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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu Zhang yanyu Zhang yan zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei Mei yan zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

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Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： Lei Xue Tong Shi Chenhui Han Heng Zhang Fenrong Liu Haorun Li yan Wang Xiaojun Gu Shanghong zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Oxygen vacancy Hydrocarbon production Reaction mechanism

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桥梁空心墩身施工组织管理

山西建筑 2011年第18期37卷 175-176页

作者：范验曾中铁十二局集团第二工程有限公司

以京沪高速铁路淮凤立交特大桥工程为例,介绍了桥梁空心墩身施工组织管理工作,着重阐述了桥梁空心墩身施工质量控制要点,包括接缝处理、测量放样、模板制作安装、墩身混凝土施工等方面内容,以指导今后同类项目。

关键词：空心墩施工组织管理质量控制大体积混凝土

2014—2016年深圳市空气污染时空分布特征

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卫生研究 2018年第2期47卷 270-276页

作者：牟敬锋赵星樊静洁严宙宁严燕曾丹罗文亮范志伟深圳市南山区疾病预防控制中心深圳518054 四川大学华西公共卫生学院深圳市妇幼保健院

目的分析深圳市空气质量指数(AQI)的时间变化和空间分布特征,为空气污染治理提供科学依据。方法收集覆盖深圳市10个行政区的19个空气质量监测点2014—2016年AQI和首要污染物的日报监测数据,汇总得到监测点小时均值、日均值、季度均值和... 详细信息

目的分析深圳市空气质量指数(AQI)的时间变化和空间分布特征,为空气污染治理提供科学依据。方法收集覆盖深圳市10个行政区的19个空气质量监测点2014—2016年AQI和首要污染物的日报监测数据,汇总得到监测点小时均值、日均值、季度均值和年均值,采用空间自相关分析研究AQI空间自相关性的强弱与集聚模式。结果研究期间深圳市AQI中位数为50.0,空气质量级别为二级。2014年深圳空气首要污染物以PM_(2.5)为主,2015年和2016年空气首要污染物以O_3为主;从时间分布看,深圳空气质量呈现"冬劣夏优"的特点,但夜间空气污染程度与白天无差异;空间自相关分析表明,研究期间AQI存在正空间自相关性,AQI全局moran's I指数为0.167(Z=2.000,P<0.05),greary系数为0.801(Z=1.711,P<0.05),光明新区AQI局部moran's I指数为1.027(P<0.05)。光明新区AQI moran散点图处于第一象限,属于高值-高值分布特点,而盐田区moran散点图处于第三象限,属于低值-低值分布特点。结论深圳市空气质量总体状况较好,PM_(2.5)和O_3是深圳主要的空气污染物,冬季应重视与加强防控空气污染,尤其在深圳的西北部几个行政区。

关键词：空气质量指数空气污染时空分析空间自相关

Potassium ions and cyano group modified g-C3N4 for effective generation of H2O2 through two-electron oxygen reduction

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Science China Chemistry 2025年第1期 192-200页

作者： Dongying Wang Shulan Pu Yongmin Chen Ke Lei Yujie Duan Linjiao Mao Xuhui zeng Xi Luo Yuntao Zhang Yuqin Dong Jin Zhong Zhang yan Sun School of Mechanical Engineering Chengdu University Department of Chemistry and Biochemistry University of California

Potassium ions （K+） doped graphitic carbon nitride （g-C3N4） was prepared by a thermal etching method using potassium hydroxide （KOH） as an ion *** transform infrared spectroscopy （FTIR） and X-ray photoelectron spectroscopy （XPS）results showed that the generation of the cyano group was detected while introducing K+.Under simulated sunlight irradiation,the sample with a K+doping amount of 10%showed the highest hydrogen peroxide （H2O2） generation rate of2,140.2μmol *** apparent quantum yield （AQY） at 400 nm and the solar-to-chemical conversion （SCC） are 4.35%and1.23%,respectively.K+acted as a bridge between g-C3N4layers,which enhanced charge transfer ***,the cyano group enhanced the adsorption capacity of protons （H+） and promoted the yield of *** catalyst exhibited excellent photocatalytic stability based on four-cycle *** addition,a mechanism study showed that superoxide radicals （·O2-）were the most important active species in the reaction *** production of H2O2was achieved through consecutive single-electron *** study deepens the understanding of the oxygen reduction reaction process and opens up a new venue for improving H2O2generation.

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Topological Stability and Pseudo-orbit Tracing Property for Homeomorphisms on Uniform Spaces

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Acta Mathematica Sinica,English Series 2022年第2期38卷 431-442页

作者： Ke Song yan fan Ping zeng School of Information and Statistics Guangxi University of Finance and EconomicsNanning 530003P.R.China

In this paper,we investigate the topological stability and pseudo-orbit tracing property for homeomorphisms on uniform *** introduce the concept of topological stability for homeomorphisms on compact uniform spaces and prove that if a homeomorphism on a compact uniform space is expansive and has pseudo-orbit tracing property,then it is topologically ***,we discuss the topological stability for homeomorphisms on uniform spaces from the view of *** introduce definitions of topologically stable point and shadowable point for homeomorphisms on uniform spaces and show that every shadowable point of an expansive homeomorphism on a compact uniform space is topologically stable.

关键词： Topological stability pseudo-orbit tracing property expansiveness uniform space

Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China Life Sciences 2025年第1期 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng yan Kun Jiang Bingbing Song He Li Maomao Cao Dianqin Sun fan yang Xinxin yan Shaoli Zhang Yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital Center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan Center for Disease Control and Prevention Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrend<0.001). Four predictors, including male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

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应用方位反向技术提取反射镜零重力面形

中国光学 2016年第5期9卷 606-612页

作者：杨利伟李志来薛栋林董得义樊延超曾雪锋中国科学院长春光学精密机械与物理研究所吉林长春130033

为了预估碳化硅反射镜在空间零重力环境下的面形精度,本文开展了在地面环境下利用方位反向技术提取碳化硅反射镜零重力面形的研究。首先,介绍了方位反向技术提取零重力面形的理论依据;其次,利用有限元分析软件,分析了方位反向对反射镜... 详细信息

为了预估碳化硅反射镜在空间零重力环境下的面形精度,本文开展了在地面环境下利用方位反向技术提取碳化硅反射镜零重力面形的研究。首先,介绍了方位反向技术提取零重力面形的理论依据;其次,利用有限元分析软件,分析了方位反向对反射镜面形的影响;然后,按照试验流程,先后检测了反射镜在0°和180°状态的面形精度,计算两次检测数据的平均值,得到了反射镜零重力面形。结果表明:反射镜地面零重力面形误差RMS值为12.3 nm,能够满足设计指标要求。最后,对数据可信度进行了分析,确认了试验数据真实可信。该结果预示了反射镜在空间零重力环境下的面形精度,对反射镜光学加工与装调有重要的指导意义。

关键词：方位反向碳化硅反射镜零重力面形光学检测