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An analysis of esophageal cancer incidence in Cixian county from 1974 to 1996

World Journal of Gastroenterology 2003年第2期9卷 209-213页

作者： Yu-TongHe JunHou Cui-YunQiao Zhi-FengChen Guo-HuiSong Shao-SenLi fan-shumeng Hong-XinJin ChaoChen HebeiCancerInstitute Shijiazhuang050011HebeiProvinceChina CixianCancerInstitute Cixiancounty056500HebeiProvinceChina

AIM: To describe the incidence of esophageal cancer (EC)in Cixian, a county of Hebei province during 1974-1996. Weanalyzed the sex and age characteristics as well as thegeographic distribution of EC, in order to determine theimpact so that methods of preventing and controlling EC inCixian can be put in ***: Since the early 1970s, the cancer registrysystem has been established, which collects the cancerincidence in Cixian county. The malignant tumors were codedaccording to International Classification of Disease IX (ICD-9). All the data were checked and analyzed using ***: The trend of the incidence rate of EC from 1974to 1996 had declined, (229.9/100 000 vs 178.5/100 000, Oddsratio= 1.47, 95 % CI: 1.32～1.63, X2=52.89. trend X2=26.54,P＜0.001). The incidence rate of males declined significantly(281.81/100 000 vs 157.96/100 000, Odds ratio=1.61, 95 %CI: 1.41～1.84, X2=47.85. Trend X2=44.86, P＜0.001),whereas, the females remained steady (157.96/100 000 vs133.41/100 000, odds ratio=1.28, 95 % CI:1.17～1.49,X2=9.26. trend X2=2.69, P＞0.05). Male average annualincidence rate was 142.80/100 000 and the female's was95.18/100 000. The sex ratio (males to females) was 1.50:*** incidence rate was increasing along with the age. As tothe geographic distribution, the incidence rate in mountainousareas and hilly areas showed a significantly declining trend(mountainous areas, trend X2=149.93, P＜0.001; hilly areas,trend X2=42.70, P＜0.001). The incidence rate of EC in plainareas had increased (trend X2=22.39, P＜0.001).CONCLUSION: The incidence rate of EC in Cixian countyshows a trend and has declined after two decades, especiallyin mountainous area. But compared to other regions in theworld, Cixian county still had a high incidence rate of EC.

关键词：磁县河北食管癌肿瘤高发地区流行病学 1974-1996年发病率

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Endoscopic survey of esophageal cancer in a high-risk area of China

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World Journal of Gastroenterology 2004年第20期10卷 2931-2935页

作者： Xu-JingLu Zhi-FengChen Cui-LanGuo Shao-SenLi Wen-LongBai Guo-LiangJin Yu-XiaWang fan-shumeng FengGao JunHou HebeiCancerInstituteandFourthAffiliatedHospitalofHebeiMedicalUniversity Shijiazhuang050011HebeiProvinceChina CixianCancerInstitute Cixian056500HebeiProvinceChina

AIM: To characterize the histological types of esophageal and cardiac mucosa by endoscopic survey of a population in a high-risk area of esophageal cancer of China. METHODS: A selected cohort of residents in Cixian County during December 2001 and May 2002 was surveyed by using Lugol's staining, followed by computer-based statistical analysis of the data with SPSS 10.0 software. RESULTS: Histologically, the detection rates of squamous epithelial acanthosis, squamous epithelial atrophy, and basal cell hyperplasia in the esophagus were 1.9% (38/2013),0.1% (3/2013) and 0.9% (18/2013) respectively, and those of mild, moderate, and severe esophagitis were 34.9% (703/2013), 1.6% (33/2013) and 0.2% (2/2013) respectively. Mild, moderate, and severe esophageal dysplasia were detected in 8.6% (172/2013), 7.8% (157/2013) and 2.6% (53/2013) respectively in the selected population, whereas in situ carcinoma, intramucosal carcinoma, invasive squamous carcinoma of the esophagus in 2.5% (50/2013),0.2% (4/2013) and 0.7% (14/2013) respectively. The detection rates of non-atrophic gastritis and atrophic gastritis of the cardia were 36.3% (730/2013) and 11.5% (232/2013) respectively, with mild and severe dysplasia of the cardia detected in 2.5% (51/2013) and 0.8% (17/2013), respectively, in this population; the rates of intramucosal adenocarcinoma and invasive adenocarcinoma of the cardia were 0.1% (3/2013) and 0.8% (17/2013) respectively. The detection rate of esophageal cancer at early stage was 79.4% (54/68). The survey rate (ratio of examined population to expected population) was 73.8% (2013/2725). CONCLUSION: Histologic types of the esophageal and cardiac mucosa were characterized by endoscopic survey in a high-risk population of esophageal cancer, which may help the early detection and treatment of esophageal and cardiac cancers and dysplasia, and reduce the mortality of such malignancies.

关键词：内窥镜测量食道癌高风险地区中国肿瘤

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双组份系统YvcPQ抑制苏云金芽胞杆菌的芽胞形成

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微生物学报 2017年第1期57卷 121-130页

作者：范青云张舒梦巩玉静何进华中农业大学生命科学技术学院农业微生物学国家重点实验室湖北武汉430070

【目的】探究双组份系统YvcPQ影响芽胞形成的机制。【方法】利用β-半乳糖苷酶活性实验验证YvcP对芽胞形成抑制因子KapD的调控作用;通过无痕基因敲除并分别比较突变株与出发菌株的芽胞产率,研究YvcPQ及KapD对芽胞形成的影响;应用细菌单... 详细信息

【目的】探究双组份系统YvcPQ影响芽胞形成的机制。【方法】利用β-半乳糖苷酶活性实验验证YvcP对芽胞形成抑制因子KapD的调控作用;通过无痕基因敲除并分别比较突变株与出发菌株的芽胞产率,研究YvcPQ及KapD对芽胞形成的影响;应用细菌单杂交实验、EMSA实验和实时荧光定量PCR技术探究转录调控因子AbrB对yvcPQ操纵子的转录调节。【结果】YvcP可以正调控kapD的表达,从而抑制芽胞形成;yvcPQ不能受YvcP的自调控,而是受AbrB转录激活。【结论】调控因子AbrB能够通过正调控yvcPQ操纵子的转录来提高细胞内YvcP的含量,进而增强YvcP对芽胞形成抑制因子编码基因kapD的表达,最终抑制芽胞的形成。

关键词：苏云金芽胞杆菌双组份系统 YvcPQ AbrB 芽胞形成

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Scalable synthesis of sub-lO0 nm hollow carbon nanospheres for energy storage applications

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Nano Research 2018年第4期11卷 1822-1833页

作者： Hongyu Zhao fan Zhang shumeng Zhang Shengnan He Fei Shen Xiaogang Han Yadong Yin Chuanbo Gao Center for Materials Chemistry Frontier Institute of Science and Technology Xi'an Jiaotong University Xi'an 710054 China Center of Nanomaterials for Renewable Energy Key Lab of Smart Grid of Shaanxi Province State Key Laboratory of Electrical Insulation and Power Equipment Xi'an Jiaotong University Xi'an 710054 China Department of Chemistry University of California Riverside CA 92521 USA

Sub-100 nm hollow carbon nanospheres with thin shells are highly desirable anode materials for energy storage applications. However, their synthesis remains a great challenge with conventional strategies. In this work, we demonstrate that hollow carbon nanospheres of unprecedentedly small sizes （down to - 32.5 nm and with thickness of - 3.9 nm） can be produced on a large scale by a templating process in a unique reverse micelle system. Reverse micelles enable a spatially confined Stober process that produces uniform silica nanospheres with significantly reduced sizes compared with those from a conventional Stober process, and a subsequent well-controlled sol-gel coating process with a resorcinol-formaldehyde resin on these silica nanospheres as a precursor of the hollow carbon nanospheres. Owing to the short diffusion length resulting from their hollow structure, as well as their small size and microporosity, these hollow carbon nanospheres show excellent capacity and cycling stability when used as anode materials for lithium/sodium-ion batteries.

关键词： hollow carbon nanospheres reverse micelles nanoreactors templating synthesis energy storage

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Boron-, Sulfur- and Nitrogen-Doped Tridecacyclic Aromatic Emitters with Multiple Resonance Effect for Narrowband Red Emission

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Chinese Journal of Chemistry 2022年第22期40卷 2671-2677页

作者： Yinuo Wang Kaiyuan Zhang fan Chen xingdong Wang Qingqing Yang shumeng Wang Shiyang Shao Lixiang Wang state Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunJilin130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefeiAnhui 230026China State Key Laboratory of Marine Resource Utilization in South China Sea School of Materials Science and EngineeringHainan UniversityHaikouHainan570228China

Two novel boron(B),sulfur(S),nitrogen(N)-doped polycyclic aromatic hydrocarbon multiple resonance emitters(DBNS and DBNS-tBu)are designed and synthesized for narrowband red emission by embedding two pairs of S and N atoms and two B atoms in para-positions of central benzene rings within a tridecacyclic aromatic skeleton to form donor-π-donor(D-π-D)and acceptor-π-acceptor(A-π-A)structures,which not only exhibit emission maximum at 641 nm with small full width at half maximum of 39 nm,but also combine high photoluminescent quantum efficiency(85%)and rapid reverse intersystem crossing(kRISC=2.2×10^(5) s^(−1)).

关键词： Multipleresonance Polycycles Donor-acceptor systems Sulfur Narrowband

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Customizable Ligand Exchange for Tailored Surface Property of Noble Metal Nanocrystals

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Research 2020年第1期2020卷 292-303页

作者： Qikui fan Hao Yang Juan Ge shumeng Zhang Zhaojun Liu Bo Lei Tao Cheng Youyong Li Yadong Yin Chuanbo Gao Frontier Institute of Science and Technology State Key Laboratory of Multiphase Flow in Power EngineeringXi’an Jiaotong UniversityXi’anShaanxi 710054China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesJoint International Research Laboratory of Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhouJiangsu 215123China Department of Chemistry University of CaliforniaRiversideCalifornia 92521USA

It is highly desirable,while still challenging,to obtain noble metal nanocrystals with custom capping ligands,because their colloidal synthesis relies on specific capping ligands for the shape control while conventional ligand exchange processes suffer from“the strong replaces the weak”limitation,which greatly hinders their ***,we report a general and effective ligand exchange approach that can replace the native capping ligands of noble metal nanocrystals with virtually any type of ligands,producing flexibly tailored surface *** key is to use diethylamine with conveniently switchable binding affinity to the metal surface as an intermediate *** a strong ligand,it in its original form can effectively remove the native ligands;while protonated,it loses its binding affinity and facilitates the adsorption of new ligands,especially weak ones,onto the metal *** this means,the irreversible order in the conventional ligand exchange processes could be *** efficacy of the strategy is demonstrated by mutual exchange of the capping ligands among cetyltrimethylammonium,citrate,polyvinylpyrrolidone,and *** novel strategy significantly expands our ability to manipulate the surface property of noble metal nanocrystals and extends their applicability to a wide range of fields,particularly biomedical applications.

关键词： properties replace mutual

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Melatonin enhances radiofrequency-induced NK antitumor immunity,causing cancer metabolism reprogramming and inhibition of multiple pulmonary tumor development

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3019-3032页

作者： Ming Li Bingjie Hao Menghuan Zhang Russel J.Reiter shumeng Lin Tiansheng Zheng Xiangyun Chen Yanbei Ren Liduo Yue Baigenzhin Abay Guojie Chen Xiao Xu Yufeng Shi Lihong fan Department of Respiratory Medicine Shanghai Tenth People's HospitalTongji University School of MedicineShanghaiChina Institute of Energy Metabolism and Health Shanghai Tenth People's HospitalTongji University School of MedicineShanghaiChina Tongji University Cancer Center Shanghai Tenth People's Hospital of Tongji UniversitySchool of MedicineTongji UniversityShanghaiChina Clinical Center For Brain And Spinal Cord Research Tongji UniversityShanghaiChina Department of Cell Systems and Anatomy University of Texas Health San AntonioSan AntonioTexasUSA National Scientific Medical Research Center AstanaKazakhstan State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghaiChina

Surgery is the comm on treatme nt for early lung cancer with multiple pulm onary no dules,but it is often accompanied by the problem of significant malignancy of other nodules in non-therapeutic *** this study,we found that a combined treatment of local rad iofreq ue ncy ablati on(RFA)and melatonin(MLT)greatly improved clinical outcomes for early lung cancer patie nts with multiple pulmonary nodules by minimizing lung function injury and reducing the probability of malignant transformation or enlargement of nodules in non-ablated ***,as demonstrated in an associated mouse lung tumor model,RFA not only effectively remove treated tumors but also stimulate antitumor immunity,which could inhibit tumor growth in non-ablated *** enhanced RFA-stimulated NK activity and exerted synergistic antitumor effects with *** and proteomics analyses of residual tumor tissues revealed enhanced oxidative phosphorylation and reduced acidification as well as hypoxia in the tumor microenvironment,which suggests reprogrammed tumor metabolism after combined treatment with RFA and *** of residual tumor further revealed the depressed activity of MAPK,NF-kappa B,Wnt,and Hedgehog pathways and upregulated P53 pathway in tumors,which was in line with the inhibited tumor *** RFA and MLT treatment also reversed the Warburg effect and decreased tumor *** findings thus demonstrated that combined treatment of RFA and MLT effectively inhibited the malignancy of non-ablated nodules and provided an innovative non-invasive strategy for treating early lung tumors with multiple pulmonary *** registration:***,identifier ChiCTR2100042695,http://***/***?proj=120931.

关键词： metabolism immunity inhibited

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考虑疲劳和恢复的混流装配线平衡问题

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系统工程学报 2020年第2期35卷 265-275页

作者：赵小松赵舒萌刘娜樊锐何桢天津大学管理与经济学部天津300072

针对混流装配线运行中人体负荷影响操作者的状态以及生产效率问题,建立了基于人因约束的多目标平衡模型.考虑了操作者的疲劳和恢复对装配任务分配的影响,以总循环时间最小化等为目标,采用遗传算法进行求解.结果表明,考虑人因约束条件,... 详细信息

针对混流装配线运行中人体负荷影响操作者的状态以及生产效率问题,建立了基于人因约束的多目标平衡模型.考虑了操作者的疲劳和恢复对装配任务分配的影响,以总循环时间最小化等为目标,采用遗传算法进行求解.结果表明,考虑人因约束条件,能够通过合理利用每个工作站的空闲时间来缓解操作者的疲劳,保证装配线平衡的同时可以有效降低人体负荷过度造成的人因风险.

关键词：混流装配线平衡人因约束疲劳恢复遗传算法

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熔结环氧粉末涂料研究进展和在管道防腐上的应用

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涂料工业 2023年第12期53卷 72-79页

作者：郭姝萌郭雷范利锁赵利张祥河北石油职业技术大学河北承德067000 海油发展珠海管道工程有限公司天津300000

介绍了熔结环氧(FBE)粉末涂料作为一种防腐材料的特点,包括其良好的耐腐蚀性、与金属的黏结性能以及环保特性。对近5年FBE粉末涂料领域的研究成果进行了总结和分析,梳理了相关的标准、组分、工艺和工程应用等方面的最新研究进展。指出... 详细信息

介绍了熔结环氧(FBE)粉末涂料作为一种防腐材料的特点,包括其良好的耐腐蚀性、与金属的黏结性能以及环保特性。对近5年FBE粉末涂料领域的研究成果进行了总结和分析,梳理了相关的标准、组分、工艺和工程应用等方面的最新研究进展。指出了提升FBE涂料在管道防腐涂料领域的研究和应用水平,有助于减少管道失效事故的发生,确保输送油气等资源的安全可靠。

关键词：熔结环氧粉末防腐蚀管道涂料粉末涂料

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空冷入口管NH_(3)-HCl-H_(2)S结晶特性预测及注水混合数值模拟

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石油学报（石油加工） 2022年第2期38卷 357-366页

作者：金浩哲赵宏利俞晨炀范志卿偶国富王超栗雪勇肖树萌浙江理工大学流动腐蚀研究所浙江杭州310018 中国石化茂名分公司广东茂名525011

加氢空冷器是炼油化工企业的关键设备之一。近年来中国进口原油以高硫高酸原油为主,原油种类超过150种,加工过程中还存在原油掺炼的情况,工况弹性大、风险突出,因此研究铵盐结晶规律以及注水工艺防护措施成为维护空冷器设备安全运行的... 详细信息

加氢空冷器是炼油化工企业的关键设备之一。近年来中国进口原油以高硫高酸原油为主,原油种类超过150种,加工过程中还存在原油掺炼的情况,工况弹性大、风险突出,因此研究铵盐结晶规律以及注水工艺防护措施成为维护空冷器设备安全运行的重要内容。以某石油化工厂加氢空冷系统入口集合管为对象,依据质量守恒,基于逆序倒推法,建立烃、水两相交互的多组分流体工艺仿真计算模型,形成了基于热力学的铵盐结晶温度预测方法;构建了含注水结构的入口集合管离散模型,使用欧拉双流体模型和Ranz-Marshall相间传热模型对管内多组分流体的流动特性进行数值模拟,获得了变工况条件下管道出口水流量、管道出口多相组分温度的分布规律。研究结果表明:氯离子质量分数大于1.5 mg/kg的管道内有NH_(4)Cl结晶,NH_(4)Cl结晶温度随着氯离子含量的上升而增加,注水质量流量30 t/h可以满足NH_(4)HS含量和液态水含量标准规定的限制。水相分率和流速的乘积是影响水流量分布的关键物理量,多点注水的水流量均匀性比单点注水具有一定优势,单点注水和多点注水所有出口截面的平均温度差别并不明显。在管道出口各相物料的温度均衡性对比中,多点注水由于各相物料换热时间短,因此管道出口各相物料温差相比于单点注水均匀性较差。

关键词：入口流动腐蚀铵盐结晶注水混合特性数值模拟

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