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Bioinspired metal-organic framework nanozyme reinforced with thermosensitive hydrogel for regulating inflammatory responses in Parkinson’s disease

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Nano Research 2024年第2期17卷 858-865页

作者： Xiaowan fan Tao zhang Xin Ding Yushuo Gu qing Li Wei Jiang Kelong fan Nanozyme Medical Center Academy of Medical ScienceZhengzhou UniversityZhengzhou 450001China Department Central-China Branch of National Center for Cardiovascular DiseasesHean Cardiovascular Disease CenterFuwai Central-China HospitalCentral China Fuwai Hospital of Zhengzhou UniversityZhengzhou 450046China Application Center for Precision Medicine the Second Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalsInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 101408China Department of General Surgery Strategic Support Force Medical CenterBeijing 100101China Department of Anesthesiology Pain and Perioperative MedicineThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Parkinson’s disease(PD)is a prevalent neurodegenerative disorder accompanied by movement disorders and neuroinflammatory ***-inflammatory intervention to regulate oxidative stress in the brain is beneficial for managing ***,traditional natural antioxidants have failed to meet the clinical treatment demands due to insufficient activity and ***,Cu-doping zeolite imidazolate framework-8(ZIF-8)nanozyme is designed to simulate Cu/Zn superoxide dismutase(SOD)by biomimetic *** nanozyme composite is then integrated into thermosensitive hydrogel(poly(lactic-co-glycolic acid)-poly(ethylene glycol)-poly(lactic-co-glycolic acid)(PLGA-PEG-PLGA))to form an effective antioxidant system(Cu-ZIF@Hydrogel).The thermosensitive hydrogel incorporating nanozymes demonstrate distinct viscoelastic properties aimed at enhancing local nanozyme adhesion,prolonging nanozyme retention time,and modulating antioxidant activity,thus significantly improving the bioavailability of *** the cellular and animal levels of PD,we find that Cu-ZIF@Hydrogel bypass the blood-brain barrier and efficiently accumulate in the nerve ***,the Cu-ZIF@Hydrogel significantly alleviate the PD’s behavioral and pathological symptoms by reducing the neuroinflammatory levels in the lesion ***,the hydrogel-incorporating nanozyme system holds great potential as a simple and reliable avenue for managing PD.

关键词： bioinspired nanozyme thermosensitive hydrogel Parkinson’s disease oxidative stress neuroinflammatory

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Brønsted-acid sites induced photocatalytic cracking of low-polarity polyethylene plastics

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Journal of Energy Chemistry 2024年第9期96卷 509-515页

作者： Qianyou Wen Quan zhang Zhengzheng Liu Huining Wang Shuya Hao fan zhang Lijuan zhang qing Han Gengfeng Zheng Laboratory of Advanced Materials Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200438China

Polyolefins such as polyethylene(PE)are one of the largest-scale synthetic plastics and play a key role in modern ***,polyethylene is extremely inert to chemical recycling owing to its lack of chemical functionality and low polarity,making it one of the most challenging environmental hazards ***,we developed a phosphorylated CeO_(2)catalyst by an organophosphate precursor and featured efficient photocatalysis of low-density polyethylene(LDPE)without the acid or alkaline *** to pristine CeO_(2),the surface phosphorylation allows to introduce Brønsted acid sites,which facilitate to form carbonium ions on LDPE via *** addition,the suitable band structure of the phosphorylated CeO_(2)catalyst enables efficient photoabsorption and generates reactive oxygen species,leading to the C–C bond cleavage of *** a result,the phosphorylated CeO_(2)catalyst exhibited an outstanding carbon conversion rate of>94%after 48 h of photocatalysis under 50 mW/cm^(2)of simulated sunlight,with a high CO_(2)product selectivity of>99%.Furthermore,the PE microparticles with sizes larger than 10μm released from LDPE plastic wrap were directly and completely degraded by photocatalysis within 12 h,suggesting an attractive and environmentally benign strategy of utilizing solar energy-based photocatalysis for reducing potential hazards of LDPE plastic trashes.

关键词： Photocatalytic cracking Polyethylene Surface phosphorylation Bronsted-acid site Carbon conversion

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Effects of Diesel Concentration on the Thermal Conductivity,Specific Heat Capacity and Thermal Diffusivity of Diesel-Contaminated Soil

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Journal of Thermal Science 2024年第2期33卷 696-709页

作者： WU Yuhao WU Yuefei LUO Gubai zhang Teng WANG qing fan Liwu SONG Xin YU Zitao Key Laboratory of Clean Energy and Carbon Neutrality of Zhejiang Province Zhejiang UniversityHangzhou310027China State Key Laboratory of Clean Energy Utilization Zhejiang UniversityHangzhou310027China Institute of Thermal Science and Power Systems School of Energy EngineeringZhejiang UniversityHangzhou310027China Center Environmental Protection Technology Company Limited Beijing100176China Institute of Soil Science Chinese Academy of SciencesNanjing210008China

High energy consumption is a serious issue associated with in situ thermal desorption(TD)remediation of sites contaminated by petroleum hydrocarbons(PHs).The knowledge on the thermophysical properties of contaminated soil can help predict accurately the transient temperature distribution in a remediation site,for the purpose of energy ***,such data are rarely reported for PH-contaminated *** this study,by taking diesel as a representative example for PHs,soil samples with constant dry bulk density but different diesel mass concentrations ranging from 0% to 20% were prepared,and the variations of their thermal conductivity,specific heat capacity and thermal diffusivity were measured and analyzed over a wide temperature range between 0℃ and 120℃.It was found that the effect of diesel concentration on the thermal conductivity of soil is negligible when it is below 1%.When diesel concentration is below 10%,the thermal conductivity of soil increases with raising the ***,when diesel concentration becomes above 10%,the change of the thermal conductivity of soil with temperature exhibits the opposite *** is mainly due to the competition between soil minerals and diesel,because the thermal conductivity of minerals increases with temperature,whereas the thermal conductivity of diesel decreases with *** analysis results showed that,compared with temperature,the diesel concentration has more significant effects on soil thermal *** of the diesel concentration,with the increase of temperature,the specific heat capacity of soil increases,while the thermal diffusivity of soil *** addition,the results of a control experiment exhibited that the relative differences of the thermal conductivity of the soil samples containing the same concentration of both diesel and a pure alkane are all below 10%,indicating that the results obtained with diesel in this study can be extended to the family of PHs.A theo

关键词： contaminated soil diesel concentration thermal conductivity specific heat capacity thermal diffusivity thermal desorption fractal model

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Effect of Y,Al Co‑Doping on Hydrogen Storage Properties of La–Mg–Ni‑Based Alloys

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Acta Metallurgica Sinica(English Letters) 2024年第8期37卷 1399-1410页

作者： Guanjiu Wu Yichao Xie Yuan Li qing Wang Chenfeng fan Wenfeng Wang Lu zhang Shumin Han Hebei Key Laboratory of Applied Chemistry Yanshan UniversityQinhuangdao 066004China State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004China

La–Mg–Ni-based hydrogen storage alloys have excellent hydrogen storage *** work reports the hydrogen storage performance of a series of A_(2)B_(7)-type La_(0.96)Mg_(0.04)N_(i3.34)Al_(0.13)alloy and La_(0.96-x)Y_(x)Mg_(0.04)Ni_(3.47–0.6x)Al_(0.6x)(x=0,0.22,0.33,0.44)alloys,and explores the effect of Y and Al element combined substitution on the microstructure and hydrogen storage performance of A_(2)B_(7)-type La–Mg–Ni-based *** alloys are composed of Ce_(2)Ni_(7)phase and LaNi_(5)*** the increase of x,the cell volume of Ce_(2)Ni_(7)phase decreases,while that of LaNi_(5)phase increases,indicating that Y atom mainly enters Ce_(2)Ni_(7)phase and Al atom mainly enters LaNi_(5)*** appropriate amount of co-substitution increases the hydrogen storage capacity and reduces the hydrogen absorption/desorption plateau pressure hysteresis of the *** x=0.44,the hydrogen storage capacity of the alloy is 1.449 wt%,and the hysteresis coefficient is *** cell volume of Ce_(2)Ni_(7)phase and LaNi_(5)phase expands to different degrees after 20 absorption/desorption *** the increase of x,the volume expansion rate decreases,and the cycle capacity retention rate also gradually *** is related to the amorphization of Ce_(2)Ni_(7)*** x=0.22,the capacity retention rate of the alloy is 91.4%.

关键词： La-Mg-Ni-based alloys Gas-phase hydrogen storage performance Ce_(2)Ni_(7)phase LaNi_(5)phase Capacity retention rate

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Learning topological defects formation with neural networks in a quantum phase transition

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Communications in Theoretical Physics 2024年第5期76卷 68-76页

作者： Han-qing Shi Hai-qing zhang Center for Gravitational Physics Department of Space ScienceBeihang UniversityBeijing 100191China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China

Neural networks possess formidable representational power,rendering them invaluable in solving complex quantum many-body *** they excel at analyzing static solutions,nonequilibrium processes,including critical dynamics during a quantum phase transition,pose a greater challenge for neural *** address this,we utilize neural networks and machine learning algorithms to investigate time evolutions,universal statistics,and correlations of topological defects in a one-dimensional transverse-field quantum Ising ***,our analysis involves computing the energy of the system during a quantum phase transition following a linear quench of the transverse magnetic field *** excitation energies satisfy a power-law relation to the quench rate,indicating a proportional relationship between the excitation energy and the kink ***,we establish a universal power-law relationship between the first three cumulants of the kink numbers and the quench rate,indicating a binomial distribution of the ***,the normalized kink-kink correlations are also investigated and it is found that the numerical values are consistent with the analytic formula.

关键词： neural networks machine learning transverse-field quantum Ising model kibble-zurek mechanism

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Seismic response of pile-supported structures considering the coupling of inertial and kinematic interactions in different soil sites

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Frontiers of Structural and Civil Engineering 2024年第9期18卷 1350-1361页

作者： Huiling ZHAO fan zhang Department of Civil Engineering Shanghai UniversityShanghai 200444China

Dynamic soil−pile−superstructure interaction is crucial for understanding pile behavior in earthquake-prone *** the safety of piles requires determining the seismic bending moment caused by combined inertial and kinematic interactions,which is *** paper addresses this problem through numerical simulations of piles in different soil sites,considering soil *** reveal that the period of the soil site significantly affects the interaction among soil,piles,and *** moments in soft and hard soil sites exceed those in medium soil sites by more than *** modes of piles exhibit distinct characteristics between hard and soft soil *** soil sites exhibit a singular inflection point,while hard soil sites show two inflection *** soft soil sites,pile-soil kinematic interaction gradually increases bending moment from tip to head,with minor influence from superstructure’s inertial *** hard soil sites,significant inertial effects from soil,even surpassing pile-soil kinematic effects near the tip,lead to reversed superposition bending ***’s inertial interaction notably impacts pile head in hard soil sites.A simplified coupling method is proposed using correlation coefficient to represent inertial and kinematic *** findings provide insights into complex seismic interactions among soil,piles,and structures.

关键词： pile seismic response soft soil inertial interaction kinematic interaction

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Ultraviolet‑Irradiated All‑Organic Nanocomposites with Polymer Dots for High‑Temperature Capacitive Energy Storage

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Nano-Micro Letters 2024年第3期16卷 398-406页

作者： Jiale Ding Yao Zhou Wenhan Xu fan Yang Danying Zhao Yunhe zhang Zhenhua Jiang qing Wang College of Chemistry Jilin UniversityChangchun 130012People’s Republic of China Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USAs Deutsches Elektronen-Synchrotron DESY Notkestr.8522607 HamburgGermany

Polymer dielectrics capable of operating efficiently at high electric fields and elevated temperatures are urgently demanded by next-generation electronics and electrical power *** inorganic fillers have been extensively utilized to improved high-temperature capacitive performance of dielectric polymers,the presence of thermodynamically incompatible organic and inorganic components may lead to concern about the long-term stability and also complicate film ***,zero-dimensional polymer dots with high electron affinity are introduced into photoactive allyl-containing poly(aryl ether sulfone)to form the all-organic polymer composites for hightemperature capacitive energy *** ultraviolet irradiation,the crosslinked polymer composites with polymer dots are efficient in suppressing electrical conduction at high electric fields and elevated temperatures,which significantly reduces the high-field energy loss of the composites at 200℃.Accordingly,the ultraviolet-irradiated composite film exhibits a discharged energy density of 4.2 J cm^(−3)at 200℃.Along with outstanding cyclic stability of capacitive performance at 200℃,this work provides a promising class of dielectric materials for robust high-performance all-organic dielectric nanocomposites.

关键词： High-temperature energy storage Polymer dots Ultraviolet irradiation All-organic composite dielectrics

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Pachymic acid exerts antitumor activities by modulating the Wnt/β-catenin signaling pathway via targeting PTP1B

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Asian Pacific Journal of Tropical Biomedicine 2024年第4期14卷 170-180页

作者： Hao zhang Kun Zhu Xue-Feng zhang Yi-Hui Ding Bing Zhu Wen Meng qing-Song Ding fan zhang Department of Emergency Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006ZhejiangChina Department of Cardiothoracic Surgery The Third Affiliated Hospital of Qiqihar Medical CollegeQiqihar 161000HeilongjiangChina Department of Cardiothoracic Surgery The Affiliated Heilongjiang Provincial Hospital of Harbin Institute of TechnologyHarbin 150036HeilongjiangChina

Objective:To determine the inhibitory effects of pachymic acid on lung adenocarcinoma(LUAD)cells and elucidate its underlying ***:CCK-8,wound healing,Transwell,Western blot,tube formation,and immunofluorescence assays were carried out to measure the effects of various concentrations of pachymic acid on LUAD cell proliferation,metastasis,angiogenesis as well as ***,molecular docking technology was used to detect the potential targeted binding association between pachymic acid and protein tyrosine phosphatase 1B(PTP1B).Moreover,PTP1B was overexpressed in A549 cells to detect the specific mechanisms of pachymic ***:Pachymic acid suppressed LUAD cell viability,metastasis as well as angiogenesis while inducing cell *** also targeted PTP1B and lowered PTP1B ***,PTP1B overexpression reversed the effects of pachymic acid on metastasis,angiogenesis,and autophagy as well as the expression of Wnt3a andβ-catenin in LUAD ***:Pachymic acid inhibits metastasis and angiogenesis,and promotes autophagy in LUAD cells by modulating the Wnt/β-catenin signaling pathway via targeting PTP1B.

关键词： Pachymic acid Lung adenocarcinoma Protein tyrosine phosphatase 1B Wnt/β-catenin signaling pathway Metastasis Angiogenesis Autophagy

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Neuromorphic circuits based on memristors: endowing robots with a human-like brain

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Journal of Semiconductors 2024年第6期45卷 47-63页

作者： Xuemei Wang fan Yang qing Liu Zien zhang Zhixing Wen Jiangang Chen Qirui zhang Cheng Wang Ge Wang Fucai Liu School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 610054China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313099China

Robots are widely used,providing significant convenience in daily life and *** the rapid development of artificial intelligence and neuromorphic computing in recent years,the realization of more intelligent robots through a pro-found intersection of neuroscience and robotics has received much *** circuits based on memristors used to construct hardware neural networks have proved to be a promising solution of shattering traditional control limita-tions in the field of robot control,showcasing characteristics that enhance robot intelligence,speed,and energy ***-ing with introducing the working mechanism of memristors and peripheral circuit design,this review gives a comprehensive analysis on the biomimetic information processing and biomimetic driving operations achieved through the utilization of neuro-morphic circuits in brain-like *** hardware neural network approaches,including digital-analog hybrid circuit design,novel device structure design,multi-regulation mechanism,and crossbar array,are summarized,which can well simulate the motor decision-making mechanism,multi-information integration and parallel control of brain at the hardware *** will be definitely conductive to promote the application of memristor-based neuromorphic circuits in areas such as intelligent robotics,artificial intelligence,and neural ***,a conclusion and future prospects are discussed.

关键词： neuromorphic devices neuromorphic circuits hardware networks memristors humanlike robots

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Soliton resolution and asymptotic stability of N-solutions for the defocusing Kundu–Eckhaus equation with nonzero boundary conditions

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Communications in Theoretical Physics 2024年第1期76卷 1-6页

作者： Engui fan Yanxi zhang School of Mathematical Sciences and Key Laboratory of Mathematics for Nonlinear Science Fudan UniversityShanghai200433China Tianjin Xinhua High School No.99 machang RoadTianjin300204China

In this paper,we address interesting soliton resolution,asymptotic stability of N-soliton solutions and the Painleve asymptotics for the Kundu-Eckhaus(KE)equation with nonzero boundary conditions iq_(t)+q_(xx)-2(l|q|^(2)-1)q+4β^(2)(lql^(4)-1)q+4iβ(lql^(2))_(x)q=0,q(x,0)=q_(0)(x)-±1,x→±∞.The key to proving these results is to establish the formulation of a Riemann-Hilbert(RH)problem associated with the above Cauchy problem and find its connection with the RH problem of the defocusing NLS *** the■-steepest descent method and the results of the defocusing NLS equation,we find complete leading order approximation formulas for the defocusing KE equation on the whole(x,t)half-plane including soliton resolution and asymptotic stability of N-soliton solutions in a solitonic region,Zakharov-Shabat asymptotics in a solitonless region and the Painlevéasymptotics in two transition regions.

关键词： defocusing Kundu-Eckhaus equation Riemann-Hilbert problems steepest descent method soliton resolution asymptotic stability Painleve transcendents

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