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Jianpi Gushen Huayu decoction ameliorated diabetic nephropathy through modulating metabolites in kidney,and inhibiting TLR4/NF-κB/NLRP3 and JNK/P38 pathways

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World Journal of Diabetes 2024年第3期15卷 502-518页

作者： Zi-Ang Ma Li-Xin Wang Hui Zhang Han-Zhou Li Li Dong Qing-Hai Wang Yuan-song Wang Bao-ChaoPan Shu-fang Zhang Huan-Tian Cui Shu-Quan Lv Graduate School Hebei University of Chinese MedicineShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Province Affiliated to Hebei University of Chinese MedicineCangzhou 061000Hebei ProvinceChina School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 300000China The First School of Clinical Medicine Yunnan University of Traditional Chinese MedicineKunming 065000Yunnan ProvinceChina Department of Endocrinology Hebei Cangzhou Hospital of Integrative MedicineCangzhou 061000Hebei ProvinceChina

BACKGROUND Jianpi Gushen Huayu Decoction(JPGS)has been used to clinically treat diabetic nephropathy(DN)for many years.However,the protective mechanism of JPGS in treating DN remains unclear.AIM To evaluate the therapeutic effects and the possible mechanism of JPGS on DN.METHODS We first evaluated the therapeutic potential of JPGS on a DN mouse model.We then investigated the effect of JPGS on the renal metabolite levels of DN mice using non-targeted metabolomics.Furthermore,we examined the effects of JPGS on c-Jun N-terminal kinase(JNK)/P38-mediated apoptosis and the inflammatory responses mediated by toll-like receptor 4(TLR4)/nuclear factor-kappa B(NF-κB)/NOD-like receptor family pyrin domain containing 3(NLRP3).RESULTS The ameliorative effects of JPGS on DN mice included the alleviation of renal injury and the control of inflammation and oxidative stress.Untargeted metabolomic analysis revealed that JPGS altered the metabolites of the kidneys in DN mice.A total of 51 differential metabolites were screened.Pathway analysis results indicated that nine pathways significantly changed between the control and model groups,while six pathways significantly altered between the model and JPGS groups.Pathways related to cysteine and methionine metabolism;alanine,tryptophan metabolism;aspartate and glutamate metabolism;and riboflavin metabolism were identified as the key pathways through which JPGS affects DN.Further experimental validation showed that JPGS treatment reduced the expression of TLR4/NF-κB/NLRP3 pathways and JNK/P38 pathway-mediated apoptosis related factors.CONCLUSION JPGS could markedly treat mice with streptozotocin(STZ)-induced DN,which is possibly related to the regulation of several metabolic pathways found in kidneys.Furthermore,JPGS could improve kidney inflammatory responses and ameliorate kidney injuries in DN mice via the TLR4/NF-κB/NLRP3 pathway and inhibit JNK/P38 pathwaymediated apoptosis in DN mice.

关键词： Diabetic nephropathy Jianpi Gushen Huayu Decoction Oxidative stress Inflammation Untargeted metabolomics Toll-like receptor 4/nuclear factor-kappa B/NOD-like receptor family pyrin domain containing 3 pathway c-Jun N-terminal kinase/P38-mediated apoptosis

Walnut peptide and ginseng Rg1 co-treatment prevents the loss of neurons and cognitive decline in mouse model with memory impairment

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Food Science and Human Wellness 2024年

作者： Junxi Fu Kuzdeuova Damira Wentian song Weijia Li Li fang Yue Leng Chunlei Liu Dan Wu Weihong Min College of Food Science and Engineering Jilin Agricultural University State Key Laboratory of Subtropical Silviculture Zhejiang A&F University College of Food and Health Zhejiang A&F University

In study， we investigated the effect of treatment with combination of < 3 kDa + Rg1 on scopolamine-induced cognitive impairment in mice and the mechanism of BDNF/TrKB/CREB signaling pathway in PC12 cells is regulated. In behavioral experiments， < 3 kDa+Rg1 treatment improved the memorizing ability of mice. Treatment with < 3 kDa+Rg1 significantly regulated the function of neurotransmitters and effectively improved the morphology of the neurons determined by H&E， Nissl， and Golgi staining. Additionally， immunohistochemistry showed that the < 3 kDa+Rg1 treatment significantly decreased AChE activity and increased ChAT content in the hippocampus. The treatment upregulated VAChT， activated the BDNF/TrKB/CREB signaling pathway， improved the remodeling of dendritic spines， and enhanced cholinergic functions. In the scopolamine-induced PC12 cells， combination treatment increased Trx-1 expression after administering TrKB and activated signaling pathway. The results showed combination of < 3 kDa+Rg1 activated the BDNF/TrKB/CREB signaling pathway by regulating function of neurotransmitters and enhanced cholinergic function to decrease cognitive impairment.

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基于UG的拖拉机大灯注塑模具设计

农机化研究 2024年第8期46卷 264-268页

作者：宋芳焦作大学河南焦作454003

以拖拉机大灯为例,分析了UG注塑模具建模的设计方法和工艺方案,建立了拖拉机大灯模型,并完成了拖拉机大灯注塑模具的设计。研究结果表明:经过UG模拟开模出来的塑料件没有出现气泡、变形、缺料和银线等缺陷,整体也没有发现熔合条纹,设计... 详细信息

以拖拉机大灯为例,分析了UG注塑模具建模的设计方法和工艺方案,建立了拖拉机大灯模型,并完成了拖拉机大灯注塑模具的设计。研究结果表明:经过UG模拟开模出来的塑料件没有出现气泡、变形、缺料和银线等缺陷,整体也没有发现熔合条纹,设计的拖拉机大灯注塑模具满足设计需求。

关键词：拖拉机大灯 UG 注塑模具

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Hematochezia due to rectal invasion by an internal iliac artery aneurysm: A case report

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World Journal of Clinical Cases 2024年第11期12卷 1980-1989页

作者： fang Li Bin Zhao Yong-Qiang Liu Guo-Qing Chen Rong-Feng Qu Chao Xu Zhui Long Jin-song Wu Mao Xiong Wei-Hang Liu Li Zhu Xiao-Ling Feng Lei Zhang Department of General Surgery Chongqing General HospitalChongqing 401147China

BACKGROUND This case report presents the rare occurrence of hematochezia due to an internal iliac artery aneurysm leading to an arterioenteric fistula,expanding the differential diagnosis for gastrointestinal bleeding.It emphasizes the importance of considering vascular origins in cases of atypical hematochezia,particularly in the absence of common gastrointestinal causes,and highlights the role of imaging and multidisciplinary management in diagnosing and treating such unusual presentations.CASE SUMMARY A 75-year-old man with a history of hypertension presented with 12 d of hematochezia,experiencing bloody stools 7-8 times per day.Initial computed tomography(CT)scans revealed an aneurysmal rupture near the right internal iliac artery with suspected hematoma development.Hemoglobin levels progressively decreased to 7 g/dL.Emergency arterial angiography and iliac arterycovered stent placement were performed,followed by balloon angioplasty.Despite initial stabilization,minor rectal bleeding and abdominal pain persisted,leading to further diagnostic colonoscopy.This identified a neoplasm and potential perforation at the proximal rectum.An exploratory laparotomy confirmed the presence of a hematoma and an aneurysm invading the rectal wall,necessitating partial rectal resection,intestinal anastomosis,and ileostomy.Postoperative recovery was successful,with no further bleeding incidents and normal follow-up CT and colonoscopy results after six months.CONCLUSION In cases of unusual gastrointestinal bleeding,it is necessary to consider vascular causes for effective diagnosis and intervention.

关键词： Iliac artery aneurysm Hematoma Rectum Hematochezia Case report

The history,research,and application of traditional Chinese medicine(TCM)guidance techniques in the clinical management of chronic

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History & Philosophy of Medicine 2024年第1期6卷 3-9页

作者： Tian-Li song Li-An Liu fang-Lin Zhu Chu-Hua Zeng Department of medicine Hubei Minzu UniversityEnshi 445000China World Federation of Chinese Medicine Societies Beijing 100029China China Association of Gerontology and Geriatrics Zhengzhou 450040China Beijing Unversity of Chinese Medicine Beijing 100105China Hubei Minzu University Library Enshi 445000China Yunnan University of Traditional Chinese Medicine Kunming 650500China

Traditional Chinese guidance techniques are an important part of traditional Chinese medicine and involve integrating three aspects:essence,energy,and spirit,while combining physical movement,breath control,and mental regulation.Traditional Chinese guidance techniques include Tai Chi,Eight Section Brocade,Five Animal Frolics,Yi Jin Jing,and Liu Zi Jue,among others.In recent years,an increasing number of clinical studies have demonstrated the beneficial effects of guidance techniques on promoting health and well-being safely.This study provides a systematic and comprehensive summary and analysis of the research on the application of Traditional Chinese guidance techniques in the management of chronic diseases,offering valuable insights for future clinical research directions and the integration of these techniques into medical practice.

关键词： Daoyin Therapy energy and spirit chronic diseases

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基于TLS数据的站场线路点云提取算法

铁道科学与工程学报 2024年第2期21卷 545-554页

作者：方一鹏宋占峰李军中南大学土木工程学院湖南长沙410075

铁路站场线路几何信息对于铁路安全管理与维护具有重要意义。由于铁路站场内包含多条线路,且轨道错综复杂,使得从大场景点云中自动提取多股道钢轨点云成为难题。地面激光扫描TLS(Terrestrial Laser Scanning)作为非接触式测量手段,可快... 详细信息

铁路站场线路几何信息对于铁路安全管理与维护具有重要意义。由于铁路站场内包含多条线路,且轨道错综复杂,使得从大场景点云中自动提取多股道钢轨点云成为难题。地面激光扫描TLS(Terrestrial Laser Scanning)作为非接触式测量手段,可快速获取铁路场景中的海量点云数据。针对TLS技术获取的铁路站场点云数据,提出一种基于Delaunay三角网聚类的多股道钢轨点云提取算法。基于分割-归并的思想,在获取铁路站场高精度点云后,沿站场线路方向将点云分为若干段,基于轨道平顺性特征,利用三角网聚类算法逐段提取钢轨顶面点云。在归并阶段整合站场中各股道轨面点云信息,将各段轨面点云连接起来,同时匹配左右轨面点云。将该方法在玉林站部分站场区域进行实例验证,提取到的轨道点云在对象层面上的总体精度为93.95%,完整度为90.57%,准确度为97.59%,相较于平面格网法,提取总体精度提升了5.65%,准确度提升了18.49%。在10处截面提取轨面宽度与轨距,统计结果表明轨面宽度中误差为5.2 mm,轨距中误差为5.3 mm,满足工程精度需要。实例结果表明,算法可准确有效提取站场多股道钢轨顶面点云,为铁路场景中其他结构物的TLS数据提取工作提供借鉴思路。

关键词：地面激光扫描点云主成分分析 Delaunay三角网聚类算法

Tuina alleviates neuropathic pain through regulate the activation of microglia and the secretion of inflammatory cytokine in spinal cord

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Journal of Traditional Chinese Medicine 2024年第4期 762-769页

作者： WU Zhiwei ZHU Qingguang KONG Lingjun song Pengfei ZHOU Xin GUO Guangxin ZHANG Shuaipan HE Tianxiang CHENG Yanbin fang Min Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine Institute of Tuina Shanghai Institute of Traditional Chinese Medicine Shuguang Hospital Shanghai University of Traditional Chinese Medicine Department of Acupuncture and Tuina Shanghai University of Traditional Chinese Medicine

OBJECTIVE: To observe the analgesic effects of Tuina on neuropathic pain(NPP) and the underlying mechanisms. METHODS: Forty-eight Sprague-Dawley(SD) rats were assigned by random into three treatment groups: sham, chronic constriction injury(CCI), and Tuina. Each group contained sixteen rats. CCI model was generated by ligating the right sciatic nerve. Behavioral changes of CCI were assessed by the paw withdrawal threshold(PWT) and paw withdrawal latency(PWL). In addition, biochemical techniques such as immunofluorescence staining, enzyme-linked immunosorbent assay(ELISA) and Western blotting were used to profile levels of microglia activation and inflammatory factors in the spinal dorsal horn(SDH) of rats. Tuina(clockwise pressing and rubbing) was performed at Chengshan(BL57) to observe the analgesic effects on CCI rats and the underlying mechanisms. RESULTS: Rats with CCI experienced significant reduction in the PWT and PWL of the right hind paw relative to CCI group at day 3. Tuina treatment rescued this situation significantly on days 10 and 14. Besides, Iba-1, microglia M1 receptor CD68, tumor necrosis factor-α(TNF-α), and interleukin-1β(IL-1β) were higher in the right SDH for CCI group compared to the sham group on day 14. As expected, Tuina partially downregulated the CCI-induced overexpressed Iba-1, CD68, TNF-α, and IL-1β in the SDH of CCI model. CONCLUSION: Tuina induces a time-dependent cumulative analgesic effect in CCI rats by inhibiting the activation of microglia and the secretion of IL-1β and TNF-α in SDH.

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Adaptive ultra-hypofractionated whole-pelvic radiotherapy in high-risk and very high-risk prostate cancer on 1.5-Tesla MR-Linac:Estimated delivered dose and early toxicity results

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Chronic Diseases and Translational Medicine 2024年第1期10卷 51-61页

作者： Linrui Gao Ran Wei Shirui Qin Yuan Tian Wenlong Xia Yongwen song Shulian Wang Hui fang Yu Tang Hao Jing Yueping Liu Yuan Tang Shunan Qi Bo Chen Yexiong Li Nianzeng Xing Ningning Lu Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina GCP Center/Clinical Research Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Urology State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background: Magnetic resonance(MR)-guided ultra-hypofractionated radiotherapy with whole-pelvic irradiation(UHF-WPRT)is a novel approach to radiotherapy for patients with high-risk(HR)and very high-risk(VHR)prostate cancer(PCa).However,the inherent complexity of adaptive UHF-WPRT might inevitably result in longer on-couch time.We aimed to estimate the delivered dose,study the feasibility and safety of adaptive UHF-WPRT on a 1.5-Tesla MR-Linac.Methods: Ten patients with clinical stage T3a-4N0-1M0-1c PCa,who consecutively received UHF-WPRT,were enrolled prospectively.The contours of the target and organ-at-risks on the position verification-MR(PV-MR),beam-on 3D-MR(Bn-MR),and post-MR(after radiotherapy delivery)were derived from the pre-MR data by deformable image registration.The physician then manually adjusted them,and dose recalculation was performed accordingly.GraphPad Prism 9(GraphPad Prism Software Inc.)was utilized for conducting statistical analyses.Results: In total,we collected 188 MR scans(50 pre-MR,50 PV-MR,44 Bn-MR,and 44 post-MR scans).With median 59 min,the mean prostate clinical target volume(CTV)-V_(100%)was 98.59%±2.74%,and the mean pelvic CTVp-V_(100%)relative percentages of all scans was 99.60%±1.18%.The median V29 Gy change in the rectal wall was−2%(−18%to 20%).With a median follow-up of 9 months,no patient had acute Common Terminology Criteria for Adverse Events(CTCAE)grade 2 or more severe genitourinary(GU)or gastrointestinal(GI)toxicities(0%).Conclusion: UHF-RT to the prostate and the whole pelvis with concomitant boost to positive nodes using an Adapt-To-Shape(ATS)workflow was technically feasible for patients with HR and VHR PCa,presenting only mild GU and GI toxicities.The estimated target dose during the beam-on phase was clinically acceptable based on the 3D-MR-based dosimetry analysis.Clinical trial registration Chinese Clinical Trial Registry ChiCTR2000033382.

关键词： dosimetry hypofractionation magnetic resonance imaging prostate cancer radiation dose radiotherapy

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基于碰撞的多方向压电电磁能量采集器研究

传感技术学报 2024年第5期37卷 783-788页

作者：周诗豪宋芳上海工程技术大学机械与汽车工程学院上海201620 上海工程技术大学工程训练中心(创新创业学院) 上海201620

针对传统单悬臂梁能量采集器工作频带窄,采集效率低,采集方向单一的问题,提出了一种基于碰撞的多方向压电电磁能量采集器。分析了引入碰撞的过程和多种工作模式的理论功率输出,建立了能量采集器的理论模型,制作了实验样机,研究了z方向... 详细信息

针对传统单悬臂梁能量采集器工作频带窄,采集效率低,采集方向单一的问题,提出了一种基于碰撞的多方向压电电磁能量采集器。分析了引入碰撞的过程和多种工作模式的理论功率输出,建立了能量采集器的理论模型,制作了实验样机,研究了z方向不同碰撞间距对压电工作模式电压输出的影响,计算了最佳间距下不同工作模式的功率输出结果。结果表明,在碰撞间距为3 mm时,z方向压电工作模式可在更多频段产生机械耦合效应,输出电压最高达19.94 V,带宽为20.5 Hz,在混合采集工作模式下在x方向和z方向输出最高功率分别为0.11 W、0.46 W,带宽分别为18.5 Hz、20.5 Hz。

关键词：振动能量收集压电电磁能量采集器机械耦合碰撞多方向