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Open Journal of Pediatrics 2021年第4期11卷 777-785页

作者： Matei Mselle Aisa Shayo Ronald Mbwasi faith mosha Jeremia Pyuza Philip Mrindoko Nyemo Peter Elton Meleki Elise Kimambo Arnold Likiliwike Lucy Frisch Magreth Swai Zaituni Hatibu Ally Iman Beatrice Maringo Linda Kissila Ikupa Minga Deborah Mchaile Department of Paediatrics and Child Health Kilimanjaro Christian Medical University College Moshi Tanzania Department of Paediatrics and Child Health Kilimanjaro Christian Medical Centre Moshi Tanzania Department of Clinical Laboratory Kilimanjaro Christian Medical Centre Moshi Tanzania

Background: Hypertriglyceridemia in children means increased plasma fasting Triglyceride levels above the 95th percentile for age and sex. For children aged 0 to 9 years, a triglyceride level greater than or equal to 100 mg/dl is considered above the 95th percentile. Hypertriglyceridemia can be mild to borderline high, moderate to high, very high, severe and very severe (>2000 mg/dl). We present the case of a 1 month and 3 weeks old baby who presented with difficulty in breathing. It was accidentally found to have strawberry yoghurt like blood during phlebotomy, of which upon investigation had very high triglyceride levels of >2000 mg/dl. Case Presentation: 1 month and 3 weeks old female baby, admitted as referral from nearby health centre presenting with difficulty in breath, her blood sample was incidentally found to appear as strawberry yoghurt like. Clinically the infant had features suggestive of respiratory distress, with no other systemic abnormalities noted. Chest X-ray that was don

关键词： Strawberry Yoghurt Like Blood Hypertriglyceridemia Tanzania

Multi‑omics integration identifies regulatory factors underlying bovine subclinical mastitis

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Journal of Animal Science and Biotechnology 2024年第3期15卷 987-1007页

作者： Mengqi Wang Naisu Yang Mario Laterriere David Gagne faith Omonijo Eveline M.Ibeagha‑Awemu Agriculture and Agri‑Food Canada Sherbrooke Research and Development CentreSherbrookeQCCanada Department of Animal Science Universite LavalQuebec CityQCCanada Quebec Research and Development Centre Agriculture and Agri-Food CanadaQuebec CityQCCanada

Background Mastitis caused by multiple factors remains one of the most common and costly disease of the dairy ***-omics approaches enable the comprehensive investigation of the complex interactions between mul-tiple layers of information to provide a more holistic view of disease ***,this study investigated the genomic and epigenomic signatures and the possible regulatory mechanisms underlying subclinical mastitis by integrating RNA sequencing data(mRNA and lncRNA),small RNA sequencing data(miRNA)and DNA methylation sequencing data of milk somatic cells from 10 healthy cows and 20 cows with naturally occurring subclinical mastitis caused by Staphylococcus aureus or Staphylococcus *** Functional investigation of the data sets through gene set analysis uncovered 3458 biological process GO terms and 170 KEGG pathways with altered activities during subclinical mastitis,provided further insights into subclin-ical mastitis and revealed the involvement of multi-omics signatures in the altered immune responses and impaired mammary gland productivity during subclinical *** abundant genomic and epigenomic signatures with sig-nificant alterations related to subclinical mastitis were observed,including 30,846,2552,1276 and 57 differential methylation haplotype blocks(dMHBs),differentially expressed genes(DEGs),lncRNAs(DELs)and miRNAs(DEMs),***,5 factors presenting the principal variation of differential multi-omics signatures were *** important roles of Factor 1(DEG,DEM and DEL)and Factor 2(dMHB and DEM),in the regulation of immune defense and impaired mammary gland functions during subclinical mastitis were *** of the omics within Factors 1 and 2 explained about 20%of the source of variation in subclinical ***,networks of impor-tant functional gene sets with the involvement of multi-omics signatures were demonstrated,which contributed to a comprehensive view of the possible regu

关键词： Candidate discriminant multi-omics signature Gene Long non-coding RNA Methylation haplotype block MicroRNA Multi-omics integration Natural killer cell mediated cytotoxicity pathway Staphylococcus aureus infection pathway

High Power Microwave Treatment Impacts on Microbes in Rough Rice

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Rice science 2024年第2期31卷 139-141,I0020,I0021页

作者： faith OUMA Luthra KAUSHIK Boreddy SREENIVASULA Oduola ABASS Griffiths G.ATUNGULU Department of Food Science University of Arkansas Division of AgricultureFayetteville 72704USA Department of Processing and Food Engineering Dr.NTR College of Agricultural EngineeringBapatla 522101India

As rice consumption increases,ensuring its safety has become a priority for the food *** address this concern,the industry is exploring a single-pass microbial inactivation treatment at the rough rice *** this study,a long-grain rice variety,RT7321[21.2%wet basis(WB)and a 20 mm bed thickness]was exposed to microwave radiation(915 MHz frequency)at powers of 16,18,and 20 kW for durations of 1,2,and 3 *** found that the highest microwave power(20 kW)and the longest exposure duration(3 min)produced the greatest reduction in total aerobic count and total fungal count,reducing them by up to 1.21 and 5.01 log(CFU/g),*** findings provided insights into the used to high-power,shortduration 915 MHz microwave technology for decontamination purposes in rough rice to help improve the microbial safety of *** aim is to develop a single-pass drying approach for microbial inactivation in rice processing facilities while ensuring that the yield and quality is not compromised.

关键词： microwave insight facilities

Nano-formulated delivery of active ingredients from traditional Chinese herbal medicines for cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1525-1541页

作者： Qi Shang Wandong Liu faith Leslie Jiapei Yang Mingmei Guo Mingjiao Sun Guangji Zhang Qiang Zhang Feihu Wang School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Key Laboratory of Blood-stasis-toxin Syndrome of Zhejiang Province Hangzhou 310053China Department of Chemical and Biomolecular Engineering Whiting School of Engineeringthe Johns Hopkins UniversityBaltimoreMD 21218USA Traditional Chinese Medicine“Preventing Disease”Wisdom Health Project Research Center of Zhejiang Hangzhou 310053China Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijing 100191China

Cancer immunotherapy has garnered promise in tumor progression, invasion, and metastasis through establishing durable and memorable immunological activity. However, low response rates, adverse side effects, and high costs compromise the additional benefits for patients treated with current chemical and biological agents. Chinese herbal medicines (CHMs) are a potential treasure trove of natural medicines and are gaining momentum in cancer immunomodulation with multi-component, multi-target, and multi-pathway characteristics. The active ingredient extracted from CHMs benefit generalized patients through modulating immune response mechanisms. Additionally, the introduction of nanotechnology has greatly improved the pharmacological qualities of active ingredients through increasing the hydrophilicity, stability, permeability, and targeting characteristics, further enhancing anti-cancer immunity. In this review, we summarize the mechanism of active ingredients for cancer immunomodulation, highlight nano-formulated deliveries of active ingredients for cancer immunotherapy, and provide insights into the future applications in the emerging field of nano-formulated active ingredients of CHMs.

关键词： Chinese herbal medicines Nano-formulation Activeingredients Drug delivery Cancer immunotherapy Innate immune system Adaptive immune system

Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu faith Teo En Ning Chang Liu Yu-Chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

Mapping Air Quality Using Remote Sensing Technology: A Case Study of Nairobi County

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Open Journal of Air Pollution 2024年第1期13卷 1-22页

作者： Quinto Juma Meltus faith Njoki Karanja Geospatial Engineering Department The University of Nairobi (UoN) Nairobi Kenya Data Management Modeling and Geoinformation Unit (DMMG) International Centre of Insect Physiology and Ecology (ICIPE) Nairobi Kenya

Nairobi County experiences rapid industrialization and urbanization that contributes to the deteriorating state of air quality, posing a potential health risk to its growing population. Currently, in Nairobi County, most air quality monitoring stations use low-cost, inaccurate monitors prone to defects. The study’s objective was to map Nairobi County’s air quality using freely available remotely sensed imagery. The Air Pollution Index (API) formula was used to characterize the air quality from cloud-free Landsat satellite images i.e., Landsat 5 TM, Landsat 7 ETM+, and Landsat 8 OLI from Google Earth Engine. The API values were computed based on vegetation indices namely NDVI, TVI, DVI, and the SWIR1 and NIR bands on the QGIS platform. Qualitative accuracy assessment was done using sample points drawn from residential, industrial, green spaces, and traffic hotspot categories, based on a passive-random sampling technique. In this study, Landsat 5 API imagery for 2010 provided a reliable representation of local conditions but indicated significant pollution in green spaces, with recorded values ranging from -143 to 334. The study found that Landsat 7 API imagery in 2002 showed expected results with the range of values being -55 to 287, while Landsat 8 indicated high pollution levels in Nairobi. The results emphasized the importance of air quality factors in API calibration and the unmatched spatial coverage of satellite observations over ground-based monitoring techniques. The study recommends the recalibration of the API formula for characteristic regions, exploring newer satellite sensors like those onboard Landsat 9 and Sentinel 2, and involving key stakeholders in a discourse to develop a suitable Kenyan air quality index.

关键词： Air Quality Air Pollution Index (API) Satellite Imagery Vegetation Indices Nairobi County

Exploring the Pathways of Leprosy Patients from Their Communities to a Diagnosis in the Districts of Mayuge, Yumbe and Kasese-Uganda

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Advances in Infectious Diseases 2024年第2期14卷 346-373页

作者： Rose Kengonzi Stavia Turyahabwe Samuel Orach Lisa Gerwing-Adima Ronald W. Nyote Vincent Kamara Kabugho faith Consolata Mpambara National Tuberculosis and Leprosy Program Ministry of Health Uganda Kampala Uganda Health Department Uganda Catholic Medical Bureau Kampala Uganda German Leprosy and Tuberculosis Relief Association Kampala Uganda National Tuberculosis and Leprosy Program Kampala Uganda

Background: Leprosy is known to cause disability that leads to severe outcomes like stigma, discrimination, mental health problems and participation restriction. Furthermore, in cases of infectious leprosy, longer delays increase the risk for the spread of the disease. Despite being preventable and curable, a significant proportion of new leprosy patients (39%) in 2019 had grade 2 (Described as Visible disability) at the time of diagnosis signifying late presentation. The aim of this study was to describe patient journeys from first symptoms suggestive of leprosy to a diagnosis and individual and community level factors associated with health seeking behavior of leprosy patients. Methods: This was a cross-sectional explorative study implemented in Kasese, Mayuge and Yumbe districts .A structured questionnaire was used to collect quantitative data. Qualitative assessment included patients, family members, health workers, voluntary health teams and the district health team. Descriptive statistics were presented in terms of percentages, frequency tables, pie Charts and graphs for easy interpretation and discussion. Results: The results indicate that 53% of the respondents identified as female. The median age of the respondents being 34 years, with a range of 1 to 76 years (Mean: 44.7, Mode: 65, Standard-Deviation: 19.6, Kurtosis: 0.6). The most common first symptom noticed by respondents was skin lesions (65%) followed by deformities (18%) (P value = 0.05%) occurring mostly in the feet (P-value = 0.48). Majority (52%) of the patients had taken more than 24 months (SD 18.72 OR 2.75) for a diagnosis to be made with a maximum delay of over 60 months. The most common cause of delay in seeking health care was lack of knowledge on leprosy (P value=Conclusions: There was a delay of 2 years in seeking health care for the majority of the patients. Key barriers to early diagnosis were lack of knowledge and infrastructure. Community sensitization and strengthening capacity buildi

关键词： Leprosy Patient Pathway Skin Lesions Disability Discrimination Delayed Diagnosis

Floristic Composition, Population Structure, and Recruitment Status of Plant Species: A Case Study of Farmer-Managed Natural Regeneration Practices in Arid and Semi-Arid Lands in Kenya

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Open Journal of Forestry 2024年第2期14卷 141-154页

作者： Simon Kosgei Choge Samson Okoth Ojunga Dub Isacko Dokata William Kimen Chepkirui Justus Musau faith Milkah Muniale Ivan Kiplagat Kiptui Kenya Forestry Research Institute-Rift Valley Eco-Region Research Program Marigat Kenya Kenya Forestry Research Institute-Lake Victoria Eco-Region Research Program Kisumu Kenya Kenya Forestry Research Institute-Rift Valley Eco-Region Research Program Londiani Kenya CRIFSUP Project World Vision Kenya Nairobi Kenya

The technique of Farmer Managed Natural Regeneration (FMNR) is being promoted as a cost-effective approach for restoring degraded arable dry lands. Its effectiveness has been observed in many countries across the globe, where it is a traditional practice, and is now being encouraged across the African continent. This study aimed to evaluate the impact of FMNR on floristic Composition, Vegetation Structure, and Regeneration Status of woody Plant Species in the severely degraded Central Rift, Kenya. The study systematically assessed how FMNR influenced species composition, vegetation structure and regeneration status from two sample plots involved in FMNR practices. Transect lines and quadrats methods were utilized to collect data, specifically regarding the floristic composition, vegetation structure, and regeneration status of woody plant species. Quadrats and sub-quadrats of varying sizes (10 m by 10 m, 5 m by 5 m, and 1 m by 1 m) were nested along the transect lines for data collection. Furthermore, measurements of tree growth and development, including root collar diameter, diameter at breast height (D130) and heights within the study blocks, were taken. The data was then analyzed using R-software. Results showed a marked progressive increase in numbers of trees, saplings, seedlings, shrubs and herbs in all FMNR sites and reductions in all non-FMNR sites. The study advocates for widespread promotion of the FMNR practice both as an environmental conservation and restoration strategy.

关键词： Farmer Managed Natural Regeneration FMNR Floristic Composition Vegetation Structure Regeneration Biodiversity

Association between Exposure to Metals during Pregnancy,Childhood Gut Microbiome,and Risk of Intestinal Inflammation in Late Childhood

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Environment & Health 2024年第10期2卷 739-749页

作者： Vishal Midya Manasi Agrawal Jamil M.Lane Chris Gennings Leonid Tarassishin Libni A.Torres-Olascoaga Joseph Eggers Jill K.Gregory Mellissa Picker Inga Peter Jeremiah J.faith Manish Arora Martha M.Tellez-Rojo Robert O.Wright Jean-Frederic Colombel Shoshannah Eggers Department of Environmental Medicine and Climate Science Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States Division of Gastroenterology Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States Center for Molecular Prediction of Inflammatory Bowel Disease(PREDICT) Department of Clinical MedicineAalborg UniversityCopenhagen 9220Denmark Department of Genetics and Genomic Sciences Icahn School of MedicineNew York 10029-6574New YorkUnited States Center for Research on Nutrition and Health National Institute of Public HealthCuernavaca 62508Mexico Department of Immunology and Immunotherapy Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States Department of Epidemiology University of Iowa College of Public HealthIowa City 52242 IowaUnited States Instructional Technology Group Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States

Alterations to the gut microbiome and exposure to metals during pregnancy have been suggested to impact inflammatory bowel ***,how prenatal exposure to metals eventually results in long-term effects on the gut microbiome,leading to subclinical intestinal inflammation,particularly during late childhood,has not been *** is also unknown whether such an interactive effect drives a specific subgroup of children toward elevated susceptibility to intestinal *** used an amalgamation of machine-learning techniques with a regression-based framework to explore if children with distinct sets of gut microbes and certain patterns of exposure to metals during pregnancy(metal−microbial clique signature)had a higher likelihood of intestinal inflammation,measured based on fecal calprotectin(FC)in late *** obtained samples from a well-characterized longitudinal birth cohort from Mexico City(n=108),*** the second and third trimesters of pregnancy,11 metals were measured in whole *** microbial abundances and FC were measured in stool samples from children 9−11 years of *** FC was defined as having FC above 100μg/g of *** identified subgroups of children in whom microbial and metal−microbial clique signatures were associated with elevated FC(false discovery rate(FDR)<0.05).In particular,we found two metal−microbial clique signatures significantly associated with elevated FC:(1)low cesium(Cs)and copper(Cu)in the third trimester and low relative abundance of Eubacterium ventriosum(OR[95%CI]:10.27[3.57,29.52],FDR<0.001)and(2)low Cu in the third trimester and high relative abundances of Roseburia inulinivorans and Ruminococcus torques(OR[95%CI]:7.21[1.81,28.77],FDR<0.05).This exploratory study demonstrates that children with specific gut microbes and specific exposure patterns to metals during pregnancy may have higher fecal calprotectin levels in late childhood,denoting an elevated risk of intestinal inflammation.

关键词： exposome metals machine learning microbiome environmental epidemiology intestinal inflammation

Papua New Guinea Rural Tourism Development Transition ——A Case of Goroka,Eastern Highlands Province.-2010–2018

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Papua New Guinea Rural Tourism Development Transition ——A ...

作者： faith Kaupa 浙江工商大学

学位级别：硕士

巴布亚新几内亚的乡村旅游是一个尚未发展的领域。虽然巴布亚新几内亚乡村旅游的发展潜力很大,但旅游业的发展仍然面临巨大挑战。这项研究旨在描述、评估和评价巴布亚新几内亚当地社区阻碍乡村旅游发展的因素。为了实现这项研究的目标,... 详细信息

巴布亚新几内亚的乡村旅游是一个尚未发展的领域。虽然巴布亚新几内亚乡村旅游的发展潜力很大,但旅游业的发展仍然面临巨大挑战。这项研究旨在描述、评估和评价巴布亚新几内亚当地社区阻碍乡村旅游发展的因素。为了实现这项研究的目标,在两个月内,作者在巴布亚新几内亚东部高地省戈罗卡的两个当地农村社区进行了一项案例研究。本研究采用了定量和定性相结合的研究方法。通过合适的研究模型框架测试关于这两个地方社区乡村旅游发展的三个假设(社会文化效益、利益相关者参与和地方社区参与)。这三个假设采用五点李克特量表构建了一份研究调查问卷,得分范围为1=强烈不同意到5=强烈同意。研究结果显示,作者提出的其中两个假设得到了显著支持(社会文化利益和当地社区参与),而其他假设则没有得到支持(利益相关者参与)。被拒绝的假设也证实了作者研究的结果,在研究中,旅游业利益相关者几乎没有或根本没有支持或参与支持这些地方社区的乡村旅游业发展。作者使用SPSS软件和SMART PLS 2.0(M3)分析收集的数据并产生结果。采用质性研究方法对访谈笔录和政策文件进行分析。在进一步讨论和得出结论后,作者提出了本研究的局限性和未来研究的内容。

关键词：乡村旅游发展旅游政策地方社区