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Hormone replacement therapy decreases noradrenaline release in human myometrium

Hormone replacement therapy decreases noradrenaline release ...

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第十五届国际药理学大会

作者： Csonka Denes Kormanyos Zsolt Zupko Istvan falkay george Department of Pharmacodynamics and Biopharmacy University of Szeged Hungary. Department of Obstetrics and Gynecology University of Szeged Hungary. Department of Pharmacodynamics and Biopharmacy University of Szeged Hungary. Department of Pharmacodynamics and Biopharmacy University of Szeged Hungary.

＜正＞ Aim: The aim of the present study was to investigate the effect of hormone replacement therapy （HRT） on noradrenaline release profile of human myometrial tissue. Samples were collected from women with different hormonal status （regular cycle, postmenopause. receiving HRT）.Method: Samples were loaded with [3H] - noradrenaline and transferred into a chamber for superfusion after excision. After a wash- out period. 3 - min fractions were collected. In the 5th and 15th fraction tissues were stimulated with electric field. [3H] - noradrenaline content of the fractions was determined together with remaining amount in the tissue for fractional release calculation. Results: Myometrial [3H] - noradrenaline release and uptake was substantially decreased among patients in postmenopause and in patients who have received HRT compared to control group. These differences were more pronounced in HRT - treated patients than in postmenopausal patients.Conclusion: HRT decreases the noradrenaline content of myometrial neurons and their stimulus - evoked noradrenaline release. These results support previous findings that found HRT to inhibit sympathetic activity.

关键词： hormone replacement myometrium noradrenaline

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