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Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia

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World Journal of Pediatrics 2019年第1期15卷 66-71页

作者： Pei-Zhong Bao Jun Ye Lian-Shu Han Wen-juan Qiu Hui-Wen Zhang Yong-guo Yu Jian-guo Wang Xue-fan Gu Department of Endocrinology and Genetics Shanghai Institute of PediatricsXinhua HospitalShanghai Jiaotong University School of Medicine1665 Kong Jiang RoadShanghai 200092China

Background This study aimed to explore the value of applying a new pterin marker (isoxanthopterin) to the traditional urine pterin analysis to reduce the rate of mis-diagnosis of 6-pyruvoyltetrahydropterin synthase deficiency (PTPSD) and improve the accuracy of *** We compared the urine neopterin (N),biopterin (B),isoxanthopterin (Iso),B% and Iso% levels between patients with phenylalanine hydroxylase deficiency and those with PTPSD,and found the most specific pterin biomarkers by ROC analysis.A positive cut-off value of urine pterins was *** effect of combined Iso% + B + B% in reducing PTPSD mis-diagnosis was evaluated,and the different urine pterin levels in PTPSD and false PTPSD (FPTPSD) were *** concordance of PTPSD diagnosis by the new pterin scheme and gene mutation analysis was *** (1) Urinary B,B%,Iso and Iso% were significantly lower in PTPSD than those in phenylalanine hydroxylase-deficiency group (P < 0.01);(2) Iso%,B%,and B were the most specific markers;(3) The positive cut-off values of B,B%,Iso% for PTPSD were < 0.17 mmoL/moLCr,< 5.0%,and < 9.5%,respectively;(4) urinary B +B% + Iso% scheme significantly reduced the false-positive rate of PTPSD compared to traditional *** Iso% levels in FPTPSD group were higher than the ones in PTPSD group;(5) an accuracy of diagnosis for PTPSD was increased by 9-19% when Iso% was introduced to urinary pterin *** Iso% is helpful to reduce the rate of misdiagnosis of PTPSD in the diagnosis by urinary pterin analysis for hyperphenylalaninemias and improve the accuracy of *** approach is worthy of further development and increased utilization.

关键词： 6-Pyruvoyltetrahydropterin synthase Hyperphenylalaninemia Isoxanthopterin Phenylalanine hydroxylase Pterin

Revised Virial Theorem for Hamiltonians with Coordinates-Momentum Coupling Terms

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Communications in Theoretical Physics 2008年第7期50卷 117-119页

作者： guo Qin fan Hong-Yi Department of Physics Jiangxi Normal University Nanchang 330022 China Department of Physics Shanghai Jiao Tong University Shanghai 200030 China Department of Material Science and Engineering University of Science and Technology of China Hefei 230026 China

Usually the Virial theorem,which can be derived from the Feynman-Hellmann theorem,applies to Hamil-tonians without coordinates-momentum *** this paper we discuss when there are such kind of couplings inHamiltonians then how the Virial theorem should be *** also discuss the energy contribution arising from thecoordinates-momentum coupling for a definite energy level.

关键词： revised Virial theorem Feynnlan Hellmann theorem coordinates-momentum coupling

Free Completely J^(e)-simple Semigroups

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Acta Mathematica Sinica,English Series 2015年第7期31卷 1086-1096页

作者： Jun Ying guo Xiao Jiang guo juan Ying DING Department of Mathematics Jiangxi Normal University

A semigroup is called completely J（e）-simple if it is isomorphic to some Rees matrix semi- group over a left cancellative monoid and each entry of whose sandwich matrix is in the group of units of the left cancellative monoid. It is proved that completely J（e）-simple semigroups form a quasivarity. Moreover, the construction of free completely J（e）simple semigroups is given. It is found that a free completely J（e）-simple semigroup is just a free completely J＊-simple semigroup and also a full subsemigroup of some completely simple semigroups.

关键词： Strongly rpp semigroup free semigroup completely J(e)-simple semigroup quasivariety

Compound 3k治疗骨关节炎:调控氧化应激通路改善软骨细胞糖酵解的作用机制

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中国组织工程研究 2025年第2期29卷 363-370页

作者：郭素蓉曹士盛穆星彤杨青张娟天津医科大学口腔医学院天津市300041 天津医科大学口腔医院口腔修复科天津市300041

背景:骨关节炎现已被认为是一种代谢性疾病,既往研究表明糖酵解在骨关节炎的发生发展中起重要作用。Compound 3k作为一种新型糖酵解小分子抑制剂,具有抗炎及抗肿瘤等功效,因此可靶向糖酵解,有望为骨关节炎治疗提供新的思路。目的:基于... 详细信息

背景:骨关节炎现已被认为是一种代谢性疾病,既往研究表明糖酵解在骨关节炎的发生发展中起重要作用。Compound 3k作为一种新型糖酵解小分子抑制剂,具有抗炎及抗肿瘤等功效,因此可靶向糖酵解,有望为骨关节炎治疗提供新的思路。目的:基于缺氧诱导因子1α/活性氧的氧化应激通路探究Compound 3k在糖酵解过度活跃所导致的骨关节炎中的作用机制。方法:取对数生长期的ATDC5成软骨细胞,用10 ng/mL白细胞介素1β作用24 h诱导骨关节炎体外细胞模型,以CCK-8法检测不同浓度(0.25,0.5,1,2.5,5,10,15μmol/L)Compound 3k的细胞毒性,选出合适浓度进行后续实验。将软骨细胞随机分为对照组、模型组、治疗组,模型组以10 ng/mL的白细胞介素1β诱导,治疗组以Compound 3k预刺激2 h后与白细胞介素1β共培养,用CCK-8法检测各组细胞增殖情况;用ELISA试剂盒检测各组细胞炎症水平;用试剂盒检测各组细胞活性氧、细胞外乳酸脱氢酶及葡萄糖含量;qRT-PCR及Western blot检测相关炎症因子白细胞介素6、肿瘤坏死因子α及糖酵解相关基因葡萄糖转运蛋白1、甘油醛3-磷酸脱氢酶、单羧酸转运蛋白1和缺氧诱导因子1α的表达水平。结果与结论:①与对照组相比,模型组细胞增殖活性下降、糖酵解水平活跃,表现为细胞外乳酸脱氢酶含量增加(P<0.001),葡萄糖含量减少(P<0.001),相关炎症因子白细胞介素6(P<0.0001)及肿瘤坏死因子α(P<0.001),糖酵解相关基因葡萄糖转运蛋白1(P<0.001)、甘油醛3-磷酸脱氢酶(P<0.001)、单羧酸转运蛋白1(P<0.001)及缺氧诱导因子1α(P<0.001)的表达水平均上调,并伴随氧化应激,活性氧过量产生。②与模型组相比,Compound 3k的治疗有效提高细胞增殖活性,抑制过度活跃的糖酵解水平的同时,抑制了骨关节炎软骨细胞炎症(P<0.001)及糖酵解相关基因的表达(P<0.001),且抑制氧化应激,缺氧诱导因子1α的表达水平下调(P<0.0001),活性氧水平下降。③上述结果证实,Compound 3k抑制了白细胞介素1β诱导的软骨细胞炎症,其机制可能与糖酵解及缺氧诱导因子1α/活性氧介导的氧化应激有关。

关键词：骨关节炎糖酵解 Compound 3k 氧化应激 HIF-1α/ROS ATDC5细胞葡萄糖代谢白细胞介素1β 小分子药物

Recent advances of Pd-π-allyl zwitterions in cycloaddition reactions

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Chinese Chemical Letters 2023年第11期34卷 3-19页

作者： juan Du Yun-fan Li Chang-Hua Ding Guangxi Key Laboratory of Natural Polymer Chemistry and Physics College of Chemistry and MaterialsNanning Normal UniversityNanning 530001China Department of Chemistry Shanghai Engineering Research Center of Organ RepairInnovative Drug Research CenterShanghai UniversityShanghai 200444China

Palladium-catalyzed cycloaddition reactions via Pd-π-allyl zwitterions have been established as significant synthetic transformations to enable numerous carbon-or heterocycles compounds that are key constituents of various biologically active natural products and *** addition to the well-known Pd-π-allyl zwitterions,including palladium-trimethylenemethane and Pd-1,3/1,4-zwitterions,chemists have recently discovered new applications of several long ago reported but less-studied Pd-π-allyl zwitterions,which can straightforwardly and efficiently construct novel cyclic ***,some impressive newly designed zwitterions have been also *** zwitterions are diverse and can serve as transient and highly reactive intermediates for the subsequent cyclization with various *** this review,we highlight recent advances in applications of these two types of zwitterions in the synthesis of complex polycyclics and medium-sized cyclic compounds.

关键词： Palladium Cycloaddition Pd-π-allyl zwitterions Asymmetric catalysis Heterocycles

Application of Automated Guided Vehicles in Smart Automated Warehouse Systems:A Survey

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Computer Modeling in Engineering & Sciences 2023年第3期134卷 1529-1563页

作者： Zheng Zhang juan Chen Qing guo Beijing University of Chemical Technology Beijing100029China

Automated Guided Vehicles(AGVs)have been introduced into various applications,such as automated warehouse systems,flexible manufacturing systems,and container terminal ***,few publications have outlined problems in need of attention in AGV applications *** this paper,several key issues and essential models are ***,the advantages and disadvantages of centralized and decentralized AGVs systems were compared;second,warehouse layout and operation optimization were introduced,including some omitted areas,such as AGVs fleet size and electrical energy management;third,AGVs scheduling algorithms in chessboardlike environments were analyzed;fourth,the classical route-planning algorithms for single AGV and multiple AGVs were presented,and some Artificial Intelligence(AI)-based decision-making algorithms were ***,a novel idea for accelerating route planning by combining Reinforcement Learning(RL)andDijkstra’s algorithm was presented,and a novel idea of the multi-AGV route-planning method of combining dynamic programming and Monte-Carlo tree search was proposed to reduce the energy cost of systems.

关键词： Automated guided vehicles(AGVs) smart automated warehouse systems AGVs scheduling AGVs route planning artificial intelligence(AI)

SEMI-ELLIPTIC SURFACE CRACK IN AN ELASTIC SOLID WITH FINITE SIZE UNDER IMPACT LOADING

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Acta Mechanica Solida Sinica 2006年第2期19卷 122-127页

作者： guo Ruiping Liu Guanting fan Tianyou Academy of Equipment Command and Technology Beijing 101416 China Department of Mathematics Inner Mongolia Normal University Huhhot 010022 China Department of Physics Beijing Institute of Technology Beijing 100081 China

In this paper a semi-elliptic surface crack problem in an elastic solid of finite size under impact loading is investigated. An analysis is performed by means of fracture dynamics and the finite element method, and a three-dimensional finite element program is developed to compute the dynamic stress intensity factor. The results reveal that the effects of the solid＇s boundary surface, crack surface, material inertia and stress wave interactions play significant roles in dynamic fracture.

关键词： surface crack solid of finite size impact loading dynamic stress intensity factor,finite element method

High spatial resolution spectroscopy of Tycho's SNR with Chandra

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Research in Astronomy and Astrophysics 2017年第2期17卷 35-42页

作者： Yun-Dong guo Xue-juan Yang School of Physics and Optoelectronics Xiangtan University Xiangtan 411105 China

t We present high spatial resolution X-ray spectroscopy of Tycho＇s supernova remnant （SNR） using observational data from Chandra. The whole remnant was divided into 26 × 27 regions, with each of them covering 20＂× 20＂. We selected 536 pixels with enough events to generate spectra and fit them with an absorbed two component non-equilibrium ionization model. We obtained maps of absorbing column density, weight-averaged temperature, ionization age and abundances for O, Ne, Mg, Si, S and Fe, with emission used to determine the weight. The abundance maps and the finding that Fe abundance is not correlated with any other element suggest that Fe is located at a smaller radius than other elements, supporting the onion shell model with emission from more massive elements peaking more toward the center. A tight correlation between Si and S abundances support both Si and S coming from explosive O-burning and/or incomplete Si-burning. O and Ne abundances show no correlation with any other element. Considering that O, Ne and Mg are all synthesized in the same process （C/Ne-burning）, we suggest that O/Ne/Mg might mix well with other elements during the explosion of the supernova and the expansion of the SNR.

关键词： ISM supernova remnants -- ISM individual (Tycho)

Optically actuating ultra-stable radicals in a large π-conjugated ligand constructed photochromic complex

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Science China Chemistry 2021年第3期64卷 432-438页

作者： Ji-Xiang Hu Xiao-fan Jiang Yu-juan Ma Xue-Ru Liu Bang-Di Ge A-Ni Wang Qi Wei guo-Ming Wang College of Chemistry and Chemical Engineering Qingdao UniversityQingdao 266071China Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education College of Chemistry and Materials ScienceNorthwest UniversityXi'an 710069China

Producing ultra-stabilized radicals via light irradiation has raised considerable concern but remains a tremendous challenge in functional materials. Herein, optically actuating ultra-stable radicals are discovered in a sterically encumbered and large π-conjugated tri(4-pyridyl)-1,3,5-triazine(TPT) ligands constructed photochromic compound Cu_(3)(H-HEDP)_(2)TPT_(2)·2H_(2)O(QDU-12;HEDP=hydroxyethylidene diphosphonate). The photogeneration of TPT· radicals is the photoactive behavior of electron transfer from HEDP motifs to TPT units. The ultra-long-lived radicals are contributed from strong interchain π-π interactions between the large π-conjugated TPT components, with the radical lifetime maintained for about 18 months under ambient conditions. Moreover, the antiferromagnetic couplings between TPT· radicals and Cu^(2+)ions plummeted the demagnetization to 35% of its original state after light irradiation, showing the largest room temperature photodemagnetization in the current radicalbased photochromic materials.

关键词： electron transfer gigantic photodemagnetization π-conjugated ligands photochromic ultra-stable radicals