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A citrullinated antigenic vaccine in treatment of autoimmune arthritis

Science Bulletin 2024年第18期69卷 2920-2929页

作者： Xu j.n Tianya Dong Qian Wang Yang Xie Xiangyu fang Chaonan Wei Shuyan Liu Xi Zheng Ping Wang Danxue Zhu Lulu Cao Suwei Dong Kechi fang Chao Zhong j.ng Wang Fanlei Hu Zhanguo Li Department of Rheumatology and Immunology Peking University People’s Hospital&Beijing Key Laboratory for Rheumatism Mechanism and Immune DiagnosisBeijing 100044China Peking-Tsinghua Center for Life Sciences Peking UniversityBeijing 100871China CAS Key Laboratory of Mental Health Institute of PsychologyChinese Academy of SciencesBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100049China Department of Chemical Biology School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Institute of Systems Biomedicine Department of ImmunologyNHC Key Laboratory of Medical Immunology(Peking University)Beijing Key Laboratory of Tumor Systems BiologyPeking University Health Science CenterBeijing 100191China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Integration of Chinese and Western Medicine School of Basic Medical SciencesPeking UniversityBeijing 100191China

Rheumatoid arthritis(RA)is an inflammatory autoimmune disease triggered by antigenic peptides with environmental and genetic risk *** has been shown that antigen-specific targeting could be a promising therapeutical strategy for RA by restoring immune tolerance to self-antigens without compromising normal *** of antigens enhances antigenic properties and induces autoimmune ***,we showed that citrullinated antigenic(citAg)vaccine ameliorated collageninduced arthritis with decreased T-helper 1(Th1)and Th17 cells,downregulated proinflammatory cytokines including interlukin-6 and tumor necrosis factor-a,and inhibited antigen recall responses.B cell receptor sequencing further revealed that citAg vaccine could dampen the dysregulated V(D)j.recombination,restoring the immune *** together,the results demonstrated that citAg vaccine might have a therapeutic effect on RA.

关键词： CitAg Citrullination Collagen typeⅡ Therapeutic vaccine Immune tolerance Rheumatoid arthritis

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Glucagon-like peptide-1 receptor agonists rescued diabetic vascular endothelial damage through suppression of aberrant STING signaling

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2613-2630页

作者： Xuemin He Siying Wen Xixiang Tang Zheyao Wen Rui Zhang Shasha Li Rong Gao j.n Wang Yanhua Zhu Dong fang Ting Li Ruiping Peng Zhaotian Zhang Shiyi Wen Li Zhou Heying Ai Yan Lu Shaochong Zhang Guoj.n Shi Yanming Chen Department of Endocrinology and Metabolic Diseases the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Guangdong Provincial Key Laboratory of Diabetology&Guangzhou Municipal Key Laboratory of Mechanistic and Translational Obesity Research the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China VIP Medical Service Center the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Clinical Immunology the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Ophthalmology the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China Department of Fundus Shenzhen Eye Hospital of Jinan UniversityShenzhen 518048China

Glucagon-like peptide-1 receptor agonists(GLP-1 RAs)protect against diabetic cardiovascular diseases and ***,their activity in diabetic retinopathy(DR)remains *** retrospective cohort study involving 1626 T2DM patients revealed superior efficacy of GLP-1 RAs in controlling DR compared to other glucose-lowering medications,suggesting their advantage in DR *** single-cell RNA-sequencing analysis and immunostaining,we observed a high expression of GLP-1R in retinal endothelial cells,which was down-regulated under diabetic *** of GLP-1 RAs significantly restored the receptor expression,resulting in an improvement in retinal degeneration,vascular tortuosity,avascular vessels,and vascular integrity in diabetic *** and GSEA analyses further implicated enhanced mitochondrial gene translation and mitochondrial functions by GLP-1 ***,the treatment attenuated STING signaling activation in retinal endothelial cells,which is typically activated by leaked mitochondrial *** of STING mRNA was positively correlated to the levels of angiogenic and inflammatory factors in the endothelial cells of human fibrovascular *** investigation revealed that the cAMP-responsive element binding protein played a role in the GLP-1R signaling pathway on suppression of STING *** study demonstrates a novel role of GLP-1 RAs in the protection of diabetic retinal vasculature by inhibiting STING-elicited inflammatory signals.

关键词： GLP-1 RAs STING signaling Retinal endothelial cells Mitochondrial leakage Retinal vascular dysfunction Diabetic retinopathy CREB Inflammation

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Heterotopic mesenteric ossification caused by trauma:A case report

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World j.urnal of Gastrointestinal Endoscopy 2024年第8期16卷 494-499页

作者： Bi-fang Zhang j.ang Liu Shuai Zhang Ling Chen j.a-Zheng Lu Ming-Qing Zhang Department of Gastroenterology The 909th HospitalSchool of MedicineXiamen UniversityZhangzhou 363000Fujian ProvinceChina

BACKGROUND Heterotopic mesenteric ossification(HMO)is a clinically rare condition characterized by the formation of bone tissue in the *** worldwide reporting of such cases is limited to j.st over 70 instances in the medical *** etiology of HMO remains unclear,but the disease is possibly induced by mechanical trauma,ischemia,or intra-left lower quadrant abdominal infection,leading to the differentiation of mesenchymal stem cells into ***,we present a rare case of HMO that occurred in a 34-year-old male,who presented with left lower quadrant abdominal *** SUMMARY We report the case of a 34-year-old male patient who presented with left lower abdominal pain following trauma to the left lower *** subsequently underwent surgical treatment,and the postoperative pathological diagnosis was *** We believe that although there is limited literature and research on HMO,when patients with a history of trauma or surgery to the left lower abdomen present with corresponding imaging findings,clinicians should be vigilant in distinguishing this condition and promptly selecting appropriate diagnostic and therapeutic interventions.

关键词： Abdominal inj.ries Heterotopic ossification Mesentery Abdominal pain Case report

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“员工创新悖论困境”破解——双元领导对员工创新的双通道作用机理

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科技进步与对策 2024年第19期41卷 151-160页

作者：邵芳孙海航西安电子科技大学经济与管理学院陕西西安710126 中国人民大学哲学院北京100872

基于社会交换理论和社会认知理论,以16家高新企业中的362名员工及其直属领导为调查对象,构建并验证双元领导对员工创新的双通道作用机理。员工在创新过程中面临突破性创新和渐进性创新难以同时进行的悖论困境,而双元领导通过授权行为和... 详细信息

基于社会交换理论和社会认知理论,以16家高新企业中的362名员工及其直属领导为调查对象,构建并验证双元领导对员工创新的双通道作用机理。员工在创新过程中面临突破性创新和渐进性创新难以同时进行的悖论困境,而双元领导通过授权行为和命令行为的双通道作用,以宽严并济、松紧得当的方式推动员工创新。研究表明:双元领导正向影响员工突破性创新和渐进性创新;个性化交易在双元领导与员工突破性创新之间发挥中介作用;领导信任在双元领导与员工渐进性创新之间发挥中介作用;认知灵活性不仅在双元领导与个性化交易之间发挥调节作用,还调节个性化交易在双元领导与员工突破性创新之间的中介作用;互动公平不仅在双元领导与领导信任之间发挥调节作用,还调节领导信任在双元领导与员工渐进性创新之间的中介作用。

关键词：双元领导个性化交易领导信任认知灵活性互动公平员工创新

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白酒摄入对小鼠肠道Akkermansia muciniphila数量的影响

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食品与发酵工业 2024年第6期50卷 1-6页

作者：成津燕方程徐岩江南大学生物工程学院酿造微生物与应用酶学研究室江苏无锡214122 江南大学工业生物技术教育部重点实验室江苏无锡214122

白酒是我国优势传统发酵食品,经固态发酵蒸馏而来,富含微生物发酵产物。然而,作为一种酒精饮料,白酒过量饮用会导致酒精性肝脏疾病(alcoholic liver disease,ALD)。Akkermansia muciniphila是一种专性厌氧的革兰氏阴性菌,为哺乳动物肠... 详细信息

白酒是我国优势传统发酵食品,经固态发酵蒸馏而来,富含微生物发酵产物。然而,作为一种酒精饮料,白酒过量饮用会导致酒精性肝脏疾病(alcoholic liver disease,ALD)。Akkermansia muciniphila是一种专性厌氧的革兰氏阴性菌,为哺乳动物肠道中最丰富的微生物之一,被认为是新一代益生菌,同时是ALD发病过程中的关键微生物。该研究以C57BL/6 j.鼠为研究对象,建立了白酒及酒精灌胃干预的小鼠模型;采用实时荧光定量PCR技术,使用系列浓度梯度的重组质粒构建标准曲线,建立了肠道***绝对定量的分析方法;测定了小鼠肠道***的数量随白酒干预的变化规律,并比较了白酒干预与酒精干预之间的差异。结果表明,白酒与酒精摄入均会导致小鼠肠道***数量的减少,且随造模时间逐步下降;同等酒精剂量条件下,白酒组小鼠肠道***的数量高于酒精组,暗示白酒中的成分可以保护酒精诱导的肠道***数量下降。该研究为***改善酒精引起相关损伤提供了理论基础,并为挖掘白酒中有益活性物质的必要性以及为白酒中的活性物质提升肠道中有益微生物的数量及阐明活性物质的功能提供理论依据。

关键词： Akkermansia muciniphila 肠道微生物白酒实时荧光定量PCR

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Nonlinear Absorption and Low-threshold Two-photon Pumped Amplified Stimulated Emission from FAPbBr_(3) Nanocrystals

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发光学报 2024年第8期45卷 1281-1291页

作者： WANG Yaj.an TAY Yong Kang Eugene WANG fang YU Sheng SUM Tze Chien LIU Wei School of Materials and Chemical Engineering Ningbo University of TechnologyNingbo 315211China School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore 637371Singapore College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityHangzhou 311300China

Formamidinium lead bromide(FAPbBr_(3))nanocrystals(NCs)have been considered to be a good optoelectronic material due to their pure green emission,excellent stability and superior carrier transport ***,two-photon pumped amplified spontaneous emission(ASE)and the corresponding nonlinear optical properties of FAPbBr_(3) NCs are scarcely ***,we synthesized colloidal FAPbBr_(3) NCs with different sizes by changing the molar ratio of FABr/PbBr_(2) in the precursor solution,using ligand assisted precipitation(LARP)technology at room ***(PL)and time resolved photoluminescence(TRPL)spectroscopy were measured to characterize their ASE *** their nonlinear optical properties were studied through the Zscan technique and the two-photon excited fluorescence *** stimulated emission properties including oneand two-photon pumped ASE have been realized from FAPbBr_(3) *** large two-photon absorption coefficient(0.27 cm/GW)and high non-linear absorption cross-section(7.52×10^(5) GM),ASE with threshold as low as 9.8μj.cm^(2) and 487μj.cm^(2) have been obtained from colloidal FAPbBr_(3) NCs using one-and two-photon *** results indicate that as a new possible green-emitting frequency-upconversion material with low thresholds,FAPbBr_(3) NCs hold great potential in the development of high-performance two-photon pump lasers.

关键词： perovskites formamidinium lead bromide nanocrystals nonlinear optical gain amplified spontaneous emission

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Corrections to the scaling of the second-order structure function in isotropic turbulence

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Acta Mechanica Sinica 2010年第2期26卷 151-157页

作者： Le fang Wouter j. T. Bos Xiaozhou Zhou Liang Shao j.an-Pierre Bertoglio Laboratoire de Mecanique des Fluides et d'Acoustique Universit6 de Lyon Ecole centrale de Lyon 69134 Ecully France Department of Mechanical Engineering Center for Biomedical Engineering Research University of Delaware 126 Spencer Laboratory Newark DE 19716 USA

The approach of Obukhov assuming a constant skewness was used to obtain analytical corrections to the scaling of the second order structure function, starting from Kolmogorov＇s 4/5 law. These corrections can be used in model applications in which explicit expressions, rather than numerical solutions are needed. The comparison with an interpolation formula proposed by Batchelor, showed that the latter gives surprisingly precise results. The modification of the same method to obtain analytical corrections to the scaling law, taking into account the possible corrections induced by intermittency, is also proposed.

关键词： Scaling law · Structure function ·Isotropic turbulence

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1-苯基-3-(1-环己胺)-丙烯Schiff碱缓蚀剂在盐酸溶液中对j.5钢的缓蚀效果

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油田化学 2024年第2期41卷 315-321页

作者：方晓君卜晓阳陕西延长石油(集团)有限责任公司研究院陕西西安710065

为改善酸化压裂施工造成的腐蚀问题,以肉桂醛和环己胺为原料合成了Schiff碱酸化缓蚀剂1-苯基-3-(1-环己胺)-丙烯(PCP),通过红外光谱和气相色谱-质谱联用对其结构进行表征,并采用失重法、电化学(极化曲线、阻抗谱、噪声)及分子动力学模... 详细信息

为改善酸化压裂施工造成的腐蚀问题,以肉桂醛和环己胺为原料合成了Schiff碱酸化缓蚀剂1-苯基-3-(1-环己胺)-丙烯(PCP),通过红外光谱和气相色谱-质谱联用对其结构进行表征,并采用失重法、电化学(极化曲线、阻抗谱、噪声)及分子动力学模拟等方法评价了PCP的缓蚀效果。结果表明,合成产物即为目标产物PCP。在15%HCl、90℃的条件下,随着PCP浓度增加,j.5钢的失重腐蚀速率及腐蚀电流密度显著减小,缓释率逐渐增大。不同PCP加量下的缓释率均可达到99%以上,缓蚀效果较好。在PCP加量达到0.15%时,腐蚀速率及缓释率随着缓蚀剂浓度的增加整体变化不大,即缓蚀剂在j.5钢表面的吸附浓度已达到临界胶束浓度,吸附量不再发生变化。PCP同时抑制了阴极析氢和阳极溶解反应,为混合型缓蚀剂。随着PCP浓度的增加,容抗弧半径、极化电阻及噪声电阻由小到大的排序均为:空白﹤0.05%﹤0.10%﹤0.15%﹤0.20%;低频的白噪声水平在电流PSD图中随着PCP浓度的增加而减小,即j.5钢的腐蚀速率不断减小,与失重法及极化曲线反应的规律一致。当PCP分子与金属发生吸附并达到平衡时,整个缓蚀剂分子处于同一平面,平行吸附在j.5钢表面,达到完全覆盖,从而有效减缓了腐蚀介质的侵入。

关键词： Schiff碱缓蚀剂金属腐蚀失重法电化学分子动力学

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The evolution and significance of medicine and food homology

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Acupuncture and Herbal Medicine 2024年第1期4卷 19-35页

作者： Huan Zhong Zhi-Qing Tang Yi-fang Li Mei Wang Wan-Yang Sun Rong-Rong He Guangdong Engineering Research Center of Traditional Chinese Medicine&Disease Susceptibility/International Cooperative Laboratory of TCM Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE)/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhouChina Naturalis Biodiversity Center Darwinweg RA Leidenthe Netherlands SU BioMedicine BD Leidenthe Netherlands School of Pharmacy Shenyang Pharmaceutical UniversityShenyangChina State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacaoChina School of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Utilization Yunnan University of Chinese MedicineKunmingChina

Historical insights into medicine and food homology(MFH)Evolution of the MFH theory MFH,a basic concept in traditional Chinese medicine(TCM),suggests that many materials function as both food and medicine,providing nourishment and simultaneously treating *** concept has evolved significantly throughout TCM history^([1]).Integral to this evolution was the discovery of certain materials with dual purposes during early searches for *** materials not only offer sustenance and nutrition but are also capable of treating simple illnesses^([2]).

关键词： evolution insight medicine

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Whole-volume histogram analysis of spectral-computed tomography iodine maps characterizes HER2 expression in gastric cancer

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World j.urnal of Gastroenterology 2024年第38期30卷 4211-4220页

作者： Wei-Ling Zhang j.ng Sun Rong-fang Huang Yi Zeng Shu Chen Xiao-Peng Wang j.n-Hu Chen Yun-Bin Chen Chun-Su Zhu Zai-Sheng Ye You-Ping Xiao Department of Radiology Clinical Oncology School of Fujian Medical University&Fujian Cancer Hospital(Fujian Branch of Fudan University Affiliated Cancer Hospital)Fuzhou 350014Fujian ProvinceChina Department of Pathology Clinical Oncology School of Fujian Medical University&Fujian Cancer Hospital(Fujian Branch of Fudan University Affiliated Cancer Hospital)Fuzhou 350014Fujian ProvinceChina Department of Gastric Surgery Clinical Oncology School of Fujian Medical University&Fujian Cancer Hospital(Fujian Branch of Fudan University Affiliated Cancer Hospital)Fuzhou 350014Fujian ProvinceChina Department of Epidemiology Clinical Oncology School of Fujian Medical University&Fujian Cancer Hospital(Fujian Branch of Fudan University Affiliated Cancer Hospital)Fuzhou 350014Fujian ProvinceChina

BACKGROUND Although surgery remains the primary treatment for gastric cancer(GC),the identification of effective alternative treatments for individuals for whom surgery is unsuitable holds ***2 overexpression occurs in approximately 15%-20%of advanced GC cases,directly affecting treatment-related ***-computed tomography(sCT)enables the quantification of material compositions,and sCT iodine concentration parameters have been demonstrated to be useful for the diagnosis of GC and prediction of its invasion depth,angioge-nesis,and response to systemic *** existing report describes the prediction of GC HER2 status through histogram analysis based on sCT iodine maps(IMs).AIM To investigate whether whole-volume histogram analysis of sCT IMs enables the prediction of the GC HER2 *** This study was performed with data from 101 patients with pathologically confirmed GC who underwent preoperative sCT *** parameters were extracted via sCT IM histogram analysis:The minimum,maximum,mean,standard deviation,variance,coefficient of variation,skewness,kurtosis,entropy,percentiles(1st,5th,10th,25th,50th,75th,90th,95th,and 99th),and lesion *** correlations of the parameters with the HER2 status and clinicopathological parameters were *** operating characteristic curves were used to evaluate the parameters’diagnostic *** Values for the histogram parameters of the maximum,mean,standard deviation,variance,entropy,and percentiles were significantly lower in the HER2+group than in the HER2–group(all P<0.05).The GC differentiation and Lauren classification correlated significantly with the HER2 status of tumor tissue(P=0.001 and 0.023,respectively).The 99th percentile had the largest area under the curve for GC HER2 status identification(0.740),with 76.2%,sensitivity,65.0%specificity,and 67.3%*** sCT IM histogram parameters correlated positively with the GC HER2 status(r=0.

关键词： Gastric cancer Spectral computed tomography Iodine map Histogram analysis

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