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Vanishing bile duct syndrome in human immunodeficiency virus: Nevirapine hepatotoxicity revisited

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World Journal of Gastroenterology 2010年第26期16卷 3335-3338页

作者： Rajan Kochar Moises I Nevah Frank J Lukens Michael B fallon Victor I Machicao Division of Gastroenterology Hepatology and Nutrition The University of Texas Health Science Center at Houston Houston TX 77030 United States

Vanishing bile duct syndrome (VBDS) refers to a group of disorders characterized by prolonged cholestasis as a result of destruction and disappearance ofintrahepatic bile ducts. Multiple etiologies have been indentifi ed including infections, neoplastic disorders, autoimmune conditions and drugs. The natural history of this condition is variable and may involve resolution of cholestasis or progression with irreversible damage. VBDS is extremely rare in human immunodeficiency virus (HIV)-infected patients and anti-retroviral therapy has never been implicated as a cause. We encountered a young pregnant female with HIV and VBDS secondary to anti-retroviral therapy. Here, we report her clinical course and outcome.

关键词： Vanishing bile duct syndrome Ductopenia Acquired immune deficiency syndrome Cholangiopathy Cholestasis Drug-induced liver injury

为什么你在社交时会感到焦虑？该如何克服？（英文）

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英语画刊(高中版) 2023年第31期 3-5页

作者： fallon Goodman

在日常生活中,社交焦虑随时可能出现。这是为什么呢?在这场演讲中,心理学家法伦·古德曼深入探讨了我们的文化中对于社交焦虑存在的误区,以及我们该如何克服社交焦虑,在社交中展现出更自信、更真实的自己。

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金凯源中心

当代建筑 2023年第7期 100-109页

作者：无 Finbarr fallon(摄影) BIG建筑师事务所不详

金凯源中心是一座高280 m的“绿洲楼”,它延续了新加坡垂直都市的先锋理念,将餐厅、办公区、公寓和空中花园等一系列多元空间集合于这座51层的建筑中。该建筑已获得新加坡建筑管理局颁发的Green Mark铂金级认证及通用设计金级PLUS认证。

关键词：通用设计空中花园金凯多元空间办公区认证

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Cardiac papillary fibroelastoma:The need for a timely diagnosis

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World Journal of Clinical Cases 2017年第1期5卷 9-13页

作者： Srikanth Yandrapalli Bella Mehta Pratik Mondal Tanush Gupta Pallavi Khattar John fallon Randy Goldberg Sachin Sule Wilbert S Aronow Department of Internal Medicine New York Medical College at Westchester Medical Center Department of Pathology New York Medical College at Westchester Medical Center Department of Cardiology New York Medical College at Westchester Medical Center

Cardiac papillary fibroelastomas(CPFs) are the second most common primary cardiac tumors and the most common cardiac valvular tumors. Although they are histologically benign and usually asymptomatic, CPFs can lead to serious and life-threatening complications like myocardial infarction, stroke, pulmonary embolus, cardiac arrest etc. CPFs represent a rare entity in clinical medicine and literature regarding their management is limited. We report two cases which illustrate such complications arising from undiagnosed CPFs on the aortic valve. We further stress on the importance of identifying CPFs early so that they can be managed appropriately based on recommendations from the available literature.

关键词： Lambl’s excrescences Aortic valve Cardiac tumors Cardiac papillary fibroelastoma Sudden cardiac death

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撤离苏丹

财新周刊 2023年第17期 12-13页

作者： Patrick T.fallon 视觉中国

当地时间2023年4月24日,肯尼亚内罗毕,从苏丹撤离回国的肯尼亚公民抵达机场.苏丹武装部队与快速支援部队15日在喀土穆爆发武装冲突,后迅速蔓延拳其他各州。苏丹卫生部26日称,该国武装冲突已造成512人死亡,另有4193人受伤。据联合国难民... 详细信息

当地时间2023年4月24日,肯尼亚内罗毕,从苏丹撤离回国的肯尼亚公民抵达机场.苏丹武装部队与快速支援部队15日在喀土穆爆发武装冲突,后迅速蔓延拳其他各州。苏丹卫生部26日称,该国武装冲突已造成512人死亡,另有4193人受伤。据联合国难民署统计,已监测到近1.2万名来自苏丹的跨境难民。

关键词：武装冲突支援部队联合国难民署肯尼亚难民苏丹撤离

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“星舰”首飞

财新周刊 2023年第16期 12-13页

作者： Patrick T.fallon(图) 视觉中国

当地时间2023年4月20日,美国得克萨斯州,Spacex“星舰”在升空后爆炸。当日9时28分至10时30分之间,Spacex公司的重型火箭“星舰”再度迎来首飞的发射窗口。发射后火箭的最高时速一度达到2000公里;发射后3分48秒左右,一级助推器理应分离... 详细信息

当地时间2023年4月20日,美国得克萨斯州,Spacex“星舰”在升空后爆炸。当日9时28分至10时30分之间,Spacex公司的重型火箭“星舰”再度迎来首飞的发射窗口。发射后火箭的最高时速一度达到2000公里;发射后3分48秒左右,一级助推器理应分离但未能成功,在38000米左右的高空,火箭开始旋转下坠并最终爆炸。对此,太空探索技术公司创始人、首席执行官埃隆·马斯克表示,该公司会总结在此次测试中所学习到的,并在“几个月后进行下一次试射”。太空探索技术公司表示,该团队将审查数据并努力进行下一次发射尝试。

关键词：太空探索重型火箭发射窗口助推器公司创始人首飞首席执行官爆炸

Gender and racial differences in nonalcoholic fatty liver disease

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World Journal of Hepatology 2014年第5期6卷 274-283页

作者： Jen-Jung Pan Michael B fallon Division of Gastroenterology Hepatology and Nutrition Department of Internal Medicine The University of Texas Health Science Center at Houston Houston TX 77030 United States

Due to the worldwide epidemic of obesity, nonalcoholic fatty liver disease(NAFLD) has become the most com-mon cause of elevated liver enzymes. NAFLD represents a spectrum of liver injury ranging from simple steato-sis to nonalcoholic steatohepatitis(NASH) which may progress to advanced fibrosis and cirrhosis. Individuals with NAFLD, especially those with metabolic syndrome, have higher overall mortality, cardiovascular mortality, and liver-related mortality compared with the general population. According to the population-based studies, NAFLD and NASH are more prevalent in males and in Hispanics. Both the gender and racial ethnic differences in NAFLD and NASH are likely attributed to interaction between environmental, behavioral, and genetic fac-tors. Using genome-wide association studies, several genetic variants have been identified to be associated with NAFLD/NASH. However, these variants account for only a small amount of variation in hepatic steatosis among ethnic groups and may serve as modifiers of the natural history of NAFLD. Alternatively, these variants may not be the causative variants but simply markers representing a larger body of genetic variations. In this article, we provide a concise review of the gender and racial differences in the prevalence of NAFLD and NASHin adults. We also discuss the possible mechanisms for these disparities.

关键词： Nonalcoholic fatty liver disease Nonalcohol-ic steatohepatitis Race Gender Prevalence Genetic polymorphism

去旅游:中国旅游、酒店管理、活动项目管理教育

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旅游学刊 2015年第10期30卷 1-4页

作者： Fleur fallon 卢思琳中山大学旅游学院广东珠海519082

作为一个外国人，从2000年起，我就有着几段在中国居住的或长或短的经历，不仅有机会直接目睹中国旅游和活动项目管理的发展，还有机会看到中国高等教育部门的扩张以及第三产业关于旅游、酒店管理和活动项目管理学习研究的发展。这篇文... 详细信息

作为一个外国人，从2000年起，我就有着几段在中国居住的或长或短的经历，不仅有机会直接目睹中国旅游和活动项目管理的发展，还有机会看到中国高等教育部门的扩张以及第三产业关于旅游、酒店管理和活动项目管理学习研究的发展。这篇文章将会反映一些在旅游业、活动项目管理产业以及中国教育部门发展轨迹中的里程碑式的事件。

关键词：项目管理教育中国旅游酒店管理旅游人才培养中外比较旅游发展第三产业教育部门

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Hematological disorders and pulmonary hypertension

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World Journal of Cardiology 2016年第12期8卷 703-718页

作者： Rajamma Mathew Jing Huang Joseph M Wu John T fallon Michael H Gewitz Department of Physiology New York Medical College Section of Pediatric Cardiology New York Medical College Department of Biochemistry and Molecular Biology New York Medical College Department of Pathology New York Medical College

Pulmonary hypertension(PH),a serious disorder with a high morbidity and mortality rate,is known to occur in a number of unrelated systemic diseases.Several hematological disorders such as sickle cell disease,thalassemia and myeloproliferative diseases develop PH which worsens the prognosis.Associated oxidant injury and vascular inflammation cause endothelial damage and dysfunction.Pulmonary vascular endothelial damage/dysfunction is an early event in PH resulting in the loss of vascular reactivity,activation of proliferative and antiapoptotic pathways leading to vascular remodeling,elevated pulmonary artery pressure,right ventricular hypertrophy and premature death.Hemolysis observed in hematological disorders leads to free hemoglobin which rapidly scavenges nitric oxide(NO),limiting its bioavailability,and leading to endothelial dysfunction.In addition,hemolysis releases arginase into the circulation which converts L-arginine to ornithine,thus bypassing NO production.Furthermore,treatments for hematological disorders such as immunosuppressive therapy,splenectomy,bone marrow transplantation,and radiation have been shown to contribute to the development of PH.Recent studies have shown deregulated iron homeostasis in patients with cardiopulmonary diseases including pulmonary arterial hypertension(PAH).Several studies have reported low iron levels in patients with idiopathic PAH,and iron deficiency is an important risk factor.This article reviews PH associated with hematological disorders and its mechanism:and iron homeostasis and its relevance to PH.

关键词：贫血症溶血熨动态平衡 Myelofibrosis 肺的高血压