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Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： Jin-fang wu Yi-Sheng Chen Yu-Chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

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Multiple targets vector miss distance measurement accuracy based on 2-D assignment algorithms

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Journal of Systems Engineering and Electronics 2008年第1期19卷 76-80页

作者： fang Bingyi wu Siliang Dept. of Electronic Engineering Beijing Inst. of Technology Beijing 100081 P. R. China

An extension of 2-D assignment approach is proposed for measurement-to-target association for improving multiple targets vector miss distance measurement accuracy. When the multiple targets move so closely, the measurements can not be fully resolved due to finite resolution. The proposed method adopts an auction algorithm to compute the feasible measurement-to-target assignment with unresolved measurements for solving this 2-D assignment problem. Computer simulation results demonstrate the effectiveness and feasibility of this method.

关键词： miss distance 2-D assignment auction algorithm data association

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A Tensor Neural Network with Layerwise Pretraining： Towards Effective Answer Retrieval

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Journal of Computer Science & Technology 2016年第6期31卷 1151-1160页

作者： Xin-Qi Bao Yun-fang wu Key Laboratory of Computational Linguistics Peking University Beijing 100871 China

In this paper we address the answer retrieval problem in community-based question answering. To fully capture the interactions between question-answer pairs, we propose an original tensor neural network to model the relevance between them. The question and candidate answers are separately embedded into different latent semantic spaces, and a 3-way tensor is then utilized to model the interactions between latent semantics. To initialize the network layers properly, we propose a novel algorithm called denoising tensor autoencoder （DTAE）, and then implement a layerwise pretraining strategy using denoising autoencoders （DAE） on word embedding layers and DTAE on the tensor layer. The experimental results show that our tensor neural network outperforms various baselines with other competitive neural network methods, and our pretraining DTAE strategy improves the system＇s performance and robustness.

关键词： artificial intelligence language parsing and understanding machine learning

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Effects of iron phthalocyanine on the inner pressure of MH/Ni battery

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Science China Chemistry 2004年第3期47卷 235-239页

作者： WANG fang wu Feng Beijing Institute of Technology National Development Center of Hi-Tech Green Materials Beijing 100081 China Beijing Institute of Technology National Development Center of Hi-Tech Green Materials Beijing 100081 China

Effects of iron phthalocyanine (FePc) on the inner pressure of MH/Ni batteries dur-ing charging were examined. Experimental results show that the battery with appropriate quantity of FePc displays a much lower inner pressure under charging and overcharging than the battery without FePc, especially the battery with 1 mg FePc exhibits the slowest increasing speed of inner pressure and the best charging efficiency and overchargeability.

关键词： inner pressure, MH/Ni batteries, iron phthalocyanine, hydrogen storage alloy, electrochemical catalyst.

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A magnetic hydroxyapatite composite scaffoldbased magnetic therapy for bone repair:an experimental study in canis lupus familiaris

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Regenerative Biomaterials 2017年第2期4卷 97-103页

作者： Jing He Hao Hu Xiaobo Zeng fang Lan fang wu Yao wu National Engineering Research Centre for Biomaterials Sichuan UniversityChengdu 610064PR China

While the beneficial effect of magnetic nanoparticle on the biological functions of calcium phosphate scaffolds has been well documented,little is known about the effect of magnetic nanoparticle on the in vivo performance of hydroxyapatite(HA)*** this study,to further investigate the influence of magnetic hydroxyapatite(MHA)scaffolds on bone repair and the interactions between the magnetic scaffolds and the exterior magnetic field in vivo,we implanted the scaffolds into a beagle dog experimental model of femur transverse *** with traditional HA scaffolds,the MHA scaffolds could accelerate bone tissue regeneration in situ,especially in the first ***,it had a synergic effect between external magnetic fields and MHA scaffolds on bone repair in *** 1 month,the bone density on MHA exposed to an external magnetic field was roughly 30%greater than that of HA,and only slightly less than the bone density observed on HA after 3 ***,the results suggest the improvement of bone ingrowth is critical for HA scaffold with magnetic fields,which is significant for the early bone fixation and repair.

关键词： magnetic nanoparticles static magnetic fields magnetic hydroxyapatite bone regeneration

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Detection of CO Outflow in Rotating Cores

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Chinese Journal of Astronomy and Astrophysics 2008年第2期8卷 230-236页

作者： Xin Guan Yue-fang wu Department of Astronomy Peking University Beijing 100871

We investigate the effect of bulk motion on the detection of molecular outflows in the sources S146, GGD27, and IRAS 22566＋5830. The traditional techniques do allow for bulk motions or systematic VLSR shifts of the core emissions, which may cause contamination of the high velocity gas emissions, and outflows may either fail to be detected or have their properties miscalculated. We used a program to follow the systematic shift of VLSR and better results have been obtained.

关键词： ISM: jets and outflows -- ISM: kinematics and dynamics -- ISM: molecules-- stars: formation

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Magnetron sputtering deposition of [FePt/Ag]_n multilayers for perpendicular recording

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Rare Metals 2006年第1期25卷 47-50页

作者： WANG fang XU Xiaohong wu Haishun School of Chemistry and Materials Science Shanxi Normal University Linfen 041004 China

[FePt/Ag]n multilayers were deposited on glass substrates by RF magnetron sputtering and ex situ annealed at 550℃ for 30 min. The effects of inserted Ag layer thickness and the number of bilayer repetitions （n） on the structure and magnetic properties of the multilayers were investigated. It was found that the difference between in-plane and out-of-plane coercivities varied with an increase of inserted Ag layer thickness in the [FePt 2 nm/Ag x nm]10 multilayers. The ratio of out-of-plane coercivity to in-plane coercivity reached the maximum value with the Ag layer thickness of 5 nm, indicating that the Ag layer thickness plays an important role in obtaining perpendicular orientation. For the [FePt 2 nm/Ag 5 um]n multilayers, perpendicular orientation is also influenced by n. The maximum value of the ratio of out-of-plane coercivity to in-plane coercivity appeared when n was given as 8. It was found that the [FePt 2 nm/Ag 5 nm]8 had a high perpendicular coercivity of 520 kA/m and a low in-plane one of 88 kA/m, which shows a strong perpendicular anisotropy.

关键词： [FePt/Ag]n multilayer perpendicular orientation magnetron sputtering coercivity

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Controllability and Its Applications to Biological Networks

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Journal of Computer Science & Technology 2019年第1期34卷 16-34页

作者： Lin wu Min Li Jian-Xin Wang fang-Xiang wu Division of Biomedical Engineering University of SaskatchewanSaskatoonSK STN 5A9Canada School of Information Science and Engineering Central South UniversityChangsha 410083China Department of Mechanical Engineering University of SaskatchewanSaskatoonSK STN 5A9Canada

Biological elements usually exert their functions through interactions with others to form various types of biological *** ability of controlling the dynamics of biological networks is of enormous benefits to pharmaceutical and medical industry as well as scientific *** there are many mathematical methods for steering dynamic systems towards desired states,the methods are usually not feasible for applying to complex biological *** difficulties come from the lack of accurate model that can capture the dynamics of interactions between biological elements and the fact that many mathematical methods are computationally intractable for large-scale ***,a concept in control theory --controllability,has been applied to investigate the dynamics of complex *** this article, recent advances on the controllability of complex networks and applications to biological networks are *** dynamic models is the prior concern for analyzing dynamics of biological ***,we introduce a widely used dynamic model for investigating controllability of complex *** recent studies of theorems and algorithms for having complex biological networks controllable in general or specific application scenarios are ***,applications to real biological networks manifest that investigating the controllability of biological networks can shed lights on many critical physiological or medical problems,such as revealing biological mechanisms and identifying drug targets,from a systematic perspective.

关键词： biological network network controllability steering node

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Preparation of a mesoporous sorption complex catalyst and its evaluation in reactive sorption enhanced reforming

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第12期14卷 915-922页

作者： Fan ZHANG Qi TANG Su-fang wu Key Laboratory of Biomass Chemical Engineering of Ministry of Education Zhejiang University Department of Chemical and Biological Engineering Zhejiang University

A mesoporous sorption complex catalyst was prepared by pore-forming modification and evaluated by the COz reactive sorption enhanced reforming （ReSER） process, which is used to produce hydrogen from methane. Three samples of polyethylene glycol （PEG） with molecular weights between 2000 and 20 000 were added as templates into a mixed slurry to create catalysts with different pore properties by further formation and calcination. The pore characteristics determined by Brunauer- Emmett-Teller （BET） analysis showed that one of the mesoporous catalysts, named M-NiAICa-6000, had a pore size of 9.2 nm and a surface area of 70.52 m2/g and the CO2 sorption capacity of this catalyst was 44% higher than that of the catalyst without the PEG 6000 modification. The catalyst was evaluated in the ReSER process in a fixed-bed reactor system at 0.1 MPa and 600 C with an H20/CH4 molar ratio of 4. An H2 concentration of 94.2% and a CH4 conversion of 86.0% were obtained at a carbon space velocity of 1700 h 1 while CO2 was hardly detected.

关键词： Hydrogen Ni catalyst Mesoporous Steam methane reforming CO2 sorption

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Detecting protein complexes from DPINs by density based clustering with Pigeon-Inspired Optimization Algorithm

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Science China(Information Sciences) 2016年第7期59卷 30-43页

作者： Xiujuan LEI Yulian DING fang-Xiang wu School of Computer Science Shaanxi Normal University School of Mathematical Sciences Nankai University Division of Biomedical Engineering University of Saskatchewan

Detecting protein complexes is crucial to understand principles of cellular organization. Plenty evidences have indicated that sub-graphs with high density in protein-protein interaction(PPI) network, especially dynamic PPI network(DPIN), usually correspond to protein complexes. As a well-known density-based clustering algorithm, Density-Based Spatial Clustering of Applications with Noise(DBSCAN) has been used in many areas due to its simplicity and the ability to detect clusters of different sizes and shapes. However, one of its limitations is that the performance of DBSCAN depends on two specified parameters ε and Min Pts, where εrepresents the maximum radius of a neighborhood from an observing point while Min Pts means the minimum number of data points contained in such a neighborhood. In this article, we develop a new method named as P-DBSCAN to detect protein complexes in DPIN by using Pigeon-Inspired Optimization(PIO) Algorithm to optimize the parameters ε and Min Pts in DBSCAN. The experiments on DIP and MIPS datasets show that P-DBSCAN outperforms the state-of-the-art methods for protein complex detection in terms of several criteria such as precision, recall and f-measure.

关键词： dynamic protein-protein interaction network(DPIN) pigeon-inspired optimization(PIO) protein complex density based clustering gene expression

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