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Bioinspired metal-organic framework nanozyme reinforced with thermosensitive hydrogel for regulating inflammatory responses in Parkinson’s disease

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Nano Research 2024年第2期17卷 858-865页

作者： Xiaowan fan Tao Zhang Xin Ding Yushuo Gu Qing Li Wei Jiang Kelong fan Nanozyme Medical Center Academy of Medical ScienceZhengzhou UniversityZhengzhou 450001China Department Central-China Branch of National Center for Cardiovascular DiseasesHean Cardiovascular Disease CenterFuwai Central-China HospitalCentral China Fuwai Hospital of Zhengzhou UniversityZhengzhou 450046China Application Center for Precision Medicine the Second Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China CAS Engineering Laboratory for Nanozyme Key Laboratory of Protein and Peptide PharmaceuticalsInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 101408China Department of General Surgery Strategic Support Force Medical CenterBeijing 100101China Department of Anesthesiology Pain and Perioperative MedicineThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Parkinson’s disease(PD)is a prevalent neurodegenerative disorder accompanied by movement disorders and neuroinflammatory ***-inflammatory intervention to regulate oxidative stress in the brain is beneficial for managing ***,traditional natural antioxidants have failed to meet the clinical treatment demands due to insufficient activity and ***,Cu-doping zeolite imidazolate framework-8(ZIF-8)nanozyme is designed to simulate Cu/Zn superoxide dismutase(SOD)by biomimetic *** nanozyme composite is then integrated into thermosensitive hydrogel(poly(lactic-co-glycolic acid)-poly(ethylene glycol)-poly(lactic-co-glycolic acid)(PLGA-PEG-PLGA))to form an effective antioxidant system(Cu-ZIF@Hydrogel).The thermosensitive hydrogel incorporating nanozymes demonstrate distinct viscoelastic properties aimed at enhancing local nanozyme adhesion,prolonging nanozyme retention time,and modulating antioxidant activity,thus significantly improving the bioavailability of *** the cellular and animal levels of PD,we find that Cu-ZIF@Hydrogel bypass the blood-brain barrier and efficiently accumulate in the nerve ***,the Cu-ZIF@Hydrogel significantly alleviate the PD’s behavioral and pathological symptoms by reducing the neuroinflammatory levels in the lesion ***,the hydrogel-incorporating nanozyme system holds great potential as a simple and reliable avenue for managing PD.

关键词： bioinspired nanozyme thermosensitive hydrogel Parkinson’s disease oxidative stress neuroinflammatory

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CMMCAN:Lightweight Feature Extraction and Matching Network for Endoscopic Images Based on Adaptive Attention

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Computers, Materials & Continua 2024年第8期80卷 2761-2783页

作者： Nannan Chong fan Yang School of Electronic and Information Engineering Hebei University of TechnologyTianjin300401China School of Information and Intelligence Engineering Tianjin Renai CollegeTianjin301636China

In minimally invasive surgery,endoscopes or laparoscopes equipped with miniature cameras and tools are used to enter the human body for therapeutic purposes through small incisions or natural ***,in clinical operating environments,endoscopic images often suffer from challenges such as low texture,uneven illumination,and non-rigid structures,which affect feature observation and *** can severely impact surgical navigation or clinical diagnosis due to missing feature points in endoscopic images,leading to treatment and postoperative recovery issues for *** address these challenges,this paper introduces,for the first time,a Cross-Channel Multi-Modal Adaptive Spatial Feature Fusion(ASFF)module based on the lightweight architecture of ***,a novel lightweight feature extraction and matching network based on attention mechanism is *** network dynamically adjusts attention weights for cross-modal information from grayscale images and optical flow images through a dual-branch Siamese *** extracts static and dynamic information features ranging from low-level to high-level,and from local to global,ensuring robust feature extraction across different widths,noise levels,and blur *** and local matching are performed through a multi-level cascaded attention mechanism,with cross-channel attention introduced to simultaneously extract low-level and high-level *** ablation experiments and comparative studies are conducted on the HyperKvasir,EAD,M2caiSeg,CVC-ClinicDB,and UCL synthetic *** results demonstrate that the proposed network improves upon the baseline EfficientViT-B3 model by 75.4%in accuracy(Acc),while also enhancing runtime performance and storage *** compared with the complex DenseDescriptor feature extraction network,the difference in Acc is less than 7.22%,and IoU calculation results on specific datasets outperform complex dense ***

关键词： Feature extraction and matching lightweighted network medical images endoscopic attention

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Cross-Modal Consistency with Aesthetic Similarity for Multimodal False Information Detection

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Computers, Materials & Continua 2024年第5期79卷 2723-2741页

作者： Weijian fan Ziwei Shi State Key Laboratory of Media Convergence and Communication Communication University of ChinaBeijing100024China Software Research Institute China United Network Communication Group Co.Ltd.Beijing100024China

With the explosive growth of false information on social media platforms, the automatic detection of multimodalfalse information has received increasing attention. Recent research has significantly contributed to multimodalinformation exchange and fusion, with many methods attempting to integrate unimodal features to generatemultimodal news representations. However, they still need to fully explore the hierarchical and complex semanticcorrelations between different modal contents, severely limiting their performance detecting multimodal falseinformation. This work proposes a two-stage detection framework for multimodal false information detection,called ASMFD, which is based on image aesthetic similarity to segment and explores the consistency andinconsistency features of images and texts. Specifically, we first use the Contrastive Language-Image Pre-training(CLIP) model to learn the relationship between text and images through label awareness and train an imageaesthetic attribute scorer using an aesthetic attribute dataset. Then, we calculate the aesthetic similarity betweenthe image and related images and use this similarity as a threshold to divide the multimodal correlation matrixinto consistency and inconsistencymatrices. Finally, the fusionmodule is designed to identify essential features fordetectingmultimodal false information. In extensive experiments on four datasets, the performance of the ASMFDis superior to state-of-the-art baseline methods.

关键词： Social media false information detection image aesthetic assessment cross-modal consistency

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Center of the Yangian double in type A

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Science China Mathematics 2024年第9期67卷 1957-1988页

作者： fan Yang Naihuan Jing Department of Mathematics Jiaying UniversityMeizhou 514000China Department of Mathematics North Carolina State UniversityRaleighNC 27695USA

We prove that the R-matrix and Drinfeld presentations of the Yangian double in type A are *** central elements of the completed Yangian double in type A at the critical level are *** images of these elements under a Harish-Chandra-type homomorphism are calculated by applying a version of the Poincaré-Birkhoff-Witt theorem for the R-matrix *** images coincide with the eigenvalues of the central elements in the Wakimoto modules.

关键词： Yangian double Harish-Chandra homomorphism Wakimoto module

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Recent Progress on Water-based Liquid Embolic Agents in Endovascular Treatment

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Chemical Research in Chinese Universities 2024年第5期40卷 776-785页

作者： QI Yi fan Hailong Department of Neurosurgery Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo060-8638Japan Institute for Chemical Reaction Design and Discovery(WPI-ICReDD) Hokkaido UniversitySapporo001-0021Japan

Vascular embolization treatment,a minimally invasive surgery for various blood vessel-related conditions,has emerged as a crucial method in treating such as hemorrhage,arteriovenous malformation,aneurysms,and hypervascular *** embolic agents are gaining prominence due to their distinct advantage in infiltrating distal regions,expanding the scope of embolization beyond the reach of solid *** strides in biomaterials and technologies have spurred the development of novel liquid embolic agents,addressing challenges posed by traditional *** mini-review provides a concise overview of the recent progress in water-based liquid embolic agents,highlighting their potential to overcome limitations associated with current embolic *** presenting selected research outcomes,we illuminate advancements that enhance the efficacy of liquid embolic ***,the review outlines essential properties for effective liquid embolic agents,offering insights for future developments in this field.

关键词： Endovascular treatment Lquid embolic agent Hydrogel

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Electrocatalytic CO_(2)reduction to syngas

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Green Energy & Environment 2024年第7期9卷 1085-1100页

作者： Bing Chang Zhaojun Min Ning Liu Nan Wang Maohong fan Jing fan Jianji Wang School of Environment Key Laboratory of Yellow River and Huai River Water Environment and Pollution ControlMinistry of EducationHenan Normal UniversityXinxiangHenan453007China School of Chemistry and Chemical Engineering Key Laboratory of Green Chemical Media and ReactionsMinistry of EducationHenan Normal UniversityXinxiangHenan453007China College of Engineering and Physical Sciences and School of Energy ResourcesUniversity of WyomingLaramieWY82071USA College of Engineering Georgia Institute of TechnologyAtlantaGA30332USA

While carbon dioxide(CO_(2))is a major greenhouse gas,it is also an important C1 *** the trend of energy conservation and emission reduction,electrocatalytic reduction has become a very promising strategy for CO_(2)utilization because it can convert CO_(2)directly to high-valued chemicals and fuels under mild *** particular,the product CO and by-product H_(2)can be combined into syngas by an electrocatalytic CO_(2)reduction reaction(CO_(2)RR)in an aqueous *** molar ratios of CO and H_(2)may be used to produce essential bulk chemicals or liquid fuels such as methanol,alkanes,and olefins through thermochemical catalysis,Fischer-Tropsch synthesis,microbial fermentation,and other *** work discusses the latest strategies in controlling the molar ratio of CO/H_(2)and improving the yield of CO_(2)*** challenges of electrocatalytic syngas production are analyzed from an industrial application perspective,and the possible measures to overcome them are proposed in terms of new catalyst design,electrolyte innovation,flow reactor optimization,anodic reaction coupling,and operando technique application.

关键词： Electrocatalysis CO_(2)reduction Syngas Electrolyte Electrolyzer

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Observation of an upward lightning flash with 21 upward positive leaders initiated from different wind turbines in wind farm

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High Voltage 2024年第1期9卷 163-171页

作者： Li Cai Yifeng Ke Wenchao fan Ruisheng Yan Mi Zhou Jianguo Wang Yadong fan Engineering Research Center of Ministry of Education for Lightning Protection and Grounding Technology School of Electrical Engineering and AutomationWuhan UniversityWuhanChina

As the wind turbine height increases,the probability of multiple upward leaders flashes within the wind farm *** this study,an upward lightning flash containing 21 upward positive leaders(UPLs)initiated from different wind turbines in Zhangbei Wind Farm was *** average speed of the UPLs was 1.2×10^(5) m/s,which mostly decreased to zero before reaching the cloud *** four UPLs developed to cloud height,with prolonged periods of bright light on three of them and with a minimum duration of 126 ms.A total of nine return strokes occurred on the other two dissipated leader channels,and the numbers of strokes on the two channels was six and three,*** average interstroke interval for the return strokes was 10.5 *** of these nine return strokes had peak currents smaller than 10 *** high-speed video frames confirmed that competition does exist between the UPLs,and the range of shielding effects increases as the height of the ULs *** effect of fan rotation on the initiation of upward leaders and the shielding effect between the wind turbines and upward leaders are discussed.

关键词： flash return initiated

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Process in laser drilling of deep microholes without taper on metal materials

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Science China(Technological Sciences) 2024年第1期67卷 37-59页

作者： fan RunZe MEI XueSong CUI JianLei State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an 710054China

Deep microhole machining is currently a prominent research area within the aerospace field,encompassing blade film cooling and fuel injection control ***,taper defects in metal materials may lead to performance degradation or even structural damage over a component’s *** and helical drilling,facilitated by ultrashort pulse lasers,have proven more suitable for achieving high-precision,deep holes in metal ***,excessive repetition rates can also result in severe thermal *** methods are commonly employed for controlling taper,including parameter optimization,assistance,and secondary *** laser beam drilling is widely utilized and has been integrated into relevant machining systems for commercial *** deep microholes include film cooling holes and injection *** drilling is a potential machining method for new materials in the aerospace *** laser drilling processing has been studied,numerous related scientific challenges and technical difficulties must be addressed before practical implementation.

关键词： aerospace laser drilling deep microhole taper control

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In memory of Robie ***(1948-2022):A scientist and a friend

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Environmental Science and Ecotechnology 2024年第2期18卷 4-6页

作者： Yi-fan Li 不详

On February 17,2022,I received an email from Julie Henderson,the life partner of Robie *** her email,she conveyed the following message:"Hello Yifan,Rob asked me to especially let you know that when he had *** admired and enjoyed working with you."As I read those words,tears welled up in my eyes,overwhelmed by profound *** was not only my scientific research colleague but also my closest *** had collaborated for more than two decades.

关键词： email friend partner

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Holographic superfluid ring with a weak link

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Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 29-38页

作者： Zhi-Hong Li Huai-fan Li Department of Physics Shanxi Datong UniversityDatong 037009China Institute of Theoretical Physics Shanxi Datong UniversityDatong 037009China

We explore the generation of topological defects in the course of a dynamical phase transition in a ring with a weak link, i.e., a SSS Josephson junction, from the AdS/CFT correspondence. By setting different parameters of the junction(width, steepness,depth) and the final temperature of the quench, the configurations of the charge density and condensate of the order parameters of the dual field theory are presented. Meanwhile, we observe that in the final equilibrium state, variations in parameters of the junctions only affect the configurations of the charge density and condensate of the order parameters, without altering their values outside the junction. However, variations in the final temperature will directly affect the values of the charge density and condensate of the order parameters outside of the junction. Moreover, in the final equilibrium state, we propose an analytic relation between the gauge-invariant velocity in the two superconducting states in the SSS Josephson junction, which agrees well with the numerical results.

关键词： AdS/CFT correspondence holographic superfluid holographic Josephson junction

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