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Heat stroke alters hippocampal and cerebellar transmitter metabonomics

World Journal of Emergency Medicine 2023年第4期14卷 287-293页

作者： Guoxin He Ancong Xu Xichong Yu Fan Huang Lei Su The First School of Clinical Medicine Southern Medical UniversityGuangzhou 510515China Department of Critical Care Medicine the Third Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China School of Pharmaceutical Sciences Wenzhou Medical UniversityWenzhou 325035China

BACKGROUND:The mechanisms underlying heat stroke(HS)-induced hippocampal injury remain unclear.This study aimed to evaluate the HS-induced metabonomics of hippocampal and cerebellar transmitters.METHODS:The HS model was established with male Sprague-Dawley rats subjected to heat exposure of up to 42℃ at a humidity of(55.0±5.0)%.The hippocampal and cerebellar transmitters and metabolites of rats were tested via ultra-high-performance liquid chromatography–mass spectrometry(UPLC-MS/MS).The primary transmitters and metabolites were identified by principal component analysis(PCA)and orthogonal partial least square-discriminant analysis(OPLS-DA).The major metabolic pathways for HS were selected after enrichment.The brain injury was evaluated by histological tests.RESULTS:HS induced hippocampal and cerebellar injuries in rats.HS upregulated the protein levels of hippocampal glutamate,glutamine,gamma-aminobutyric acid,L-tryptophan(Trp),5-hydroxy-indoleacetic acid,and kynurenine;however,it downregulated asparagine,tryptamine,5-hydroxytryptophan,melatonin,3,4-dihydroxyphenylalanine(L-DOPA),and vanillylmandelic acid.HS also sharply elevated the protein levels of cerebellar methionine and Trp,and decreased the levels of serotonin,L-alanine,L-asparagine,L-aspartate,cysteine,norepinephrine,spermine,spermidine,and tyrosine.Hippocampal glutamate,monoamine transmitters,cerebellar aspartate acid,and catecholamine transmitters’metabolic pathways were identified as the main metablic pathways in HS.CONCLUSION:The hippocampus and cerebellum were injured in rats with HS,possibly induced the disorder of hippocampal glutamate and serotonin metabolism,cerebellar aspartate acid and catecholamine transmitter metabolism,and related metabolic pathways.

关键词： Heat stroke Transmitters Rat Hippocampus Cerebellum Metabonomics

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Polymeric Nanotherapeutics for Alzheimer's Disease:Summary and Outlook

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Chinese Journal of Polymer Science 2023年第6期41卷 839-841页

作者： Lin-Lin Xu Fan Huang Lin-Qi Shi State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials of Ministry of EducationCollege of ChemistryNankai University Key Laboratory of Radiopharmacokinetics for Innovative Drugs Chinese Academy of Medical Sciencesand Institute of Radiation MedicineChinese Academy of Medical Sciences&Peking Union Medical College State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials of Ministry of EducationCollege of ChemistryNankai University Haihe Laboratory of Sustainable Chemical Transformations

Alzheimer’s disease(AD),one of the most prevalent progressive neurodegenerative disorders,is characterized by neurological dysfunction and is closely linked to learning and memory impairment.Despite tremendous effort being involved,several anti-AD drugs come into clinical trials difficult to succeed due to the complex AD pathogenesis and the blood-brain barrier(BBB).

关键词： Alzheimer drugs clinical

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Anti-Disturbance Control for Tethered Aircraft System With Deferred Output Constraints

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IEEE/CAA Journal of Automatica Sinica 2023年第2期10卷 474-485页

作者： Mengshi Song fan Zhang Bingxiao huang Panfeng huang the Research Center of Intelligent Robotics the School of AstronauticsNorthwestern Polytechnical UniversityXi’an 710072China IEEE

In this paper,we investigate the peaking issue of extended state observers and the anti-disturbance control problem of tethered aircraft systems subject to the unstable flight of the main aircraft,airflow disturbances and deferred output constraints.Independent of exact initial values,a modified extended state observer is constructed from a shifting function such that not only the peaking issue inherently in the observer is circumvented completely but also the accurate estimation of the lumped disturbance is guaranteed.Meanwhile,to deal with deferred output constraints,an improved output constrained controller is employed by integrating the shifting function into the barrier Lyapunov function.Then,by combining the modified observer and the improved controller,an anti-disturbance control scheme is presented,which ensures that the outputs with any bounded initial conditions satisfy the constraints after a pre-specified finite time,and the tethered aircraft tracks the desired trajectory accurately.Finally,both a theoretical proof and simulation results verify the effectiveness of the proposed control scheme.

关键词： Anti-disturbance control deferred output constraint extended state observer shifting function tethered aircraft system(TAS)

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In-situ TEM studies on stick–slip friction characters of sp^(2) nanocrystallited carbon films

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Friction 2022年第10期10卷 1635-1649页

作者： Xue fan Zelong HU Wenchao huang Institute of Nanosurface Science and Engineering Guangdong Provincial Key Laboratory of Micro/Nano Optomechatronics EngineeringCollege of Mechatronics and Control EngineeringShenzhen UniversityShenzhen 518060China

Carbon films with two different kinds of sp^(2) nanocrystallited structure were investigated to study the stick–slip friction with the in-situ and ex-situ tests.In-situ transmission electron microscope(TEM)observation and nanofriction tests revealed that the origins of stick and slip varied with shear stress and film deformation.At the stick stage,shear stress gradually increased with the contact strengthened until reached the shear strength to break the interfacial adhesion;at the slip stage,the shear stress decreased and accompanied with film deformation.During the sliding process,adhesive deformation resulted in the large stick–slip step while ploughing deformation led to a smoother step.Ex-situ nanofriction tests on a series of sp^(2) nanocrystallited carbon films with different irradiation energies showed the expected sliding behavior with the in-situ results.This study first clarified the mechanism of stick–slip friction with the in-situ TEM observation,which plays the important role for the micro and nano application of sp2 nanocrystallited carbon films.

关键词： carbon films stick-slip contact interface deformation in-situ transmission electron microscope(TEM)

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Tumor microenvironment reprogramming by nanomedicine to enhance the effect of tumor immunotherapy

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 1-37页

作者： Yu huang Hui fan Huihui Ti School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China Guangdong Province Precise Medicine Big Date of Traditional Chinese Medicine Engineering Technology Research Center Guangdong Pharmaceutical UniversityGuangzhou 510006China School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhou 510006China

With the rapid development of the fields of tumor biology and immunology, tumor immunotherapy has been used in clinical practice and has demonstrated significant therapeutic potential, particularly for treating tumors that do not respond to standard treatment options. Despite its advances, immunotherapy still has limitations, such as poor clinical response rates and differences in individual patient responses, largely because tumor tissues have strong immunosuppressive microenvironments. Many tumors have a tumor microenvironment (TME) that is characterized by hypoxia, low pH, and substantial numbers of immunosuppressive cells, and these are the main factors limiting the efficacy of antitumor immunotherapy. The TME is crucial to the occurrence, growth, and metastasis of tumors. Therefore, numerous studies have been devoted to improving the effects of immunotherapy by remodeling the TME. Effective regulation of the TME and reversal of immunosuppressive conditions are effective strategies for improving tumor immunotherapy. The use of multidrug combinations to improve the TME is an efficient way to enhance antitumor immune efficacy. However, the inability to effectively target drugs decreases therapeutic effects and causes toxic side effects. Nanodrug delivery carriers have the advantageous ability to enhance drug bioavailability and improve drug targeting. Importantly, they can also regulate the TME and deliver large or small therapeutic molecules to decrease the inhibitory effect of the TME on immune cells. Therefore, nanomedicine has great potential for reprogramming immunosuppressive microenvironments and represents a new immunotherapeutic strategy. Therefore, this article reviews strategies for improving the TME and summarizes research on synergistic nanomedicine approaches that enhance the efficacy of tumor immunotherapy.

关键词： Tumor immunotherapy Tumor micr oenvir onment Nanomedicine Tumor repr ogramming

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Three‑Dimensional Numerical Study on the Metal Rotating Spray Transfer Process of High‑Current GMAW

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Chinese Journal of Mechanical Engineering 2022年第6期35卷 234-246页

作者： Lei Xiao Ding fan Jiankang huang School of Materials Science and Engineering Lanzhou Jiaotong UniversityLanzhou 730070China State Key Laboratory of Advanced Processing and Recycling of Non‑ferrous Metals Lanzhou University of TechnologyLanzhou 730050China School of Materials Science and Engineering Lanzhou University of TechnologyLanzhou 730050China

A three-dimensional numerical model based on the volume-of-fluid(VOF)method is typically preferred for studying high-current gas metal arc welding(GMAW)metal transfer mechanism and then controlling it.It is informed that the rotating spray transfer is extremely complicated,and some researchers have focused on simplified models without considering the energy conservation to make analysis manageable for the unstable metal transfer process.Using our created numerical model,the metal transfer of high-current GMAW with shielding gas of different conductivities has been studied by analyzing acting forces and fluid flows in the metal liquid column,especially for the contributions of the self-induced electromagnetic force,equivalent volume force of the capillary pressure of the surface tension(Named surface tension force in this work),static arc pressure.It is found that the unbalanced electromagnetic force greatly promotes the metal rotating motion in 500 A metal inert gas(MIG)welding with pure argon shielding gas and it pushes the metal liquid column to rotate.Considering the arc constricting effect in active shielding gas by simply changing the arc conductivity,it is found that the metal liquid column no longer rotates,it turns to swing since the unbalanced electromagnetic force is large enough to break the rotating motion.The calculated results of the metal liquid column deflected angle and rotating/swing frequency agree well with the experiment of high-speed camera observations.

关键词： Gas metal arc welding Rotating spray transfer Three-dimensional model Electromagnetic force Surface tension

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An Agent-based Simulation Model of Wheat Market Operation:The Benefit of Support Price

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Journal of Systems Science and Systems Engineering 2022年第4期31卷 437-456页

作者： Jingsi huang fan Zhang Jie Song Wei Li Department of Economy and Management North China Electric Power UniversityBaoding071000China Department of Industrial Engineering and Management Peking UniversityBeijing100871China

Grain security is one of the most important issues worldwide.Many developing countries,including China,have adopted the Agriculture Support Price(ASP)program to stimulate farmers’enthusiasm for growing grain,to ensure self-sufficiency in grain and the stable development of the grain market.To propose decision support for the government in designing a more reasonable support price in the ASP program,we formulate an agent-based model to simulate the operation of the wheat market in the harvest period.To formulate the formation process of the market price influenced by farmers’expected sale price,processors’expected purchase price,and the ASP,the time series and regression methods are adopted.Based on the proposed market price model,to quantitatively analyze the grain transaction process and the ASP program’s impacts on market agents,we develop an agent-based simulation model to describe the adaptive evolution and interaction among market agents.Furthermore,we validate and implement the simulation model with public wheat market data.Finally,insights and suggestions about the decision of the ASP program are provided.

关键词： Agent-based simulation(ABS) wheat market agriculture support price decision support public policy

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Weakly Supervised Network with Scribble-Supervised and Edge-Mask for Road Extraction from High-Resolution Remote Sensing Images

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Computers, Materials & Continua 2024年第4期79卷 549-562页

作者： Supeng Yu Fen huang Chengcheng fan College of Artificial Intelligence Nanjing Agricultural UniversityNanjing210095China Innovation Academy for Microsatellites of CAS Shanghai201210China Shanghai Engineering Center for Microsatellites Shanghai201210China Key Laboratory of Satellite Digital Technology Shanghai201210China

Significant advancements have been achieved in road surface extraction based on high-resolution remote sensingimage processing. Most current methods rely on fully supervised learning, which necessitates enormous humaneffort to label the image. Within this field, other research endeavors utilize weakly supervised methods. Theseapproaches aim to reduce the expenses associated with annotation by leveraging sparsely annotated data, such asscribbles. This paper presents a novel technique called a weakly supervised network using scribble-supervised andedge-mask (WSSE-net). This network is a three-branch network architecture, whereby each branch is equippedwith a distinct decoder module dedicated to road extraction tasks. One of the branches is dedicated to generatingedge masks using edge detection algorithms and optimizing road edge details. The other two branches supervise themodel’s training by employing scribble labels and spreading scribble information throughout the image. To addressthe historical flaw that created pseudo-labels that are not updated with network training, we use mixup to blendprediction results dynamically and continually update new pseudo-labels to steer network training. Our solutiondemonstrates efficient operation by simultaneously considering both edge-mask aid and dynamic pseudo-labelsupport. The studies are conducted on three separate road datasets, which consist primarily of high-resolutionremote-sensing satellite photos and drone images. The experimental findings suggest that our methodologyperforms better than advanced scribble-supervised approaches and specific traditional fully supervised methods.

关键词： Semantic segmentation road extraction weakly supervised learning scribble supervision remote sensing image

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Multitarget Flexible Grasping Detection Method for Robots in Unstructured Environments

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Computer Modeling in Engineering & Sciences 2023年第11期137卷 1825-1848页

作者： Qingsong fan Qijie Rao Haisong huang Key Laboratory of Modern Manufacturing Technology Ministry of EducationGuizhou UniversityGuiyang550025China

In present-day industrial settings,where robot arms performtasks in an unstructured environment,theremay exist numerousobjects of various shapes scattered in randompositions,making it challenging for a robot armtoprecisely attain the ideal pose to grasp the object.To solve this problem,a multistage robotic arm flexible grasp detection method based on deep learning is proposed.This method first improves the Faster RCNN target detection model,which significantly improves the detection ability of the model for multiscale grasped objects in unstructured scenes.Then,a Squeeze-and-Excitation module is introduced to design a multitarget grasping pose generation network based on a deep convolutional neural network to generate a variety of graspable poses for grasped objects.Finally,a multiobjective IOU mixed area attitude evaluation algorithm is constructed to screen out the optimal grasping area of the grasped object and obtain the optimal grasping posture of the robotic arm.The experimental results show that the accuracy of the target detection network improved by the method proposed in this paper reaches 96.6%,the grasping frame accuracy of the grasping pose generation network reaches 94%and the flexible grasping task of the robotic arm in an unstructured scene in a real environment can be efficiently and accurately implemented.

关键词： Unstructured scene robot target detection grab pose detection deep learning

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Filter-cluster attention based recursive network for low-light enhancement

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Frontiers of Information Technology & Electronic Engineering 2023年第7期24卷 1028-1044页

作者： Zhixiong huang Jinjiang LI Zhen HUA Linwei fan School of Information and Electronic Engineering Shandong Technology and Business UniversityYantai 264005China Co-innovation Center of Shandong Colleges and Universities:Future Intelligent Computing Shandong Technology and Business UniversityYantai 264005China School of Computer Science and Technology Shandong Technology and Business UniversityYantai 264005China School of Computer Science and Technology Shandong University of Finance and EconomicsJinan 250014China

The poor quality of images recorded in low-light environments affects their further applications.To improve the visibility of low-light images,we propose a recurrent network based on filter-cluster attention(FCA),the main body of which consists of three units:difference concern,gate recurrent,and iterative residual.The network performs multi-stage recursive learning on low-light images,and then extracts deeper feature information.To compute more accurate dependence,we design a novel FCA that focuses on the saliency of feature channels.FCA and self-attention are used to highlight the low-light regions and important channels of the feature.We also design a dense connection pyramid(DenCP)to extract the color features of the low-light inversion image,to compensate for the loss of the image's color information.Experimental results on six public datasets show that our method has outstanding performance in subjective and quantitative comparisons.

关键词： Low-light enhancement Filter-cluster attention Dense connection pyramid Recursive network

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