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Transcriptional regulation of secondary metabolism and autophagy genes in response to DNA replication stress in Setosphaeria turcica

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Journal of Integrative Agriculture 2023年第4期22卷 1068-1081页

作者： meng Ya-nan ZHANG Xin-jie ZENG fan-li ZHAI Wei-bo LI Pan HU Jing-jing XIAO Sheng-lin HAO zhi-min CAO zhi-yan CHEN Chuan DONG Jin-gao State Key Laboratory of North China Crop Improvement and Regulation Hebei Agricultural UniversityBaoding 071001P.R.China College of Life Sciences Hebei Agricultural UniversityBaoding 071001P.R.China Key Laboratory of Microbial Diversity Research and Application of Hebei Province School of Life SciencesHebei UniversityBaoding 071001P.R.China Key Laboratory of Hebei Province for Plant Physiology and Molecular Pathology Hebei Agricultural UniversityBaoding 071001P.R.China College of Plant Protection Hebei Agricultural UniversityBaoding 071001P.R.China

The fungal pathogen Setosphaeria turcica causes northern corn leaf blight(NCLB),which leads to considerable crop *** turcica elaborates a specialized infection structures called appressorium for maize ***,we demonstrated that the *** triggers an S-phase checkpoint and ATR(Ataxia Telangiectasia and Rad3 related)-dependent self-protective response to DNA genotoxic insults during maize ***,how the regulatory mechanism works was still largely ***,we report a genome wide transcriptional profile analysis during appressorium formation in the present of DNA replication *** performed RNA-Seq analysis to identify *** genes responsive to DNA replication *** the current work,we found that appressorium-mediated maize infection by *** is significantly blocked by S-phase checkpoint.A large serial of secondary metabolite and melanin biosynthesis genes were blocked in appressorium formation of *** during the replication *** secondary metabolite biosynthesis genes including alcohol dehydrogenase GroES-like domain,multicopper oxidase,ABCtransporter families,cytochrome P450 and FAD-containing monooxygenase were related to plant pathogen *** addition,we demonstrated that autophagy in *** is up-regulated by ATR as a defense response to *** identified StATG3,StATG4,StATG5,StATG7 and StATG16 genes for autophagy were induced by ATR-mediated S-phase *** therefore propose that in response to genotoxic stress,*** utilizes ATR-dependent pathway to turn off transcription of genes governing appressorium-mediated infection,and meanwhile inducing transcription of autophagy genes likely as a mechanism of self-protection,aside from the more conservative responses in eukaryotes.

关键词： Setosphaeria turcica appressorium secondary metabolite autophagy DNA replication stress

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Safety of Curcuma aromatica oil gelatin microspheres administered via hepatic artery

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World Journal of Gastroenterology 2004年第18期10卷 2637-2642页

作者： Shi-GuiDeng zhi-FengWu Wei-YingLi zhi-GangYang GangChang fan-Zhemeng Li-LiMo SecondAffiliatedHospitalofGuangzhouUniversityofTraditionalChineseMedicine Guangzhou510120GuangdongProvinceChina

AIM: To evaluate the safety of Curcurna aromatica oil gelatin microspheres (CAO-GMS) infused via hepatic artery against primary liver ***: The safety of CAO-GMS was evaluated in view of its acute toxicity in rats, long-term toxicity in Beagle dogs and general pharmacology in rats and mongrel ***: The 50% lethal dose (LDs0) of CAO-GMS infused via the hepatic artery was 17.19 mg/kg, and the serum biochemical indices of dying rats after the administration changed markedly while those of survived rats did *** pathological examination of the tissues from the dead rats indicated improper embolism. Similar edema and small necrotic foci in the hepatic Iobule were found in the hepatic tissue of rats receiving 10 and 5 mg/kg CAO-GMS and GMS 60 d after the last administration, while not in the rats of the blank control group, indicating that microspheres infused via the hepatic artery may induce irreversible liver damage dose-dependently. General pharmacological study showed that the activities (posture and gait), respiration frequency, blood pressure or heart rate of the dogs were not affected by CAO-GMS, nor were salivation, tremor or pupil changes of the rats observed or their balancing ability compromised, suggesting CAO-GMS infused via the hepatic artery did not significantly affect the nervous, respiratory and cardiovascular ***: CAO-GMS embolization administered via the hepatic artery is safe but undesired embolization induced by vascular variation should be given due attention in its clinical application. Individualized embolization dosage and super-selective catheterization technique are recommended to avoid undesired embolism and reduce complications.

关键词：保险装置郁金油微球体凝胶肝动脉肝癌肿瘤

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基于荧光光谱和拉曼光谱技术的中药检测研究

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光谱学与光谱分析 2025年第1期45卷 139-145页

作者：逯美红张凡暴雅婷王志军雷海英王翔宇高鹏慧长治学院物理系山西长治046011 西安信息职业大学物理实验中心陕西西安710125 长治学院生命科学系山西长治046011

中医药是中华文化的瑰宝和中华文明的结晶,在全民健康中发挥着重要作用。由于中药生长环境受限及市场需求量的增大,市场上出现了许多以次充好、以假乱真的中药,这对中药发展及质量保障都极为不利。因此,对中药的检测和鉴定非常重要。为... 详细信息

中医药是中华文化的瑰宝和中华文明的结晶,在全民健康中发挥着重要作用。由于中药生长环境受限及市场需求量的增大,市场上出现了许多以次充好、以假乱真的中药,这对中药发展及质量保障都极为不利。因此,对中药的检测和鉴定非常重要。为了探究中药的荧光光谱和拉曼光谱特性,选取白芷、苏木、山药、地榆四种中药进行分类检测研究。一方面,从化学成分和结构的角度分析中药白芷和苏木产生荧光的可能性,采用F-4600型荧光光谱仪(200~750 nm)分别在不同激发波长和不同浓度下测试了白芷和苏木水浸液的荧光光谱,探究了白芷和苏木水浸液的荧光光谱特性,并对荧光强度与不同浓度、激发波长的关系进行了探讨。另一方面,采用共聚焦显微拉曼光谱仪(100~4000 cm^(-1))对4种不同产地的山药和2种不同产地的地榆中药饮片的拉曼光谱分别进行测试研究。结果表明,白芷水浸液在波长260~350 nm的光激发下,产生较强荧光,最佳激发波长是340 nm,荧光峰值波长为420 nm,其荧光强度随浓度的增大而增强,且样品浓度较低时,荧光强度与浓度成线性关系;苏木水浸液在200~290 nm的光激发下,产生较强荧光,最佳激发波长为220 nm,荧光峰值波长为345 nm,随浓度的增加,荧光强度先增强后减弱,在浓度为0.175 mg·mL^(-1)时荧光强度达到最大。白芷水浸液和苏木水浸液的荧光强度都与激发波长的关系呈现高斯分布,符合荧光规律。分析山药和地榆的拉曼光谱,发现不同产地的拉曼特征基本一致,确认山药的拉曼特征峰主要集中在477、862、939、1080、1258、1337和1457 cm^(-1)处;地榆的拉曼特征峰主要集中在862和1337 cm^(-1)处,主要归属与已有的化学成分研究结果相符。部分特征峰处拉曼活性出现差异,可以作为区分不同产地中药的依据。该研究结果不仅为荧光光谱在中药鉴定及质量分析中的应用提供了实验数据和方法参考,也为利用拉曼光谱技术实现中药的快速准确检测及产地归属奠定了基础。

关键词：白芷苏木山药地榆荧光光谱拉曼光谱

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Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-fan Yang zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-fang Ying zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

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Comparative Studies on Properties of Polymers with Bulky Side Groups Synthesized by Cyclopolymerization of α,ω-Dienes and α,ω-Diynes

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Chinese Journal of Polymer Science 2019年第2期37卷 149-156页

作者： Shao-Fei Song Xiao-Yu Liu Hao Zhang zhi-Sheng Fu Jun-Ting Xu zhi-Qiang fan Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University

Four polymers containing five-membered rings in the main chain, with or without conjugation structure along the backbone and with or without conjugated pendent groups, were designed and synthesized by metathesis cyclopolymerization of functionalized α,ω-diynes, and cyclopolymerization of functionalized α,ω-dienes catalyzed by the α-diimine palladium-based catalyst, respectively. High to moderate monomer conversions were achieved. Chain structure, molecular weight, and molecular weight distribution(MWD) of the cyclopolymerization products were characterized by ~1 H-, ^(13) C-NMR, FTIR, and GPC. The polymers showed regular main chain structures,moderately high molecular weight, and narrow MWD. Thermal properties and chain stacking behaviors of the polymers were investigated by differential scanning calorimetry(DSC) and X-ray diffraction(XRD) as well as atomic force microscopy(AFM). The polymer with conjugation system in both the backbone and the pendent groups exhibited UV-Vis absorption at a much longer wavelength than those with the conjugation only in the backbone or only in the side groups. The polymers with conjugated backbone need more space for chain stacking, and the conjugated backbone causes enhanced size of polymer particles assembled from solution. The results showed that primary microstructures of the polymer exerted significant influences on the physical properties.

关键词： Cyclopolymerization α,ω-Diene α,ω-Diyne Conjugation system Properties

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Optimization of electrical parameters for micro-arc oxidation of zirconium hydride alloy

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Rare Metals 2022年第7期41卷 2324-2330页

作者： zhi-Gang Wang Wei-Dong Chen Shu-fang Yan Xiu-Juan fan Feng Guo zhi-Gao Xu College of Materials and Engineering Inner Mongolia University of TechnologyHohhot 010051China Division of Mineral Resources Metallurgy and MaterialsGeneral Research Institute for Nonferrous MetalsBeijing 100088China Key Laboratory for Green Chemical Process of Ministry of Education Wuhan Institute of TechnologyWuhan 430073China

The present work aims to present the micro-arc oxidation(MAO)zirconia coating with superior compact-ness and moderate thickness on zirconium *** experiments were designed according to L16(44)orthog-onal array to optimize electrical parameters(frequency,negative voltage,positive voltage and MAO time),with four levels of each *** optimized value was pre-dicted and verified by the confirmation *** anti-permeation effect was tested by means of vacuum dehydrogenation *** optimized coating parameters are listed as follows:treating time of 25 min,frequency of 200 Hz,negative voltage of 150 V and pos-itive voltage of 380 *** results show that the optimized coating exhibits the highest compactness of 0.3705 mg·μm^(-1).This dense coating significantly enhan-ces the hydrogen anti-permeation effects,and the PRF value is improved by nearly 13 times in contrast with that of uncoated ZrH_(1.8).

关键词： coating alloy zirconium

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New insight into surface properties of LB film of an amphiphilic terpolymer

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Chinese Chemical Letters 2011年第2期22卷 241-244页

作者： Xiu Li Yue fang Ma, zhi Fei Dai meng Liu Lei Xing Hai Yan fan Zhan Wen Xing Shao Qin Liu Nanobiotechnology Division State Key Laboratory of Urban Water Resources and Environment School of Sciences Harbin Institute of Technology Harbin 150001 China Received 4 June 2010

Amphiphilic terpolymer（TPR） exhibits good film-forming behavior on pure water observed by means ofπ-A *** gain insight into physical properties of TPR,the films have been deposited on silicon substrates at different surface pressure by Langmuir-Blodgett（LB） *** was found that the increase in peak intensities of stretching mode was due to orderly packing of the *** contact angles increased with increasing surface pressure,indicating an increase in hydrophobicity due to dense packing of chains of *** cyclic voltammetric measurements indicated that TPR showed good current shielding effect for *** a word,LB films of TPR can produce a variety of structures with varied topography,enabling us to control not only the functionality of the surface,but also the interfacial transport characteristics.

关键词： Terpolymer Monolayer Langmuir-Blodgett film Surface

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Syntheses of Substituted Indan-1-onesand Indenes

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Chemical Research in Chinese Universities 1999年第3期15卷 281-285页

作者： YASIN Tariq fan zhi-qiang FENG Lin-xian Department of Polymer Science and Engineering Zhejiang UniversityHangzhou 310027P.R.China

The syntheses of three novel substituted indanones namely 2,7 dimethylindan 1 one, 2 methyl 4,7 diethylindan 1 one and 2,4 dimethyl 7 methoxyindan 1 one are described. These indanones were prepared by different routes involving intramolecular ring closure of aryl substituted compounds by Friedel Crafts reaction. The t butyl was used as the positional protective group in the selective preparation of 2,7 dimethylindan 1 one. The corresponding indenes were prepared by reduction and dehydration reactions from these indanones.

关键词： Friedel Crafts reaction 1 Indanone Substituted indene

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Low-PMEPR rotatable pilot sequences for MIMO-OFDM systems

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Science China(Information Sciences) 2022年第12期65卷 319-320页

作者： Yajing ZHOU Zhengchun ZHOU zhi GU Pingzhi fan School of Information Science and Technology Southwest Jiaotong University School of Mathematics Southwest Jiaotong University Institute of Mobile Communications Southwest Jiaotong University

Dear editor,The multiple-input multiple-output orthogonal frequency division multiplexing(MIMO-OFDM) is the core of many advanced Wi-Fi standards, such as Wi-Fi 4, 5, and 6, to increase the throughput. Operating at the 5-GHz band and considering the phase tracking of the very high throughput long training field(VHT-LTF) sequences,

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Magneto-optical effect of La_(0.7)Ca_(0.3)MnO_3 at low temperature

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Nuclear Science and Techniques 2006年第1期17卷 24-28页

作者： WAN fan HAN Jia-Guang ZHU zhi-Yuan Shanghai Institute of Applied Physics the Chinese Academy of Sciences Shanghai 201800 China Graduate School of the Chinese Academy of Sciences Beijing 100049 China

The magneto-optical Kerr effect of La0.7Ca0.3MnO3 at low temperature in far-infrared terahertz and mid-infrared region from 0.2 to 1.2 eV is theoretically investigated by means of the Drude model. The complex con-ductivity and dielectric constants are obtained. The spectra of Kerr rotation with different external magnetic fields B and temperatures T are numerically analyzed. A large Kerr rotation in mid-infrared region could be explained as the incoherent hopping motion of polarons.

关键词：磁光效应 La0.7Ca0.3MnO3 低温 Kerr效应

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