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Involvement of endothelial progenitor cells in the formation of plexiform lesions in broiler chickens:possible role of local immune/inflammatory response

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第1期18卷 59-69页

作者： Xun TAN fan-guo juan Ali Q.SHAH Department of Veterinary Medicine College of Animal Sciences Zhejiang University Hangzhou 310058 China

Plexiform lesions （PLs）, which are often accompanied by perivascular infiltrates of mononuclear cells, represent the hallmark lesions of pulmonary arteries in humans suffering from severe pulmonary arterial hypertension （PAH）. Endothelial progenitor cells （EPCs） have been recently implicated in the formation of PLs in human patients. PLs rarely develop in rodent animal models of PAH but can develop spontaneously in broiler chickens. The aim of the present study was to confirm the presence of EPCs in the PLs in broilers. The immune mechanisms involved in EPC dysfunction were also evaluated. Lungs were collected from commercial broilers at 1 to 4 weeks of age. The right/total ventricle ratios indicated normal pulmonary arterial pressures for all sampled birds. Immunohistochemistry was per- formed to determine the expressions of EPC markers （CD133 and VEGFR-2） and preangiogenic molecule hepatocyte growth factor （HGF） in the lung samples. An EPC/lymphocyte co-culture system was used to investigate the functional changes of EPCs under the challenge of immune cells. PLs with different cellular composition were detected in the lungs of broilers regardless of age, and they were commonly surrounded by moderate to dense perivascular mono- nuclear cell infiltrates. Immunohistochemical analyses revealed the presence of CD133＊ and VEGFR-2＊ cells in PLs. These structures also exhibited a strong expression of HGF. Lymphocyte co-culture enhanced EPC apoptosis and completely blocked HGF-stimulated EPC survival and in vitro tube formation. Taken together, this work provides evidence for the involvement of EPCs in the development of PLs in broilers. It is suggested that the local immune cell infiltrate might serve as a contributor to EPC dysfunction by inducing EPC death and limiting their response to angi- ogenic stimuli. Broiler chickens may be valuable for investigating reversibility of plexogenic arteriopathy using gene- modified inflammation-resistant EPCs.

关键词： Plexiform lesions Endothelial progenitor cells Immune response Hepatocyte growth factor Broilerchicken

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一种基于改进的Snake模型的指纹分割算法

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计算机工程与应用 2008年第1期44卷 209-210,231页

作者：范国娟尹义龙山东大学计算机科学与技术学院济南250100

通过对Snake模型和指纹图像约束信息和目标形状等先验知识的分析,提出了一种基于改进的Snake模型的指纹分割算法。实验结果表明,基于改进的Snake模型的分割算法较传统的指纹分割有着更高的准确率,具有一定的应用价值。

关键词：指纹图像分割 Snake模型贪婪算法

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Bandgap characteristics analysis and graded design of a novel metamaterial for flexural wave suppression

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 1-24页

作者： fan YANG Zhaoyang MA Xingming guo Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering ScienceShanghai University Shanghai Institute of Aircraft Mechanics and Control

A novel elastic metamaterial is proposed with the aim of achieving lowfrequency broad bandgaps and bandgap regulation. The band structure of the proposed metamaterial is calculated based on the Floquet-Bloch theorem, and the boundary modes of each bandgap are analyzed to understand the effects of each component of the unit cell on the bandgap formation. It is found that the metamaterials with a low elastic modulus of ligaments can generate flexural wave bandgaps below 300 Hz. Multi-frequency vibrations can be suppressed through the selective manipulation of bandgaps. The dual-graded design of metamaterials that can significantly improve the bandgap width is proposed based on parametric studies. A new way that can regulate the bandgap is revealed by studying the graded elastic modulus in the substrate. The results demonstrate that the nonlinear gradient of the elastic modulus in the substrate offers better bandgap performance. Based on these analyses, the proposed elastic metamaterials can pave the way for multi-frequency vibration control, low-frequency bandgap broadening, and bandgap tuning.

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一种新的残留指纹图像分割方法

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中国图象图形学报 2007年第10期12卷 1893-1896页

作者：范国娟尹义龙山东大学计算机科学与技术学院济南250100

指纹图像分割主要是去除非脊线区域、不可恢复的脊线区域和残留脊线区域,提高特征提取的准确率和减少图像处理的时间。一般说来,残留脊线具有清晰的脊线结构,单单采用基于指纹图像的特征参数很难将其有效分割。本文提出了两级分割的方法... 详细信息

指纹图像分割主要是去除非脊线区域、不可恢复的脊线区域和残留脊线区域,提高特征提取的准确率和减少图像处理的时间。一般说来,残留脊线具有清晰的脊线结构,单单采用基于指纹图像的特征参数很难将其有效分割。本文提出了两级分割的方法,首先通过面积参数去除分离的残留脊线区域;然后在二级分割中利用形状参数将粘连的残留脊线区域分割掉。实验结果表明,基于本文方法的细节点检测的准确率更高。

关键词：指纹图像分割残留脊线线段编码链码

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A surface engineering strategy for the stabilization of zinc metal anodes with montmorillonite layers toward long-life rechargeable aqueous zinc ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 94-105页

作者： Wenbo Wang Ruifeng Xu Xu Zhang Peiyu Wang Bao Yang Bingjun Yang juan Yang Kailimai Su Pengjun Ma Yanan Deng Xianfeng fan Wanjun Chen Key Laboratory for Electronic Materials College of Electrical Engineering Northwest Minzu University Resource Chemistry and Energy Materials Research Center State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute for Materials and Processes School of Engineering University of Edinburgh

Rechargeable aqueous zinc-ion batteries （AZIBs） exhibit appreciable potential in the domain of electrochemical energy ***,there are serious challenges for AZIBs,for instance zinc dendrite growth,hydrogen evolution reaction （HER）,and corrosion side ***,we propose a surface engineering modification strategy for coating the montmorillonite （MMT） layer onto the surface of the Zn anode to tackle these issues,thereby achieving high cycling stability for rechargeable *** results reveal that the MMT layer on the surface of the Zn anode is able to provide ordered zincophilic channels for zinc ions migration,facilitating the reaction kinetics of zinc *** functional theory（DFT） calculations and water contact angle （CA） tests prove that MMT@Zn anode exhibits superior adsorption capacity for Zn2+and better hydrophobicity than the bare Zn anode,thereby achieving excellent cycling ***,the MMT@Zn||MMT@Zn symmetric cell holds the stable cycling over 5600 h at 0.5 mA cm-2and 0.125 m A h cm-2,even exceeding 1800 h long cycling under harsh conditions of 5 m A cm-2and 1.25 m A h *** MMT@Zn||V2O5full cell reaches over 3000 cycles at 2 A g-1with excellent rate ***,this surface engineering modification strategy for enhancing the electrochemical performance of AZIBs represents a promising application.

关键词： Surface engineering strategy Montmorillonite layer Protection mechanism of Zn anode Cycling stability Aqueous zinc ion batteries

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数字化手术导板在口腔即刻种植中的临床应用

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口腔医学研究 2017年第9期33卷 1007-1011页

作者：包凡刘娟郭慧刘颖婷云南省第一人民医院/昆明理工大学附属医院口腔医学中心云南昆明650032 昆明医科大学第二附属医院心血管内科云南昆明650101

目的：研究和评估数字化种植导板在口腔即刻种植中的应用效果。方法：选择2015年1月~2016年12月于云南省一院口腔中心就诊的患者22例,这些患者口腔内有1个或者数个牙根无法保留需行种植修复,在种植数字化导板引导下不翻瓣于拔除牙根同... 详细信息

目的：研究和评估数字化种植导板在口腔即刻种植中的应用效果。方法：选择2015年1月~2016年12月于云南省一院口腔中心就诊的患者22例,这些患者口腔内有1个或者数个牙根无法保留需行种植修复,在种植数字化导板引导下不翻瓣于拔除牙根同期植入植体,收集患者影像学资料并对比分析种植体实际植入位置和预设位置之间的偏差,进行系统性研究。分别测量术后即刻和术后半年永久性修复时的边缘骨水平,永久修复完成后第2天以及1年以后随访时软组织指数并进行统计学分析。结果：共39颗种植体纳入本研究,28例患者均无种植体脱落现象,植入种植体的角度偏差为（3.25±1.6）°,位置偏差（0.54±0.38） mm,深度偏差（0.51±0.38） mm;术后半年种植体颊侧垂直向骨吸收（1.3±0.6） mm,舌侧垂直向骨吸收为（0.3±0.2） mm,改良出血指数（mBI）为（0.91±0.45）,探诊深度（PD）为（2.05±0.3） mm;随访时39颗种植体的mBI为（1.18 ± 0.72）,PD为（2.10±0.2） mm。随访时mBI较术后半年时有所降低,且差异有统计学意义（P〈0.05）。结论：在即刻种植中应用数字化导板,可以固定种植钻针,引导种植体按照预设位置精确植入,保证种植修复的效果。在组织稳定性和美学效果的稳定性方面还需要长期的临床观察。

关键词：数字化导板即刻种植角度偏差位置偏差

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Clinical value of combining epirubicin with mindfulness intervention in patients with urinary system tumors and depression

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World Journal of Psychiatry 2025年第1期15卷 54-62页

作者： juan Liu Yan-Ping guo Yan-Mei Lu Bei-Lin Wang Department of Urology Surgery Zhumadian Central HospitalZhumadian 463000Henan ProvinceChina Department of Psychiatry Zhumadian Mental HospitalZhumadian 463000Henan ProvinceChina

BACKGROUND Urinary system tumors often cause negative psychological symptoms,such as depression and dysphoria which significantly impact immune function and indirectly affect cancer *** epirubicin(EPI)is recommended by the European Association of Urology and can improve prognosis,its long-term use can cause toxic side effects,reduce treatment compliance,and increase psycho-logical ***,an appropriate intervention mode is *** This was a retrospective study including 110 patients with urinary system tumors and depression admitted to Zhumadian Central Hospital between March 2021 and July *** were divided into conventional(n=55)and joint inter-vention(n=55)*** conventional group received mitomycin and routine nursing,while the joint intervention group received EPI and mindfulness *** groups underwent three cycles of *** function(CD4+cells,CD8+cells,CD4+/CD8+ratio),tumor marker levels[urinary bladder cancer antigen(UBC),bladder tumor antigen(BTA)and nuclear matrix protein 22(NMP22)],quality of life questionnaire-core 30(QLQ-C30),17-item Hamilton depression scale(HAMD-17),and cancer-related fatigue[cancer fatigue scale(CFS)]were *** reactions and nursing satisfaction were recorded and *** Post-intervention,CD4+,CD8+,and CD4+/CD8+levels increased in both groups,with the joint intervention group showing more significant improvement(P<0.05).Tumor marker levels(NMP22,BTA,and UBC)were lower in the joint intervention group compared to the conventional group(P<0.05).The joint intervention group also showed a greater reduction in HAMD-17 scores(9.38±3.12 vs 15.45±4.86,P<0.05),higher QLQ-C30 scores,and lower CFS scores(both P<0.05).Additionally,the joint intervention group had a lower incidence of adverse reactions and higher nursing satisfaction(P<0.05).CONCLUSION EPI combined with mindfulness intervention significantly improved clinical outcomes in patients with urinar

关键词： Urinary system tumor Bladder cancer Prostate cancer Depression Epirubicin

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结节性痒疹发病机制及治疗的部分研究进展

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中国麻风皮肤病杂志 2014年第2期30卷 91-92页

作者：范国娟张池金刘丽平天津中医药大学第一附属医院皮肤科 300073 山东省潍坊市妇幼保健院 261011

结节性痒疹(PN)是以四肢发生结节并伴严重瘙痒为主要特征的皮肤病。其发病机制尚不清楚,目前治疗多不能取得满意疗效。本文仅就近几年国外有关本病的研究进展进行了综述。

关键词：结节性痒疹病理机制

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Sequence-activated chemiluminescence probes: programmable illumination for high-contrast in vivo sensing and imaging

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Science China Chemistry 2025年第1期 26-34页

作者： Yutao Zhang juan Li Wei-Hong Zhu Zhiqian guo Shanghai Key Laboratory of Functional Materials Chemistry Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science & Technology

Sequence-activated chemiluminescence(CL) technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution. The fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under complex physiological conditions. This sequential activation could be triggered by enzymes, reactive oxygen species(ROS), biothiols or changes in the microenvironment. These unique sequence-activated CL probes bestow several advantages, including minimal background, deep-tissue penetration, and the ability of non-invasive or minimally invasive detection. The sequence-activated CL techniques represent a significant advancement in molecular imaging and diagnostics. In this mini-review, we focus on the latest developments in sequential CL probes, addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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