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Predicting short-term thromboembolic risk following Roux-en-Y gastric bypass using supervised machine learning

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1097-1108页

作者： Hassam Ali faisal Inayat Vishali Moond Ahtshamullah Chaudhry Arslan Afzal Zauraiz Anjum Hamza Tahir Muhammad Sajeel Anwar Dushyant Singh Dahiya Muhammad Sohaib Afzal Gul Nawaz Amir H Sohail Muhammad aziz Department of Gastroenterology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Internal Medicine Allama Iqbal Medical CollegeLahorePunjab 54550Pakistan Department of Internal Medicine Saint Peter's University Hospital and Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901United States Department of Internal Medicine St.Dominic's HospitalJacksonMS 39216United States Department of Internal Medicine Rochester General HospitalRochesterNY 14621United States Department of Internal Medicine Jefferson Einstein HospitalPhiladelphiaPA 19141United States Department of Internal Medicine UHS Wilson Medical CenterJohnsonNY 13790United States Division of Gastroenterology Hepatology and MotilityThe University of Kansas School of MedicineKansasKS 66160United States Department of Internal Medicine Louisiana State University HealthShreveportLA 71103United States Department of Surgery University of New Mexico School of MedicineAlbuquerqueNM 87106United States Department of Gastroenterology and Hepatology The University of ToledoToledoOH 43606United States

BACKGROUND Roux-en-Y gastric bypass(RYGB)is a widely recognized bariatric procedure that is particularly beneficial for patients with class III *** aids in significant weight loss and improves obesity-related medical *** its effectiveness,postoperative care still has *** evidence shows that venous thromboembolism(VTE)is a leading cause of 30-d morbidity and mortality after ***,a clear unmet need exists for a tailored risk assessment tool for VTE in RYGB *** To develop and internally validate a scoring system determining the individualized risk of 30-d VTE in patients undergoing *** Using the 2016–2021 Metabolic and Bariatric Surgery Accreditation Quality Improvement Program,data from 6526 patients(body mass index≥40 kg/m^(2))who underwent RYGB were analyzed.A backward elimination multivariate analysis identified predictors of VTE characterized by pulmonary embolism and/or deep venous thrombosis within 30 d of *** resultant risk scores were derived from the coefficients of statistically significant *** performance of the model was evaluated using receiver operating curves through 5-fold *** Of the 26 initial variables,six predictors were *** included a history of chronic obstructive pulmonary disease with a regression coefficient(Coef)of 2.54(P7%(Coef 1.19,P<0.001),venous stasis history(Coef 1.43,P<0.001),and preoperative anticoagulation use(Coef 1.24,P<0.001).These variables were weighted according to their regression coefficients in an algorithm that was generated for the model predicting 30-d VTE risk *** risk model's area under the curve(AUC)was 0.79[95%confidence interval(CI):0.63-0.81],showing good discriminatory power,achieving a sensitivity of 0.60 and a specificity of *** training,the same model performed satisfactorily

关键词： Roux-en-Y gastric bypass Venous thromboembolism Machine learning Bariatric surgery Predictive modeling

National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma

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World Journal of Gastroenterology 2024年第9期30卷 1018-1042页

作者： faisal Saud Dar Zaigham Abbas Irfan Ahmed Muhammad Atique Usman Iqbal Aujla Muhammad Azeemuddin Zeba aziz Abu Bakar Hafeez Bhatti Tariq Ali Bangash Amna Subhan Butt Osama Tariq Butt Abdul Wahab Dogar Javed Iqbal Farooqi faisal Hanif Jahanzaib Haider Siraj Haider Syed Mujahid Hassan Adnan Abdul Jabbar Aman Nawaz Khan Muhammad Shoaib Khan Muhammad Yasir Khan Amer Latif Nasir Hassan Luck Ahmad Karim Malik Kamran Rashid Sohail Rashid Mohammad Salih Abdullah Saeed Amjad Salamat Ghias-un-Nabi Tayyab Aasim Yusuf Haseeb Haider Zia Ammara Naveed Department of Hepatopancreatic Biliary Surgery&Liver Transplant Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Hepatogastroenterology and Liver Transplantation Dr.Ziauddin University HospitalKarachi 75600SindhPakistan University of Aberdeen Aberdeen B243FXUnited Kingdom Department of Pathology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Gastroenterology&Hepatology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Radiology Aga Khan UniversityKarachi 74800Pakistan Department of Oncology Hameed Latif HospitalLahore 54000Pakistan Division of Hepatopancreatic Biliary Surgery&Liver Transplantation Shifa International HospitalIslamabad 44000Pakistan Department of Hepatopancreatic Biliary Surgery&Liver Transplant Shaikh Zayed Hospital and Post Graduate Medical InstituteLahore 54000Pakistan Department of Medicine Aga Khan University HospitalKarachi 74800Pakistan Department of Liver Transplant Pir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Medicine&Gastroenterology Lifecare Hospital and Research CentrePeshawar 25000Khyber PakhtunkhwaPakistan Department of Hepatopancreatobiliary&Liver Transplant Bahria International HospitalLahore 54000Pakistan Department of Surgery Hepatopancreatobiliary&Liver TransplantDow University of Health SciencesKarachi 74800Pakistan Department of Gastroenterology Hepatology&NutritionPir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Oncology Dr.Ziauddin HospitalKarachi 74800Pakistan Department of Radiology Rehman Medical InstitutePeshawar 25000Pakistan Army Liver Transplant Unit Pak Emirates Military HospitalRawalpindi 46000Pakistan Department of Gastroenterology Sindh Institute of Urology and TransplantationKarachi 75500Pakistan Rashid Nursing Home and Cancer Clinic Rashid Nursing Home and Cancer ClinicRawalpindi 46000Pakistan Department of Gastroentero

A consensus meeting of national experts from all major national hepatobiliary centres in the country was held on May 26,2023,at the Pakistan Kidney and Liver Institute&Research Centre(PKLI&RC)after initial consultations with the *** Pakistan Society for the Study of Liver Diseases(PSSLD)and PKLI&RC jointly organised this *** effort was based on a comprehensive literature review to establish national practice guidelines for hilar cholangiocarcinoma(hCCA).The consensus was that hCCA is a complex disease and requires a multidisciplinary team approach to best manage these *** coordinated effort can minimise delays and give patients a chance for curative treatment and effective *** diagnostic and staging workup includes high-quality computed tomography,magnetic resonance imaging,and magnetic resonance *** cytology or biopsy utilizing endoscopic retrograde cholangiopancreatography is a mainstay for ***,histopathologic confirmation is not always required before *** ultrasound with fine needle aspiration of regional lymph nodes and positron emission tomography scan are valuable adjuncts for *** only curative treatment is the surgical resection of the biliary tree based on the Bismuth-Corlette *** patients with unresectable hCCA can be considered for liver *** chemotherapy should be offered to patients with a high risk of *** use of preoperative biliary drainage and the need for portal vein embolisation should be based on local multidisciplinary *** with acute cholangitis can be drained with endoscopic or percutaneous biliary *** chemotherapy with cisplatin and gemcitabine has shown improved survival in patients with irresectable and recurrent hCCA.

关键词： Hilar cholangiocarcinoma Bismuth-Corlette classification Memorial Sloan Kettering Cancer Centre Staging Preoperative biliary drainage Portal vein embolisation Surgical resection Hepatectomy

Early versus delayed necrosectomy in pancreatic necrosis:A population-based cohort study on readmission,healthcare utilization,and in-hospital mortality

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World Journal of Methodology 2024年第3期14卷 55-67页

作者： Hassam Ali faisal Inayat Vinay Jahagirdar Fouad Jaber Arslan Afzal Pratik Patel Hamza Tahir Muhammad Sajeel Anwar Attiq Ur Rehman Muhammad Sarfraz Ahtshamullah Chaudhry Gul Nawaz Dushyant Singh Dahiya Amir H Sohail Muhammad aziz Division of Gastroenterology and Hepatology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Internal Medicine Allama Iqbal Medical CollegeLahorePunjab 54550Pakistan Department of Internal Medicine University of Missouri-Kansas CityKansas CityMO 64108United States Division of Gastroenterology Mather Hospital and Zucker School of Medicine at Hofstra UniversityPort JeffersonNY 11777United States Department of Internal Medicine Jefferson Einstein HospitalPhiladelphiaPA 19141United States Department of Internal Medicine UHS Wilson Medical CenterJohnson CityNY 13790United States Division of Gastroenterology and Hepatology Geisinger Wyoming Valley Medical CenterWilkes-BarrePA 18711United States Department of Internal Medicine St.Dominic's HospitalJacksonMS 39216United States Division of Gastroenterology Hepatologyand MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Department of Surgery University of New Mexico School of MedicineAlbuquerqueNM 87106United States Division of Gastroenterology and Hepatology The University of ToledoToledoOH 43606United States

BACKGROUND Acute necrotizing pancreatitis is a severe and life-threatening *** poses a considerable challenge for clinicians due to its complex nature and the high risk of *** minimally invasive and open necrosectomy procedures have been *** advancements in treatment modalities,the optimal timing to perform necrosectomy lacks *** To evaluate the impact of necrosectomy timing on patients with pancreatic necrosis in the United *** A national retrospective cohort study was conducted using the 2016-2019 Nationwide Readmissions *** with non-elective admissions for pancreatic necrosis were *** participants were divided into two groups based on the necrosectomy timing:The early group received intervention within 48 hours,whereas the delayed group underwent the procedure after 48 *** various intervention techniques included endoscopic,percutaneous,or surgical *** major outcomes of interest were 30-day readmission rates,healthcare utilization,and inpatient *** A total of 1309 patients with pancreatic necrosis were *** propensity score matching,349 cases treated with early necrosectomy were matched to 375 controls who received delayed *** early cohort had a 30-day readmission rate of 8.6% compared to 4.8%in the delayed cohort(P=0.040).Early necrosectomy had lower rates of mechanical ventilation(2.9%vs 10.9%,P<0.001),septic shock(8%vs 19.5%,P<0.001),and in-hospital mortality(1.1%vs 4.3%,P=0.01).Patients in the early intervention group incurred lower healthcare costs,with median total charges of $52202 compared to$147418 in the delayed *** in the early cohort also had a relatively shorter median length of stay(6 vs 16 days,P<0.001).The timing of necrosectomy did not significantly influence the risk of 30-day readmission,with a hazard ratio of 0.56(95%confidence interval:0.31-1.02,P=0.06).CONCLUSION Our findings show that

关键词： Acute necrotizing pancreatitis Pancreatic necrosis Early necrosectomy Delayed necrosectomy Readmission,Healthcare costs Mortality

Enhancing Mild Cognitive Impairment Detection through Efficient Magnetic Resonance Image Analysis

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Computers, Materials & Continua 2024年第8期80卷 2081-2098页

作者： Atif Mehmood Zhonglong Zheng Rizwan Khan Ahmad Al Smadi Farah Shahid Shahid Iqbal Mutasem K.Alsmadi Yazeed Yasin Ghadi Syed aziz Shah Mostafa M.Ibrahim Department of Computer Science and Technology Zhejiang Normal UniversityJinhua321002China Zhejiang Institute of Photoelectronics&Zhejiang Institute for Advanced Light Source Zhejiang Normal UniversityJinhua321004China Department of Data Science and Artificial Intelligence Zarqa UniversityZarqa13100Jordan School of Chemical and Environmental Engineering College of ChemistryChemical Engineering andMaterials ScienceSoochow UniversitySuzhou215123China Department of Management Information Systems College of Applied Studies and Community ServiceImam Abdulrahman Bin Faisal UniversityDammam32244Saudi Arabia Department of Computer Science Al Ain UniversityAbu Dhabi999041United Arab Emirates Department of Electrical Engineering Faculty of EngineeringMinia UniversityMinia61519Egypt Healthcare Technology and Innovation Theme Faculty Research Centre for Intelligent HealthcareCoventry UniversityCoventryCV48BWUK

Neuroimaging has emerged over the last few decades as a crucial tool in diagnosing Alzheimer’s disease(AD).Mild cognitive impairment(MCI)is a condition that falls between the spectrum of normal cognitive function and ***,previous studies have mainly used handcrafted features to classify MCI,AD,and normal control(NC)*** paper focuses on using gray matter(GM)scans obtained through magnetic resonance imaging(MRI)for the diagnosis of individuals with MCI,AD,and *** improve classification performance,we developed two transfer learning strategies with data augmentation(i.e.,shear range,rotation,zoom range,channel shift).The first approach is a deep Siamese network(DSN),and the second approach involves using a cross-domain strategy with customized *** performed experiments on the Alzheimer’s Disease Neuroimaging Initiative(ADNI)dataset to evaluate the performance of our proposed *** experimental results demonstrate superior performance in classifying the three binary classification tasks:NC ***,NC ***,and MCI ***,we achieved a classification accuracy of 97.68%,94.25%,and 92.18%for the three cases,*** study proposes two transfer learning strategies with data augmentation to accurately diagnose MCI,AD,and normal control individuals using GM *** findings provide promising results for future research and clinical applications in the early detection and diagnosis of AD.

关键词： Alzheimer’s disease mild cognitive impairment normal control transfer learning classification augmentation

Peptides-based vaccine against SARS-nCoV-2 antigenic fragmented synthetic epitopes recognized by T cell and β-cell initiation of specific antibodies tofightthe infection

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Bio-Design and Manufacturing 2021年第3期4卷 490-505页

作者： Zainularifeen Abduljaleel faisal A.Al-Allaf Syed A.aziz Department of Medical Genetics Faculty of MedicineUmm Al-Qura UniversityP.O.Box715Mecca21955Kingdom of Saudi Arabia Science and Technology Unit UmmAl-Qura UniversityP.O.Box 715Mecca21955Kingdom of SaudiArabia The Regional Laboratory Molecular Diagnostics UnitDepartment of Molecular BiologyMinistry of Health(MOH)P.O.Box 6251MeccaKingdom of SaudiArabia Department of Pathology and Lab Medicine University of Ottawa451Smyth RoadOttawaONK1H8M5Canada

The World Health Organization has declared the rapidly spreading coronavirus to be a global *** FDA is yet to approve a vaccine for human novel ***,we developed a peptide-based vaccine and used high-throughput screening by molecular dynamics simulation to identify T-cell-and p-cell-recognized epitopes for producing specific antibod-ies against *** construct~12 P'antigenic epitope peptides to develop a more effective vaccine and identify specific *** epitope peptides selectively presented the best antigen presentation scores for both human pMHC class I and II alleles to develop a strong binding *** antigens identified of SARS-nCoV-2 different proteins by each attached specific~1-7 L linker adaptor were used to construct a broad single peripheral peptide *** is expected to be highly antigenic with a minimum allergic *** a result of these exciting outcomes,expressing a vaccine using the intimated peptide was highly promising and positive to be highly proposed as epitope-based peptide vaccine of specific antibody against SARS-nCoV-2 by initiating T cells and β-*** in vitro study for the proposed peptide-based vaccine *** *** clinical trials are required to check the efficacy of this vaccine.

关键词： COVID-19 SARS-nCoV-2 Peptide-based vaccine Cell-penetrating peptides Lipid membrane Vaccine efficacy

A Rare Tumor in a Rare Location: Ganglioneuroma

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Surgical Science 2022年第6期13卷 294-299页

作者： faisal El Mouhafid Abderrahmane Hajoujji Ait Ali Abdelmounaime aziz Zentar Department of Visceral Surgery Mohammed V Military Teaching Hospital Rabat Morocco

Ganglioneuroma is a rare benign tumor Neuronagliomas of the adrenal gland are a rare pathology. Therefore, this case will be of interest to urologists, surgeons, oncologists, and pathologists. Located in the adrenal gland (20%), along the sympathetic chain, and particularly in the posterior mediastinum (40%) and the retroperitoneum (30%). Ganglioneuroma poses a positive diagnostic and therapeutic problem. We report the case of a patient aged 48 admitted for pain in the right hypochondrium. He had no significant past medical or surgical history. On a physical examination, there were no noticeable findings except for mild tenderness and a mass on palpation. He underwent abdominal CT, which showed a relatively homogenous right adrenal tumor measuring. Endocrine work-up including urine catecholamine and cortisol levels was normal. Due to the tumor size and with consideration of the differential diagnosis of a malignant lesion, we elected to operate on the patient. Right adrenalectomy was performed, with no related complications. The final histopathologic report revealed adrenal ganglioneuroma. Although benign, the ganglioneuroma can present malignant aspects, in particular, CT scans and biological that can mislead the clinician, so histology remains the examination of choice for making the diagnosis.

关键词： Tumor Adrenal Glands Gangioneuroma

Risk factor profiles for gastric cancer prediction with respect to Helicobacter pylori:A study of a tertiary care hospital in Pakistan

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Artificial Intelligence in Gastroenterology 2023年第1期4卷 10-27页

作者： Shahid aziz Simone König Muhammad Umer Tayyab Saeed Akhter Shafqat Iqbal Maryum Ibrar Tofeeq Ur-Rehman Tanvir Ahmad Alfizah Hanafiah Rabaab Zahra faisal Rasheed Patients Diagnostic Lab Isotope Application DivisionPakistan Institute of Nuclear Science and TechnologyIslamabad 44000Pakistan Department of Microbiology Quaid-i-Azam UniversityIslamabad 45320Pakistan Interdisciplinary Center for Clinical Research Core Unit ProteomicsUniversity of MünsterMünster 48149Germany Management Information System Division Pakistan Institute of Nuclear Science and TechnologyIslamabad 44000Pakistan Centre for Liver and Digestive Diseases Holy Family HospitalRawalpindi 46300Pakistan Pakistan Scientific and Technological Information Centre Quaid-i-Azam UniversityIslamabad 45320Pakistan Department of Pharmacy Quaid-i-Azam UniversityIslamabad 45320Pakistan Faculty of Medicine Department of Medical Microbiology and ImmunologyUniversiti Kebangsan MalaysiaCherasKuala Lumpur 56000Malaysia

BACKGROUND Gastric cancer(GC)is the fourth leading cause of cancer-related deaths *** relies on histopathology and the number of endoscopies is *** pylori(***)infection is a major risk *** To develop an in-silico GC prediction model to reduce the number of diagnostic surgical *** meta-data of patients with gastroduodenal symptoms,risk factors associated with GC,and *** infection status from Holy Family Hospital Rawalpindi,Pakistan,were used with machine *** A cohort of 341 patients was divided into three groups[normal gastric mucosa(NGM),gastroduodenal diseases(GDD),and GC].Information associated with socioeconomic and demographic conditions and GC risk factors was collected using a *** infection status was determined based on urea breath *** association of these factors and histopathological grades was assessed statistically.K-Nearest Neighbors and Random Forest(RF)machine learning models were *** This study reported an overall frequency of 64.2%(219/341)of *** infection among enrolled *** was higher in GC(74.2%,23/31)as compared to NGM and GDD and higher in males(54.3%,119/219)as compared to *** abdominal pain(72.4%,247/341)was observed than other clinical symptoms including vomiting,bloating,acid reflux and *** majority of the GC patients experienced symptoms of vomiting(91%,20/22)with abdominal pain(100%,22/22).The multinomial logistic regression model was statistically significant and correctly classified 80%of the GDD/GC ***,income level,vomiting,bloating and medication had significant association with GDD and GC.A dynamic RF GC-predictive model was developed,which achieved>80%test *** GC risk factors were incorporated into a computer model to predict the likelihood of developing GC with high sensitivity and *** model is dynamic and will be further improved and validated by including n

关键词： Gastric cancer Gastritis Machine learning Prediction model Helicobacter pylori

Response to(Comment on the paper "Theoretical & Applied Mechanics Letters 7(2017) 235–242”)

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Theoretical & Applied Mechanics Letters 2019年第4期9卷 274-275页

作者： Yahaya Shagaiya Daniel Zainal Abdul aziz Zuhaila Ismail faisal Salah UTM Centre for Industrial and Applied Mathematics Universiti Teknologi MalaysiaJohorMalaysia Department of Mathematics Faculty of ScienceUniversity of KordofanElobid 51111Sudan

Equation(1)in Ref.[1]with parameter RD is the standard governing equation for entropy generation of nanofluid flow over a stretching sheet via Buongiorno's *** to countless published papers,as few are listed below[2–... 详细信息

关键词： Response pap sheet via

Entropy analysis in electrical magnetohydrodynamic(MHD) flow of nanofluid with effects of thermal radiation,viscous dissipation,and chemical reaction

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Theoretical & Applied Mechanics Letters 2017年第4期7卷 235-242页

作者： Yahaya Shagaiya Daniel Zainal Abdul aziz Zuhaila Ismail faisal Salah UTM Centre for Industrial and Applied Mathematics Universiti Teknologi Malaysia Department of Mathematics Faculty of Science University of Kordofan

The unsteady mixed convection flow of electrical conducting nanofluid and heat transfer due to a permeable linear stretching sheet with the combined effects of an electric field, magnetic field, thermal radiation, viscous dissipation, and chemical reaction have been investigated. A similarity transformation is used to transform the constitutive equations into a system of nonlinear ordinary differential *** resultant system of equations is then solved numerically using implicit finite difference *** velocity, temperature, concentration, entropy generation, and Bejan number are obtained with the dependence of different emerging parameters examined. It is noticed that the velocity is more sensible with high values of electric field and diminished with a magnetic field. The radiative heat transfer and viscous dissipation enhance the heat conduction in the system. Moreover, the impact of mixed convection parameter and Buoyancy ratio parameter on Bejan number profile has reverse effects. A chemical reaction reduced the nanoparticle concentration for higher values.

关键词： Entropy generation MHD nanofluid Thermal radiation Bejan number Chemical reaction Viscous dissipation