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Immunological and metabolic characteristics of the Omicron variants infection

Signal Transduction and Targeted Therapy 2023年第2期8卷 784-794页

作者： Jiejie Geng Xu yang Kun Wang ke Wang Ruo Chen Zhi-Nan Chen Chuan qin Guizhen Wu Youchun Wang ke Xu Peng Du Jiangning Liu Shirui Chen Tao Zhang Xiuxuan Sun Ting Guo Ying Shi Zheng Zhang Ding Wei Peng Lin qingyi Wang Jing Yuan Jiuxin Qu Jin Zou Yingxia Liu Hongzhou Lu Ping zhu Huijie Bian Liang Chen Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital Fourth Military Medical UniversityXi’an 710032China key Laboratory of Human Disease Comparative Medicine Chinese Ministry of HealthKey Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100871China MHC key Laboratory of Biosafety National Institute for Viral Disease Control and Preven-tionChinese Center for Disease Control and PreventionBeijing 100871China Division of HIV/AIDS and Sex-transmitted Virus Vaccines Institute for Biological Product ControlNational Institutes for Food and Drug Control(NIFDC)and WHO Collaborating Center for Standardization and Evaluation of BiologicalsBeijing 102629China Beijing Institute of Biotechnology Beijing 100871China School of Basic Medicine Fourth Military Medical UniversityXi’an 710032China The Third People’s Hospital of Shenzhen Shenzhen 518112China School of Medicine Shanghai UniversityShanghai 200444China

The Omicron variants of SARS-CoV-2,primarily authenticated in November 2021 in South Africa,has initiated the 5th wave of global ***,we systemically examined immunological and metabolic characteristics of Omicron variants *** found Omicron resisted to neutralizing antibody targeting receptor binding domain(RBD)of wildtype *** could hardly be neutralized by sera of Corona Virus Disease 2019(COVID-19)convalescents infected with the Delta *** mass spectrometry on MHC-bound peptidomes,we found that the spike protein of the Omicron variants could generate additional CD8+T cell epitopes,compared with *** epitopes could induce robust CD8+T cell ***,we found booster vaccination increased the cross-memory CD8+T cell responses against *** regulome analysis of Omicron-specific T cell showed a metabolic profile that promoted the response of memory T ***,a greater fraction of memory CD8+T cells existed in Omicron stimulated peripheral blood mononuclear cells(PBMCs).In addition,CD147 was also a receptor for the Omicron variants,and CD147 antibody inhibited infection of ***147-mediated Omicron infection in a human CD147 transgenic mouse model induced exudative alveolar *** together,our data suggested that vaccination booster and receptor blocking antibody are two effective strategies against Omicron.

关键词： infection inhibited neutral

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Functional analysis of type Ⅵ secretion system in Pectobacterium carotovorum ***

Functional analysis of type Ⅵ secretion system in Pectobact...

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中国植物病理学会2015年学术年会

作者： yang Liu-ke WANG Jia-ju WANG Huang WANG Chun-ting fan Jia-qin College of Plant Protection Nanjing Agricultural University

The type Ⅵ secretion system（T6SS） was recently described and characterized in several animal pathogens,such as Vibrio cholerae and Pseudomonas aeruginosa,but fewer in plant *** this work,we focused on the functions of T6 SS genes in Pectobacterium carotovorum ***（Pec）,a phytopathogen causing soft rot disease in many important crops,especially on pathogenicity related of *** sequencing and alignment analysis of nucleic acid sequence of PccS1 indicated that its T6 SS was composed by a T6 SS cluster consisting of 17 genes and some homologous genes outside this cluster,including 8 hcp genes and 4 vgrG *** constructed 17 gene deletion mutants of each gene in T6 SS cluster by homologous recombination,and the results of pathogenicity assay showed that AimpG was the only one mutant of virulence significantly attenuated,while the other 16 genes had no difference of pathogenicity on the hosts comparing with that of the wild *** was observed that the activities of the extracellular enzymes and the gene transcription of celC,pell and prtW were all significantly repressed inΔ***,carbapenem secreted by ΔimpG was almost lost,and the expression of carC was severely *** is important in the synthesis of carbapenem by which the pathogen competes with environmental organisms,one of the T6 SS functions in *** growth rates in different media and colonization in the host were identical between AimpG and the wild ***,the results showed that AimpG could not induce hypersensitive response in tobacco and the expression of hrpN,hrpA,hrpI,hrpQ and hrcN were all significandy down-regulated when impG was ***,the protein expression demonstrated that impG is also crucial to Hep exo-secretion as many other genes in the *** mutants of the orthologous genes of T6 SS outside the cluster in PccSl were also constructed,and the 12 mutants showed no difference in pathogenicity comparing with the wild

关键词： Pectobacterium carotovorum subsp.carotovorum T6SS impG Hcp

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三峡库区云阳县农村留守中学生心理弹性影响因素结构方程模型分析

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上海交通大学学报（医学版） 2014年第5期34卷 731-735,740页

作者：郭雪刘琴张帆黄轲汪洋重庆医科大学公共卫生与管理学院重庆400016

目的建立结构方程模型,探讨三峡库区云阳县农村留守中学生的心理弹性影响因素。方法采用青少年发展与心理弹性量表(RYDM)和自编的社会人口学问卷对三峡库区云阳县的1 049名留守中学生进行调查,并利用结构方程模型进行统计分析。结果最... 详细信息

目的建立结构方程模型,探讨三峡库区云阳县农村留守中学生的心理弹性影响因素。方法采用青少年发展与心理弹性量表(RYDM)和自编的社会人口学问卷对三峡库区云阳县的1 049名留守中学生进行调查,并利用结构方程模型进行统计分析。结果最终结构模型的拟合指数显示模型的拟合优度效果较好,所有的路径系数及其他参数估计差异均有统计学意义。留守中学生心理弹性影响因素分为外部保护因素和内部保护因素,前者受到父母外出打工情况(β=0.024,P=0.024)和内部保护因素(β=1.136,P=0.000)的直接影响;后者受到年级(β=-0.080,P=0.000)、对父母外出打工的态度(β=-0.034,P=0.003)以及是否担心父母在外打工会出事(β=0.050,P=0.000)的直接影响;而走读情况间接作用于心理弹性外部及内部保护因素。结论三峡库区留守中学生心理弹性受到来自外部和内部多方面因素的影响,因此需要家庭、学校以及学生自身情况有机结合起来,促进留守中学生良好适应。

关键词：留守中学生心理弹性影响因素结构方程模型

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Effectiveness and safety of early lens extraction during par plana vitrectomy for proliferative diabetes retinopathy with mild cataract:a randomized clinical trial

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 528-536页

作者： Wei-Bo Feng Lei Zheng Ying-Qi Li Yong-Hao Li Guo-Ming Zhang Xian Wang Bing-Qian Liu Ling Jin Yi-Nuo Huang yang-fan yang Zi-Dong Chen Da-Hui Ma qing-Shan Chen Chao-Jun qin Bing-Min Feng zhu-Min yang Xing Huang Cheng-Jie yang Sheng-Hui Liu Ming-Xing Wu State key Laboratory of Ophthalmology Guangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesZhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510275Guangdong ProvinceChina Shenzhen Eye Hospital Affiliated to Jinan University Shenzhen 518040Guangdong ProvinceChina The Affiliated Hospital of Guizhou Medical University Guiyang 550004Guizhou ProvinceChina Guangzhou Aier Eye Hospital Guangzhou 510000Guangdong ProvinceChina

●AIM:To evaluate the effectiveness and safety of early lens extraction during pars plana vitrectomy(PPV)for proliferative diabetic retinopathy(PDR)compared to those of PPV with subsequent cataract surgery.●METHODS:This multicenter randomized controlled trial was conducted in three Chinese hospitals on patients with PDR,aged>45y,with mild *** participants were randomly assigned to the combined(PPV combined with simultaneously cataract surgery,i.e.,phacovitrectomy)or subsequent(PPV with subsequent cataract surgery 6mo later)group and followed up for *** primary outcome was the change in best-corrected visual acuity(BCVA)from baseline to 6mo,and the secondary outcomes included complication rates and medical expenses.●RESULTS:In total,129 patients with PDR were recruited and equally randomized(66 and 63 in the combined and subsequent groups respectively).The change in BCVA in the combined group[mean,36.90 letters;95%confidence interval(CI),30.35–43.45]was significantly better(adjusted difference,16.43;95%CI,8.77–24.08;P<0.001)than in the subsequent group(mean,22.40 letters;95%CI,15.55–29.24)6mo after the PPV,with no significant difference between the two groups at *** overall surgical risk of two sequential surgeries was significantly higher than that of the combined surgery for neovascular glaucoma(17.65%vs 3.77%,P=0.005).No significant differences were found in the photocoagulation spots,surgical time,and economic expenses between two *** the subsequent group,the duration of work incapacity(22.54±9.11d)was significantly longer(P<0.001)than that of the combined group(12.44±6.48d).●CONCLUSION:PDR patients aged over 45y with mild cataract can also benefit from early lens extraction during PPV with gratifying effectiveness,safety and convenience,compared to sequential surgeries.

关键词： lens extraction pars plana vitrectomy proliferative diabetic retinopathy cataract simultaneously operations

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East Asian winter monsoon forecasting schemes based on the NCEP's Climate Forecast System

East Asian winter monsoon forecasting schemes based on the N...

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第35届中国气象学会年会

作者： Baoqiang Tian ke fan Hongqing yang Nansen-zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of Sciences Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science & Technology University of Chinese Academy of Sciences Department of Atmospheric Sciences Yunnan University

The East Asian winter monsoon(EAWM)is the major climate system in the Northern Hemisphere during boreal *** this study,we developed two schemes to improve the forecasting skill of the interannual variability of the EAWM index(EAWMI)using the interannual increment prediction method,also known as the DY ***,we found that version 2 of the NCEP’s Climate Forecast System(CFSv2)showed higher skill in predicting the EAWMI in DY form than ***,based on the advantage of the DY method,Scheme-I was obtained by adding the EAWMI DY predicted by CFSv2 to the observed EAWMI in the previous *** scheme showed higher forecasting skill than ***,during 1983–2016,the temporal correlation coefficient between the Scheme-I-predicted and observed EAWMI was 0.47,exceeding the 99%significance level,with the root-mean-square error(RMSE)decreased by 12%.The autumn Arctic sea ice and North Pacific sea surface temperature(SST)are two important external forcing factors for the interannual variability of the ***,a second(hybrid)prediction scheme,Scheme-II,was also *** scheme not only involved the EAWMI DY of CFSv2,but also the sea-ice concentration(SIC)observed the previous autumn in the Laptev and East Siberian seas and the temporal coefficients of the third mode of the North Pacific SST in DY *** found that a negative SIC anomaly in the preceding autumn over the Laptev and the East Siberian seas could lead to a significant enhancement of the Aleutian low and East Asian westerly jet in the following ***,the intensity of the winter Siberian high was mainly affected by the third mode of the North Pacific autumn ***-I and Scheme-II also showed higher predictive ability for the EAWMI in negative anomaly years compared to *** importantly,the improvement in the prediction skill of the EAWMI by the new schemes,especially for Scheme-II,could enhance the forecasting skill of the winter 2-m air temperature(T-2m)in most

关键词： East Asian winter monsoon year-to-year increment method hybrid prediction CFSv2

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SPS循环热处理对93W-4.9Ni-2.1Fe合金组织和性能的影响

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稀有金属材料与工程 2018年第7期47卷 2210-2215页

作者：关模李小强胡可杨帆朱德智华南理工大学国家金属材料近净成形工程技术研究中心广东广州510640

基于放电等离子烧结(SPS)技术对烧结态的93W-4.9Ni-2.1Fe高密度钨合金进行真空循环热处理,并通过光学显微镜、SEM、EDS和三点弯曲实验分析循环热处理对合金的显微组织、成分和力学性能的影响规律。结果表明,随着循环次数的不断增加,粘... 详细信息

基于放电等离子烧结(SPS)技术对烧结态的93W-4.9Ni-2.1Fe高密度钨合金进行真空循环热处理,并通过光学显微镜、SEM、EDS和三点弯曲实验分析循环热处理对合金的显微组织、成分和力学性能的影响规律。结果表明,随着循环次数的不断增加,粘结相渗入W-W界面不断增多,W-W连接度和二面角不断降低,而钨晶粒尺寸变化较小;粘结相则因W含量的增加得到了固溶强化,进而致使合金的硬度有所提高。合金的抗弯强度在循环2次后明显提高,当循环次数增加到20次后,合金的平均抗弯强度达到2321 MPa,相比液相烧结后淬火处理的合金提高了约160 MPa。因此,SPS循环热处理可以明显改善93W-4.9Ni-2.1Fe高密度钨合金的组织和力学性能。

关键词： 93W-4.9Ni-2.1Fe 放电等离子烧结循环热处理抗弯强度

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The Inhibiting Effects and It's Molecular Mecanisms of the Fungi of Huai Er's on Human Large Cell Lung Cancer Cell Line L9981

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中国肺癌杂志 2009年第6期12卷 492-493页

作者： Yu fan Zhilin SUN yang qin Wen zhu Li REN Jun CHEN Sen WEI Zhigang LI Hongyu LIU Haisu WAN Zhihao WU ke XU qinghua ZHOU Tianjin key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment Tianjin Lung Cancer Institute Tianjin Medical University Hospital Tianjin 300052 China The key Laboratory of Lung Cancer Molecular Biology of Sichuan Province West China Hospital Sichuan Universit Chengdu 610041 China

Background and Objective Lung cancer, which threatens human’s health and life, is the malignant tumor with the most rapid increase of morbidity. Although recent years the basic

关键词：肺癌治疗疗效临床

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鞘内药物输注系统植入术治疗难治性神经病理性疼痛初步疗效观察

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中国现代神经疾病杂志 2013年第9期13卷 778-782页

作者：杨阳杨克勤樊碧发卫生部中日友好医院全国疼痛诊疗研究中心北京100029

目的观察鞘内药物输注系统植入术治疗难治性神经病理性疼痛的疗效,以及对患者生活质量的改善情况。方法采用鞘内药物输注系统植入术治疗3例典型神经病理性疼痛且药物治疗效果欠佳,或出现严重药物不良反应患者,共随访6~14个月,观察疼痛... 详细信息

目的观察鞘内药物输注系统植入术治疗难治性神经病理性疼痛的疗效,以及对患者生活质量的改善情况。方法采用鞘内药物输注系统植入术治疗3例典型神经病理性疼痛且药物治疗效果欠佳,或出现严重药物不良反应患者,共随访6~14个月,观察疼痛缓解率、睡眠改善程度、镇痛药物服用剂量及药物不良反应。结果治疗后3例患者视觉模拟评分均显著下降,由术前的中至重度疼痛改善至术后轻度疼痛,爆发痛次数减少;镇痛药物服用剂量约降至术前的10%;睡眠质量明显改善。随访期间均未发生手术相关性并发症和吗啡不良反应。结论鞘内药物输注系统对经鞘内吗啡试验镇痛效果满意的难治性神经病理性疼痛患者具有较为肯定的近期疗效。

关键词：疼痛,顽固性输注泵,植入型吗啡

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Lifetime measurements in 138Nd

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Nuclear Science and Techniques 2021年第10期32卷 72-78页

作者： Jian Zhong Xiao-Guang Wu Shi-Peng Hu Ying-Jun Ma Yun Zheng Cong-Bo Li Guang-Sheng Li Bao-Ji zhu Tian-Xiao Li Yan-Jun Jin Yan-Xiang Gao Qi-Wen fan ke-Yan Ma Dong yang Hui-Bin Sun Hai-Ge Zhao Lin Gan Qi Luo Zheng-Xin Wu College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China China Institute of Atomic Energy Beijing 102413China College of Physics Jilin UniversityChangchun 621010China

Lifetimes of the 2_(1)^(+),4_(1)^(+),7_(2)^(-),10_(2)^(+),12_(2)^(+),and 14_(1)^(+) states in 138 Nd populated via the 123 Sb(19 F,4n)138 Nd fusion–evaporation reaction were measured with the recoil distance Doppler shift technique in combination with the differential decay curve *** B(E2;2_(1)^(+)→0_(1)^(+))value fit well with the systematic trend in the Nd isotope chain and Grodzins rule,which proved that 138Nd is a transitional nucleus.

关键词： Lifetime measurement Recoil distance Doppler shift technique Differential decay curve method

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论中国式体育教育现代化

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成都体育学院学报 2023年第5期49卷 38-46页

作者：孙科杨帆朱天宇樊菁中国科学院大学体育部北京100049 北京教育学院体育与艺术教育学院北京100120

加快中国式体育教育现代化进程,实现体育教育高质量发展,是建成教育强国、体育强国的应有之义。文章溯源了中国体育教育现代化的有关理论成果,诠释了中国式体育教育现代化的内涵,分析了中国式体育教育现代化存在的问题及原因,提出了中... 详细信息

加快中国式体育教育现代化进程,实现体育教育高质量发展,是建成教育强国、体育强国的应有之义。文章溯源了中国体育教育现代化的有关理论成果,诠释了中国式体育教育现代化的内涵,分析了中国式体育教育现代化存在的问题及原因,提出了中国式体育教育现代化的推进策略。研究认为,中国体育教育由于没有处理好整体与部分、继承与创新、抽象与直观的辩证逻辑关系,导致中国式体育教育现代化在“立德树人”落实力度、体育教育教学观念更新、体育教育学段衔接与内容优化、体育教育教学科学性评价等方面存在着严峻的挑战。今后,我们应该加强体育教育改革,把握好体育课程改革的方向、导向、理念,做好体育教学的实施、评价、指导,构建出具有中国特色世界先进水平的体育教育体系。

关键词：中国式现代化体育教育现代化课程标准学校体育体育教学

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