检索结果-南通市图书馆

SOLUTION PROPERTIES OF ANTITUMOR CARboXYMETHYLATED DERIVATIVES OF α-(1→3)-D-GLUCAN FROM GANODERMA LUCIDUM

Chinese Journal of Polymer Science 2001年第3期19卷 283-289页

作者： Li-na Zhang Mei Zhang Jing-hua Chen fan-bo zeng department of chemistry wuhan university, wuhan 430072, china pharmacy college, tongji medical university, wuhan 430072, china wuhan Univ Dept Chem Wuhan 430072 Peoples R China tongji Med Univ Coll Pharm Wuhan 430072 Peoples R China

Fractions of a water insoluble α-(1→3)-D-glucan (GL) extracted from Ganoderma lucidum were carboxy-methylated (CM) to obtain water-soluble carboxymethylated derivatives (CM-GL) having a degree of substitution (DS) of0.38～0.51. Weight-average molecular weight M_w and intrinsic viscosity [η] of the samples CM-GL were measured by gelpermeation chromatography combined with laser light scattering (GPC-LLS) and viscometry. The CM-GL exhibits a stifferchain in aqueous solution at 25℃ than the original glucan, The antitumor activities against Ehrlich ascites carcinoma (EAC,5×10~6) of the carboxymethylated derivatives from the α-glucan and curdlan, a β-glucan, are significantly higher than thoseof the original glucans. The effects of the relatively low molecular weight, expanded chains and better water-solubility of theCM-GL on the enhancement of antitumor activity could not be neglected. The chain stiffness decreased speedily withincrease of temperature from 40 to 60℃ or NaOH concentration from 0.1 to 0.4 in the solution, respectively, and the changeof the chain stiffness is reversible.

关键词： Solution properties Antitumor activity Carboxymethylated derivative α-D-glucan Ganoderma lucidum

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Kinsenoside:A Promising Bioactive Compound from Anoectochilus Species

引用

Journal of Huazhong university of Science and Technology(medical Sciences) 2018年第1期38卷 11-18页

作者： Chang-xing QI Qun ZHOU Yuan ZHOU zeng-wei LUO Chong DAI Hu-cheng ZHU Chun-mei CHEN Yong-bo XUE Jian-ping WANG Ya-fen WANG Ya-ping LIU Ming XIANG Wei-guang SUN Jin-wen ZHANG Yong-hui ZHANG Hubei Key Laboratory of Natural Medicinal chemistry and Resource Evaluation Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China department of pharmacy Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030 China

Kinsenoside is a main active component isolated from plants of the genus Anoectochilus,and exhibits many biological activities and pharmacological effects,including hepatoprotective,anti-hyperglycemic,anti-hyperliposis,anti-inflammatory,vascular protective and anti-osteoporosis effects and so on,which is contributing to its promising potency in disease *** review aims to recapitulate the pharmacological functions of kinsenoside,as well as its source,extraction,identification,quantitative analysis,pharmacokinetics,synthesis and patent *** data reported in this work can confirm the therapeutic potential of kinsenoside and provide useful information for further new drug development.

关键词： Anoectochilus roxburghii kinsenoside bioactivity synthesis review

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：