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Benefit-Risk Assessment of Chinese Medicine Injections for Primary Liver Cancer Based on Multi-criteria Decision Analysis

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Chinese Journal of Integrative Medicine 2024年第6期30卷 559-564页

作者： ZHANG Rong-rong SHAO Ming-yi FU yu ZHAO Rui-xia WANG Jing-wen fang yu-xuan The First Clinical Medical College of Henan University of Traditional Chinese Medicine Zhengzhou450046China Personal Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Scientific Research Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Digestive Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China

ObjectiveTo evaluate the benefit-risk of 3 commonly used Chinese medicine injections, Aidi Injection (ADI), Cinobufagin Injection (CINI) and Compound Kushen Injection (CKI), in the treatment of primary liver cancer (PLC), so as to provide a reference for clinical decision-making.MethodsRandomized controlled trials (RCTs) of ADI, CINI and CKI in the treatment of PLC published in the databases of China National Knowledge Infrastructure, Wanfang, China Science and Technology Journal Database, SinoMed, PubMed, Cochrane Library, and Web of Science were retrieved from January 2020 to October 2022. The data of benefit and risk indicators were combined to obtain the effect value. The multi-criteria decision analysis (MCDA) model was applied to build the decision tree. The benefit value, risk value and benefit risk value of the 3 injections in PLC treatment were calculated. Monte Carlo simulation was carried out to calculate the 95% confidence interval and probability of differences among the 3 injections, so as to optimize the evaluation results.ResultsA total of 71 RCTs were included. The benefit values of ADI, CINI and CKI combined with transcatheter arterial chemoembolization (TACE) were 42, 38 and 36, respectively. The risk values were 42, 25 and 37, respectively. The benefit risk values were 42, 31 and 37, respectively. The benefit risk differences of ADI vs. CINI, ADI vs. CKI, and CKI vs. CINI were 11 (−0.86, 17.75), 5 (−5.01, 11.09), and 6 (−1.87, 12.63), respectively. The probability that ADI superior to CINI, ADI superior to CKI, and CKI superior to CINI was 96.26%, 77.27%, and 92.62%, respectively.ConclusionBased on the results of MCDA model, CINI combined with TACE has the greatest risk in the treatment of the PLC. Considering the efficacy and safety, the possible priority of the 3 Chinese medicine injections combined with TACE in the treatment of PLC is ADI, CKI and CINI.

关键词： multi-criteria decision analysis benefit-risk assessment Chinese medicine injections primary livercancer

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3D NAND闪存中TiN与氧化表面F吸附作用的第一性原理研究

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物理学报 2024年第12期73卷 385-392页

作者：方语萱杨益夏志良霍宗亮中国科学院微电子研究所北京100029 中国科学院大学北京101408 长江存储科技有限责任公司武汉430071 长江先进存储产业创新中心有限责任公司武汉430014

随着3D NAND技术的发展,存储阵列工艺的堆叠层数越来越高,后栅工艺中金属钨(W)栅字线(WL)层填充的工艺也面临越来越严峻的挑战.钨栅沉积工艺中的主要挑战在于氟攻击问题,钨栅填充时产生的空洞导致了含氟(F)副产物的积聚,并在后续高温制... 详细信息

随着3D NAND技术的发展,存储阵列工艺的堆叠层数越来越高,后栅工艺中金属钨(W)栅字线(WL)层填充的工艺也面临越来越严峻的挑战.钨栅沉积工艺中的主要挑战在于氟攻击问题,钨栅填充时产生的空洞导致了含氟(F)副产物的积聚,并在后续高温制程的激发下,扩散侵蚀其周边氧化物层,致使字线漏电,严重影响器件的良率及可靠性.为改善氟攻击问题,通常在钨栅沉积之前再沉积一层薄的氮化钛作为阻挡层.然而在对栅极叠层组分分析中发现,F元素聚集在TiN薄膜表面,并且难以通过退火排出.本文采用第一性原理计算,研究了TiN薄膜表面吸附含F物种的情况,提出TiN的表面氧化能加剧对含F物种的吸附作用,仿真结果指导了栅极工艺过程的优化方向.基于第一性原理计算结果,提出氨气吹扫表面处理方法,有效改善了3D NAND中的氟攻击问题,将字线漏电率降低25%,晶圆翘曲度降低43%.

关键词： 3D NAND闪存氟攻击问题第一性原理

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3D NAND闪存中氟攻击问题引起的字线漏电的改进

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物理学报 2024年第6期73卷 368-373页

作者：方语萱夏志良杨涛周文犀霍宗亮中国科学院微电子研究所北京100029 中国科学院大学北京101408 长江存储科技有限责任公司武汉430071 长江先进存储产业创新中心有限责任公司武汉430014

随着3D NAND闪存向更高层数堆叠,后栅工艺下,金属钨(W)栅字线(WL)层填充工艺面临的挑战进一步增大.由于填充路径增长,钨栅在沉积过程中易产生空洞,造成含氟(F)副产物的聚集,引起氟攻击问题.具体表现为,在后续高温制程的激发下,含氟副产... 详细信息

随着3D NAND闪存向更高层数堆叠,后栅工艺下,金属钨(W)栅字线(WL)层填充工艺面临的挑战进一步增大.由于填充路径增长,钨栅在沉积过程中易产生空洞,造成含氟(F)副产物的聚集,引起氟攻击问题.具体表现为,在后续高温制程的激发下,含氟副产物向周围结构扩散,侵蚀其周边氧化物层,导致字线漏电,影响器件的良率及可靠性.本文首先分析了在3D NAND闪存中氟攻击的微观原理,并提出了通过低压退火改善氟攻击问题的方法.接下来对平面薄膜叠层与三维填充结构进行常压与低压下的退火实验,并使用多种方法对残留氟元素的浓度与分布进行表征.实验结果表明,适当条件下的低压退火,使得钨栅中的残余氟有效地被排出,可以有效降低字线的漏电指数,提高3D NAND闪存的质量.

关键词： 3D NAND闪存氟攻击问题字线漏电低压退火

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Efficacyand Safetyof Huashi Baidu Granules in Treating Patients with SARS-CoV-2Omicron Variant: A Single-Center Retrospective Cohort Study

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Chinese Journal of Integrative Medicine 2024年第2期30卷 107-114页

作者： CHEN Cai-yu ZHANG Wen XU Xiang-ru PU yu-ting TU Ya-dan PENG Wei YAO xuan ZHOU Shuang fang Bang-jiang Department of Emergency Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai(200032)China Department of Classical Traditional Chinese Medicine Chongqing Hospital of Traditional Chinese MedicineChongqing(400021)China Acupuncture and Massage College Shanghai University of Traditional Chinese MedicineShanghai(201203)China Institute of Emergency and Critical Care Medicine Shanghai University of Traditional Chinese MedicineShanghai(200032)China

Objective:To evaluate the efficacy and safety of Huashi Baidu Granules(HSBD)in treating patients with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant.Methods:A single-center retrospective cohort study was conducted during COVID-19 Omicron epidemic in the Mobile Cabin Hospital of Shanghai New International Expo Center from April 1st to May 23rd,2022.All COVID-19 patients with asymptomatic or mild infection were assigned to the treatment group(HSBD users)and the control group(non-HSBD users).After propensity score matching in a 1:1 ratio,496 HSBD users of treatment group were matched by propensity score to 496 non-HSBD users.Patients in the treatment group were administrated HSBD(5 g/bag)orally for 1 bag twice a day for 7 consecutive days.Patients in the control group received standard care and routine treatment.The primary outcomes were the negative conversion time of nucleic acid and negative conversion rate at day 7.Secondary outcomes included the hospitalized days,the time of the first nucleic acid negative conversion,and new-onset symptoms in asymptomatic patients.Adverse events(AEs)that occurred during the study were recorded.Further subgroup analysis was conducted in vaccinated(378 HSBD users and 390 non-HSBD users)and unvaccinated patients(118 HSBD users and 106 non-HSBD users).Results:The median negative conversion time of nucleic acid in the treatment group was significantly shortened than the control group[3 days(IQR:2-5 days)vs.5 days(IQR:4-6 days);P<0.01].The negative conversion rate of nucleic acid in the treatment group were significantly higher than those in the control group at day 7(91.73%vs.86.90%,P=0.014).Compared with the control group,the hospitalized days in the treatment group were significantly reduced[10 days(IQR:8-11 days)vs.11 days(IQR:10.25-12 days);P<0.01].The time of the first nucleic acid negative conversion had significant differences between the treatment and control groups[3 days(IQR:2-4 days)vs.5 days(IQR:4-6 days);P<0.01].The incidence of new-onset sym

关键词： Huashi Baidu Granule severe acute respiratory syndrome coronavirus 2 Omicron variant retrospective cohort trial Chinese medicine

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Comparative analysis between single-train passing and double-train intersection in a tunnel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第5期25卷 429-442页

作者： Jianming DU Qian fang xuan ZHANG Hualao WANG Bridge and Tunnel Research Center Research Institute of Highway Ministry of TransportBejing 100088China Tunnel and Underground Engineering Research Center of Ministry of Education Beijing Jiaotong UniversityBeijing 00044China

Aerodynamic pressure significantly impacts the scientific evaluation of tunnel service performance.The aerodynamic pressure of two trains running in a double-track tunnel is considerably more complicated than that of a single train.We used the numerical method to investigate the difference in aerodynamic pressure between a single train and two trains running in a double-track tunnel.First,the numerical method was verified by comparing the results of numerical simulation and on-site monitoring.Then,the characteristics of aerodynamic pressure were studied.Finally,the influence of various train-tunnel factors on the characteristics of aerodynamic pressure was investigated.The results show that the aerodynamic pressure variation can be divided into stage I:irregular pressure fluctuations before the train tail leaves the tunnel exit,and stage II:periodic pressure declines after the train tail leaves the tunnel exit.In addition,the aerodynamic pressure simultaneously jumps positively or drops negatively for a single train or two trains running in double-track tunnel scenarios.The pressure amplitude in the two-train case is higher than that for a single train.The maximum positive peak pressure difference(P_(STP))and maximum negative peak pressure difference(P_(STN))increase as train speed rises to the power from 2.256 to 2.930 in stage I.The P_(STP) and P_(STN) first increase and then decrease with the increase of tunnel length in stage I.The P_(STP) and P_(STN) increase as the blockage ratio rises to the power from 2.032 to 2.798 in stages I and II.

关键词： Railway tunnel Aerodynamic effect Pressure characteristic Train speed Tunnel length Blockage ratio

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Enantioselective Synthesis of Benzimidazole Atropisomers Featuring a N-N Axis

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Chinese Journal of Chemistry 2024年第7期42卷 711-718页

作者： fang-Bei Ge Qi-Kun Yin Chuan-Jun Lu xuan xuan Jia Feng Ren-Rong Liu College of Chemistry and Chemical Engineering Qingdao UniversityQingdaoShandong 266071China School of Pharmacy Key Laboratory of Mlecular Pharmacoogy and Drug EvaluationMinistry of EducationYantai Universit YantaiShandong 264005China

Atroposelective synthesis of N-N atropisomers is an emerging area but remains underexplored;in particular,the synthesis of N-N benzimidazole atropisomers is still unprecedented.Herein,the first enantioselective synthesis of N-N benzimidazole atropisomers via the palladium-catalyzed de novo construction of benzimidazole skeleton is presented.With readily available palladium catalyst and biphosphine ligand,a broad range of nonbiaryl benzimidazole and indole-benzimidazole atropisomers were conveniently ac-cessed in high yields and with excellent enantioselectivities.Significantly,these N-N benzimidazole atropisomers showed great anti-tumor activity and selectivity to breast cancer MCF-7 cells.The simple catalytic system,broad substrate scope,high enantioselectivi-ty,and good bioactivity make this approach highly attractive.

关键词： Asymmetric synthesis Atropisomerism Palladium Benzimidazole Antitumor

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Therapeutic advances in atrial fibrillation based on animal models

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 135-152页

作者： Qian GONG xuan LE Pengcheng yu Lenan ZHUANG Institute of Genetics and Reproduction College of Animal SciencesZhejiang UniversityHangzhou310058China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou310016China

Atrial fibrillation(AF)is the most prevalent sustained cardiac arrhythmia among humans,with its incidence increasing significantly with age.Despite the high frequency of AF in clinical practice,its etiology and management remain elusive.To develop effective treatment strategies,it is imperative to comprehend the underlying mechanisms of AF;therefore,the establishment of animal models of AF is vital to explore its pathogenesis.While spontaneous AF is rare in most animal species,several large animal models,particularly those of pigs,dogs,and horses,have proven as invaluable in recent years in advancing our knowledge of AF pathogenesis and developing novel therapeutic options.This review aims to provide a comprehensive discussion of various animal models of AF,with an emphasis on the unique features of each model and its utility in AF research and treatment.The data summarized in this review provide valuable insights into the mechanisms of AF and can be used to evaluate the efficacy and safety of novel therapeutic interventions.

关键词： Atrial fibrillation Animal model Therapeutic

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Small nucleolar RNA and its potential role in the oncogenesis and development of colorectal cancer

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World Journal of Gastroenterology 2024年第2期30卷 115-127页

作者： Yang-Zheng Lan Zheng Wu Wen-Jia Chen Ze-xuan fang Xin-Ning yu Hua-Tao Wu Jing Liu The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

Small nucleolar RNAs(snoRNAs)represent a class of non-coding RNAs that play pivotal roles in post-transcriptional RNA processing and modification,thereby contributing significantly to the maintenance of cellular functions related to protein synthesis.SnoRNAs have been discovered to possess the ability to influence cell fate and alter disease progression,holding immense potential in controlling human diseases.It is suggested that the dysregulation of snoRNAs in cancer exhibits differential expression across various cancer types,stages,metastasis,treatment response and/or prognosis in patients.On the other hand,colorectal cancer(CRC),a prevalent malignancy of the digestive system,is characterized by high incidence and mortality rates,ranking as the third most common cancer type.Recent research indicates that snoRNA dysregulation is associated with CRC,as snoRNA expression significantly differs between normal and cancerous conditions.Consequently,assessing snoRNA expression level and function holds promise for the prognosis and diagnosis of CRC.Nevertheless,current comprehension of the potential roles of snoRNAs in CRC remains limited.This review offers a comprehensive survey of the aberrant regulation of snoRNAs in CRC,providing valuable insights into the discovery of novel biomarkers,therapeutic targets,and potential tools for the diagnosis and treatment of CRC and furnishing critical cues for advancing research into CRC and the judicious selection of therapeutic targets.

关键词： Small nucleolar RNAs Colorectal cancer Dysregulation Biomarker

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Control of Virtual Synchronous Generator for Frequency Regulation Using a Coordinated Self-adaptive Method

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 175-184页

作者： Hongwei fang Zhiwei yu School of Electrical and Information Engineering and Key Laboratory of Tianjin Electric Power System Simulation and Control Tianjin UniversityTianjin 300072China

Power inverter adopting virtual synchronous generator(VSG)control can provide inertia support for distributed generation systems.However,it cannot take into account the dynamic regulation characteristics of frequency.Thus,when the system encounters a sudden change in load or disturbance,the dynamic process of frequency regulation will be greatly influenced.In view of this issue,an improved VSG control strategy based on a coordinated self-adaptive(CSA)method is proposed.The time domain analysis method is used to study the influences of virtual inertia and damping parameter perturbation on the system steady and dynamic performances.Furthermore,in order to make the control strategy suitable for large load changes and suppress frequency variations beyond the limit,the secondary frequency modulation is introduced into the control loop.Through the coordinated adaptive control of virtual inertia,virtual damping and frequency modulation,the dynamic performance of vSG frequency regulation can be obviously improved.Simulation and experiment results have verified the effectiveness of the proposed CSA control strategy.

关键词： Coordinated self-adaptive method frequency regulation time domain analysis virtual synchronous generator

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Capture Efficiency Analysis in the Circular Restricted Three-body Problem

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Research in Astronomy and Astrophysics 2024年第5期24卷 198-210页

作者： yu-xuan Miao Xi-yun Hou Department of Astronomy and Space Science Nanjing UniversityNanjing 210023China Institute of Space Environment and Astrodynamics Nanjing UniversityNanjing 210023China Key Laboratory of Modern Astronomy and Astrophysics Ministry of EducationNanjing 210023China

Temporary capture efficiency is studied in the framework of the circular restricted three-body problem in two steps.First, a non-uniform distribution of test particles around the secondary's orbit is obtained by fully accounting the secondary's gravitational influence. Second, the capture efficiency is computed based on the non-uniform distribution. Several factors influencing the result are discussed. By studying the capture efficiency in the circular restricted three-body problem of different mass ratios, a power-law relation between the capture efficiency(p) and the mass ratio(μ) is established, which is given by p ≈ 0.27 × μ^(0.53), within the range of 3.0035 ×10^(-6)≤ μ ≤ 3.0034 × 10^(-5). Taking the Sun–Earth system as an example, the influence from the orbit eccentricity of the secondary on the non-uniform distribution and the capture efficiency is studied. Our studies find that the secondary's orbit eccentricity has a negative influence on the capture efficiency.

关键词： methods numerical-celestial mechanics-planets and satellites dynamical evolution and stability

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