼系统组织的修复与再生

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中国组织工程研究 2025年第4期29卷 846-855页

作者：张煜徐睿安方蕾历龙飞刘姝妍丁凌雪王悦熹郭子琰田丰薛佳佳有机无机复合材料国家重点实验室生物医用材料北京实验室先进弹性体材料研究中心材料科学与工程学院北京化工大学北京市100029

背景:梯度人工骨修复支架模拟了骨骼系统中的独特特征,在骨骼系统再生中具有巨大的应用潜力。目的:综述梯度人工骨修复支架在骨骼系统组织工程中的最新研究进展,并阐述了其优势与制造策略。方法:由第一作者检索Web of Science和PubMed... 详细信息

背景:梯度人工骨修复支架模拟了骨骼系统中的独特特征,在骨骼系统再生中具有巨大的应用潜力。目的:综述梯度人工骨修复支架在骨骼系统组织工程中的最新研究进展,并阐述了其优势与制造策略。方法:由第一作者检索Web of Science和PubMed数据库2000-2023年发表的文献,英文检索词为“gradient,bone regeneration,scaffold”,最终筛选后对76篇文献进行分析总结。结果与结论:①作为骨骼系统组织高效、高质量修复的重要手段,梯度人工骨修复支架目前针对骨组织、骨-软骨、肌腱-骨组织的天然梯度特征进行了仿生设计,这些支架能够一定程度地从结构、成分上模拟原生组织的细胞外基质,从而促进细胞黏附、迁移、增殖和分化,促进受损组织向原生状态再生恢复。②先进制造技术为梯度人工骨修复支架制备提供了更多可能;目前已经开发了通过空间差异化纤维排布和生物活性物质加载构建的梯度电纺纤维支架;分层叠加、分级孔隙率与生物3D打印技术制造的梯度3D打印支架;原位分层注射、简单逐层叠加、冷冻干燥法制造的梯度水凝胶支架;另外还包括其他方式或多方法联用的支架;这些支架在体外实验中展示了良好的生物相容性,在小型动物实验中能够加速组织再生并且观察到组织学结构明显改善。③目前开发的梯度人工骨修复支架仍需进一步优化,提高在梯度尺度上的匹配性,进一步明确材料与组织相互作用,避免降解产物导致的副反应等问题,未来需要结合相关学科优势与临床需求进一步优化。

关键词：梯度支架骨骼系统先进制造组织再生应用策略骨组织修复静电纺丝水凝胶 3D打印

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基于信令数据的出行强度影响因素分析模型

交通运输系统工程与信息 2020年第5期20卷 51-55,71页

作者：雷方舒北京交通发展研究院城市交通运行仿真与决策支持北京市重点实验室城市交通北京市国际科技合作基地北京100073

为探究城市交通出行强度影响因素及不同因素的影响程度,本文从土地利用与交通基础设施建设两方面出发,分析包括土地利用混合指数,职住混合率熵指数,公共交通站点500 m覆盖率,路网可达性等17个指标与出行强度的相关关系;基于相关系数和... 详细信息

为探究城市交通出行强度影响因素及不同因素的影响程度,本文从土地利用与交通基础设施建设两方面出发,分析包括土地利用混合指数,职住混合率熵指数,公共交通站点500 m覆盖率,路网可达性等17个指标与出行强度的相关关系;基于相关系数和拟合优度分析,提取7个与出行强度强相关指标,基于所识别指标构建北京市中心城区出行强度多元回归模型.模型结果表明,职住混合率熵指数对出行强度的影响最为显著,公共交通站点覆盖率对出行强度的影响比道路网密度和可达性更为明显.此外,给出单一土地利用/交通基础设施指标对出行强度拟合结果的离群特征分析方法,用于评估不同区域基础设施供给与交通出行需求之间的平衡关系.

关键词：智能交通影响因素多元回归模型出行强度土地利用交通基础设施

Prolonged progression-free survival and overall survival are associated with diabetes mellitus but inversely associated with levels of blood glucose in patients with lung cancer

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Chinese Medical Journal 2020年第7期133卷 786-791页

作者： Ning-fang Wang Hong-Mei Tang fang-lei Liu Qun-Ying Hong Department of Pulmonary Medicine Zhongshan HospitalFudan UniversityShanghai 200032China

Background:Previous studies have provided conflicting evidence about the increased overall survival(OS)in lung cancer patients with diabetes mellitus(DM)compared with those without *** study assessed progression-free survival(PFS)/OS in lung cancer patients with or without DM and tentatively analyzed the impact of blood glucose levels on PFS/OS in lung cancer ***:Data were collected from lung cancer patients based upon admission records from January 2010 to January 2012 and follow-up records from January 2010 to January 2015 in the Department of Pulmonary Medicine,Zhongshan Hospital,Fudan University,*** data included patient sex,age,body mass index(BMI),smoking status,history of DM,level of blood glucose,pathological type,clinical stage of cancer,chemotherapy regimen,and history of anti-DM *** Cox regression model and Kaplan-Meier method were used for the analysis of hazard factors and PFS/*** comparison of PFS/OS in lung cancer with or without DM,patients were divided into three groups:lung cancer with DM,lung cancer without DM but with elevated level of blood glucose,lung cancer without DM or elevated level of blood ***:In total,the data from 200 lung cancer patients(138 males/62 females,aged 29.0 to 78.0 years,mean 60.0±8.6 years)were *** the comparison of PFS/OS in lung cancer patients with or without DM,patients were divided into three groups:lung cancer with DM(n=31);lung cancer without DM but with elevated levels of blood glucose(n=40);and lung cancer without both DM and elevated levels of blood glucose(n=128),whereas 1 patient dropped out of the *** the patients underwent complete chemotherapy and were followed up for 36.0 to 60.0 ***-Meier survival analysis showed that lung cancer patients with DM had increased PFS and OS compared with those without DM(log-rank,P<0.05,P<0.01);the median PFS in lung cancer with DM was 12.0 months(95%confidence interval[CI],4.0-16.0)vs.6.0 months in thos

关键词： Diabetes mellitus Lung cancer Overall survival Progression-free survival Serum glucose level

Pluralistic Efficiency-Equity Tradeoffs in Locating Public Services

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Journal of Systems Science and Information 2014年第2期2卷 130-143页

作者： lei fang Hecheng LI Nankai University Department of Mathematics Qinghai Normal University Business School

Aside from efficiency, equity is a particularly salient objective in siting public *** this paper, we develop and test a bicriteria mixed integer program that trades off the efficiency and equity measures between an individual and the group. Individual efficiency is measured by data envelopment analysis(DEA) while individual equity is modeled by a center location model. On the other hand, group efficiency is measured by the median location model, while group equity is measured by the Gini coefficient. Available computational results suggest that the multicriteria model provides a promising approach to locate public services in a pluralistic society, when the individual rights are often weighed against common good.

关键词： efficiency data envelopment analysis equity median center

Spatial patterns of interprovincial mountain geographical names in China and implications for regional governance

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Journal of Mountain Science 2018年第11期15卷 2517-2530页

作者： ZHANG Sheng-rui WANG Ying-jie JU Hong-run ZHANG Tong-yan LI Dai-chao fang lei WANG Ying-ying Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of Resources and Environmental Information Systems Institute of Geographic and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China School of Tourism and Geography Science Qingdao University Oingdao 266071 China

Suffering from fragile environment, poor accessibility and infrastructure, as well as social,political and economic marginality, the interprovincial mountain geographical entities are difficult areas for the regional governance in *** analyzing the spatial patterns and the influencing factors of the interprovincial mountain geographical names(IMGNs), the goal of this research is to clarify the geographical features of IMGNs and offer alternatives for the management of interprovincial mountain regions in China. The spatial visualization,the analysis of spatial agglomeration and the influencing factors of IMGNs were all implemented under a geographical information system. Results showed that there were 6869 IMGNs in China according to the database of "China's Second National Survey of Geographical Names(2014-2018)",including 4209 mountain geographical names, 1684 mountain peak geographical names and 976 the other mountain geographical names. Hunan Province had the largest number of names while Shanghai had the smallest number of names. In addition, the spatial variance of the mountain peak names and the mountain names were larger than that of the other mountain geographical names, and the IMGNs showed a significant clustering phenomenon in the southern part of China. The relative elevation and the population had an impact on the distribution of the IMGNs. The largest number of the names occurred where the relative elevation was between 1000-2000 m and where the population was between 40-50 million. Density of unnamed interprovincial mountain geographical entities declined from west to east in China. The analysis of generic names of different types of IMGNs implied that the naming of IMGNs is inconsistent. Based on these analyses, it is suggested that the government should take the IMGNs as management units, strengthen the naming of unnamed interprovincial mountain geographical entities, standardize the generic names of IMGNs and identify areas of poverty based on

关键词： Interprovincial mountain geographical names Spatial association Spatial variance GIS Regional governance China

Improving Rice Blast Resistance by Mining Broad-Spectrum Resistance Genes at Pik Locus

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Rice science 2022年第2期29卷 133-142页

作者： ZHOU Ying WAN Tao YUAN Bin lei fang CHEN Meijuan WANG Qiong HUANG Ping KOU Shuyan QIU Wenxiu LIU Li College of Life Science and Health Wuhan University of Science and TechnologyWuhan 430065China College of Life Sciences Hubei UniversityWuhan 430062China Key Laboratory of Integrated Management of Crops of Central China Ministry of Agriculture and Rural Affairs/Hubei Key Laboratory of Crop DiseaseInsect Pests and Weeds ControlWuhan 430064China College of Information Huazhong Agricultural UniversityWuhan 430070China College of Plant Science and Technology Huazhong Agricultural UniversityWuhan 430070China Institute of Food Crops Yunnan Academy of Agriculture SciencesKunming 650205China

Magnaporthe oryzae is known for its genetic diversity and pathogenic variability,leading to rapid breakdown of resistance in *** multiple broad-spectrum blast resistance genes into rice cultivars would extend disease resistance *** resistance breeding in rice therefore requires continual enrichment of the reservoir of resistance genes and *** conducted a large-scale screen of rice blast resistance in about 2000 rice *** them,247 accessions showed at least medium resistance to the natural infection of rice blast and 7 novel Pik alleles were identified from *** in gene sequences were then correlated with the phenotypic trait to enable the identification of favorable *** the seven novel Pik alleles,the resistant rate of Pik-R0/ME/7017 donors was greater than 80%,and the disease score was less than *** molecular marker-assisted backcross breeding,we successfully transferred the three Pik alleles,Pik-R0/ME/7017,into an elite cultivated line Kongyu 131 to obtain BC_(3)F_(2)lines,which showed enhanced resistance to rice blast compared with the recurrent *** of these near-isogenic lines in the greenhouse using 31 isolates of *** from Heilongjiang Province of China revealed that the resistant levels of the BC_(3)F_(2)lines with Pik-R0/ME/7017 were significantly higher than those of the established cloned resistance genes Pik-m and *** such alleles will enrich our gene library for resistance to rice blast.

关键词： genetic diversity near-isogenic line Pik gene resistance gene allele rice blast R gene