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肺痹方干预肺纤维化小鼠肺泡上皮细胞线粒体途径凋亡的机制

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中国组织工程研究 2025年第11期29卷 2334-2339页

作者：程雪荆焕熙张运克方泓河南中医药大学河南省郑州市450046 上海中医药大学附属龙华医院上海市200032

背景:研究表明,线粒体介导的肺泡上皮细胞凋亡在肺纤维化发病中起着重要的作用,而肺痹方可以减轻肺纤维化,抑制肺纤维化小鼠细胞外机制转化。目的:探讨肺痹方对博来霉素致肺纤维化小鼠肺泡上皮细胞线粒体途径凋亡的机制。方法:40只C57B... 详细信息

背景:研究表明,线粒体介导的肺泡上皮细胞凋亡在肺纤维化发病中起着重要的作用,而肺痹方可以减轻肺纤维化,抑制肺纤维化小鼠细胞外机制转化。目的:探讨肺痹方对博来霉素致肺纤维化小鼠肺泡上皮细胞线粒体途径凋亡的机制。方法:40只C57BL/6雄性小鼠随机分为空白对照组、模型组、吡非尼酮组、肺痹方组,每组10只。除空白对照组外,其他3组腹腔注射博来霉素[7.5 mg/(kg·d)]建立肺纤维化模型,连续注射10 d。造模后第1天各药物组小鼠灌胃给药[51.43/(kg·d)]吡非尼酮或[12.86 mg/(kg·d)肺痹方],连续给药28 d。用药结束后取材,采用苏木精-伊红染色和Masson染色观察小鼠肺组织的形态学变化,ELISA法检测血清中白细胞介素1、白细胞介素6、白细胞介素17、白细胞介素37水平,Western-blot法检测肺组织中Bax、Bcl-2、Beclin-1和Caspase3表达。结果与结论:①肺组织的形态学观察显示,模型组肺泡间隔及肺泡腔有大量炎症细胞浸润,出现大片融合成团的纤维灶;吡非尼酮组肺泡间隔增厚,炎症细胞少量浸润,出现肺纤维灶;肺痹方组肺泡结构增宽,少量的炎症细胞浸润,肺泡结构几乎无明显受损,少量肺纤维灶。②与空白对照组相比,模型组小鼠血清白细胞介素1、白细胞介素6、白细胞介素17和白细胞介素37质量浓度明显升高(P<0.01),两用药组明显低于模型组(P<0.01),肺痹方组低于非尼酮组。③与空白对照组相比,模型组小鼠肺组织Bax和Caspase3蛋白表达显著升高,两用药组均低于模型组;与空白对照组相比,模型组Bcl-2和Beclin-1蛋白表达显著降低,两用药组均高于模型组。④结论:肺痹方可以减轻肺纤维化,其机制可能与下调白细胞介素1、白细胞介素6、白细胞介素17和白细胞介素37水平,以及调节线粒体凋亡Bax、Bcl-2、Beclin-1和Caspase3相关蛋白从而减少肺泡上皮细胞凋亡有关。

关键词：肺痹方肺纤维化线粒体博来霉素 C57BL/6小鼠

Drug-induced erythroderma in patients with acquired immunodeficiency syndrome

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World Journal of Emergency Medicine 2021年第4期12卷 299-302页

作者： Wei-fang Zhu De-ren fang hong fang Department of Dermatology the First Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310003China

BACKGROUND: To explore the clinical manifestations, diagnosis, and treatment of patients with acquired immunodeficiency syndrome(AIDS) complicated with drug-induced ***: The clinical data of 12 AIDS patients with drug-induced erythroderma in our hospital were retrospectively analyzed. The general information, offending medications, complications, modified severity-of-illness score for toxic epidermal necrolysis(SCORTEN) scores, and disease outcome spectrums were ***: Drug-induced erythroderma was mostly caused by antiviral drugs, antituberculosis drugs, antibiotics, traditional Chinese medicine, and immune checkpoint inhibitors. The spectrum of sensitizing drugs was broad, the clinical situation was complex, and infections were common. The affected areas were greater than 40% body surface area in all patients. The modified SCOTERN score averaged 3.01±0.99. All patients were treated with glucocorticoids, and nine patients were treated with intravenous immunoglobulin(IVIG) pulse therapy at the same time. The average time to effectiveness was 7.08±2.23 days, and the average hospital stay was 17.92±8.46 days. Eleven patients were cured, and one patient died of secondary multiple infections, who had a modified SCORTEN score of 5 points. The mortality rate in this study was 8.3%.CONCLUSIONS: The clinical situation of AIDS patients with drug-induced erythroderma in hospitalized patients is complex and the co-infection rate is high. The use of modified SCORTEN score may objectively and accurately assess the conditions, and the use of glucocorticoid combined with IVIG therapy may improve the prognosis.

关键词： Acquired immunodeficiency syndrome Drug eruption Erythroderma Modified severity-of-illness score for toxic epidermal necrolysis

Dynamical Feedback between Synoptic Eddy and Low-Frequency Flow as Simulated by BCC_CSM1.1(m)

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Advances in Atmospheric Sciences 2017年第11期34卷 1316-1332页

作者： fang ZHOU hong-Li REN Laboratory for Climate Studies National Climate CenterChina Meteorological Administrationbeijing 100081china CMA-NJU Joint Laboratory for Climate Prediction Studies School of Atmospheric SciencesNanjing Universitynanjing 210093china Department of Atmospheric Science School of Environmental StudiesChina University of Geosciencewuhan 430074china

Since the interaction between atmospheric synoptic eddy （SE）（2-8 days） activity and low-frequency （LF）（monthly） flow （referred to as SELF） plays an essential role in generating and maintaining dominant climate modes, an evaluation of the performance of BCC_CSMI.I（m） in simulating the SE feedback onto the LF flow is given in this paper. The model captures well the major spatial features of climatological eddy vorticity forcing, eddy-induced growth rate, and patterns of SELF feedback for the climate modes with large magnitudes in cold seasons and small magnitudes in warm seasons for both the Northern and Southern Hemisphere. As in observations, the eddy-induced growth rate and SELF feedback patterns in the model also show positive SE feedback. Overall, the relationships between SE and LF flow show that BCC_CSM1. l（m） satisfactorily captures the basic features of positive SE feedback, which demonstrates the simulation skill of the model for LF variability. Specifically, such an evaluation can help to find model biases of BCC_CSM1.1 （m） in simulating SE feedback, which will provide a reference for the model＇s application.

关键词： model evaluation synoptic eddy feedback simulation eddy vorticity forcing eddy-induced growth rate patternsof synoptic eddy feedback

Survey on skin aging status and related influential factors in Southeast China

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第1期10卷 57-66页

作者： Yi-na WANG hong fang Wei-fang ZHU Department of Dermatology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective： To investigate cutaneous aging patterns of residents in Hangzhou, Zhejiang, China, and their contributing factors. Methods： Eight hundred and forty-eight Hangzhou residents received the survey between March 2004 and September 2004. Results： Facial wrinkling first occurred at 21 years of age and skin elasticity began to lose at 22 years of age. In middle-aged and old people, facial wrinkling and looseness escalated with the increase of ultraviolet （UV）-exposure time, indicating the accelerating effect of a higher accumulative dose of UV radiation on skin aging. Only Fitzpatrick types Ⅱ, Ⅲ and Ⅳ were found in the skin phototypes of residents in Hangzhou area, and Fitzpatrick type Ⅱ seemed to be much more subject to severe wrinkling, elasticity destruction and skin tumors than types Ⅲ and Ⅳ. The oily skin was more protected against wrinkling and facial looseness than dry skin. However, as to concomitant cutaneous diseases, no difference was found among different skin types. Conclusion： Age, solar-exposure time, Fitzpatrick type and skin type are the associated forces in promoting skin aging, and emotional factor seems to be another independent risk factor. The age of 49 years and 2 h/d of solar-exposure time seem to be the turning points responsible for dramatic changes of cutaneous appearance in the process of skin aging in Southeast China.

关键词： Skin aging Influential factor Fitzpatrick type Solar exposure Skin type Concomitant facial disease

Preparation of a Novel Highly Effective and Environmental Friendly Wheat Seed Coating Agent

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Agricultural Sciences in China 2010年第7期9卷 937-941页

作者： ZENG De-fang WANG hong School of Resource and Environmental Engineering Wuhan University of Technology Wuhan 430070 PR. China

A novel environmental friendly wheat seed coating agent was prepared from the natural polymer,biological pesticide,microfertilizer,microelements and other *** laboratory and field test results showed that it could enhance the yield up to 16% and reduce its input cost to 1/6 as compared with the conventional wheat seed coating *** is safe without causing any pollution and would have significant economic and environmental benefits.

关键词： wheat seed coating agent polysaccharide sprouting tendency germination rate bacteriostatic ratio field experiment

NUMERICAL ANALYSIS FOR CIRCULATION DISTRIBUTION OF PROPELLER BLADE

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Journal of Hydrodynamics 2010年第4期22卷 488-493页

作者： hong fang-wen DONG Shi-tang China Ship Scientific Research Center Wuxi 214082 China

A process for numerical analysis of radial circulation distribution of propeller blade is proposed and *** is based on the results of numerical simulation of the velocity field around propeller blades and in the *** well-known traditional method using tangential velocity data in the wake and applying Stockes＇s theorem was also examined in the *** results from two approaches are compared with each *** is found that if the traditional way is utilized,in many cases an unexpected ＂hump＂ appears in the circulation distribution at certain outer *** authors calculated the circulations directly around blade sections,and it is referred as direct *** unexpected hump of the circulation distribution disappears in the results of direct *** article also discusses the reasons of the appearance of the unexpected hump in traditional *** direct method is proposed to have a potential in analyzing or verifying the radial road distribution for designed propeller and the numerical analysis instead of experimental validation for circulation distribution can be as a tool in the propeller design process.

关键词： propeller blade circulation distribution load distribution

Modification of k-ω Turbulence Model for Predicting Airfoil Aerodynamic Performance

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Journal of Thermal Science 2015年第3期24卷 221-228页

作者： PENG Bo YAN Hao fang hong WANG Ming School of Economics and Management Beihang University National Key Laboratory of Science and Technology on Aero-Engine Aero-Thermodynamics School of Energy and Power Engineering Beihang University Shenyang Aeroengine Research Institute

Predicting wind turbine S825 airfoil＇s aerodynamic performance is crucial to improving its energy efficiency and reducing its environmental impact. In this paper, a numerical simulation on the wind turbine S825 airfoil is con- ducted with k-to turbulence model at different attack angles. By comparing with experimental data, a new method of modifying k-to model is proposed. A modifying function is proposed to limit the production term in ω equation based on fluid rotation and deformation. This method improves turbulent viscosity and decreases separating re- gion when the airfoil works at large separating conditions. The predictive accuracy could be improved by using the modified k-to turbulence model.

关键词： S825 airfoil separation k-ω model aerodynamic performance non-equilibrium

ANALYSIS OF SEEPAGE FLOW IN A CONFINED AQUIFER WITH A STANDING COLUMN WELL

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Journal of Hydrodynamics 2007年第1期19卷 84-91页

作者： LI Min DIAO Nai-ren fang Zhao-hong Engineering college Guangdong Ocean University Zhanjiang 524088 China The Ground Source Heat Pump Research Center Shandong Jianzhu University Jinan 250101 China

The standing column well for ground source heat pump systems is a promising technology with high efficiency and environmental benefit, where groundwater is drawn from the bottom of a well and then re-injected to its top after transferring heat with heat pumps. Heat transfer analysis of great significance and aquifer involves complex problems. Determining the groundwater seepage flow is a precondition to solve the energy equation describing the heat transfer of the system. Only when piezometric head is obtained, the seepage velocity can be determined according to Darcy＇s law. In this article the groundwater seepage flow in an axial symmetrical geometry was studied under the assumption that gross groundwater flow is neglected. An analytical solution of the groundwater seepage flow for a confined aquifer was acquired by using the integral transform method, which may provide a foundation for heat transfer analysis of the standing column well system.

关键词： ground source heat pump standing columnwell seepage flow heat transfer

In Vitro Interaction of Nicotine and Hemoglobin under Liver Cell Metabolizing Condition

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Chinese Chemical Letters 2001年第5期12卷 449-452页

作者： Yan WANG hong fang SUN Hai fang WANG Yuan fang LIU Department of Technical Physics Peking UniversityBeijing 100871

The in vitro interaction of nicotine and hemoglobin (Hb) in a metabolizing System was studied by spectroscopy assays. Visible spectra showed two isobestics, and fluorescence spectra showed static quenching with increasing of nicotine dose. Meanwhile, the CD spectra intensity reduced, showing the conformation of Hb varied markedly through the interaction. All these results suggested that the interaction of nicotine or its metabolites and Hb might do harm to physicological function of Hb.

关键词： Nicotine hemoglobin visible absorption fluorescence CD