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蒲参胶囊致肝损伤

药物不良反应杂志 2024年第11期26卷 695-697页

作者：高荧凡纪琮李峥嵘山东省郯城县第一人民医院药学部郯城276199 临沂市人民医院药学部临沂276000

1例55岁女性患者体检发现三酰甘油水平升高,予蒲参胶囊4粒口服、3次/d。服药3 d后出现乏力、食欲减退、恶心呕吐,20 d后出现皮肤发黄伴瘙痒、深黄色尿液、白陶土样大便。实验室检查示丙氨酸转氨酶(ALT)1274 U/L,天冬氨酸转氨酶(AST)946 ... 详细信息

1例55岁女性患者体检发现三酰甘油水平升高,予蒲参胶囊4粒口服、3次/d。服药3 d后出现乏力、食欲减退、恶心呕吐,20 d后出现皮肤发黄伴瘙痒、深黄色尿液、白陶土样大便。实验室检查示丙氨酸转氨酶(ALT)1274 U/L,天冬氨酸转氨酶(AST)946 U/L,碱性磷酸酶(ALP)283 U/L,γ-谷氨酰转移酶(GGT)271 U/L,总胆红素(TBil)126μmol/L,直接胆红素(DBil)116μmol/L。排除病毒性肝炎、自身免疫性肝病、脂肪肝、肝硬化等因素后,诊断为药物性肝损伤,考虑与蒲参胶囊有关。停用蒲参胶囊,给予保肝降酶治疗。治疗28 d后患者上述症状明显好转,实验室检查示ALT 31 U/L,AST 38 U/L,ALP 98 U/L,GGT 110 U/L,TBil 17μmol/L,DBil 11μmol/L。查阅文献后考虑患者的肝损伤很可能与蒲参胶囊中的生何首乌有关。

关键词：中草药化学和药物性肝损伤蒲参胶囊

Soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

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Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： Andrew Gregory Chengyun Tang fan fan Department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug

Tackling the microlensing wave effects of strong lensing gravitational waves with TAAH

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 257-258页

作者： Zuhui fan South-Western Institute for Astronomy Research Yunnan University

The rapid development of gravitational wave（GW） observations since their first detection in 2015 [1] has opened a completely new window for exploring the Universe. Consequently, astronomical research has entered the multimessenger era, allowing us to use different tracers to view the cosmos from various perspectives. Among others, the appealing application of gravitational wave events from compact binary mergers is that they can act as standard sirens to determine absolute cosmic distances entirely independent of standard candles. This approach is one of the most promising means to solve the current H0tension problem.

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一种快速验证FPGA互连线连接正确性的方法

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电子与封装 2018年第4期18卷 30-32页

作者：范继聪惠锋徐彦峰胡凯中国电子科技集团公司第五十八研究所江苏无锡214072 无锡中微亿芯有限公司江苏无锡214072

随着FPGA规模的不断增大,互联线验证变得越来越困难。传统互连线验证采用功能仿真的方法,具有仿真速度慢、覆盖率低等不足。基于互连网络比对,设计了一种快速验证FPGA互连线连接正确性的方法。相对于功能仿真验证,该方法可以快速完成FPG... 详细信息

随着FPGA规模的不断增大,互联线验证变得越来越困难。传统互连线验证采用功能仿真的方法,具有仿真速度慢、覆盖率低等不足。基于互连网络比对,设计了一种快速验证FPGA互连线连接正确性的方法。相对于功能仿真验证,该方法可以快速完成FPGA互连线连接正确性的验证,覆盖率高达100%,在保证互连正确的前提下,极大地缩短了设计时间。

关键词： FPGA 互连线覆盖率

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一种改进型可配置逻辑块的结构设计

电子与封装 2022年第11期22卷 63-67页

作者：蔡宏瑞范继聪徐彦峰陈波寅无锡中微亿芯有限公司江苏无锡214072

可配置逻辑块(CLB)是FPGA中最重要的模块,其主要由查找表、选择器、触发器等子模块组成,可以通过配置来实现组合逻辑和时序逻辑,其性能直接影响到整个FPGA的表现。为了提高CLB的利用率和性能,提出了一种改进型的CLB结构。基于VPR平台对... 详细信息

可配置逻辑块(CLB)是FPGA中最重要的模块,其主要由查找表、选择器、触发器等子模块组成,可以通过配置来实现组合逻辑和时序逻辑,其性能直接影响到整个FPGA的表现。为了提高CLB的利用率和性能,提出了一种改进型的CLB结构。基于VPR平台对修改后的CLB结构进行架构建模,选用不同类型的基准电路测试了CLB结构对延时和面积等性能的影响。实验结果表明,改进后的结构在关键路径延时平均增大8.86%的前提下,所用CLB数量节省了24.88%,总面积减小了12.95%。且该结构能够在VPR中被正确描述与解析,测试结果对FPGA的结构设计与分析具有参考价值。

关键词：可配置逻辑块 FPGA 架构建模

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基于VPR的FPGA架构建模研究

电子与封装 2020年第12期20卷 44-47页

作者：蔡宏瑞范继聪徐彦峰闫华胡凯无锡中微亿芯有限公司江苏无锡214072 中国电子科技集团公司第五十八研究所江苏无锡214072

在FPGA设计过程中,架构建模评估为重要的一环。架构建模是指对于给定的特定类型FPGA,对其每一个子模块,例如可配置逻辑块、开关块、布线通道等,进行语言描述。将FPGA架构抽象化之后,计算机软件能基于建模文件提取参数和信息,做布局布线... 详细信息

在FPGA设计过程中,架构建模评估为重要的一环。架构建模是指对于给定的特定类型FPGA,对其每一个子模块,例如可配置逻辑块、开关块、布线通道等,进行语言描述。将FPGA架构抽象化之后,计算机软件能基于建模文件提取参数和信息,做布局布线分析。VPR为一个开源的布局布线工具。使用VPR工具进行试验,对于架构属性进行评估,根据评估的结果,能够得知在不同参数下的性能好坏,在实际运用中,对于不同的用户需求提供一个架构设定的方向。

关键词： FPGA 架构建模 VPR工具布局布线

Bandgap characteristics analysis and graded design of a novel metamaterial for flexural wave suppression

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 1-24页

作者： fan YANG Zhaoyang MA Xingming GUO Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering ScienceShanghai University Shanghai Institute of Aircraft Mechanics and Control

A novel elastic metamaterial is proposed with the aim of achieving lowfrequency broad bandgaps and bandgap regulation. The band structure of the proposed metamaterial is calculated based on the Floquet-Bloch theorem, and the boundary modes of each bandgap are analyzed to understand the effects of each component of the unit cell on the bandgap formation. It is found that the metamaterials with a low elastic modulus of ligaments can generate flexural wave bandgaps below 300 Hz. Multi-frequency vibrations can be suppressed through the selective manipulation of bandgaps. The dual-graded design of metamaterials that can significantly improve the bandgap width is proposed based on parametric studies. A new way that can regulate the bandgap is revealed by studying the graded elastic modulus in the substrate. The results demonstrate that the nonlinear gradient of the elastic modulus in the substrate offers better bandgap performance. Based on these analyses, the proposed elastic metamaterials can pave the way for multi-frequency vibration control, low-frequency bandgap broadening, and bandgap tuning.

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Dynamic behaviors of graphene platelets-reinforced metal foam piezoelectric beams with velocity feedback control

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 63-80页

作者： Jie CHEN Xinyue ZHANG Mingyang fan School of Mathematics Statistics and Mechanics Beijing University of Technology College of Mechanical & Energy Engineering Beijing University of Technology

Graphene platelets(GPLs)-reinforced metal foam structures enhance the mechanical properties while maintaining the lightweight characteristics of metal foams. Further bonding piezoelectric actuator and sensor layers on the surfaces of GPLs-reinforced metal foam beams enables active vibration control, greatly expanding their applications in the aerospace industry. For the first time, this paper investigates the vibration characteristics and active vibration control of GPLs-reinforced metal foam beams with surfacebonded piezoelectric layers. The constant velocity feedback scheme is used to design the closed-loop controller including piezoelectric actuators and sensors. The effects of the GPLs on the linear and nonlinear free vibrations of the beams are numerically *** Newmark-β method combined with Newton's iteration technique is used to calculate the nonlinear responses of the beams under different load forms including harmonic loads,impact loads, and moving loads. Additionally, special attention is given to the vibration reduction performance of the velocity feedback control on the responses of the beam.

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Effects of carbon content on the microstructure and tensile properties of a low-density steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 391-401页

作者： Yongxuan Shang Mingyu fan Shuyong Jiang Zhongwu Zhang Key Laboratory of Superlight Materials and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China State Key Laboratory of Metal Material for Marine Equipment and Application Iron&Steel Research Institute of Ansteel Group CorporationAnshan 114009China

Carbon can change the phase components of low-density steels and influence the mechanical *** this study,a new method to control the carbon content and avoid the formation ofδ-ferrite by decarburization treatment was *** microstructural changes and mechanical characteristics with carbon content induced by decarburization were systematically ***-Jaoul(C-J)analysis was employed to examine the work hardening characteristics during the tensile *** decarburization by heat treatments,the carbon content within the austenite phase decreased,while Mn and Al were almost unchanged;this made the steel with full austenite transform into the austenite and ferrite dual ***,(Ti,V)C carbides existed in both matrix phase and the mole fraction almost the *** addition,the formation of other carbides *** loss induced a decrease in strength due to the weakening of the carbon solid *** the steel with the single austinite,the deformation mode of austenite was the dislocation planar glide,resulting in the formation of *** the dual-phase steel,the deformation occurred by the dislocation planar glide of austenite first,with the increase in strain,the cross slip of ferrite took place,forming dislocation cells in *** the late stage of deformation,the work hardening of austinite increased rapidly,while that of ferrite increased slightly.

关键词： low-density steels carbon content decarburization strengthening mechanisms work hardening behavior