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Influence of High-Speed Milling Process on Mechanical and Microstructural Properties of Ultrafine Grained Profiles Produced by Linear Flow Splitting

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Transactions of Nanjing University of Aeronautics and Astronautics 2017年第4期34卷 349-356页

作者： Abele Eberhard Müller Clemens Turan Emrah Niehuesbernd Joern Bruder Enrico falk Florian Institute of Production Management Technology and Machine Tools(PTW)Technische Universitt Darmstadt Physical Metallurgy(PhM) Technische Universitt Darmstadt

The effects of milling parameters on the surface quality,microstructures and mechanical properties of machined parts with ultrafine grained(UFG)gradient microstructures are *** effects of the cutting speed,feed per tooth,cutting tool geometry and cooling strategy are *** has been found that the surface quality of machined grooves can be improved by increasing the cutting ***,cryogenic cooling with CO_2 exhibits no significant improvement of surface *** and hardness investigations revealed similar microstructure and hardness variations near the machined groove walls for both utilized tool ***,cryogenic cooling can decrease more far-ranging hardness reductions due to high process temperatures,especially in the UFG regions of the machined parts,whilst it cannot prevent the drop in hardness directly at the groove walls.

关键词： high-speed milling ultrafine grained microstructure linear flow splitting hardness

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Liver transplantation for hepatocellular carcinoma- factors influencing outcome and disease-free survival

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World Journal of Gastroenterology 2015年第42期21卷 12071-12082页

作者： René Fahrner Felix Dondorf Michael Ardelt Yves Dittmar Utz Settmacher falk RauchfuB Department of General Visceral and Vascular Surgery Jena University Hospital

Hepatocellular carcinoma is one of the leading causes of cancer-related death worldwide. Liver transplantation can be a curative treatment in selected patients. However, there are several factors that influence disease-free survival after transplantation. This review addresses the pre-, intra- and postoperative factors that influence the risk of tumor recurrence after liver transplantation.

关键词： Hepatocellular carcinoma Survival Risk factor Diagnostics Recurrence Liver transplantation

Pathogen detection in patients with perihilar cholangiocarcinoma:Implications for targeted perioperative antibiotic therapy

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Hepatobiliary & Pancreatic Diseases International 2023年第5期22卷 512-518页

作者： Felix Dondorf Maximilian Graf Aladdin Ali Deeb Oliver Rohland Philipp Felgendreff Michael Ardelt Utz Settmacher falk Rauchfuss Department of General Visceral and Vascular SurgeryJena University HospitalJena 07747Germany Research Program"Else Kröner-Forschungskolleg AntiAge" Jena University HospitalJena 07747Germany

Background:Cholestasis should be relieved by biliary drainage prior to major liver *** condition is often associated with bacterial colonization of the otherwise sterile biliary *** reduces the regenerative capacity of the remaining ***,targeted antibiotic therapy is a key feature in perioperative treatment in patients with perihilar cholangiocarcinoma(pCCC).Methods:Between December 1999 and December 2017,251 pCCC patients were treated in our *** total,115 patients underwent a microbiological *** addition to the characterization of the specific microorganisms and antibiotic resistance,we analyzed subgroups according to preoperative ***:Enterococci(87/254,34%)and Enterobacteria(65/254,26%)were the most frequently detected *** 43%(50/115)of patients,Enterococcus faecalis was found in the bile duct *** faecium(29/115)and Escherichia coli(29/115)were detected in 25%of *** patients with percutaneous transhepatic biliary drainage(3/8,38%)or stents(24/79,30%),Enterococcus faecium was diagnosed most frequently(P<0.05).Enterococcus faecium and Klebsiella oxytoca were significantly more frequently noted in the time period after 2012(P<0.05).With regard to fungal colonization,the focus was on various Candida strains,but these strains generally lacked ***:pCCC patients exhibit specific bacterial colonization features depending on the type of preoperative biliary ***,targeted antibiosis should be applied in this patient cohort to minimize the risk of biliary complications after major liver *** our cohort,the combination of meropenem and vancomycin represents an effective perioperative medical approach.

关键词： Perihilar cholangiocarcinoma Klatskin tumor Cholangitis Targeted antibiotic therapy Biliary drainage

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基于眼动跟踪技术的界面可用性评估

东南大学学报（自然科学版） 2010年第2期40卷 331-334页

作者：刘青薛澄岐 falk Hoehn 东南大学机械工程学院南京211189 Industrial Design Department Fachhochschule Hannover

为解决因界面而造成的整体系统效率低下的问题,以认知学为理论基础,提出将眼动跟踪技术运用于界面可用性检测.首先讨论了眼动跟踪设备的优势与技术原理,然后以德国汉堡城市轻轨U4线站台界面的交互设计为例,描述眼动跟踪实验的流程.最后... 详细信息

为解决因界面而造成的整体系统效率低下的问题,以认知学为理论基础,提出将眼动跟踪技术运用于界面可用性检测.首先讨论了眼动跟踪设备的优势与技术原理,然后以德国汉堡城市轻轨U4线站台界面的交互设计为例,描述眼动跟踪实验的流程.最后从眼动路径、热度、信息量、任务用时和注视频率等方面对新旧界面进行实验,以定量实验方法评估新旧界面的优劣.实验结果分析比较表明:新界面的各项实验检测数据都明显优于旧界面,更符合用户的需求和认知习惯;同时,眼动跟踪实验的可靠性高,数据结果比较精确,适合进一步推广应用,并为后续航电系统界面设计研究工作提供了一种有效的评估方法.

关键词：眼动跟踪定量分析视觉轨迹人机界面

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Oesophageal adenocarcinoma:In the era of extended lymphadenectomy,is the value of neoadjuvant therapy being attenuated?

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World Journal of Gastrointestinal Surgery 2021年第10期13卷 1235-1244页

作者： Jin-Soo Park Hans Van der Wall Catherine Kennedy Gregory L falk Upper GI Surgery Concord Repatriation General HospitalSydney 2137NSWAustralia Department of Medicine University of Notre DameSydney 2007NSWAustralia CNI Molecular Imaging Notre Dame UniversitySydney 2114NSWAustralia

BACKGROUND Neoadjuvant chemotherapy(NACT)and oesophagectomy is the standard of care for resectable oesophageal *** outcomes following resection have been improving over time while NACT remain largely ***,a recent meta-analysis of randomized control trials did not demonstrate a survival benefit in adding NACT,raising the possibility that improved surgical techniques may be reducing the perceived effectiveness of *** To compare the effect of addition of NACT to a standardized surgery and lymphadenectomy on overall and disease-free survival in patients undergoing curative oesophagectomy for oesophageal *** Patient data were analysed from a prospectively maintained surgical survival ***,surgical,and survival outcomes were compared between groups according to treatment and nodal *** The data of 243 consecutive patients were identified.79 patients were given NACT and 162 had surgery *** NACT group were younger,and there was less frequent stage I *** survival was similar between NACT and surgery only groups(5YS:48.7%vs 42.5%;P=0.113),as was diseasefree survival(5YS:40.6%vs 39.9%;P=0.635).There were≥30 nodes removed in 46 patients,and<30 in 197 patients,but were otherwise *** was improved survival in patients with≥30 nodes removed than those with<30 nodes(5YS:64.4%vs 40.7%;P=0.015),and a better disease-free survival that neared significance(5YS:54.9%vs 36.6%;P=0.078).CONCLUSION NACT did not appear to affect overall or disease-free ***,an overall survival benefit was observed in patients with≥30 lymph nodes removed,and a benefit in disease-free survival which was not significant.

关键词： Oesophagectomy Oesophageal adenocarcinoma Neoadjuvant chemotherapy Lymphadenectomy Survival outcome Surgical technique

Robotic surgery of the pancreas

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World Journal of Gastroenterology 2014年第40期20卷 14726-14732页

作者： Daniel Joyce Gareth Morris-Stiff Gavin A falk Kevin El-Hayek Sricharan Chalikonda R Matthew Walsh Department of General Surgery Digestive Disease Institute Cleveland Clinic Cleveland OH 44195 United States

Pancreatic surgery is one of the most challenging and complex fields in general *** minimally invasive surgery has become the standard of care for many intra-abdominal pathologies the overwhelming majority of pancreatic surgery is performed in an open *** is attributed to the retroperitoneal location of the pancreas,its intimate relationship to major vasculature and the complexity of reconstruction in the case of ***,we describe the application of robotic technology to minimally invasive pancreatic *** unique capabilities of the robotic platform have made the minimally invasive approach feasible and safe with equivalent if not better outcomes(e.g.,decreased length of stay,less surgical site infections)to conventional open ***,it is unclear whether the robotic approach is truly superior to traditional laparoscopy;this is a key point given the substantial costs associated with procuring and maintaining robotic capabilities.

关键词： Robotic surgery Pancreatoduodenectomy Pancreatectomy Minimally invasive surgery Pancreatic cancer

Spatially resolved transcriptomics in immersive environments

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Visual Computing for Industry,Biomedicine,and Art 2022年第1期5卷 12-24页

作者： Denis Bienroth Hieu TNim Dimitar Garkov Karsten Klein Sabrina Jaeger-Honz Mirana Ramialison falk Schreiber Department of Computer and Information Science University of KonstanzKonstanzGermany Cell Biology Murdoch Children’s Research InstituteParkvilleMelbourneVICAustralia Australian Regenerative Medicine Institute Monash UniversityClaytonMelbourneVICAustralia Systems Biology Institute Australia ClaytonMelbourneVICAustralia Faculty of Information Technologies Monash UniversityMelbourneAustralia

Spatially resolved transcriptomics is an emerging class of high-throughput technologies that enable biologists to systematically investigate the expression of genes along with spatial *** data acquisition,one major hurdle is the subsequent interpretation and visualization of the datasets *** address this challenge,VR-Cardiomics is presented,which is a novel data visualization system with interactive functionalities designed to help biologists interpret spatially resolved transcriptomic *** implementing the system in two separate immersive environments,fish tank virtual reality(FTVR)and head-mounted display virtual reality(HMD-VR),biologists can interact with the data in novel ways not previously possible,such as visually exploring the gene expression patterns of an organ,and comparing genes based on their 3D expression ***,a biologist-driven use-case is presented,in which immersive environments facilitate biologists to explore and compare the heart expression profiles of different genes.

关键词： Spatially-resolved transcriptomics Spatial transcriptomics Virtual reality Fish tank virtual reality Head-mounted display Immersive analytics Immersive environment

Adipose tissue induces a better liver regeneration after living liver donation in normal weight donors

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Hepatobiliary Surgery and Nutrition 2023年第3期12卷 341-350页

作者： Aladdin Ali Deeb Utz Settmacher Michael Ardelt Felix Dondorf Oliver Rohland falk Rauchfuß Department of General Visceral and Vascular SurgeryJena University HospitalJenaGermany

Background:Extrahepatic body fat could be a relevant factor affecting liver regeneration after partial *** aim of this study was to evaluate the potential role of body fatty tissue in liver regeneration capacity after liver resection in a cohort of living ***:We observed liver regeneration in 120 patients:70 living donors who underwent right hepatectomy and 50 recipients who got a right graft *** volumetry and body fat analysis were performed based on the computed tomography images with volumetry *** gain of liver volume was calculated between three points in time considering the absolute and percentage values:before surgery and early(median 10 days,range 4-21 days)and late(median 27 weeks,range 18-40 weeks)after ***’s correlation was used to examine the potential correlation between adipose tissue and liver ***:Pearson’s correlation showed a significant correlation between the subcutaneous fat mass index(sFMI)and early(r=0.173,P=0.030),as well late(r=0.395,P=0.0004)percental liver volume gain in the whole *** stratification in donor’s and recipient’s collectives,the effect of extrahepatic adipose tissue appears in multiple regression only in the donor’s collective:early(β=0.219,T=2.137,P=0.036)and late(β=0.390,T=2.552,P=0.015)percental volume ***:Subcutaneous adipose tissue is a positive predictive factor to estimate the goodness of liver regeneration after partial hepatectomy in normosthenic donors.

关键词： Partial hepatectomy fat mass index living donation liver transplantation

Data Mining and Machine Learning Methods Applied to A Numerical Clinching Model

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Computer Modeling in Engineering & Sciences 2018年第12期117卷 387-423页

作者： Marco Gotz Ferenc Leichsenring Thomas Kropp Peter Müller Tobias falk Wolfgang Graf Michael Kaliske Welf-Guntram Drossel Institute for Structural Analysis Technische UniversitatDresdenGermany Fraunhofer Institute for Machine Tools and Forming Technology DresdenGermany

Numerical mechanical models used for design of structures and processes are very complex and high-dimensionally *** understanding of the model characteristics is of interest for engineering tasks and subsequently for an efficient *** analysis methods are known and available to gain insight into existing *** this contribution,selected methods from various fields are applied to a real world mechanical engineering example of a currently developed clinching *** selection of introduced methods comprises techniques of machine learning and data mining,in which the utilization is aiming at a decreased numerical *** methods of choice are basically discussed and references are given as well as challenges in the context of meta-modelling and sensitivities are *** incremental knowledge gain is provided by a step-bystep application of the numerical methods,whereas resulting consequences for further applications are ***,a visualisation method aiming at an easy design guideline is *** visual decision maps incorporate the uncertainty coming from the reduction of dimensionality and can be applied in early stage of design.

关键词： Design data mining computational intelligence meta-modelling permissible design space sensitivity analysis self-organizing maps inverse problem early stage of design clinching