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Evaluation of inpatients Clostridium difficile prevalence and risk factors in Cameroon

Infectious Diseases of Poverty 2020年第4期9卷 172-172页

作者： Ingrid Cécile Djuikoue Ernest Tambo Gildas Tazemda Omer Njajou Denise Makoudjou Vanessa Sokeng Morelle Wandji Charlène Tomi Aubain Nanfack Audrey Dayomo Suzie Lacmago falubert tassadjo Raissa Talla Sipowo Caroline Kakam Aicha Bibiane Djoko Clement Nguedia Assob Antoine Andremont Frédéric Barbut Département de Microbiologie de la Facultédes Sciences de la Santéde l’Universitédes Montagnes BangangteCameroon Prevention and Control Foundation BangangteCameroon Medical Diagnostic Centerto Yaounde YaoundeCameroon Laboratoire de Bactériologie du Centre Pasteur du Cameroun YaoundeCameroon Faculty of Health Sciences University of BueaPO Box 63BueaSW RegionCameroon Faculty of Medicine Xavier-Bichat CampusUniversity of Paris VII–Denis DiderotParisFrance Faculty of Pharmacy Paris–University of Paris DescartesParisFrance

Background Clostridium difficile,rarely found in hospitals,is a bacterium responsible for post-antibiotic diarrhea and Pseudomembranous Colitis(CPM).*** selective pressure represents potential public health problem due to the production of toxins A and B serious pathologies effects/consequences.A transversal and analytic study was to assess the risk factors of *** infection and to determine the prevalence of *** in patients received in randomly selected five hospitals in Yaoundé,*** A total of 300 stool samples were collected from consented patients using a transversal and analytic study conducted from 10th July to 10th November 2018 in five hospitals in *** detection or diagnostic kit was CerTest *** Glutamate Dehydrogenase+Toxin A+Toxin B based on immuno-chromatographic assay.A univariate and multivariate analysis allowed us to highlight the associated *** The results showed a prevalence of *** of 27.33%(82/300 stool patients’samples taken).Of these 27.33%,the production of Toxin A and Toxin B were 37.80 and 7.31%*** univariate analysis,hospitalization was a significant(P=0.01)risk factor favoring *** *** multivariate analysis,corticosteroids and quinolones use/administration were significantly(adjusted Odd Ratio,aOR=14.09,95%CI:1.62–122.54,P=0.02 and aOR=3.39,95%CI:1.00–11.34,P=0.05 respectively)risk factor for this *** The prevalence of *** infections(CDI)remain high in these settings and may be related not only to permanent steroids and *** education to both medical staff and patients on the prevalence and public health impact of *** can be core inimproving rationale prescription of steroids and antibiotics to patients and promote human health and exponential growth in Cameroon.

关键词： Clostridium difficile Prevalence Diarrhea Risk factors Quinolone Cephalosporin Cameroon

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