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Insights into postural orthostatic tachycardia syndrome after COVID-19 in pediatric patients

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World Journal of Pediatrics 2024年第3期20卷 201-207页

作者： Ya-Xi Cui Jun-Bao Du hong-fang Jin Department of Pediatrics Peking University First HospitalNo.1 Xi-an Men StreetWest DistrictBeijing 100034China State Key Laboratory of Vascular Homeostasis and Remodeling Peking UniversityBeijing 100191China

The pandemic caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)profoundly threatened human health globally and greatly impacted the world economy[1].While most patients recovered,some suff... 详细信息

关键词： acute patients tachycardia

Management of orthostatic intolerance in children: the state of the art

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World Journal of Pediatrics 2020年第6期16卷 543-548页

作者： Chun-Yan Tao hong-fang Jin Jun-Bao Du Department of Pediatrics Peking University First HospitalNo.1Xi'an-men StreetWest DistrictBeijing 100034China Research Unit of Clinical Diagnosis and Treatment of Pediatric Syncope and Cardiovascular Diseases Chinese Academy of Medical SciencesBeijingChina Key Laboratory Molecular Cardiovascular Science the Ministry of EducationPeking UniversityBeijing.China

Orthostatic intolerance(OI)is characterized by symptoms and signs of dizziness,headache,visual difficulties,a loss of consciousness,nausea,abdominal discomfort,pallor,tachycardia or hypotension;and OI is primarily elicited by a rapid postural change from supine to standing or prolonged quiet standing which can be resolved by lying down[1,2].About 15%of children and adolescents are affected by OI,with the median peak age of the first OI onset at 15 years[3].OI accounts for a noticeable proportion of emergency department *** or indeliberately,the injection of normal saline always plays a role,which“rescues”the *** or occasional episodes of OI are often overlooked by some patients;and children with recurrent OI symptoms often experience depression,and have diminished quality of life。

关键词： tachycardia injection nausea

Baroreflex sensitivity and its implication in neurally mediated syncope inchildren

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World Journal of Pediatrics 2023年第11期19卷 1023-1029页

作者： Ya-Xi Cui Jun-Bao Du hong-fang Jin Department of Pediatrics Peking University First HospitalBeijing 100034China Key Laboratory of Molecular Cardiovascular Sciences Ministryof EducationBeijing 100191China

Neurally mediated syncope(NMS)refers to an entity of syncopal disorders that can be triggered by a psychological stimulus,standing for a long time,sudden position change from supine to upright,or a muggy *** syncope(VVS),also known as acute orthostatic intolerance(OI),is the main form of NMS[1]and seriously affects the quality of life of ***,the pathogenesis of NMS has not yet been fully *** mechanisms underlying NMS are considered to involve autonomic regulation abnormalities.

关键词： syncope acute pathogenesis

All-trans Retinoic Acid,Arsenic Trioxide,and Anthracycline-based Chemotherapy Improves Outcome in Newly Diagnosed Acute Promyelocytic Leukemia Regardless of FLT3-ITD Mutation Status

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Current Medical Science 2021年第3期41卷 491-497页

作者： Lin-wei XU Yong-zhong SU hong-fang TAO Department of Hematologyf the First Affiliated Hospital of Shantou University Medical College Shantou 515041China

All-trans retinoic acid(ATRA)and pre-upfront arsenic trioxide(ATO)have revolutionized the therapy of acute promyelocytic leukemia(APL).However,internal tandem duplication of FMS-like tyrosine kinase 3(FLT3-ITD)mutations is associated with increased risk of *** aim of this study was to analyze the prognostic impact of FLT3-ITD on APL patients who received remission induction with ATRA,idarubicin(IDA)and/or ATO,followed by ATRA plus ATO along with anthracycline,as consolidation therapy.A total of 72 patients newly diagnosed with APL were included in this study.83.3%of the patients achieved complete remission(CR)after induction ***3-ITD mutations were detected in 16(22.2%)patients and closely related to bcr-3 PML-RARa transcript(P<0.001).The 5-year overall survival(OS)rate was 100%in both FLT3-ITDposltlve and FLT3-ITD^(negatlve)groups,and there was no significant difference in 5-year event-free survival(EFS)between the two groups(78.3%vs.83.3%,P=0.85).ATRA plus ATO and anthracycline-based chemotherapy achieved great outcome in newly diagnosed APL regardless of the FLT3-ITD mutation status.

关键词： all-trans retinoic acid acute promyelocytic leukemia arsenic trioxide anthracycline internal tandem duplication of FMS-like tyrosine kinase 3

Electron Transport through Hydrogen Bonded Single-Molecule Junctions

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Chinese Journal of Chemistry 2023年第23期41卷 3433-3446页

作者： Jiu-hong fang Zhi-Hao Zhao Ang-Xuan Li Lin Wang Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastesNational Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of Geosciences (Beijing)Beijing100083 China State Key Laboratory of Solidification Processing and School of Materials Science and Engineering Northwestern Polytechnical UniversityXi'anShaanxi710072 China

Hydrogen bonding is a vital driving force for organizing the hierarchy of molecular structure,especially in biologic *** to its directionality,selectivity and moderate strength,hydrogen bonding has been extensively introduced into the molecular recognition,sensing and electronic *** measurements at single-molecule level facilitate the investigation of hydrogen bonds and provide a comprehensive understanding of the electron transport properties governed by the hydrogen bonding,which is essential for the development of self-assembled electronic *** review provides a detailed overview of recent advancements in constructing single-molecule junctions utilizing intramolecular and intermolecular hydrogen *** first introduce the methods utilized for characterizing the electric and dynamic properties of non-covalent ***,we discuss the mechanisms of electron transport,relevant influencing factors,and typical applications utilizing electrical signals based on single-molecule ***,we propose our perspective on the existing challenges and prospective opportunities in utilizing hydrogen bonding for electronic device applications.

关键词： Electron transport Hydrogen bond Single-molecule junction Molecular devices Molecular assembly

A new development of Al-Ti-C grain refining master alloys

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中国有色金属学会会刊：英文版 2000年第3期10卷 298-303页

作者： ZHANG Bai qing(张柏清) LI Jian guo(李建国) MA hong tao(马洪涛) fang hong sheng(方鸿生) Tsing Hua Univ Dept Mat Sci & Engn Beijing 100084 Peoples R China

Al Ti C master alloys have been prepared with a novel production method. A combination of X ray phase analysis, SEM and EDS was used to examine the phases and microstructures of the master alloys. The master alloys have block like Al 3Ti particles and submicron size TiC X with X ranging from 0.49 to 0.78 and show excellent grain refining performance for commercially pure aluminum. Titanium carbides were observed at the crystallization centers in refined castings.

关键词： Al Ti C master alloy microstructure grain refinement

A rabbit model of pediatric nonalcoholic steatohepatitis: The role of adiponectin

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World Journal of Gastroenterology 2009年第8期15卷 912-918页

作者： Jun-Fen Fu Yan-Lan fang Li Liang Chun-Lin Wang fang hong Guan-Ping Dong Department of Endocrinology The Children's Hospital of Zhejiang University School of Medicine Hangzhou 310003 Zhejiang Province China

AIM： To create a rabbit model of pediatric nonalcoholic steatohepatitis （NASH） and to evaluate the role of adiponectin in the process. METHODS： Thirty-two specific pathogen-free male New Zealand rabbits were divided randomly into three groups：（1） the normal control group （n = 10） was fed with standard diet for 12 wk; （2） the model group A （n = 11）; and （3） model group B （n = 11） were fed with a highfat diet （standard diet ＋ 10% lard ＋ 2% cholesterol） for 8 and 12 wk, respectively. Hepatic histological changes were observed and biochemical parameters as well as serum levels of adiponectin, interleukin （IL）-6, IL-10 and tumor necrosis factor （TNF）-α were measured. RESULTS： Typical histological hepatic lesions of NASH were observed in both model groups described as liver steatosis, liver inflammatory infiltration, cytologic ballooning, perisinusoidal fibrosis and overall fibrosis. Compared with the normal control group, there were significant increases in model groups A and B in weight gain （1097.2 ± 72.3, 1360.5± 107.6 vs 928.0 ±58.1, P 〈 0.05, P 〈 0.01）, liver weight （93.81±6.64, 104.6±4.42 vs 54.4±1.71, P 〈 0.01）, Lg （ALT）（1.9±0.29, 1.84± 0.28 vs 1.60±0.17, P 〈 0.01）, and Lg （TG）（1.03 ±0.24, 1.16 ±0.33 vs 0.00 ±0.16, P 〈 0.01）. Weight gain was much more in model group B than in model group A （1360.5± 107.6 vs 1097.2 ±72.3, P 〈 0.05）. But, there was no significant difference between the two groups concerning the other indexes. Pro-inflammatory cytokines （IL-6 and TNF-α） increased in model group B compared with that of control and model group A （IL-6：1.86±0.21 vs 1.41 ±0.33, 1.38± 0.42, P 〈 0.01; TNF-α： 1.18±0.07 vs 0.66 ±0.08, 0.86 ±0.43, P 〈 0.01, P 〈 0.05）, whereas serum adiponectin and IL-10 decreased in model groups compared with that in the control （adiponectin： A： 21.87±4.84 and B： 21.48 ±4.60 vs 27.36 ±7.29, P 〈 0.05. IL-10： A： 1.72± 0.38 and B： 1.83 ±0.39 vs 2.26±0.24, P 〈 0.01）. Lg （TC） and the degree of liver fatty infiltration was an independent determi

关键词： Nonalcoholic steatohepatitis Pediatricanimal model Adiponectin Interleukin 6 Tumornecrosis factor

Effect of Chromium on CCT Diagrams of Novel Air-Cooled Bainite Steels Analyzed by Neural Network

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Journal of Iron and Steel Research International 2007年第4期14卷 39-42页

作者： YOU Wei XU Wei-hong LIU Ya-xiu BAI Bing-zhe fang hong-sheng Department of Mechanical and Electrical Engineering North China Institute of Science and Technology Beijing 101601 China Department of Electronics and Information Engineering North China Institute of Science and Technology Beijing 101601 China Department of Materials Science and Engineering Tsinghua University Beijing 100084 China

The quantitative effects of chromium content on continuous cooling transformation （CCT） diagrams of novel air-cooled bainite steels were analyzed using artificial neural network models. The results showed that the c... 详细信息

关键词： novel air-cooled bainite steel CCT diagram artificial neural network chromium content quantitative effect

A COUPLED 1-D AND 2-D CHANNEL NETWORK MATHEMATICAL MODEL USED FOR FLOW CALCULATIONS IN THE MIDDLE REACHES OF THE YANGTZE RIVER

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Journal of Hydrodynamics 2011年第4期23卷 521-526页

作者： HAN Dong fang hong-wei BAIJing HE Guo-jian Department of Hydraulic Engineering and State Key Laboratory of Hydroscience and Engineering Tsinghua University Beijing 100084 China

A coupled one-dimensional （1-D） and two-dimensional （2-D） channel network mathematical model is proposed for flow calculations at nodes in a channel network system in this article. For the 1-D model, the finite difference method is used to discretize the Saint-Venant equations in all channels of a looped network. The Alternating Direction Implicit （ADI） method is adopted for the 2-D model at the nodes. In the coupled model, the 1-D model provides a good approximation with small computational effort, while the 2-D model is applied for complex topography to achieve a high accuracy. An Artificial Neural Network （ANN.） method is used for the data exchange and the connectivity between the 1-D and 2-D models. The coupled model is applied to the Jingjiang-Dongting Lake region, to simulate the tremendous looped channel network system, and the results are compared with field data. The good agreement shows that the coupled hydraulic model is more effective than the conventional 1-D model.

关键词： Coupled 1-D and 2-D model looped channel network system Alternating Driection Implicit (ADI) Jingjiang-Dongting Lake region