检索结果-南通市图书馆

Optimal therapy for HIV infection containment and virions inhibition

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Disease Modelling 2024年第1期9卷 10-26页

作者： Paolo Di Giamberardino daniela Iacoviello Muhammad Zubair Dept.of Computer Control and Management EngineeringSapienzaUniversity of RomeVia Ariosto 2500185RomeItaly

Prevention and early diagnosis are the best and most effective ways for defeating *** is still no vaccine,but treatments with antiretroviral drugs are now available which,in many cases,allow the infection to become ***,research has highlighted side effects of these drugs and the fact that a flare-up of the infection occurs if the therapy is *** recent years,the presence of virus reserves located in various parts of the body,including the brain,has been *** possibility of controlling the infection of healthy cells and of interrupting the proliferation of virions inside the brain has been studied,proposing optimal control strategies.

关键词： Epidemic modeling HIV-AIDS Optimal control

Litter production and leaf nutrient concentration and remobilization in response to climate seasonality in the central Amazon

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2024年第3期35卷 131-141页

作者： Ricardo Antonio Marenco Saul Alfredo Antezana-Vera daniela Pereira Dias Luiz Antonio Candido Instituto Nacional de Pesquisas da Amazonia Coordenagao de Uso da Terra e Mudanca ClimaticaAv.Andre Araujo 2936ManausAM69067-375Brazil Programa de pos-Graduagao em Agricultura no Tropico Umido Instituto Nacional de Pesquisas da Amazonia-INPAManausAMBrazil Unidade Academica de Ciencias Agrarias Universidade Federal de JataiBR 364km 195JataiGO 75801-615Brazil

Litterfall is the largest source of nutrients to for-est soils of tropical ***,variability in lit-terfall production,nutrient remobilization,and changes in leaf nutrient concentration with climate seasonality remain largely unknown for the central *** study meas-ured litterfall production,leaf nutrient remobilization,and leaf area index on a forest plateau in the central *** was measured at monthly intervals during 2014,while nitrogen,phosphorus,potassium,calcium and mag-nesium concentrations of leaf litter and canopy leaves were measured in the dry and rainy seasons,and remobilization rates *** area index was also recorded in the dry and rainy *** litterfall varied from 33.2(in the rainy season)to 87.6 g m^(-2) in the dry season,while leaf area index increased slightly in the rainy *** seasonality had no effect on concentrations of nitrogen,calcium,and magnesium,whereas phosphorous and potassium responded to rainfall seasonality *** phosphorous increased,potassium decreased during the dry *** seasons,nitrogen,potassium,and phosphorous decreased in leaf litter;calcium increased in leaf litter,while magnesium remained unaffected with leaf ***,the five nutrients had similar remobilization rates over the *** absence of climate seasonality on nutrient remobilization suggests that the current length of the dry season does not alter nutrient remobilization rates but this may change as dry periods become more prolonged in the future due to climate change.

关键词： Throughfall Nutrient cycling Climatic seasonality Leaf mass per area

Unusual presentation of metastatic adenocarcinoma of the lung

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2016年第7期6卷 630-632页

作者： Blerina Resuli Roberto Lisi daniela Musio Vincenzo Tombolini Department of Radiation Oncology Poyiclinic Umberto I "Sapienza" University

On September 2013, a 62-year-old man with metastatic adenocarcinoma of the lung complained tenderness and pain of the first terminal phalange of his right hand. The biopsy confirmed metastatic adenocarcinoma of the lung to the finger. A single 8-Gy fraction of palliative radiotherapy was delivered to the patient's right hand. The patient received magnetic resonance-guided focused ultrasound surgery treatment to the phalange because he showed few improvement of clinical symptoms and persistence of moderate pain after radiotherapy. After magnetic resonance-guided focused ultrasound surgery, the clinical symptoms improved significantly. No serious adverse effects were reported and the patient compliance was very high. Our patient showed improvement of clinical symptoms after combined treatment. The patient remains in good health conditions.

关键词： Adenocarcinoma of the lung Radiation therapy Phalange metastasis Combined treatment

Stakeholders’power in the networking structuration processes of the urban resilience concept in Habitat III agenda(2012-2016)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geography and Sustainability 2022年第1期3卷 46-57页

作者： daniela Mariño Céline Rozenblat Institute of Geography and Sustainability Faculty of GeosciencesUniversity of LausanneLausanne 1015Switzerland

The urban resilience concept was introduced in 2016 as a key concept in the Habitat III New Urban Agenda for the next 20 *** wonder how this urban resilience concept was elaborated and who influenced it the most?The preparatory events structured several stakeholders’*** relations between stakeholders allowed the flow of ideas in the consultation and production *** influential stakeholders strongly oriented definition of urban resilience concepts by taking power in the networking process of the consecutive *** paper analyzes the network of stakeholders/concepts,during the building process between 2012 and 2016(5,539 discourses from 290 stakeholders,in 357 events).The application of textual mining and machine learning topic modelling algorithm exposed the structure of the principal topics for building the concept of urban resilience,and presented how relations of main stakeholders with funders was crucial for the investment in policy ***,we underlined for the first time in an empirical way,different kinds of actors’power in the construction process that supported the Habitat III resilience *** demonstrated how far some official stakeholders,but also external and private ones,oriented the construction of ideologies to validate the knowledge that supported the related actions in laboratory cities.

关键词： Urban resilience Cities Habitat III Urban agenda Networks of power Global

Rectal perforation from endometriosis in pregnancy:Case report and literature review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第5期16卷 648-651页

作者： Adolfo Pisanu daniela Deplano Stefano Angioni Rossano Ambu Alessandro Uccheddu Department of Surgery Clinica ChirurgicaUniversity of CagliariOspedale San Giovanni di DioVia Ospedale 4609124CagliariItaly Department of Obstetrics and Gynecology University of CagliariOspedale San Giovanni di DioVia Ospedale 4609124CagliariItaly Department of Pathology University ofCagliariOspedale San Giovanni di DioVia Ospedale 4609124CagliariItaly

This case report describes a woman with spontaneous rectal perforation from decidualized endometriosis in pregnancy.A 37-year-old woman was admitted to our hospital at 30 wk of pregnancy with symptoms suggestive of pyelonephritis,which persisted until 33 wk of gestation when delivery of a premature male baby was performed through a cesarean section. On postoperative day 2,an abdominal computed tomography showed free air in the peritoneal cavity and a pelvic *** celiotomy revealed a diffuse severe fecaloid peritonitis that originated from a 3-cm wide rectal perforation.A Hartmann operation was then *** findings wereconsistent with decidualization of the rectal *** 20 cases of intestinal perforation due to endometriosis have been reported in the *** report is believed to be the first case of spontaneous rectal perforation from endometriosis in pregnancy,and it shows the potential occurrence of serious and unexpected complications of the disease.

关键词： Endometriosis Colonic perforation Acute abdomen Peritonitis Pregnancy

Pancreatic cancer stem cells:Perspectives on potential therapeutic approaches of pancreatic ductal adenocarcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2018年第11期10卷 172-182页

作者： Claudia Di Carlo Jessica Brandi daniela Cecconi Department of Biotechnology Proteomics and Mass Spectrometry Laboratory University of Verona

Pancreatic ductal adenocarcinoma is one of the most aggressive solid tumours of the pancreas, characterised by a fve-year survival rate less than 8%. Recent reports that pancreatic cancer stem cells （PCSCs） contribute to the tumorigenesis, progression, and chemoresistance of pancreatic cancer have prompted the investigation of new therapeutic approaches able to directly target PCSCs. In the present paper the non-cancer related drugs that have been proposed to target CSCs that could potentially combat pancreatic cancer are revi-ewed and evaluated. The role of some pathways and deregulated proteins in PCSCs as new therapeutic tar-gets are also discussed with a focus on selected speci-fic inhibitors. Finally, advances in the development of nanoparticles for targeting PCSCs and site-specifc drug delivery are highlighted, and their limitations considered.

关键词： Pancreatic cancer stem cells Pancreatic cancer Therapeutic approaches Pancreas Treatment

X-linked Toll-like receptor 7 polymorphism associated with susceptibility to Chikungunya Fever

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2019年第3期12卷 137-141页

作者： daniela M.Rauseo Mercedes Fernández-Mestre Laboratorio de Fisiopatología Centro de Medicina ExperimentalIVIC

Objective: To investigate the association between TLR3 and TLR7 polymorphisms with susceptibility and clinical manifestations of Chikungunya ***: A total of 177 individuals were studied: 73 patients with a confirmed diagnosis for Chikungunya virus and 104 non-infected individuals. Polymorphisms were determined by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism(PCR-RFLP).Results: Our analysis showed an increased CC genotype frequency of the TLR7 rs3853839 polymorphism in male patients compared to control(29% versus 2%,respectively; OR=20.69; 95% CI=2.55-167.36; P<0.001). Furthermore,arthritis(acute and chronic) was frequently found in CC male patients. On the contrary,65% of CG carriers were no-infected males(29% versus 65%,respectively; OR=0.23,95% CI=0.48-3.04; P=0.002). Finally,we observed a higher frequency of lymphopenia in CG male patients(CG=666.86±233.77,GG=1,314.27±752.29 cells/mm3,P=0.047). Conclusions: Our results suggest the TLR7 rs3853839 polymorphism is associated with lymphopenia and increased susceptibility to Chikungunya Fever in males.

关键词： Chikungunya Fever Toll-like-receptors Single-nucleotide polymorphisms Disease susceptibility

Use of DREAM to assess relative risks of presence of pharmaceuticals and personal care products from a wastewater treatment plant

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2024年第9期18卷 91-104页

作者： daniela M.Pampanin Daniel Schlenk Matteo Vitale Pierre Liboureau Magne O Sydnes Department of Chemistry Bioscience and Environmental EngineeringUniversity of StavangerStavanger 224021Norway Department of Environmental Sciences University of California RiversideRiversideCA 92521USA

Concerns related to environmental risks associated with pharmaceuticals and personal care products(PPCPs)have led researchers to seek methods for assessing and monitoring these contaminants in the aquatic *** and validating risk assessment tools that can evaluate ecological concerns and risks associated with PPCPs is ***,the suitability of a dose-related risk and effect assessment model,which estimates predicted environmental concentrations and allowed comparisons with predicted no effect concentrations determined,in combination with in vitro analyses of the whole effluent toxicity,was verified for the characterization of a PPCP *** of the most utilized PPCPs in Norway were measured in influent and effluent samples and used to parameterize the fate *** than 90%removal was attained for 12 out of 22 detected *** was not dependent on the class or the concentration of the specific substance and varied between 12%and 100%.The PPCPs detected in the discharged wastewater were utilized to assess individual contributions to the risk of the effluent,and no risk was identified for the targeted 30 *** simulations provided valuable information regarding the discharge plume distribution over time,which can aid planning of future environmental monitoring ***(using fish liver cells,PLHC-1)were used for assessing overall effluent toxicity,through cell viability,production of reactive oxygen species,and ethoxyresorufin-O-deethylase(EROD)*** present study may allow regulators to use risk-based strategies over removal criteria for monitoring studies and confirms the importance to take PPCP contamination into consideration when establishing environmental regulations.

关键词： Pharmaceuticals Wastewater effluent Ciprofloxacin Metoprolol Amitriptyline Carbamazepine Modelling Risk assessment Monitoring

Outcomes after combined excisional goniotomy and manual small incision cataract surgery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2022年第10期15卷 1707-1713页

作者： daniela Alvarez-Ascencio Gabriel Lazcano-Gomez Malik Y Kahook Department of Glaucoma Asociación Para Evitar la Ceguera en México(APEC)Mexico City 04030Mexico Department of Ophthalmology University of Colorado School of MedicineAuroraColorado 80145United States

AIM: To report the long-term outcomes of combined excisional goniotomy and manual small incision cataract surgery(MSICS).METHODS: This is a retrospective case series of patients with open angle glaucoma and visually significant cataracts that underwent combined excisional goniotomy and MSICS with one-year follow-up. The medical history, demographic information, and clinical characteristics of each case were recorded. Data regarding changes in vision, intraocular pressure(IOP), the number of glaucoma medications, and the evolution of the disease after surgery were reported. RESULTS: Three patients, with open angle glaucoma and cataracts underwent combined excisional goniotomy and MSICS without adverse events. All patients had improvement in vision compared to baseline measurements. The range of IOP at baseline was from 14 to 18 mm Hg and decrease to a range of 10 to 14 mm Hg after one year of follow-up. Additionally, two patients also decreased their dependence on IOP-lowering medications at the last follow up visit with one patient maintaining baseline level of medication ***: A combination of excisional goniotomy and MSICS illustrates both the safety and efficacy to treat patients with visually significant cataract and glaucoma. This procedure allows for a more cost-effective surgical approach that matches the needs of resource strained territories around the globe.

关键词： excisional goniotomy microincisional glaucoma surgery manual small incision cataract surgery Kahook Dual Blade