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General anesthetic agents induce neurotoxicity through astrocytes

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Neural Regeneration Research 2024年第6期19卷 1299-1307页

作者： Yanchang Yang Tiantian Liu Jun Li Dandan Yan Yuhan Hu Pin Wu Fuquan fang Patrick M.McQuillan Wenxin Hang Jianhang leng Zhiyong Hu Department of Anesthesiology The First Affiliated Hospital Zhejiang University School of Medicine Department of Anesthesiology Ningbo Women and Children's Hospital 3. Department of Anesthesiology Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College 4. Cell Biology Department Yale University 5. Department of Anesthesiology Penn State Hershey Medical Centre Penn State College of Medicine 6. Department of Central Laboratory Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine

Neuroscientists have recognized the importance of astrocytes in regulating neurological function and their influence on the release of glial transmitters. Few studies, however, have focused on the effects of general anesthetic agents on neuroglia or astrocytes. Astrocytes can also be an important target of general anesthetic agents as they exert not only sedative, analgesic, and amnesic effects but also mediate general anesthetic-induced neurotoxicity and postoperative cognitive dysfunction. Here, we analyzed recent advances in understanding the mechanism of general anesthetic agents on astrocytes, and found that exposure to general anesthetic agents will destroy the morphology and proliferation of astrocytes, in addition to acting on the receptors on their surface, which not only affect Ca2+signaling, inhibit the release of brain-derived neurotrophic factor and lactate from astrocytes, but are even involved in the regulation of the pro-and anti-inflammatory processes of astrocytes. These would obviously affect the communication between astrocytes as well as between astrocytes and neighboring neurons, other neuroglia, and vascular cells. In this review, we summarize how general anesthetic agents act on neurons via astrocytes, and explore potential mechanisms of action of general anesthetic agents on the nervous system. We hope that this review will provide a new direction for mitigating the neurotoxicity of general anesthetic agents.

关键词： astrocytes brain-derived neurotrophic factor general anesthetic agents N-methyl-D-aspartate receptor neuron neurotoxicity perioperative neurocognition Toll-like receptor γ-aminobutyric acid receptor

General anesthetic agents induce neurotoxicity through oligodendrocytes in the developing brain

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Zoological Research 2024年第3期45卷 691-703页

作者： Wen-Xin Hang Yan-Chang Yang Yu-Han Hu Fu-Quan fang Lang Wang Xing-Hua Qian Patrick M.McQuillan Hui Xiong Jian-Hang leng Zhi-Yong Hu Department of Anesthesiology First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China Department of Cell Biology Yale UniversityNew HavenCT 06520USA Department of Neurology of the First Affiliated Hospital Interdisciplinary Institute of Neuroscience and TechnologySchool of Brain Science and Brain MedicineZhejiang University School of MedicineHangzhouZhejiang 310027China Department of Anesthesiology Jiaxing Maternity and Childcare Health HospitalJiaxingZhejiang 314009China Department of Anesthesiology Penn State Hershey Medical CentrePenn State College of MedicineHersheyPA 17033USA Department of Central Laboratory Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang 310006China

General anesthetic agents can impact brain function through interactions with neurons and their effects on glial cells.Oligodendrocytes perform essential roles in the central nervous system,including myelin sheath formation,axonal metabolism,and neuroplasticity regulation.They are particularly vulnerable to the effects of general anesthetic agents resulting in impaired proliferation,differentiation,and apoptosis.Neurologists are increasingly interested in the effects of general anesthetic agents on oligodendrocytes.These agents not only act on the surface receptors of oligodendrocytes to elicit neuroinflammation through modulation of signaling pathways,but also disrupt metabolic processes and alter the expression of genes involved in oligodendrocyte development and function.In this review,we summarize the effects of general anesthetic agents on oligodendrocytes.We anticipate that future research will continue to explore these effects and develop strategies to decrease the incidence of adverse reactions associated with the use of general anesthetic agents.

关键词： Oligodendrocytes General anesthetic agents Neurotoxicity Central nervous system Perioperative neurocognitive disorders

Walnut peptide and ginseng Rg1 co-treatment prevents the loss of neurons and cognitive decline in mouse model with memory impairment

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Food Science and Human Wellness 2024年

作者： Junxi Fu Kuzdeuova Damira Wentian Song Weijia Li Li fang Yue leng Chunlei Liu Dan Wu Weihong Min College of Food Science and Engineering Jilin Agricultural University State Key Laboratory of Subtropical Silviculture Zhejiang A&F University College of Food and Health Zhejiang A&F University

In study， we investigated the effect of treatment with combination of < 3 kDa + Rg1 on scopolamine-induced cognitive impairment in mice and the mechanism of BDNF/TrKB/CREB signaling pathway in PC12 cells is regulated. In behavioral experiments， < 3 kDa+Rg1 treatment improved the memorizing ability of mice. Treatment with < 3 kDa+Rg1 significantly regulated the function of neurotransmitters and effectively improved the morphology of the neurons determined by H&E， Nissl， and Golgi staining. Additionally， immunohistochemistry showed that the < 3 kDa+Rg1 treatment significantly decreased AChE activity and increased ChAT content in the hippocampus. The treatment upregulated VAChT， activated the BDNF/TrKB/CREB signaling pathway， improved the remodeling of dendritic spines， and enhanced cholinergic functions. In the scopolamine-induced PC12 cells， combination treatment increased Trx-1 expression after administering TrKB and activated signaling pathway. The results showed combination of < 3 kDa+Rg1 activated the BDNF/TrKB/CREB signaling pathway by regulating function of neurotransmitters and enhanced cholinergic function to decrease cognitive impairment.

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Sequentially releasing self-healing hydrogel fabricated with TGFβ3-microspheres and bFGF to facilitate rat alveolar bone defect repair

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Asian Journal of Pharmaceutical Sciences 2022年第3期17卷 425-434页

作者： Fenglin Yu Dezhi Geng Zhanpeng Kuang Shiyi Huang Yating Cheng Yini Chen fang leng Yu Bei Yueping Zhao Qingxia Tang Yadong Huang Qi Xiang Department of Cell Biology College of Life Science and TechnologyJinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Bioengineering Medicine Jinan UniversityGuangzhou 510632China Biopharmaceutical R&D Center of Jinan University Guangzhou 510632China Department of Stomatology Jinan University Medical CollegeGuangzhou 510632China

Resorption and loss of alveolar bone leads to oral dysfunction and loss of natural or implant teeth. Biomimetic delivery of growth factors based on stem cell recruitment and osteogenic differentiation, as the key steps in natural alveolar bone regenerative process, has been an area of intense research in recent years. A mesoporous self-healing hydrogel(DFH) with basic fibroblast growth factor(bFGF) entrapment and transforming growth factor β3(TGFβ3)-loaded chitosan microspheres(CMs) was developed. The formulation was optimized by multiple tests of self-healing, in-bottle inversion, SEM, rheological, swelling rate and in vitro degradation. In vitro tubule formation assays, cell migration assays, and osteogenic differentiation assays confirmed the ability of DFH to promote blood vessels, recruit stem cells, and promote osteogenic differentiation. The optimum DFH formula is 0.05 ml 4ArmPEG-DF(20%) added to 1 ml CsGlu(2%) containing bFGF(80 ng) and TGFβ3-microspheres(5 mg). The results of in vitro release studied by Elisa kit, indicated an 95% release of b FGF in7 d and long-term sustained release of TGFβ3. For alveolar defects rat models, the expression levels of CD29 and CD45, the bone volume fraction, trabecular number, and trabecular thickness of new bone monitored by Micro-CT in DFH treatment groups were significantly higher than others(*P < 0.05, vs Model). HE and Masson staining show the same results.In conclusion, DFH is a design of bionic alveolar remodelling microenvironment, that is in early time microvessels formed by b FGF provide nutritious to recruited endogenous stem cells, then TGFβ3 slowly released speed up the process of new bones formation to common facilitate rat alveolar defect repair. The DFH with higher regenerative efficiency dovetails nicely with great demand due to the requirement of complicated biological processes.

关键词： Self-healing hydrogel TGFβ3 microspheres bFGF Sequential release Alveolar defects

基于扰动状态概念的砂土-混凝土桩接触面荷载传递模型研究

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中南大学学报（自然科学版） 2024年第2期55卷 550-561页

作者：邓煜晨陈琛杨奇冷伍明徐方中南大学土木工程学院湖南长沙410075 湘潭大学土木工程学院湖南湘潭411105 中南大学重载铁路工程结构教育部重点实验室湖南长沙410075

基于扰动状态概念理论,考虑砂土密实度对扰动函数的影响,建立混凝土桩-砂土接触面荷载传递模型。用混凝土板表征桩侧粗糙度效应,采用大型直剪仪开展不同密实度的砂土-混凝土桩接触面力学行为的试验模拟,研究砂土密实度对混凝土桩-砂土... 详细信息

基于扰动状态概念理论,考虑砂土密实度对扰动函数的影响,建立混凝土桩-砂土接触面荷载传递模型。用混凝土板表征桩侧粗糙度效应,采用大型直剪仪开展不同密实度的砂土-混凝土桩接触面力学行为的试验模拟,研究砂土密实度对混凝土桩-砂土接触面的力学特性的影响规律,分析接触面模型初始剪切系数、模型扰动参数(A和Z)对桩-砂土接触面荷载传递模型的作用机制。研究结果表明:1)混凝土桩-砂土接触面易呈现应变软化,在低法向应力条件下,混凝土桩-密砂接触面的应变软化程度最大。2)模型扰动参数Z在数值上近似等于孔隙比。模型扰动参数A越大,砂土与混凝土桩接触面的软化显著程度越大。参数A随着密实度增大而增大。随着法向应力增大,密砂的扰动参数A呈近似线性衰减,松砂和中密砂的扰动参数A近似呈双折线衰减。3)初始剪切系数k_s随着法向应力增大而增大,密实度越大,增速越快。4)基于扰动状态概念的桩-砂土接触面荷载传递模型可靠、参数的物理意义明确且易确定,能很好地表征桩-砂土接触面的应变软化及硬化等力学特征。

关键词：密实度桩-砂土接触面荷载传递模型扰动状态概念

NaYSiO_(4)∶Ce^(3+)蓝色荧光粉的发光性质及其在白光发光二极管上的应用

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发光学报 2024年第5期45卷 745-752页

作者：陈蕾杨星宇张瀚月宋芳冷稚华西安建筑科技大学化学与化工学院陕西西安710055 西安建筑科技大学分析测试中心陕西西安710055

采用高温固相法合成了NaYSiO_(4)∶xCe^(3+)(0.01≤x≤0.05)系列蓝色荧光粉。NaYSiO_(4)∶xCe^(3+)荧光粉在250~360 nm之间的宽带吸收能与紫外LED芯片很好地匹配。NaYSiO_(4)∶xCe^(3+)荧光粉中存在多个Ce^(3+)离子荧光中心,且在紫外光激发下表现出峰值波长位于414 nm附近的宽带蓝光发射。NaYSiO_(4)∶0.02Ce^(3+)荧光粉在300~350 nm紫外光激发下量子效率在25%以上。NaYSiO_(4)∶0.02Ce^(3+)荧光粉表现出优良的化学稳定性,在水中浸泡14 d后荧光强度和量子效率几乎不变。将NaYSiO_(4)∶0.02Ce^(3+)蓝色荧光粉、商用(Sr,Ba)_2SiO_(4)∶Eu^(2+)绿色荧光粉和商用(Ca,Sr)AlSiN_(3)∶Eu^(2+)红色荧光粉涂覆于310 nm紫外LED芯片上制备得到了显色指数高达95的LED器件。当驱动电流从50 mA逐渐增大到300 mA时,制备的LED器件表现出稳定的暖白光发射,其色坐标几乎不变。上述结果说明,本研究报道的NaYSiO_(4)∶0.02Ce^(3+)蓝色荧光粉在紫外LED芯片驱动的白光发光二极管照明上有着潜在应用价值。

关键词： NaYSiO_(4):Ce^(3+) 高温固相蓝色荧光粉白光发光二极管高显色指数

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双线重载铁路路基动力响应规律研究

铁道学报 2024年第1期46卷 145-155页

作者：董俊利冷伍明徐方张期树杨奇刘思慧中南大学土木工程学院湖南长沙410075 中南大学高速铁路建造技术国家工程实验室湖南长沙410075

建立双线重载线路的轨枕-路基-地基三维有限元仿真模型,分析双线重载路基的动力响应规律。研究发现,列车于本侧轨道下方路基面引起的动应力沿横向均呈“马鞍形”分布。上行线列车通过时,本侧线路钢轨下方路基动应力均随深度的增加而减小... 详细信息

建立双线重载线路的轨枕-路基-地基三维有限元仿真模型,分析双线重载路基的动力响应规律。研究发现,列车于本侧轨道下方路基面引起的动应力沿横向均呈“马鞍形”分布。上行线列车通过时,本侧线路钢轨下方路基动应力均随深度的增加而减小;不同运行模式下,路基中心处动应力则均随深度的增加先增大后减小。路基面竖向动位移沿横向呈现明显的凹形分布特性,满载列车单向运行引起的动位移峰值可达到空载列车单向运行的5.36倍。列车轴重对路基速度响应的影响相对较小;轴重由25 t增至30 t时,本侧线路钢轨下方路基面处加速度峰值增加约10%。双线列车运行引起的路基动力响应水平大于单向列车运行的工况;上行线满载列车在下行线钢轨下方路基面引起的加速度、速度和动位移峰值均大于空载列车单向运行于下行线的工况。

关键词：双线重载铁路路基有限元分析动力响应

考虑加载次序影响的沥青非线性疲劳损伤累积研究

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工程力学 2024年第5期41卷 68-76页

作者：房辰泽冷真郭乃胜李辉蒋继望陆国阳王昊鹏大连海事大学交通运输工程学院辽宁大连116026 香港理工大学土木及环境工程学系中国香港九龙999077 诺丁汉大学诺丁汉交通工程中心英国诺丁汉NG72RD

变幅加载下沥青的疲劳损伤累积具有明显的非线性特征,传统的Miner’s线性疲劳损伤累积准则无法表征不同变幅加载次序下沥青的非线性疲劳损伤累积(NLFDA)。该研究旨在建立考虑加载次序影响的NLFDA模型,准确表征加载次序对沥青疲劳损伤累... 详细信息

变幅加载下沥青的疲劳损伤累积具有明显的非线性特征,传统的Miner’s线性疲劳损伤累积准则无法表征不同变幅加载次序下沥青的非线性疲劳损伤累积(NLFDA)。该研究旨在建立考虑加载次序影响的NLFDA模型,准确表征加载次序对沥青疲劳损伤累积的影响。通过开展应力控制的沥青恒幅加载疲劳试验,采用耗散伪应变能(DPSE)表征沥青疲劳损伤,分析恒幅加载下沥青的疲劳损伤累积规律;采用低-高和高-低两种加载次序,开展应力控制的沥青变幅加载疲劳试验,分析变幅加载下沥青的疲劳损伤累积规律;基于损伤等效准则,建立考虑加载次序影响的NLFDA模型,分析加载次序对疲劳损伤累积的影响。结果表明:应力控制模式下的沥青疲劳损伤,呈先缓慢后急剧的非线性增加演化趋势;恒幅加载下沥青疲劳损伤服从Miner’s准则发生线性累积,且累积寿命分数等于1;变幅加载下沥青疲劳损伤不服从Miner’s准则而发生非线性累积。低-高和高-低变幅加载次序下,沥青累积疲劳寿命随一级寿命分数的增大而分别增加和减小,累积寿命分数分别大于1和小于1;建立的NLFDA模型可克服Miner’s准则缺陷,并较为准确地表征加载次序对沥青疲劳损伤累积的影响。

关键词：道路工程沥青材料非线性疲劳损伤累积加载次序耗散伪应变能疲劳寿命

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基于形变势理论的掺杂计算Sb_(2)Se_(3)空穴迁移率

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物理学报 2024年第4期73卷 256-262页

作者：张冷张鹏展刘飞李方政罗毅侯纪伟吴孔平南京大学物理学院固体微结构国家实验室南京210093 金陵科技学院电子信息工程学院南京211169 南京工业大学数理科学学院南京211816

硒化锑(Sb_(2)Se_(3))是一种元素丰富、经济且无毒的太阳电池吸收层材料.太阳电池的性能在很大程度上取决于载流子的传输特性,然而在Sb_(2)Se_(3)中,这些特性尚未得到很好的理解.通过密度泛函理论和形变势理论,本文对纯Sb_(2)Se_(3)以... 详细信息

硒化锑(Sb_(2)Se_(3))是一种元素丰富、经济且无毒的太阳电池吸收层材料.太阳电池的性能在很大程度上取决于载流子的传输特性,然而在Sb_(2)Se_(3)中,这些特性尚未得到很好的理解.通过密度泛函理论和形变势理论,本文对纯Sb_(2)Se_(3)以及掺杂了As,Bi的Sb_(2)Se_(3)的空穴传输特性进行研究,计算并分析了影响迁移率的3个关键参数:有效质量、形变势和弹性常数.结果显示,有效质量对迁移率具有最大影响,掺杂Bi的Sb_(2)Se_(3)表现出最高的平均迁移率.同时发现,Sb_(2)Se_(3)的空穴迁移率呈现出明显的各向异性,其中x方向的迁移率远高于y,z方向,这应该与x方向的原子主要以较强的共价键连接,而y,z方向以较弱的范德瓦耳斯力连接有关.载流子传输能力强的方向有助于有效传输和收集光生载流子,本研究从理论上强调了控制Sb_(2)Se_(3)沿特定方向生长的重要性.

关键词： Sb_(2)Se_(3) 迁移率形变势掺杂