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Danshen-Chuanxiongqin Injection attenuates cerebral ischemic stroke by inhibiting neuroinflammation via the TLR2/ TLR4-MyD88-NF-κB Pathway in tMCAO mice

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Chinese Journal of Natural Medicines 2021年第10期19卷 772-783页

作者： XU xiao-Jing LONG Jin-Bo JIN Kai-Yu CHEN Li-Bing LU xiao-Yan fan xiao-hui Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China State Key Laboratory of Component-Based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Danshen-Chuanxiongqin Injection(DCI)is a commonly used traditional Chinese medicine for the treatment of cerebral ischemic stroke in ***,its underlying mechanisms remain completely *** current study was designed to explore the protective mechanisms of DCI against cerebral ischemic stroke through integrating whole-transcriptome sequencing coupled with network pharmacology ***,using a mouse model of cerebral ischemic stroke by transient middle cerebral artery occlusion(tMCAO),we found that DCI(4.10 mL·kg−1)significantly alleviated cerebral ischemic infarction,neurological deficits,and the pathological injury of hippocampal and cortical neurons in ***,the whole-transcriptome sequencing was performed on brain *** cerebral ischemia disease(CID)network was constructed by integrating transcriptome sequencing data and cerebrovascular disease-related *** results showed CID network was imbalanced due to tMCAO,but a recovery regulation was observed after DCI *** analysis of the key genes with recovery efficiency showed that the neuroinflammation signaling pathway was highly enriched,while the TLR2/TLR4-MyD88-NF-κB pathway was predicted to be ***,the in vivo validation experiments confirmed that DCI exhibited protective effects against cerebral ischemic stroke by inhibiting neuroinflammation via the TLR2/TLR4-MyD88-NF-κB *** interestingly,DCI markedly suppressed the neutrophils infiltrated into the brain parenchyma via the choroid plexus route and showed anti-neuroinflammation *** conclusion,our results provide dependable evidence that inhibiting neuroinflammation via the TLR2/TLR4-MyD88-NF-κB pathway is the main mechanism of DCI against cerebral ischemic stroke in mice.

关键词： Danshen-Chuanxiongqin Injection Cerebral ischemic stroke Network pharmacology Neuroinflammation Neutrophil Choroid plexus

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Simultaneous Determination of Two Types of Active Components with Different Physicochemical Properties in Kushen by HPLC-UV

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Chemical Research in Chinese Universities 2011年第3期27卷 375-379页

作者： ZHANG Yu-feng ZHAO Qin-qin SHAO Qin fan xiao-hui Department of Chinese Medicine Science&Engineering Zhejiang UniversityHangzhou 310058P.R.China

A simple, reliable and accurate high performance liquid chromatography(HPLC) coupled with a UV detector at varied wavelength was developed for the quantitation of two types of anti-carcinogenic compounds, namely, Kushen alkaloids(KS-As) and Kushen flavonoids(KS-Fs), in Kushen. Their remarkable difference in physicochemical properties was circumvented by integrated optimization of column and mobile phase. The separation was achieved on an alkaline-resisting C18 column via gradient elution with acetonitrile(ACN) and 0.025%(volume ratio) diethylamine(DEA) in water as mobile phase. The flow rate was 0.7 mL/min, and the column temperature was maintained at 35 °C. UV detection wavelength was set at 225 nm to monitor KS-As, and then changed to 335 nm for KS-Fs at 26th min, which was kept for 30 min before returning to the original wavelength. All the calibration curves show good linearity(r20.999) within test ranges. The intra- and inter-day precision values of these components were less than 3.82%, and the average recovery rates obtained were in a range of 97.24%―102.64% for all the samples with RSD below 3.94%. This assay was successfully applied to determining the major active components in commercial herbal samples of Kushen. Moreover, the possible relationship between sample and the geographical region was visualized based on the contents of the 6 compounds in the light of principal component analysis(PCA). The results suggest that the proposed method facilitates the quality control of Kushen.

关键词： Column liquid chromatography Sophora flavescen Kushen alkaloid Kushen flavonoid

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Research and Application of Expert System Skeleton for Controlling Sintering Process

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Journal of Iron and Steel Research International 2008年第5期15卷 6-8页

作者： LONG Hong-ming fan xiao-hui JIANG Tao DAI Lin-qing School of Metallurgy and Resource Anhui University of Technology Ma＇anshan 243002 Anhui China School of Resources Processing and Bioengineering Central South University Changsha 410083 Hunan China

An expert system skeleton tool of sintering process was constructed using object-oriented method, which can actualize two functions, i. e. , the shell function and the program function. The skeleton tool offered a platform to build a prototype system, to program class code, and to develop the expert system. Four branch expert systems were developed using the skeleton tool including the control of chemical composition, the control of sintering process state, the control of expended energy, and the diagnosis of abnormity. It is found that the performance of all systems is satisfactory in practice.

关键词： sintering process expert system skeleton tool knowledge base illation engine

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Temperature Field Simulation Model for Rotary Kiln of Iron Ore Oxidized Pellet

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Journal of Iron and Steel Research International 2013年第4期20卷 16-19页

作者： fan xiao-hui LI Jun CHEN Xu-ling WANG Yi GAN Min School of Minerals Processing and Bioengineering Central South University

Based on conduction,convection and radiation heat transfer among the flue gas,kiln wall,and the pellet bed material,and on the basis of the coal combustion and analysis of reaction heat of pellet induration in the rotary kiln,the temperature field model of rotary kiln was *** visual studio net,matlab and open source computer vision library as development tools,combining with the ActiveX data objects database technology,the temperature field simulation system for rotary kiln of iron ore oxidized pellet production was *** distribution of pellet and flue gas in rotary kiln was dynamically displayed.

关键词： iron ore oxidized pellet rotary kiln temperature distribution mathematical model

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Ammonia Volatilization and Nitrogen Utilization Efficiency in Response to Urea Application in Rice Fields of the Taihu Lake Region,China

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Pedosphere 2007年第5期17卷 639-645页

作者： LIN De-Xi fan xiao-hui HU Feng ZHAO Hong-Tao LUO Jia-Fa Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 （China） Department of Soil and Water Science Tropical Research and Education Center Institute of Food and Agricultural Sciences University of Florida Homestead FL33031 （USA） College of Resource and Environmental Sciences Nanjing Agricultural University Nanjing 210095 （China） College of Resource and Environmental Sciences Fujian Agriculture ＆ Forestry University Fuzhou 350007 （China） Land and Environmental Management Group AgResearch Ruakura Research Centre Private Bag 3123 Hamilton （New Zealand）

Ammonia volatilization losses, nitrogen utilization efficiency, and rice yields in response to urea application to a rice field were investigated in Wangzhuang Town, Changshu City, Jiangsu Province, China. The N fertilizer treatments, applied in triplicate, were 0 （control）, 100, 200, 300, or 350 kg N ha^-1. After urea was applied to the surface water, a continuous airflow enclosure method was used to measure ammonia volatilization in the paddy field. Total N losses through ammonia volatilization generally increased with the N application rate, and the two higher N application rates （300 and 350 kg N ha^-1） showed a higher ratio of N lost through ammonia volatilization to applied N. Total ammonia loss by ammonia volatilization during the entire rice growth stage ranged from 9.0% to 16.7% of the applied N. Increasing the application rate generally decreased the ratio of N in the seed to N in the plant. For all N treatments, the nitrogen fertilizer utilization efficiency ranged from 30.9% to 45.9%. Surplus N with the highest N rate resulted in lodging of rice plants, a decreased rate of nitrogen fertilizer utilization, and reduced rice yields. Calculated from this experiment, the most economical N fertilizer application rate was 227 kg ha^-1 for the type of paddy soil in the Taihu Lake region. However, recommending an appropriate N fertilizer application rate such that the plant growth is enhanced and ammonia loss is reduced could improve the N utilization efficiency of rice.

关键词： ammonia volatilization N application rate N utilization efficiency paddy soil rice yield

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Ammonia volatilization losses and ^(15)N balance from urea applied to rice on a paddy soil

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Journal of Environmental Sciences 2006年第2期18卷 299-303页

作者： fan xiao-hui SONG Yong-sheng LIN De-xi YANG Lin-zhang LUO Jia-fa Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 China Land and Environmental Management Group AgRsearch Ruakura Research Centre East Street Private Bag 3123 Hamilton New Zealand

Ammonia volatilization loss and ^15N balance were studied in a rice field at three different stages after urea application in Taihu Lake area with a micrometeorological technique. Factors such as climate and the NH4^＋-N concentration in the field floodwater affecting ammonia loss were also investigated. Results show that the ammonia loss by volatilization accounted for 18.6%-38.7% of urea applied at different stages, the greatest loss took place when urea was applied at the tillering stage, the smallest at the ear bearing stage, and the intermediate loss at the basal stage. The greatest loss took place within 7 d following the fertilizer application. Ammonia volatilization losses at three fertilization stages were significantly correlated with the ammonium concentration in the field floodwater after the fertilizer was applied. ^15N balance experiment indicated that the use efficiency of urea by rice plants ranged between 24.4% and 28.1%. At the early stage of rice growth, the fertilizer nitrogen use efficiency was rather low, only about 12%. The total amount of nitrogen lost from different fertilization stages in the rice field was 44.1%-54.4%, and the ammonia volatilization loss was 25.4%-33.3%. Reducing ammonia loss is an important treatment for improving N use efficiency.

关键词： ammonia volatilization urea ^15N balance rice influence factors, Taihu region

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Systematic chemical characterization of Xiexin decoctions using high performance liquid chromatography coupled with electrospray ionization mass spectrometry

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Chinese Journal of Natural Medicines 2021年第6期19卷 464-472页

作者： SHEN Li-Juan LUO Ke-Di WEN Xue-Xun WANG Shu-fang fan xiao-hui Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China State Key Laboratory of Component Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 300193China

Xiexin decoctions(XXDs)display beneficial anti-inflammatory and anti-diabetic effects,which raises interests on this group of formulae for broad clinical ***,there was no report about systematic analysis of XXDs to elucidate the constitution of chemical components,which hampers further investigations on the therapeutic values of *** this work,crude herbs were extracted and prepared to obtain the XXDs for systemic analysis on their chemical compositions,according to the information described in the ancient Zhang Zhongjing’s herbal ***-MS analysis of five XXDs was carried out to facilitate recognition of the source herbs for compounds in the mixture.A total number of 93 compounds were identified through our methods and their chemical classes encompassed five major groups,including protoberberine alkaloids,flavonoids,stilbenes,anthraquinones and *** current work provided important information about material basis for pharmacological studies on XXDs and would help shed light on relationships between chemical compositions and therapeutic effects.

关键词： Traditional Chinese Medicine Analogous formulae HPLC-MS Xiexin decoctions Systematic chemical characterization

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Influence of O_2 Content in Circulating Flue Gas on Iron Ore Sintering

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Journal of Iron and Steel Research International 2013年第6期20卷 1-6页

作者： fan xiao-hui YU Zhi-yuan GAN Min LI Wen-qi JI Zhi-yun School of Minerals Processing and Bioengineering Central South University

Circulating flue gas can reduce the emission of flue gas , and furthermore , it can reuse the waste heat effectively in the sintering *** with conventional sintering , O2 that gets through the sintering bed decreases because of substituting circulating gas for *** influences of O2 content on sintering process are studied through simulating the flue gas circulation sintering with artificial *** shows that , with the reducing of O2 content in circulating gas , the combustion speed of fuel decreases and incomplete combustion degree increases , which makes the flame front fall behind the heat front and reduces the heat utilization efficiency of *** ultimate result is that the temperature of sintering bed decreases and the liquid phase *** addition , the reducing atmosphere is strengthened because of flue gas circulation , which makes the magnetite increase yet calcium ferrite reduce gradually. Because the content of calcium ferrite with good strength reduces , the sinter yield and tumble strength *** ensure the sinter index , the favorable O2 content of circulating flue gas is no less than 15%.

关键词： flue gas circulation sintering heat front flame front sintering metallogenium

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An extended chain Ising model and its Glauber dynamics

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Chinese Physics B 2012年第2期21卷 504-508页

作者： Zhao Xing-Yu Huang Xin-Ru fan xiao-hui Huang Yi-Neng Physical College and Xinjiang Laboratory of Phase Transitions and Microstructures in Condensed Matters Yili Normal UniversityYining 835000China Physical College and National Laboratory of Solid State Microstructures Nanjing UniversityNanjing 210093China Department of Physics Shihezi UniversityShihezi 832003China

It was first proposed that an extended chain Ising （ECI） model contains the Ising chain model, single spin doublewell potentials and a pure phonon heat bath of a specific energy exchange with the spins. The extension method is easy to apply to high dimensional cases. Then the single spin-flip probability （rate） of the ECI model is deduced based on the Boltzmann principle and general statistical principles of independent events and the model is simplified to an extended chain Glauber-Ising （ECGI） model. Moreover, the relaxation dynamics of the ECGI model were simulated by the Monte Carlo method and a comparison with the predictions of the special chain Clauber-Ising （SCGI） model was presented. It was found that the results of the two models are consistent with each other when the Ising chain length is large enough and temperature is relative low, which is the most valuable case of the model applications. These show that the ECI model will provide a firm physical base for the widely used single spin-flip rate proposed by Glauber and a possible route to obtain the single spin-flip rate of other form and even the multi-spin-flip rate.

关键词： Ising model Glauber dynamics single spin-flip probability

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Potential hepatic and renal toxicity induced by the biflavonoids from Ginkgo biloba

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Chinese Journal of Natural Medicines 2019年第9期17卷 672-681页

作者： LI Yun-Ying LU xiao-Yan SUN Jia-Li WANG Qing-Qing ZHANG Yao-Dan ZHANG Jian-Bing fan xiao-hui Tianjin University of Traditional Chinese Medicine Tianjin 301617China Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Zhejiang University-Wanbangde Pharmaceutical Group Joint Research Center for Chinese Medicine Modernization Hangzhou 310058China

Evidence continues to grow on potential health risks associated with Ginkgo biloba and its *** biflavonoid is a subclass of the flavonoid family in Ginkgo biloba with a plenty of pharmacological properties,the potential toxicological effects of biflavonoids remains largely ***,the aim of this study was to investigate the in vitro and in vivo toxicological effects of the biflavonoids from Ginkgo biloba(i.e.,amentoflavone,sciadopitysin,ginkgetin,isoginkgetin,and bilobetin).In the in vitro cytotoxicity test,the five biflavonoids all reduced cell viability in a dose-dependent manner in human renal tubular epithelial cells(HK-2)and human normal hepatocytes(L-02),indicating they might have potential liver and kidney *** the in vivo experiments,after intragastrical administration of these biflavonoids at 20 mg·kg^–1·d^–1 for 7 days,serum biochemical analysis and histopathological examinations were *** activity of alkaline phosphatase was significantly increased after all the bifl avonoid administrations and widespread hydropic degeneration of hepatocytes was observed in ginkgetin or b ilobetin-treated ***,the five biflavonoids all induced acute kidney injury in treated mice and the main pathological lesions were confirmed to the tubule,glomeruli,and interstitium *** the in vitro and in vivo results suggested that these biflavonoids may be more toxic to the kidney than the liver,we further detected the mechanism of biflavonoids-induced *** increased TUNEL-positive cells were detected in kidney tissues of biflavonoids-treated mice,accompanied by elevated expression of proapoptotic protein BAX and unchanged levels of antiapoptotic protein BCL-2,indicating apoptosis was involved in biflavonoids-induced *** together,our results suggested that the five biflavonoids from Ginkgo biloba may have potential hepatic and renal toxicity and more attentions should be paid to ensure Ginkgo biloba p

关键词： Biflavonoids Ginkgo biloba Potential toxicity Liver Kidney Apoptosis

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