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Circular RNAs:implications of signaling pathways and bioinformatics in human cancer

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Cancer Biology & Medicine 2023年第2期20卷 104-128页

作者： fan hu Yin Peng Xinmin fan Xiaojing Zhang Zhe Jin Guangdong Provincial Key Laboratory of Genome Stability and Disease Prevention and Regional Immunity and Diseases Department of PathologySchool of Basic Medical SciencesMedical SchoolShenzhen UniversityShenzhen 518060China

Circular RNAs(circRNAs)form a class of endogenous single-stranded RNA transcripts that are widely expressed in eukaryotic *** RNAs mediate post-transcriptional control of gene expression and have multiple functions in biological processes,such as transcriptional regulation and *** serve predominantly as microRNA sponges,RNA-binding proteins,and templates for *** importantly,circRNAs are involved in cancer progression,and may serve as promising biomarkers for tumor diagnosis and *** traditional experimental methods are usually time-consuming and laborious,substantial progress has been made in exploring potential circRNA-disease associations by using computational models,summarized signaling pathway data,and other ***,we review the biological characteristics and functions of circRNAs,including their roles in ***,we focus on the signaling pathways associated with carcinogenesis,and the status of circRNA-associated bioinformatics ***,we explore the potential roles of circRNAs as prognostic biomarkers in cancer.

关键词： circRNA cancer signaling pathway database bioinformatics

On Mutual Transform Between Number-Difference State and Phase State Corresponding to Operational Phase Operator

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Communications in Theoretical Physics 2005年第3X期44卷 537-540页

作者： fan Hong-Yi hu Hai-Peng Department of Material Science and Engineering University of Science and Technology of China Hefei 230026 China

In the mutual transform between the number-difference state and the phase state corresponding to the operational phase operator we find that there exists an end-point ambiguousness. This problem can be avoided by Ligh... 详细信息

关键词： operational phase operator phase state end-point ambiguousness

A Generalized Hankel Transformation Derived by Parametrized Entangled State Representations

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Communications in Theoretical Physics 2008年第7期50卷 85-88页

作者： fan Hong-Yi hu Li-Yun Department of Physics Shanghai Jiao Tong University Shanghai 200030 China

Using the parametrized entangled state representations we have found a generalized Hankel transformationwith the integral kernel being a combination of Bessel *** generalized Hankel transformation corresponds tothe ap... 详细信息

关键词： parametrized bipartite entangled state generalized Hankel transformation

Correction:Cognitive Impairment in Idiopathic Normal Pressure Hydrocephalus

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Neuroscience Bulletin 2022年第9期38卷 1121-1122页

作者： Haoyun Xiao fan hu Jing Ding Zheng Ye Institute of Neuroscience Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai200031China University of Chinese Academy of Sciences Beijing100049China Department of Neurosurgery Zhongshan HospitalFudan UniversityShanghai200032China Department of Neurology Zhongshan HospitalFudan UniversityShanghai200032China

Idiopathic normal pressure hydrocephalus (iNPH) is a significant cause of the severe cognitive decline in the elderly population. There is no cure for iNPH, but cognitive symptoms can be partially alleviated through cerebrospinal fluid (CSF) diversion. In the early stages of iNPH, cognitive deficits occur primarily in the executive functions and working memory supported by frontostriatal circuits. As the disease progresses, cognition declines continuously and globally, leading to poor quality of life and daily functioning. In this review, we present recent advances in understanding the neurobiological mechanisms of cognitive impairment in iNPH, focusing on (1) abnormal CSF dynamics, (2) dysfunction of frontostriatal and entorhinal-hippocampal circuits and the default mode network, (3) abnormal neuromodulation, and (4) the presence of amyloid-β and tau pathologies.

关键词： Idiopathic normal pressure hydrocephalus Cognitive impairment Cerebrospinal fluid dynamics Frontostriatal circuits Entorhinal-hippocampal circuits Neuromodulation Amyloid-β pathology Tau pathology

Impact crater recognition methods:A review

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Science China Earth Sciences 2024年第6期67卷 1719-1742页

作者： Dong CHEN fan hu Liqiang ZHANG Yunzhao WU Jianli DU Jiju PEETHAMBARAN College of Civil Engineering Nanjing Forestry UniversityNanjing 210037China Department of Geography State Key Laboratory of Remote Sensing ScienceFaculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China Key Laboratory of Space Object and Debris Observation Chinese Academy of SciencesNanjing 210023China Department of Mathematics and Computing Science Saint Mary’s UniversityHalifaxNS B3H 3C3Canada

Impact craters are formed due to the high-speed collisions between small to medium-sized celestial *** is the most significant driving force in the evolution of celestial bodies,and the impact craters provide crucial insights into the formation,evolution,and impact history of celestial *** this paper,we present a detailed review of the characteristics of impact craters,impact crater remote sensing data,recognition algorithms,and applications related to impact *** first provide a detailed description of the geometric texture,illumination,and morphology characteristics observed in remote sensing data of *** we summarize the remote sensing data and cataloging databases for the four terrestrial planets(i.e.,the Moon,Mars,Mercury,and Venus),as well as the impact craters on ***,we study the advancement achieved in the traditional methods,machine learning methods,and deep learning methods applied to the classification,segmentation,and recognition of impact ***,based on the analysis results,we discuss the existing challenges in impact crater recognition and suggest some ***,we explore the implementation of impact crater detection algorithms and provide a forward-looking perspective.

关键词： Terrestrial planets Deep space exploration Impact crater Impact crater recognition Deep learning

Multi-Level Max-Margin Analysis for Semantic Classification of Satellite Images

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Wuhan University Journal of Natural Sciences 2015年第1期20卷 47-54页

作者： hu fan XIA Gui-Song SUN Hong Electronic Information School Wuhan University State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing Wuhan University

The performance of scene classification of satellite images strongly relies on the discriminative power of the low-level and mid-level feature representation. This paper presents a novel approach, named multi-level max-margin analysis （M 3 DA） for semantic classification for high-resolution satellite images. In our M 3 DA model, the maximum entropy discrimination latent Dirichlet allocation （MedLDA） model is applied to learn the topic-level features first, and then based on a bag-of-words repre- sentation of low-level local image features, the large margin nearest neighbor （LMNN） classifier is used to optimize a multiple soft label composed of word-level features （generated by SVM classifier） and topic-level features. The categorization performances on 21-class land-use dataset have demonstrated that the proposed model in multi-level max-margin scheme can distinguish different categories of land-use scenes reasonably.

关键词： satellite image classification topic model maximum entropy discrimination latent Dirichlet allocation large margin nearest neighbor classifier multi-level max-margin

Decentralized State Estimation of Combined Heat and Power System Considering Communication Packet Loss

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Journal of Modern Power Systems and Clean Energy 2020年第4期8卷 646-656页

作者： Wenjian Zheng Zhigang Li Xinyu Liang Jiehui Zheng Q.H.Wu fan hu School of Electric Power Engineering South China University of TechnologyGuangzhou 510641China Guangzhou Power Supply Guangdong Power Grid Co.Ltd.Guangzhou 510000China

In order to obtain an accurate state estimation of the operation in the combined heat and power system,it is necessary to carry out state *** to the limited information sharing among various energy systems,it is practical to perform state estimation in a decentralized ***,the possible communication packet loss is seldomly considered among various energy *** paper bridges this gap by proposing a relaxed alternating direction method of multiplier *** can also improve the computation efficiency compared with the conventional alternating direction of the multiplier *** studies of two test systems are carried out to show the validity and superiority of the proposed algorithm.

关键词： Alternating direction of multiplier algorithm combined heat and power system communication packet loss decentralized optimization state estimation

Influence of age on prevalence rates of chronic complications of hospitalized aged patients with hypertension -- analysis of 17,682 cases

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Journal of Geriatric Cardiology 2009年第2期6卷 91-94页

作者： hua Cui Yixin hu Li fan Guoliang hu Wei Dai The second department of the Geriatric Cardiology Chinese PLA General Hospital Beijing 100853China

Objective To understand the relationship between age and chronic complications in hospitalized aged patients with hypertension, to provide evidence for hypertension prevention and control. Methods To retrospectively analyze the clinical and laboratory data on 17,682 patients with essential hypertension during Jan 1 s,, 1993-Dec 12th, 2008 in PLA general hospital. Results 1） Among all of the inrolled cases, those aged 60-64 account for 27.87%, 65-69 years group account for 26.55%, 70-74 years group accounted for 23.96%, 75-79 years group accounted for 14.14%, 80-84 years group accounted for 5.26%, 85-89 years group accounted for 1.69%, 〉 90 years accounted for 0.41%. 2） The prevalence rate of chronic complications in 60-69 years group were 31.3-31.2% for diabetes and,22.6-27.0% for cerebrovascular disease, 9.5-11.1% for myocardial infarction, 6.7-9.1% for heart failure, 5.8-6.0% for renal dysfanction 4.9-6.8% for atrial fibrillation, 0.1-0.3% for multiple organ dysfunction syndrome （MODS） in the elderly（P 〈0.05 ）. 3） The first four complications of hypertension were diabetes（33.5%）, cerebrovascular disease （31.9%）, myocardial infarction（13.2%） and heart failure（12.3%） in 70-74 years group （P〈0.05）, cerebrovascular disease （42.8%）, diabetes （32.8%）, heart failure （16.5%） and myocardial infarction（15.9%） in 75-79 years group （P〈0.05）, cerebrovascular disease （45.4%）, diabetes （35.0%）, heart failure （21.1%） and myocardial infarction（l 5.9%） in 80-84 years group （P〈0.05）, cerebrovascular disease（42.5%）, diabetes （35.8%）, heart failure （23.1%） and renal dysfanction （17.7%） in 85-89 years group（P〈0.05 ）,and cerebrovascular disease （45. 2%）, heart failure（31.5%） , diabetes （26.0%） and renal dysfanction （20.5%） in patients more than 90 years group （P〈0.05）. Conclusions The prevalence rate and kinds of chronic complications in hospitalized aged patients with hypertension were changed with the increasing age, and the first kind of complication is cerebrovascular disease. It is

关键词： Hypertension stroke myocardial infarction outcome

Review on research and development of oxy-coal burner for carbon capture

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Science China(Technological Sciences) 2024年第3期67卷 647-672页

作者： GUO JunJun LIU JingZhang ZHANG Tai hu fan LI PengFei LIU Zhaohui ZHENG ChuGuang State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and Technology Wuhan 430074China CCRC King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Kingdom of Saudi Arabia Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China National Key Laboratory of High Efficiency and Low Carbon Utilization of Coal Beijing 100049China Institute of Energy Research Jiangxi Academy of SciencesNanchang 330096China Carbon Neutrality Research Center of Jiangxi Province Nanchang 330096China Faculty of Engineering China University of Geosciences(Wuhan)Wuhan 430074China National Energy Research and Development Center of Clean and Low Carbon Coal-based Power Generation Technologies Wuhan 430074China

In the past two decades, the oxy-fuel combustion of pulverized coal has been extensively developed, leading to the completion of several large industrial pilot oxy-fuel plants worldwide. Various types of oxy-fuel burners have been designed and tested in largescale pilot plants as key components of oxy-fuel combustion. These burners face major challenges in terms of their flame stability because of their decreasing stream momentum ratio and increasing carbon dioxide concentration. However, it offers flexibility in adjusting the oxygen concentration in each burner stream. This study aims to provide a comprehensive review of the state-of-the-art knowledge on oxy-coal burner design and operation in power plants. First, the combustion characteristics under oxy-fuel conditions are briefly introduced. Subsequently, the principal requirements and fundamental parameters of the oxy-coal burners are discussed. The development process of oxy-fuel burners is also presented. Moreover, a compatible design strategy and scaling-up techniques are described for oxy-coal burners developed by the authors over the past ten years. The performances of oxy-coal burners in three large pilot oxy-fuel plants worldwide are summarized and compared. Finally, concluding remarks are provided and potential research needs are suggested.

关键词： carbon capture oxy-fuel combustion oxy-fuel burner pulverized coal compatible design