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Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： jia fang Zhuangzhuang Li Pengjun Wang Xiaoxu Zhang Song Mao Yini Li Dongzhen Yu Xiaoyan Li Yazhi Xing Haibo Shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

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高温下HMX热分解反应分子动力学模拟

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原子与分子物理学报 2025年第2期42卷 105-110页

作者：陈芳贾方硕陈瑶李天浩郭国琦董羚中北大学化学与化工学院太原030051

本文采用ReaxFF-lg反应分子动力学方法研究了奥克托金(HMX)在六种不同温度下的初始反应热分解过程,验证了ReaxFF-lg势函数对HMX体系的适用性,计算了不同温度下HMX体系势能、总物种演化趋势、初始反应产物以及指前因子和活化能.结果表明,... 详细信息

本文采用ReaxFF-lg反应分子动力学方法研究了奥克托金(HMX)在六种不同温度下的初始反应热分解过程,验证了ReaxFF-lg势函数对HMX体系的适用性,计算了不同温度下HMX体系势能、总物种演化趋势、初始反应产物以及指前因子和活化能.结果表明,HMX热分解过程主要有三种初始分解机理:N-NO_(2)键的断裂,HONO的解离和主环上C-N键的断裂,计算得到的初始分解阶段活化能Ea和指前因子ln(A),与实验值相吻合.

关键词： HMX 反应分子动力学(RMD) ReaxFF-lg 热分解温度

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Parseval Theory of Complex Wavelet Transform for Wavelet Family Including Rotational Parameters

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Communications in Theoretical Physics 2008年第9期50卷 598-602页

作者： ZHOU Nan-Run jia fang Department of Electronics Information Engineering Nanchang University Nanchang 330031 China College of Physics ＆ Communication Electronics Jiangxi Normal University Nanchang 330022 China

A rotational parameter Rθ has been introduced to complex wavelet transform （CWT）. The rotational CWT （RCWT） corresponds to a matrix element 〈φ｜U2（θ;μ;κ）[F〉 in the context of quantum mechanics, where U2（θ;μ;κ） is a two-mode rotational displacing-squeezing operator in the 〈η｜ representation. Based on this, the Parseval theorem and the inversion formula of RCWT have been proved. The concise proof not only manifestly shows the merit of Dirac＇s representation theory but also leads to a new orthogonal property of complex mother wavelets in parameter space.

关键词： complex wavelet transform representation theory quantum mechanics

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Effects of Strontium,Magnesium Addition,Temperature Gradient,and Growth Velocity on Al-Si Eutectic Growth in a Unidirectionally-solidified Al-13 wt%,Si Alloy

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Journal of Materials Science & Technology 2014年第2期30卷 146-153页

作者： Hengcheng Liao Wanru Huang Qigui Wang fang jia School of Materials Science and Engineering Southeast UniversityJiangsu Key Laboratory for Advanced Metallic Materials Materials Technology GM Global Powertrain Engineering School of Mechanical Engineering Southeast University

Al-Si eutectic growth mechanism was investigated in a directionally-solidified AI-1 3 wt% Si alloy with different strontium （Sr） and magnesium （Mg） additions, growth velocities and temperature gradients. Macro- and micro- scale metallographic analyses revealed that addition level of Sr and Mg, temperature gradient and growth velocity are important factors affecting stability of solidifying AI-Si eutectic front and the final morphology of eutectic grains in the solidified A1-13 wt% Si alloys. By varying （tailoring） these factors, a variety of eutectic grain structures and morphologies such as planar front, cellular structure, a mix of cellular and columnar, or equiaxed dendrites, can be obtained. Increasing temperature gradient, reducing growth velocity, or decreasing Sr and Mg contents is beneficial to stabilizing planar growth front of eutectic grains, which is qualitatively in accordance with constitutional supercooling criterion for binary eutectic growth. In contrast, adding more Sr and Mg, increasing growth velocity, or decreasing temperature gradient produces large constitutional supercooling, leading to columnar-equiaxed transition （CET） of eutectic structure, which can be interpreted on the basis of Hunt＇s Model. It is also found that both solute concentration and solidification variables have significant impact not only on eutectic growth, but also on gas porosity formation.

关键词： Al-Si alloy Directional solidification Eutectic growth Strontium Magnesium Temperature gradient Growth velocity

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Moving horizon based wavelet de-noising method of dual-observed geomagnetic signal for nonlinear high spin projectile roll positioning

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Defence Technology（防务技术） 2020年第2期16卷 417-424页

作者： Ting-ting Yin fang-xiu jia Xiao-ming Wang ZNDY of Ministerial Key Laboratory Nanjing University of Science and TechnologyNanjing210094China

Phase-frequency characte ristics of approximate sinusoidal geomagnetic signals can be used fo r projectile roll positioning and other high-precision trajectory correction *** sinusoidal geomagnetic signal deforms in the exposed and magnetically contaminated *** order to preciously recognize the roll information and effectively separate the noise component from the original geomagnetic sequence,based on the error source analysis,we propose a moving horizon based wavelet de-noising method for the dual-observed geomagnetic signal filtering where the captured rough roll frequency value provides reasonable wavelet decomposition and reconstruction level selection basis for sampled sequence;a moving horizon window guarantees real-time performance and non-cumulative calculation *** complete geomagnetic data in full ballistic range and three intercepted paragraphs are used for performance *** positioning performance of the moving horizon wavelet de-noising method is compared with the band-pass *** results show that both noise reduction techniques improve the positioning accuracy while the wavelet de-noising method is always better than the band-pass *** results suggest that the proposed moving horizon based wavelet de-noising method of the dual-observed geomagnetic signal is more applicable for various launch conditions with better positioning performance.

关键词： High-spin projectile roll positioning Dual-observed geomagnetic signal Wavelet de-noising Discrete wavelet transform

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Design and cold test of S-BAND cavity BPM for HLS

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Science China(Physics,Mechanics & Astronomy) 2011年第S2期54卷 292-295页

作者： LUO Qing SUN BaoGen jia QiKa HE DuoHui fang jia National Synchrotron Radiation Laboratory School of Nuclear Science and TechnologyUniversity of Science and Technology of ChinaHefei 230029China

An S-band cavity BPM is designed for a new injector in National Synchrotron Radiation Laboratory. A re-entrant position cavity is tuned to the TM110 mode as position cavity. Cut-through waveguides are used as pickups to suppress the monopole signal. Theoretical resolution of this design is 31 nm. A prototype cavity BPM system is manufactured for off-line cold tests. The wire scanning method is used to calibrate the BPM and estimate the performance of the on-line BPM system. A cross-talk problem has been detected during the cold test. Racetrack cavity BPM design can be used to suppress the cross-talk. With the nonlinear effect being ignored, transform matrix can be used to correct cross-talk. Analysis of cold test results shows that the position resolution of prototype BPM is better than 3 μm.

关键词： cavity BPM re-entrant cut-through waveguide cold test wire scanning resolution cross-talk

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SnS2/graphene nanocomposite：A high rate anode material for lithium ion battery

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Chinese Chemical Letters 2017年第2期28卷 324-328页

作者： Wei Wei fang-fang jia Ke-Feng Wang Peng Qu Henan Key Laboratory of Biomolecular Recognition and Sensing School of Chemistry and Chemical Engineering Shangqiu Normal University Shangqiu 476000 China College of Chemistry and Molecular Engineering Zhengzhou University Zhengzhou 450001 China School of Information Engineering Zhengzhou University Zhengzhou 450001 China

In this work,via a facile solvothermal route,we synthesized an anode material for lithium ion batteries（LIBs）—SnS2 nanoparticle/graphene（SnS2 NP/GNs） *** nanocomposite consists of SnS2nanoparticles with an average diameter of 4 nm and graphene nanosheets without *** SnS2 nanoparticles are firmly anchored on the graphene *** an anode material for LIBs,the nanocomposite exhibits good Li storage performance especially high rate *** the high current rate of 5,10,and 20 A/g,the nanocomposite delivered high capacities of 525,443,and 378 mAh/g,*** good conductivity of the graphene nanosheets and the small particle size of SnS2contribute to the electrochemical performance of SnS2 NP/GNs.

关键词： SnS2 Graphene Nanocomposite Anode Lithium ion battery

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Health Risks Assessment of Heavy Metal Pollution in the Soil-Crop System from an E-Waste Dismantling Area

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Phyton-International Journal of Experimental Botany 2022年第12期91卷 2669-2685页

作者： Shengting Rao jia fang Keli Zhao Key Laboratory of Soil Contamination Bioremediation of Zhejiang Province Zhejiang Agriculture and Forestry UniversityHangzhou311300China

Soil is an essential resource for agricultural *** order to investigate the pollution situation of heavy metals in the soil-crop system in the e-waste dismantling area,the crop and soil samples(226 pairs,including leaf vegetables,solanaceous vegetables,root vegetables,and fruits)around the e-waste dismantling area in southeastern Zhejiang Province were *** concentrations of Cd,Cu,Pb,and Cr were *** average concentrations of Cd,Cu,Pb,and Cr in soils were 0.94,107.79,80.28,and 78.14 mg kg-1,respectively,and their corresponding concentrations in crops were 0.024,0.7,0.041,and 0.06 mg kg-1,*** transfer capacity of leaf vegetables was significantly higher than that of non-leaf vegetables,and the accumulation of four heavy metals in crops tended to be Cd>Cu>Cr/*** pollution index’s results revealed that the soil pollution degree under different land uses ranked as root vegetables soil>leaf vegetables soil>solanaceous vegetables soil>fruit *** carcinogenic and non-carcinogenic risks of heavy metal exposure were ranked as food intake>accidental ingestion>dermal contact>*** comprehensive non-carcinogenic risk was ranked as Cr>Cd>Pb/*** results could be used to provide useful information for further crop cultivation layout in the study area,which can guarantee the local residents’health and food safety.

关键词： E-waste dismantling area soil-crop system heavy metal pollution risk assessment

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Visible and Ultraviolet Reflectivity of Hg_(0.8)Cd_(0.2)Te

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Chinese Physics Letters 1996年第12期13卷 937-939页

作者： jiaNG Run-qing HU Xie-rong fang jia-xiong Infrared and Remote Sensing Research Laboratory Shandong UniversityJi’nan 250100 Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai 200083

The fundamental reflectivity spectra of Hg_(0.8)Cd_(0.2)Te have been *** feature of the spectra is the presence of E_(1) and E_(2) peaks within the fundamental absorption region.A three dimensional saddle point is used to fit the E_(1) and E_(1)+Δ_(1) critical point and some simulated calculation is done for E_(2) at X *** measured and calculated reflectivities are compared and prominent features of the reflectivity spectra are identified with critical point transition at the and X points in the Brillouin zone.

关键词： reflectivity critical spectra

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Microstructure and properties of indium tin oxide thin films deposited by RF-magnetron sputtering

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Rare Metals 2006年第4期25卷 359-364页

作者： LI Shitao QIAO Xueliang CHEN jianguo jia fang WU Changle State Key Laboratory of Plastic Forming Simulation and Die ＆ Mould Technology Huazhong University of Science and Technology Wuhan 430074China

Tin-doped indium oxide （ITO） thin films were prepared using conventional radio frequency （RF） planar magnetron sputtering equipped with IR irradiation using a ceramic target of In2O3/SnO2 with a mass ratio of 1：1 at various IR irradiation temperatures T1 （from room temperature to 400℃）. The refractive index, deposited ratio, and resistivity are functions of the sputtering Ar gas pressure. The microstructure of ITO thin films is related to IR T1, the crystalline seeds appear at T1= 300℃, and the films are amorphous at the temperature ranging from 27℃ to 400℃. AFM investigation shows that the roughness value of peak-valley of ITO thin film （Rp-v） and the surface microstructure of rio thin films have a close relation with T1. The IR irradiation results in a widening value of band-gap energy due to Burstein-Moss effect and the maximum visible transmittance shifts toward a shorter wavelength along with a decrease in the film＇s refractive index. The plasma wavelength and the refractive index of ITO thin films are relative to the T1. XPS investigation shows that the photoelectrolytic properties can be deteriorated by the sub-oxides. The deterioration can be decreased by increasing the oxygen flow rote （fo2）, and the mole ratio of Sn/In in the samples reduces with an increase info2.

关键词： indium-tin oxide (ITO) photoelectrolytic properties RF-magnetron sputtering IR irradiation temperature microstructure refractive index

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