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J-family genes redundantly regulate flowering time and increase yield in soybean

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The Crop Journal 2024年第3期12卷 944-949页

作者： Haiyang Li Zheng chen fan Wang Hongli Xiang Shuangrong Liu Chuanjie Gou chao fang Liyu chen Tiantian Bu fanjiang kong Xiaohui Zhao Baohui Liu Xiaoya Lin Guangdong Key Laboratory of Plant Adaptation and Molecular Design/Guangzhou Key Laboratory of Crop Gene Editing/Innovative Center of Molecular Genetics and Evolution School of Life SciencesGuangzhou UniversityGuangzhou 510006GuangdongChina

Soybean(Glycine max)is a short-day crop whose flowering time is regulated by *** longjuvenile trait extends its vegetative phase and increases yield under short-day *** variation in J,the major locus controlling this trait,modulates flowering *** report that the three J-family genes influence soybean flowering time,with the triple mutant Guangzhou Mammoth-2 flowering late under short days by inhibiting transcription of E1-family genes.J-family genes offer promising allelic combinations for breeding.

关键词： Soybean Flowering time Yield J-family genes

A Low Cost, Green Sustainable and Biodegradable Biomass-based Fluorine-free Water and Oil Repellent

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Chinese Journal of Polymer Science 2024年第4期42卷 480-491页

作者： Zhi-Wei shen Shu-Feng Hu chen Zeng Wei-Qing kong Mei-fang Zhu State Key Laboratory for Modification of Chemical Fibers&Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China State Key Laboratory of Pulp and Paper Engineering School of Light Industry and EngineeringSouth China University of TechnologyGuangzhou510630China

With the global ban on plastics intensifying, the substitution of plastic with paper has garnered increasing attention. However, the inadequate water and oil repellency of pulp molding hinders its practical applications. Currently, the common method to enhance the oil and water repellency of pulp molding is by adding fluorinated water and oil repellents. Nevertheless, fluorinated compounds are environmentally and physiologically harmful. Therefore, the development of fluorine-free, water and oil repellent alternatives is crucial. In this study, chitosan and stearic acid were utilized as the first and second layers of the oil and water repellent coatings, respectively. The coated samples exhibited favorable water repellency, with a water contact angle of 116.4°, and excellent oil repellency, achieving a 12/12 rating on the kit scale. Importantly, the samples did not exhibit any leakage after being soaked in hot water and hot oil at 95±5℃ for 30 min, demonstrating remarkable performance as a barrier against hot water and oil. Moreover, the coated samples displayed outstanding mechanical properties, thermal stability, biodegradability, and recyclability. The approach presented in this study is simple, cost-effective, environmentally friendly, and represents a promising technique for producing fluoride-free, oil-and water-resistant pulp molding products.

关键词： Biomass Fluoride-free Oil-andwater-resistant Plasticfree

Relationships among Sedentary Time,Electronic Product Addiction,and Depression in Adolescents during the COVID-19 Epidemic:A Cross-Lagged Study

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International Journal of Mental Health Promotion 2024年第3期26卷 221-228页

作者： Feng sheng chen kong chao Li Teaching Department of Sports Qufu Normal UniversityQufu273165China Teaching Department of Sports Shandong Management UniversityJinan250100China General Education Center Weifang Vocational CollegeWeifang262737China

Objective:This study was conducted to explore the relationships among sedentary behavior(SB),electronic product addiction(EPA),and depression(D)in adolescents during the COVID-19 ***:A total of 604 adolescents(including 309 girls and 295 boys aged 12-18)were selected from Qufu City,Shandong Province,China for three rounds of *** model was constructed using AMOS 23.0 software,and cross-lagged analysis was ***:SB at T1 can significantly positively predict SB and EPA at T2(p<0.05).EPA at T1 can significantly positively predict SB and D at T2(p<0.05).Physical activity level and SB at T2 can significantly predict SB and EPA at T3(p<0.05).EPA at T2 can significantly predict SB,EPA,and D at T3(p<0.05).Conclusions:SB and EPA are predictive factors for ***,SB can significantly positively predict D and indirectly predict D through the mediating effect of EPA.

关键词： COVID-19 electronic product addiction depression sedentary behavior

Progress and Implications from Genetic Studies of Bipolar Disorder

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Neuroscience Bulletin 2024年第8期40卷 1160-1172页

作者： Lingzhuo kong Yiqing chen Yuting shen Danhua Zhang chen Wei Jianbo Lai Shaohua Hu Department of Psychiatry the First Affiliated HospitalZhejiang University School of MedicineHangzhou310003China The Key Laboratory of Mental Disorder Management in Zhejiang Province Hangzhou310003China Brain Research Institute of Zhejiang University Hangzhou310003China Zhejiang Engineering Center for Mathematical Mental Health Hangzhou310003China Department of Neurobiology NHC and CAMS Key Laboratory of Medical NeurobiologySchool of Brain Science and Brian Medicineand MOE Frontier Science Center for Brain Science and Brain-machine IntegrationZhejiang University School of MedicineHangzhou310003China

With the advancements in gene sequencing technologies,including genome-wide association studies,polygenetic risk scores,and high-throughput sequencing,there has been a tremendous advantage in mapping a detailed blueprint for the genetic model of bipolar disorder(BD).To date,intriguing genetic clues have been identified to explain the development of BD,as well as the genetic association that might be applied for the development of susceptibility prediction and pharmacogenetic *** genes of BD,such as CACNA1C,ANK3,TRANK1,and CLOCK,have been found to be involved in various pathophysiological processes correlated with *** the specific roles of these genes have yet to be determined,genetic research on BD will help improve the prevention,therapeutics,and prognosis in clinical *** latest preclinical and clinical studies,and reviews of the genetics of BD,are analyzed in this review,aiming to summarize the progress in this intriguing field and to provide perspectives for individualized,precise,and effective clinical practice.

关键词： Bipolar disorder Genetics Risk gene Genome-wide association study Sequencing technology

Anchoring heterometallic cluster on P-doped carbon nitride for efficient photocatalytic nitrogen fixation in water and air ambient

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Chinese Chemical Letters 2024年第4期35卷 176-180页

作者： chao-Long chen Rong chen La-sheng Long Lan-Sun Zheng Xiang-Jian kong Collaborative Innovation Center of Chemistry for Energy Materials State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China

Light-driven nitrogen fixation to produce ammonia is a green and economical technology of nitrogen reduction but is still quite challenging, especially in an air atmosphere without any sacrificial ***, we demonstrate efficient photocatalytic nitrogen fixation using water and air directly by loading lanthanide–transition metal(4f–3d) cluster NdCo_(3) on two-dimensional P-doped graphitic carbon nitrides(PCN) material surface. Benefiting from the increase in the number of nitrogen vacancies(NVs) and highly matched band gap structure and excellent hole trapping ability of clusters, the NdCo_(3)/PCN photocatalyst exhibits efficient nitrogen reduction activity with 371(in air) and 825 μmol h^(-1)g^(-1)(in pure nitrogen)without any sacrificial reagents. The introduction of potassium sulfate inhibits hydrogen production and promotes nitrogen reduction activation. This work suggests that anchoring precisely structured clusters on 2D materials may enhance photocatalytic nitrogen reduction under normal temperature and pressure.

关键词： Photocatalytic Nitrogen fixation 4f-3d Cluster Air atmosphere

Rapidly growing primordial black holes as seeds of the massive high-redshift JWST Galaxies

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Science China(Physics,Mechanics & Astronomy) 2024年第10期Mechanics & Astronomy) .卷 143-150页

作者： Guan-Wen Yuan Lei Lei Yuan-Zhu Wang Bo Wang Yi-Ying Wang chao chen Zhao-Qiang shen Yi-Fu Cai Yi-Zhong fan Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of Sciences School of Astronomy and Space Science University of Science and Technology of China Institute of High Energy Physics Chinese Academy of Sciences Deep Space Exploration Laboratory/Department of Astronomy School of Physical SciencesUniversity of Science and Technology of China Jockey Club Institute for Advanced Study The Hong Kong University of Science and Technology

A group of massive galaxies at redshifts of z■7 have been recently detected by the James Webb Space Telescope（JWST）, which were unexpected to form at such an early time within the standard Big Bang cosmology. In this work, we propose that this puzzle can be explained by the presence of some primordial black holes（PBHs） with a mass of ～1000M⊙. These PBHs act as seeds for early galaxy formation with masses of ～10～8-1010M⊙at high redshift, hence accounting for the JWST observations. We use a hierarchical Bayesian inference framework to constrain the PBH mass distribution models, and find that the Lognormal model with the Mc～750M⊙is preferred over other hypotheses. These rapidly growing BHs are expected to have strong radiation and may appear as high-redshift compact objects, similar to those recently discovered by JWST. Although we focused on PBHs in this work, the bound on the initial mass of the seed black holes remains robust even if they were formed through astrophysical channels.

关键词： primordial black hole dark matter halo black hole accretion primordial galaxies

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Improving surface integrity of micro-holes in ECDM using ultrahigh-speed rotary of tool cathode and non-water-based electrolyte

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Chinese Journal of Aeronautics 2024年第5期37卷 506-519页

作者： Jiwen shen Weijing kong Zhengyang XU Yongbin ZENG Jiangsu Key Laboratory of Precision and Micro-Manufacturing Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China

The surface integrity of metal micro-hole structures produced by electrochemical discharge machining is unsatisfactory owing to the insufficient reaction area and strength of electrolysis action.A novel ultrahigh-speed Rotary Electrochemical Discharge Machining(R-ECDM)using non-water-based electrolyte is proposed to improve surface integrity by changing the breakdown medium of spark discharge and increasing the reaction area and strength of electrolysis.A mathematical model was developed to establish the relationship between rotational speed and forces acting on the *** on the magnitude of forces,controlling rotational speed changed the behavior and departure radius of bubbles on the cathode ***-speed photographs validate that,in the mathematical model,the number and departure radius of bubbles on the cathode surface gradually decrease with the increase of rotational *** experimental results show that the roughness(Ra)of the micro-hole sidewall decreases from 2.54μm to 0.20μm when the rotational speed increases from 500 r/min to 40000 r/*** length loss and wear ratio of the cathode are only 9.75μm and 6.5%,***,the micro-holes array with recast-free and surface roughness of 0.20μm is fabricated,demonstrating that the proposed approach contributes to improving surface integrity of metal micro-holes.

关键词： Electrochemical discharge machining Micro-holes Recast layer Ultrahigh-speed rotary Bubbles Force analysis Non-water-based solution

Constitutive modelling of concrete material subjected to low-velocity projectile impact:insights into damage mechanism and target resistance

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第2期25卷 161-182页

作者： shen LIU Xieping HUANG Xiangzhen kong Qin fanG Center for Hypergravity Experiment and Interdisciplinary Research Zhejiang UniversityHangzhou310058China Institute of Geotechnical Engineering Zhejiang UniversityHangzhou310058China State Key Laboratory of Disaster Prevention&Mitigation of Explosion&Impact Army Engineering University of PLANanjing210007China

This paper presents a numerical study to improve the understanding of the complex subject of penetration and perforation of concrete targets impacted by low-velocity *** main focus is on the damage mechanisms and the major factors that account for the target resistance of the *** improved continuous surface cap model recently proposed was *** model was first equipped with element erosion criteria and was adequately validated by comparisons with ballistic *** numerical simulations were carried out where the individual influence of tensile,shear,and volumetric behaviors(pore collapse)of a concrete target on its ballistic performance was *** demonstrated that cratering on the front face and scabbing on the rear face of the concrete target were mainly dominated by its tensile *** major target resistance came from the second tunneling stage which was primarily governed by the shear and volumetric behaviors of the ***,this study captured the pore collapse-induced damage phenomenon during the high-pressure tunneling stage,which has been extensively reported in experiments but has usually been neglected in previous numerical investigations.

关键词： Penetration Perforation Damage mechanism Target resistance Projectile impact Pore collapse

Immune checkpoint inhibitors:breakthroughs in cancer treatment

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Cancer Biology & Medicine 2024年第6期21卷 451-472页

作者： Xueqing kong Jinyi Zhang Shuwei chen Xianyang Wang Qing Xi Han shen Rongxin Zhang Laboratory of Immunology and Inflammation School of Life Sciences and BiopharmaceuticsGuangdong Pharmaceutical UniversityGuangzhou 510006China Department of Biology School of Life Sciences and BiopharmaceuticsGuangdong Pharmaceutical UniversityGuangzhou 510006China

Over the past two decades,immunotherapies have increasingly been considered as first-line treatments for most *** such treatment is immune checkpoint blockade(ICB),which has demonstrated promising results against various solid tumors in clinical *** antibodies(mAbs)are currently available as immune checkpoint inhibitors(ICIs).These ICIs target specific immune checkpoints,including cytotoxic T-lymphocyte-associated antigen-4(CTLA-4)and programmed cell death protein 1(PD-1).Clinical trial results strongly support the feasibility of this immunotherapeutic ***,a substantial proportion of patients with cancer develop resistance or tolerance to treatment,owing to tumor immune evasion mechanisms that counteract the host immune ***,substantial research focus has been aimed at identifying additional ICIs or synergistic inhibitory receptors to enhance the effectiveness of anti-PD-1,anti-programmed cell death ligand 1(anti-PD-L1),and anti-CTLA-4 ***,several immune checkpoint molecular targets have been identified,such as T cell immunoreceptor with Ig and ITIM domains(TIGIT),mucin domain containing-3(TIM-3),lymphocyte activation gene-3(LAG-3),V-domain immunoglobulin suppressor of T cell activation(VISTA),B and T lymphocyte attenuator(BTLA),and signal-regulatory proteinα(SIRPα).Functional m Abs targeting these molecules are under ***-4,PD-1/PD-L1,and other recently discovered immune checkpoint proteins with distinct structures are at the forefront of *** review discusses these structures,as well as clinical progress in m Abs targeting these immune checkpoint molecules and their potential applications.

关键词： Immunotherapy cancer ICIs PD-1 CTLA-4