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Gender Discourse

校园英语 2016年第15期 210-211页

作者： ran fan-min College of Foreign Language Harbin University of Commerce

Gender discourse was paid much attention in recent years. The primary objective of this fundamental research is to perceive the distinction between direct and indirect in gender discourse. The method used in this stud... 详细信息

关键词： gender discourse direct indirect

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模版特征线匹配的牙齿形状修复

计算机辅助设计与图形学学报 2014年第2期26卷 280-286页

作者：范然金小刚浙江大学CAD&CG国家重点实验室杭州310058

牙齿形状修复是牙科修复CAD系统的核心问题,其中结构特征线,如颈缘线、修复边缘线是决定修复体制造精度的关键要素.针对现有牙齿形状自动修复算法未考虑结构特征线附近的咬合面形状约束以及仅能处理部分缺失情况的问题,提出了结合模版... 详细信息

牙齿形状修复是牙科修复CAD系统的核心问题,其中结构特征线,如颈缘线、修复边缘线是决定修复体制造精度的关键要素.针对现有牙齿形状自动修复算法未考虑结构特征线附近的咬合面形状约束以及仅能处理部分缺失情况的问题,提出了结合模版特征线匹配与移动最小二乘变形的修复体曲面重建算法.该算法采用智能剪刀算法半自动指定牙齿预备体上的结构特征线,并采用曲面拟合技术将该结构特征线投影至模版牙齿模型以建立曲线约束;再用近似刚性的移动最小二乘变形算法将模版牙齿模型匹配到牙齿预备体上;最后将移动最小二乘变形算法并行化,实现了以特征线为控制句柄的修复体形状交互设计.实验结果表明,由于引入了曲线约束,文中算法重建的修复体在结构特征线附近可获得更自然的咬合面形态.

关键词：牙科修复CAD系统特征线匹配移动最小二乘变形近似刚性曲线约束

Ester-Derivatized Indoles as Fluorescent and Infrared Probes for Hydration Environments

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Chinese Journal of Chemical Physics 2018年第4期31卷 477-484,614页

作者： Xin-yue Huang MinYou Guang-liu ran Hao-ran fan Wen-kai Zhang Department of Physics and Applied Optics Beijing Area Major Laboratory Center for Advanced Quantum StudiesBelling Normal UniversityBelling 100875China Department of Chemistry Belling Normal UniversityBelling 100875China

Tryptophan derivatives have long been used as site-specific biological probes. 4-Cyanotrypto- phan emits in the visible region and is the smallest blue fluorescent amino acid probe for bio- logical applications. Other indole or tryptophan analogs may emit at even longer wavelengths than 4-cyanotryptophan. We performed FTIR, UV-Vis, and steady-state and time-resolved fluorescence spectroscopy on six ester-derivatized indoles in different solvents. Methyl indole- 4-carboxylate emits at 450 nrn with a long fluorescence lifetirne, and is a promising candidate for a fluorescent probe. The ester-derivatized indoles could be used as spectroscopic probes to study local protein environments. Our measurements provide a guide for choosing esterderivatized indoles to use in practice and data for computational modeling of the effect of substitution on the electronic transitions of indole.

关键词： Infrared probe Fluorescent probe Typtophan derivative Indole derivative

罗莎·卢森堡的《资本积累论》与当代资本主义

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河北学刊 2012年第2期32卷 167-171页

作者：范冉冉南开大学哲学院天津300071

《资本积累论》是罗莎·卢森堡的主要代表作之一,自创作至今已整整一百周年。回顾东西方马克思主义学术界围绕这部著作的百年论战史,可以发现一个奇怪的现象:学者们一方面批评卢森堡的资本积累理论是她在学理上对一个"虚假问题"作出的"... 详细信息

《资本积累论》是罗莎·卢森堡的主要代表作之一,自创作至今已整整一百周年。回顾东西方马克思主义学术界围绕这部著作的百年论战史,可以发现一个奇怪的现象:学者们一方面批评卢森堡的资本积累理论是她在学理上对一个"虚假问题"作出的"幼稚回答",另一方面却又在探讨当代资本主义的全球化现象时不断地返回到卢森堡去寻求答案。这无疑令人好奇:这部著作的"魅力"究竟何在,以至于学术界在面对它时如此自相矛盾?本文试图回归该著文本去探寻卢森堡创立资本积累理论的总体逻辑,并在此基础上为现时代汲取一定的理论养分。

关键词：《资本积累论》扩大再生产图式 “第三市场”理论当代资本主义

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卢森堡和列宁在党的组织策略上的共识与分歧

河北大学学报（哲学社会科学版） 2012年第3期37卷 51-55页

作者：范冉冉南开大学哲学院天津300071

卢森堡和列宁在无产阶级政党的组织策略各有所见,主要体现在关于克服党内机会主义的具体途径、如何处理党内民主与集中的关系以及对党内知识分子的纪律观念的认识等方面,但不可否认两位马克思主义者的最终目的是一致的:即建立一个"统一... 详细信息

卢森堡和列宁在无产阶级政党的组织策略各有所见,主要体现在关于克服党内机会主义的具体途径、如何处理党内民主与集中的关系以及对党内知识分子的纪律观念的认识等方面,但不可否认两位马克思主义者的最终目的是一致的:即建立一个"统一的紧密团结的无产阶级政党"。尽管这场论战已过去百年之久,但对新的历史条件下加强和改进党的建设、保持党的先进性和纯洁性工作仍具有重要的理论和实践意义。

关键词：卢森堡列宁组织策略机会主义党内民主

Detection of CYP2E1,a Genetic Biomarker of Susceptibility to Benzene Metabolism Toxicity in Immortal Human Lymphocytes Derived from the Han Chinese Population

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Biomedical and Environmental Sciences 2011年第3期24卷 300-309页

作者： ZHANG Juan YIN LiHong LIANG GeYu LIU ran fan KaiHong PU YuePu Key Laboratory of Environmental Medicine Engineering Ministry of Education' School of Public HealthSoutheast University Nanjing 210009 Jiangsu China

Objective Cytochrome P450 2E1 （CYP2E1） is an important metabolizing enzyme involved in oxidative stress responses to benzene, a chemical associated with bone marrow toxicity and leukemia, We aimed to identify the CYP2E1 genetic biomarkers of susceptibility to benzene toxicity in support of environmental and occupational exposure prevention, and to test whether a model using immortal human lymphocytes might be an efficient tool for detecting genetic biomarkers. Methods Immortalized human lymphocyte cell lines with independent genotypes on four CYP2E1 SNP sites were induced with 0.01% phenol, a metabolite of benzene. CYP2E1 gene function was evaluated by mRNA expression and enzyme activity. DNA damage was measured by Single-Cell Gel Electrophoresis （SCGE）. Results Among the four SNPs, cells with rs2070673TT and rs2030920CC showed higher levels of ~YP2E1 transcription and enzymatic activity than the other genotypes in the same SNP site. Cells with higher gene expression genotypes also showed higher comet rates compared with lower gene expression genotypes. Conclusion These results suggest that CYP2E1 rs2070673 and rs2030920 might be the genetic biomarkers of susceptibility to benzene toxicity and that the immortalized human lymphocytes model might be an efficient tool for the detection of genetic biomarkers of susceptibility to chemicals.

关键词： Cytochrome P450 2E1 Single-nucleotide polymorphism Genetic biomarker Human immortalized B lymphocytes Benzene Phenol

Metabolites Identification of Curcumin,Demethoxycurcumin and Bisdemethoxycurcumin in Rats After Oral Administration of Nanoparticle Formulations by Liquid Chromatography Coupled with Mass Spectrometry

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World Journal of Traditional Chinese Medicine 2016年第4期2卷 29-37页

作者： Rui Li Qi Wang Jing-ran fan Jun-Bin He Xue Qiao Cheng Xiang De-An Guo Min Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University 38 Xueyuan RoadBeijing 100191 China Key Laboratory of Food Biotechnology of Sichuan Province School of Bioengineering Xihua University Chengdu 610039 China School of Chinese Materia Medica Beijing University of Chinese Medicine Beijing 100102 China

Background: Curcuminoids are promising cancer chemopreventive agents. Curcumin, demethoxycurcumin(DMC) and bisdemethoxycurcumin(BDMC) are the major bioactive curcuminoids in turmeric. However, comprehensive metabolic studies of these three curcuminoids are still ***: To identify the metabolites of curcumin, DMC and BDMC in rats after oral administration of solid lipid nanoparticles(SLNs).Methods: Male Sprague-Dawley rats(250 ± 20 g, body weight) were randomly divided into 4 groups(n=3), and were orally administered with curcumin-SLN, DMC-SLN, BDMC-SLN, or blank-SLN, respectively. Plasma samples(500 μL) via the angular vein were collected at 1, 2 and 4 h post dosing, and the urine and feces samples were collected at 0–12 h and 12–24 h post-intake. An HPLC-DAD-ESI-MSnmethod was developed to identify the metabolites. The structures of phase II metabolites were further confirmed by enzyme ***: A total of 34 metabolites were identified in rats plasma, urine, and feces. Most of them were phase II metabolites, including glucuronide conjugates and sulfate conjugates. Among them, the glucuronide conjugates were the major metabolites in rats plasma. In the meanwhile, the three parent curcuminoids were detected in high amounts in the urine and feces ***: The possible metabolic pathways of curcuminoids in rats were proposed.

关键词： Curcumin Demethoxycurcumin Bisdemethoxycurcumin Solid lipid nanoparticles Metabolic pathway

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先灵公司与中国八仙

装饰 2005年第10期 68-69页

作者：冉凡

这套以中国民间传说中的八仙人物为主体的广告设计是由世界著名的跨国药品公司先灵公司(Schering Corporation)驻美国新泽西州布卢姆菲尔德镇(Bloomfield)的分公司在20世纪40年代设计发行的.先灵公司的起步和发展具有类似于许多著名大... 详细信息

这套以中国民间传说中的八仙人物为主体的广告设计是由世界著名的跨国药品公司先灵公司(Schering Corporation)驻美国新泽西州布卢姆菲尔德镇(Bloomfield)的分公司在20世纪40年代设计发行的.先灵公司的起步和发展具有类似于许多著名大公司的传奇经历,它的前身是由有抱负的化学家、药剂师兼企业家恩斯特·先灵(Ernst Schering)先生于1851年在德国柏林开设的'绿色药房'.1871年,先灵有限公司正式成立.

关键词：公司中国 20世纪40年代广告设计民间传说新泽西州药品

Input associativity underlies fear memory renewal

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National Science Review 2021年第9期8卷 121-136页

作者： Wei-Guang Li Yan-Jiao Wu Xue Gu Hui-ran fan Qi Wang Jia-Jie Zhu Xin Yi Qin Wang Qin Jiang Ying Li Ti-Fei Yuan Han Xu Jiangteng Lu Nan-Jie Xu Michael Xi Zhu Tian-Le Xu Center for Brain Science of Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Center for Neuroscience and Department of Neurology of the Second Affiliated Hospital NHC and CAMS Key Laboratory of Medical Neurobiology Zhejiang University School of Medicine Department of Anatomy and Physiology Shanghai Jiao Tong University School of Medicine Shanghai Research Center for Brain Science and Brain-Inspired Intelligence Department of Integrative Biology and Pharmacology Mc Govern Medical School University of Texas Health Science Center at Houston

Synaptic associativity, a feature of Hebbian plasticity wherein coactivation of two inputs onto the same neuron produces synergistic actions on postsynaptic activity, is a primary cellular correlate of associative learning. However, whether and how synaptic associativity are implemented into context-dependent relapse of extinguished memory(i.e. fear renewal) is unknown. Here, using an auditory fear conditioning paradigm in mice, we show that fear renewal is determined by the associativity between convergent inputs from the auditory cortex(ACx) and ventral hippocampus(v HPC) onto the lateral amygdala(LA) that reactivate ensembles engaged during learning. Fear renewal enhances synaptic strengths of both ACx to LA and the previously unknown v HPC to LA monosynaptic inputs. While inactivating either of the afferents abolishes fear renewal, optogenetic activation of their input associativity in the LA recapitulates fear renewal. Thus, input associativity underlies fear memory renewal.

关键词： fear renewal memory ensembles input associativity long-term potentiation ventral hippocampus auditory cortex lateral amygdala