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Application of autologous tumor cell vaccine and NDV vaccine in treatment of tumors of digestive traet

World Journal of Gastroenterology 2003年第3期9卷 495-498页

作者： WeiLiang HuiWang Tie-MieSun Wen-QingYao Li-LiChen YuJin Chun-LingLi fan-juanmeng LiaoningProvincalTumorResearchInstitute Shenyang110042LiaoningProvinceChina DepartmentofColoproctologySurgeryofLiaoningTumorHospital Shenyang110042LiaoningProvinceChina

AIM. TO treat patients with stage I-IV malignant tumors of digestive tract using autologous tumor cell vaccine and NDV(Newcastle disease virus) vaccine, and observe the survival period and curative ***: 335 patients with malignant tumors of digestive tract were treated with autologous tumor cell vaccine and NDV vaccine. The autologous tumor cell vaccine received were assigned for long-term survival observation. While these failed to obtain the autologous tumor tissue were given with NDV vaccine for a received short-term observation on curative ***: The colorectal cancer patients treated with autologous tumor cell vaccine were divided into two groups:the controlled group (subjected to resection alone) (n=257),the vaccine group (subjected to both resection and immunotherapy) (n=310). 25 patients treated with NDV immunotherapy were all at stage IV without having *** postoperation adjuvant therapy patients, the 5, 6 and 7-year survival rates were 66.51%, 60.52 %, 56.50 %respectively; whereas in patients with resection alone, only 45.57 %, 44.76 % and 43.42 % respectively. The average survival period was 5.13 years (resection alone group 4.15 years), the median survival period was over 7 years (resection alone group 4.46 years). There were significant differences between the two groups. The patients treated with resection plus vaccine were measured delayed-type hypersensitivity (DTH) reactions after vaccination, (indurative scope >5 mm).The magnitude of DTH was related to the prognosis. The 5-year survival rate was 80 % for those with indurations greater than 5 mm, compared with 30 % for those with indurations less than 5 ram. The 1-year survival rate was 96 % for 25 patients treated with NDV immunotherapy. The total effective rate (CR+PR) was 24.00 % in NDV immunotherapy; complete remission (CR) in 1 case (4.00 %), partial remission (PR) in 5 cases (20.00 %), stabilizedin in 16 cases (64.00 %),progression (PD) in 1 case (4.00 %). After NDV

关键词：消化道肿瘤同源性肿瘤细胞疫苗 NDV疫苗免疫疗法生存率

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