检索结果-南通市图书馆

Microglia:A Central Player in Depression

第九届全国钙信号和细胞功能研讨会

作者： Yi Luo,Jun-Qi Zhang,Peng-Fei Wu,Li-Hong Long,fang wang,jian-guo chen department of pharmacology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China

Impairment of glucose utilization contributes to neuronal degeneration of Alzheimer’s disease(AD)*** glucose utilization can be regulated by calcium-dependent signaling ***(RSV) is a plant-derived polyphenol with multiple beneficial effects,including neuroprotection and metabolic ***,we investigated the effect of RSV on neuronal calcium signal and glucose *** was found that RSV elevated intracellular calcium in cortical neurons via modulation of secondary messenger system including nitrous oxide(NO),

关键词： Cell=neurons Method=calcium imaging Topic=glucose utilization

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Current Medical Science 2020年第3期40卷 391-400页

作者： Si-long DENG jian-guo chen fang wang department of pharmacology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province Wuhan 430030China Tongji-Rongcheng Center for Biomedicine Huazhong University of Science and TechnologyWuhan 430030China

Microglia are the major immune cells in the central nervous system and play a key role in the normal function of the *** exhibit functional diversity,and they control the inflammation in central nervous system through releasing inflammatory cytokine,clearing apoptotic cells via phagocytosis,regulating synaptic plasticity and the formation of neural network by synapse *** studies have strongly indicated that the microglial dysfunction is associated with a variety of neuropsychiatric diseases such as depression,which have been termed as“microgliopathy”.The emergency of advanced technologies and tools has enabled us to comprehensively understand the role of microglia in physiology and pathology,and growing studies have targetted microglia to explore the treatment of neuropsychiatric ***,we describe the key progress of microglia research,and review the recent developments in the understanding of the role of microglia in physiology and etiology of depression.

关键词： microglia central nervous system development adult depression

Modulation of long-term potentiation in the hippocampus by pharmacological approach:A novel strategy for the development of cognitive enhancers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2010年第30期55卷 3374-3382页

作者： YANG Yuanjian WU PengFei wang fang chen jian guo department of pharmacology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Key Laboratory of Neurological Diseases (HUST) Ministry of Education of China Wuhan 430030 China Institutes of Biomedicine and Drug Discovery Huazhong University of Science and Technology Wuhan 430030 China

Learning and memory not only provide the foundations of cognition, but are also closely related to sensory and motor function. Neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease are accompanied by deficits in synaptic function and cognition to varying degrees. The discovery of long-term potentiation (LTP) of hippocampal synaptic transmission, which has been recognized as a classical model of learning and memory at the cellular level, has spurred substantial progress in the development of cognitive enhancers in the past 20 years. Following intensive investigations into LTP, a variety of compounds and biologically active substances have been found to modulate hippocampal LTP via numerous molecular mechanisms including regulating presynaptic neurotransmitter release, postsynaptic N-methyl D-aspartate (NMDA) receptor activity, postsynaptic signal transduction and gene transcription. This review focuses on the progress of investigations into the overarching mechanisms of LTP, the drugs modulating LTP and prospects for the development of new drugs for treating cognitive impairments in the future.

关键词：药物治疗海马生物活性物质阿尔茨海默氏病突触传递电位调制分子机制

维普期刊数据库

circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第3期24卷 323-337页

作者： Xing-Ya guo fang Sun jian-Neng chen Yu-Qin wang Qin Pan jian-Gao Fan department of Gastroenterology Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 200092China department of Hepatology Zhengxing HospitalZhangzhou 363000Fujian ProvinceChina Shanghai Key Laboratory of Children’s Digestion and Nutrition Shanghai 200092China

AIM To investigate micro(mi)R-34 a-antagonizing circular(circ)RNA that underlies hepatocellular *** The effect of circ RNA on mi R-34 a was recognized by the mi RNA response element(MRE), and validated by the dual-luciferase reporter assay. Its association with hepatocellular steatosis was investigated in Hep G2-based hepatocellular steatosis induced by free fatty acids(FFAs; 2:1 oleate:palmitate) stimulation. After normalization of the steatosis-related circRNA by expression vector, analysis of mi R-34 a activity,peroxisome proliferator-activated receptor(PPAR)α level, and expression of downstream genes were carried out so as to reveal its impact on the mi R-34 a/PPARα regulatory system. Both triglyceride(TG) assessment and cytopathological manifestations uncovered the role of circRNA in miR-34 a-dependent *** Bioinformatic and functional analysis verified circRNA_0046366 to antagonize the activity of mi R-34 a via MRE-based complementation. In contrast to its lowered level during FFA-induced hepatocellular steatosis, circ RNA_0046366 up-regulation abolished the mi R-34 a-dependent inhibition of PPARα that played a critical role in metabolic signaling pathways. PPARα restoration exerted transcriptional improvement to multiple genes responsible for lipid metabolism. TGspecific lipolytic genes [carnitine palmitoyltransferase 1 A(CPT1 A) and solute-carrier family 27 A(SLC27 A)] among these showed significant increase in their expression levels. The circ RNA_0046366-related rebalancing of lipid homeostasis led to dramatic reduction of TG content, and resulted in the ameliorated phenotype of hepatocellular *** Dysregulation of circ RNA_0046366/mi R-34 a/PPARα signaling may be a novel epigenetic mechanism underlying hepatocellular steatosis. circ RNA_0046366 serves as a potential target for the treatment of hepatic steatosis.

关键词： hepatocytes steatosis circRNA_0046366 miR-34a peroxisome proliferator-activated receptorα

HTPB对PYX耐热炸药性能微观影响的分子动力学模拟

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

原子与分子物理学报 2025年第1期42卷 8-12页

作者：毛舰森王保国陈亚芳田鑫赵文虎张彦亮康建成中北大学环境与安全工程学院太原030051 山西北方晋东化工有限公司阳泉045000 空军装备部驻太原地区军事代表室太原030006

为了研究聚合物粘结剂羟基封端聚丁二烯(HTPB)对2,6-双(苦氨基)-3,5-二硝基吡啶(PYX)耐热炸药性能微观影响,基于分子动力学(MD)方法,在PYX的(011)晶面建立了PYX/HTPB的高聚物粘结炸药(PBX)模型,并对其结合能、内聚能密度、径向分布函数... 详细信息

为了研究聚合物粘结剂羟基封端聚丁二烯(HTPB)对2,6-双(苦氨基)-3,5-二硝基吡啶(PYX)耐热炸药性能微观影响,基于分子动力学(MD)方法,在PYX的(011)晶面建立了PYX/HTPB的高聚物粘结炸药(PBX)模型,并对其结合能、内聚能密度、径向分布函数和力学性能进行了模拟.结果表明:PBX在298K时拥有最高的结合能,随着温度升高,结合能总体呈下降趋势;PYX和PBX的内聚能密度随着温度的升高而降低,且PBX的内聚能密度比PYX低20%左右;径向分布函数显示,PYX和HTPB分子间存在氢键和范德华力的共同作用;添加HTPB降低了PYX的刚度,并提高了其延展性.

关键词： PYX/HTPB 耐热炸药分子动力学感度力学性能

维普期刊数据库博看期刊

A Brassica miRNA Regulates Plant Growth and Immunity through Distinct Modes of Action

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2020年第2期13卷 231-245页

作者： chen Cui Jing-Jing wang jian-Hua Zhao Yuan-Yuan fang Xiang-Feng He Hui-Shan guo cheng-guo Duan State Key Laboratory of Plant Genomics Institute of MicrobiologyAcademy of Seed DesignChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of the Chinese Academy of SciencesBeijing 100049China Shanghai Center for Plant Stress Biology and Center of Excellence in Molecular Plant Sciences Chinese Academy of SciencesShanghai 201602China State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475004China These authors contributed equally to this article Present address:department of Molecular Cellularand Developmental BiologyUniversity of Colorado BoulderBoulderCO USA sc7Present address:College of Landscape Architecture Beijing University of AgricultureBeijingChina

In plants,high disease resistance often results in a reduction of ***,breeding crops with balanced yield and disease resistance has become a major ***,microRNA(miRNA)-mediated R gene turnover has been shown to be a protective mechanism used by plants to prevent autoimmunity in the absence of ***,whether these miRNAs play a role in plant growth and how miRNA-mediated R gene turnover responds to pathogen infection have rarely been ***,we found that a Brassica miRNA,miR1885,targets both an immune receptor gene and a development-related gene for negative regulation through distinct modes of ***1885 directly silences the TIR-NBS-LRR class of R gene BraTNL1 but represses the expression of the photosynthesis-related gene BraCP24 by targeting the Trans-Acting Silencing(TAS)gene BraTIR1 for trans-acting small interfering RNAs(tasiRNAs)-mediated *** found that,under natural conditions,miR1885 was kept at low levels to maintain normal development and basal immunity but peaked during the floral transition to promote ***,upon Turnip mosaic virus(TuMV)infection,miR1885-dependent trans-acting silencing of BraCP24 was enhanced to speed up the floral transition,whereas miR1885-mediated R gene turnover was overcome by TuMV-induced BraTNL1 expression,reflecting precise regulation of the arms race between plants and ***,our results demonstrate that a single Brassica miRNA dynamically regulates both innate immunity and plant growth and responds to viral infection,revealing that Brassica plants have developed a sophisticated mechanism in modulating the interplay between growth,immunity,and pathogen infection.

关键词： MicroRNA disease resista nee development Brassica virus

Identification and Function of Acid-sensing Ion Channels in RAW 264.7 Macrophage Cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Medical Science 2018年第3期38卷 436-442页

作者： Lan NI Peng fang Zhuang-li HU Hai-yun ZHOU jian-guo chen fang wang You JIN department of pharmacology School of Basic Medicine Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Key Laboratory of Neurological Diseases (HUST) Ministry of Education of China Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province Institute of Brain Research School of Basic Medicine Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Activation of acid-sensing ion channels （ASICs） plays an important role in neuroinflammation. Macrophage recruitment to the sites of inflammation is an essential step in host defense. ASIC1 and ASIC3 have been reported to mediate the endocytosis and maturation of bone marrow derived macrophages. However, the expression and inflammation-related functions of ASICs in RAW 264.7 cells, another common macrophage, are still elusive. In the present study, we first demonstrated the presence of ASIC 1, ASIC2a and ASIC3 in RAW 264.7 macrophage cell line by using reverse transcriptase polymerase chain reaction （RT-PCR）, Western blotting and immunofluorescence experiments. The non-specific ASICs inhibitor amiloride and specific homomeric ASICla blocker PcTxl reduced the production of iNOS and COX-2 by LPS-induced activating RAW 264.7 cells. Furthermore, not only amiloride but also PcTxl inhibited the migration and LPS-induced apoptosis of RAW 264.7 cells. Taken together, our findings suggest that ASICs promote the inflammatory response and apoptosis of RAW 264.7 cells, and ASICs may serve as a potential novel target for immunological disease therapy.

关键词： acid-sensing ion channels (ASICs) RAW 264.7 cells inflammation apoptosis migration

Thermal and ignition properties of hexanitrostilbene(HNS) microspheres prepared by droplet microfluidics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2023年第7期25卷 166-173页

作者： Rui-shan Han Fei-peng Lu fang Zhang Yan-lan wang Mi Zhou guo-sheng Qin jian-hua chen Hai-fu wang En-yi Chu State Key Laboratory of Explosion and Technology Beijing Institute of TechnologyBeijing100081China Science and Technology on Applied Physical Chemistry Laboratory Shaanxi Applied Physics-Chemistry Research InstituteXi'an710061ShaanxiChina

HNS-IV(Hexanitrostilbene-IV) is the main charge of the exploding foil initiators(EFI), and the microstructure of the HNS will directly affect its density, flowability, sensitivity, and stability. HNS microspheres were prepared using droplet microfluidics, and the particle size, morphology, specific surface area, thermal performance, and ignition threshold of the HNS microspheres were characterized and tested. The results shown that the prepared HNS microspheres have high sphericity, with an average particle size of 20.52 μm(coefficient of variation less than 0.2), and a specific surface area of 21.62 m^(2)/g(6.87 m^(2)/g higher than the raw material). Without changing the crystal structure and thermal stability of HNS-IV, this method significantly enhances the sensitivity of HNS-IV to short pulses and reduces the ignition threshold of the slapper detonator to below 1000 V. This will contribute to the miniaturization and low cost of EFI.

关键词： Microfluidics HNS microspheres Thermal stability Ignition threshold

维普期刊数据库

Association between Macroscopic-factors and Identified HIV/AIDS Cases among Injecting Drug Users: An Analysis Using Geographically Weighted Regression Model

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2014年第4期27卷 311-318页

作者： XING jian Nan guo Wei QIAN Sha Sha DING Zheng Wei chen fang fang PENG Zhi Hang QIN Qian Qian wang Lu National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention department of Epidemiology and Biostatistics School of Public Health Nanjing Medical University

Drug use （DU）, particularly injecting drug use （IDU） has been the main route of transmission and spread of Human Immunodeficiency Virus （HIV）/Acquired Immune Deficiency Syndrome （AIDSJ among injecting drug users （IDUs）[1]. Previous studies have proven that needles or cottons sharing during drug injection were major risk factors for HIV/AIDS transmission at the personal level[z4]. Being a social behavioral issue, HIV/AIDS related risk factors should be far beyond the personal level. Therefore, studies on HIV/AIDS related risk factors should focus not only on the individual factors, but also on the association between HIV/AIDS cases and macroscopic-factors, such as economic status, transportation, health care services, etc[1]. The impact of the macroscopic-factors on HIV/AIDS status might be either positive or negative, which are potentially reflected in promoting, delaying or detecting HIV/AIDS epidemics.

关键词： AIDS HIV An Analysis Using Geographically Weighted Regression Model

维普期刊数据库