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硫原子在前体农药中的作用

世界农药 1983年第2期 21-25页

作者： T.R.Fukuto M.A.h.fahmy 赵祖培美国加利福尼亚大学昆虫系毒理生理学部美国加利福尼亚大学昆虫系毒理生理学部

众所周知,硫代磷酸酯类杀虫剂对硫磷、马拉硫磷对乙酰胆碱酯酶的抑制能力较差,需在动物体内活化成能抗胆碱酯酶的对氧磷和马拉氧磷后使动物中毒。因此,含硫的硫酮型磷酸酯必须经代谢活化才能发挥其杀虫活性,这类农药可称之为前体农药(pr... 详细信息

众所周知,硫代磷酸酯类杀虫剂对硫磷、马拉硫磷对乙酰胆碱酯酶的抑制能力较差,需在动物体内活化成能抗胆碱酯酶的对氧磷和马拉氧磷后使动物中毒。因此,含硫的硫酮型磷酸酯必须经代谢活化才能发挥其杀虫活性,这类农药可称之为前体农药(propesticide)或前体杀虫剂(proinsecticide)。

关键词：氨基甲酸动物毒性硫基衍生物毒力小白鼠有机磷杀虫剂

Partial Characterization of Thrombin Inhibitor(s) Derived from Salivary Glands of the Tick, <i>hyalomma dromedarii</i>, and Related Anti-Cancer Potential

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Advances in Entomology 2021年第1期9卷 1-19页

作者： Wessam S. Ibrahim Fatma S. A. Mohamed Walaa A. Moselhy Emtithal M. Abdel Samie Aly fahmy Mohamed Zoology and Entomology Department Faculty of Science (Girls) Al-Azhar University Cairo Egypt Entomology Department Faculty of Science Cairo University Giza Egypt Egypt Center for Research and Regenerative Medicine (ECRRM) Cairo Egypt VACSERA Giza Egypt

A long-term blood feeder, like the hyalomma dromedarii tick, requires extended control over all hemostatic defense mechanisms generated by the host during feeding, including blood coagulation. To overcome this, ticks ... 详细信息

A long-term blood feeder, like the Hyalomma dromedarii tick, requires extended control over all hemostatic defense mechanisms generated by the host during feeding, including blood coagulation. To overcome this, ticks have evolved numerous molecules that target proteases in the blood coagulation cascade. New insights into the role of clotting factors in the development and progression of cancer have identified anticoagulant treatment as a potential therapeutic approach. In this context, the present work assessed the anticoagulation activities of crude and fractionated salivary gland extract (SGE) prepared from semi-fed H. dromedarii females. Additionally, the antitumor effects of the potent anti-thrombin fractions were determined against colon cancer (Caco-2) and normal skin (HFB4) cells. Crude SGE significantly prolonged clotting time in prothrombin time (PT), activated partial thromboplastin time (aPTT) and thrombin time (TT) assays and inhibited thrombin in FII-activity assay. Using anion-exchange chromatography, the fractions that strongly inhibited thrombin (3.A4 and 3.A5) were eluted. Both fractions prolonged the aPTT and TT clotting times and reduced the activity of FII significantly. The protein profiles of both fractions indicated the presence of a single polypeptide band of about 99 kDa. Regarding anti-cancer potential of the tested fractions, Caco-2 cells showed reduced viability with obvious morphological changes, induced apoptosis and a reduced level of vascular endothelial growth factor (VEGF). G2/M cell cycle arrest was observed only in 3.A5-treated cells. No cytotoxic effects were observed in hFB4 cells. These results demonstrated the potential of tick-derived anticoagulants, specifically thrombin inhibitors, as effective tools in colorectal cancer treatment. Further purification of the effector molecul

关键词： hyalomma dromedarii Salivary Glands Thrombin Inhibitor Apoptosis VEGF

Evaluation of the Quality for the Egyptian Red Sea Coastal Waters during 2011-2013

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Journal of Environmental Protection 2016年第12期7卷 1810-1834页

作者： Mamdouh A. fahmy Laila M. Abdel Fattah Ahmed M. Abdel-halim Mohamed A. Aly-Eldeen Ehssan M. Abo-El-Khair hoda h. Ahdy hoda h. Ahdy Ahmed hemeilly Ahmed Abu El-Soud Mohamed A. Shreadah National Institute of Oceanography and Fisheries Alexandria Egypt Environmental Affairs Agency Ministry of Environmental Affairs Cairo Egypt

To assess the quality of the Egyptian Red Sea coastal waters for the sustainable use and development, due to its importance for the national income, four field campaigns were annually carried out during the period from 2011-2013 to investigate the hydrography, nutrient salts, heavy metals and petroleum hydrocarbons. Except for the area of Bir Shalatein, the results of beach litter cleared out that the shoreline of the studied area is not affected by man-made litter. No sewage could be observed. The results of the present study showed that water temperature followed seasonal changes in air temperature. Red Sea water is more saline than adjacent Arabian Sea. DO revealed high values and presence of well oxygenated waters. Minor changes in the distribution of ph, BOD, DOM and COD, revealed that limited effects of human impacts and depend mainly on the dynamics of its water as well as on the geographical location. Low Chl-a and TSM concentrations and high transparency revealed that also the effect of human impacts is almost negligible. Significantly higher sea water temperatures, TSM, ph, DO, BOD, DOM, and COD were observed in summer season compared to their corresponding values in winter season. Dissolved inorganic nitrogen concentrations were quite low because there is little nutrient input from soil, agriculture and pollution on land. Based on the annual mean values, the pattern concentrations of dissolved inorganic nitrogen forms followed the order: NO3 > Nh4 > NO2. The Red Sea coastal waters are classified as oligotrophic to mesotrophic state. A remarkable increase of PO4 concentration was observed in the middle Red Sea stations due to huge amounts of effluents enriched with phosphate from the main shipping and industry of Phosphate Companies. SiO4 displayed a large variability due to the supply of SiO4, which flows in the Red Sea through the strait of Bab El-Mandab, biological consumption, organic ma

关键词： hydrography Nutrient Salts heavy Metals Petroleum hydrocarbons Coastal Water Red Sea

Assessment of the hydrochemical Characteristics of the Suez Gulf Coastal Waters during 2011-2013

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Journal of Environmental Protection 2016年第11期7卷 1497-1521页

作者： Ehssan M. Abo-El-Khair Laila M. Abdel Fattah Ahamed M. Abdel-halim Mohamed A. Abd-Elnaby Mamdouh A. fahmy hoda h. Ahdy Ahamed hemeilly Ahamed Abu El-Soud Mohamed A. Shreadah Environmental Affairs Agency Ministry of Environmental Affairs Cairo Egypt National Institute of Oceanography and Fisheries Alexandria Egypt Environmental Affairs Agency Ministry of Environmental Affairs Cairo Egypt

The coastal region of the Suez Gulf, is one of the most densely industrialized zones in Egypt. In order to assess the quality of Suez Gulf coastal waters for the sustainable use and development, and consequently for the national income, 12 field campaigns were carried out in 3 years (2011-2013). The results of beach litter cleared out that the shoreline of the Suez Gulf, especially Ras Gharib area was subjected to many factors which undoubtedly affected the rate of man-made litter accumulation. The most abundant visible items were general litter as they represented 30.64% of the total items encountered. Oil, seaweeds as well as old and new tar constituted 15.41%, 14.85% and 11.84%, respectively. The increase on the levels of water temperature, Chl-a, TSM, DO, BOD, DOM, COD, ammonium ion, nitrite, nitrate, total phosphorus, silicate and total nitrogen developed a eutrophic region. In general, dissolved inorganic nitrogen (DIN) species were almost 9 times higher in the northern parts compared to the south-ern ones revealing that the northern parts of the Gulf were more affected by human impacts compared to the southern area. Moreover, concentrations of most studied metals such as Zn, Mn, Ni, Cu, Cr, Cd, Pb, and hg were higher in Northern parts com-pared to southern parts of the Gulf. The concentrations of dissolved metals in the northern and southern Suez Gulf followed the following order: Fe ≥ Zn ≥ Cu > Pb > Mn > Ni > Cr > Cd ≥ hg. Except for hg, concentrations of metals were in the accepta-ble ranges recommended internationally. hg concentrations especially in the northern Suez Gulf were slightly higher than the permissible levels. As the northern parts of the Gulf were more suffered from oil pollution, total petroleum hydrocarbons revealed higher concentrations in the northern parts compared to the southern parts of the Gulf. Seasonal variations, on the other hand, indicated higher levels of DO, BOD, DOM and COD, chloropyll-a, TSM, ammonia, nitrate, total nitrogen

关键词： hydrography Nutrient Salts heavy Metals Petroleum hydrocarbons Coastal Water Suez Gulf

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用环磷酰胺作绵羊化学剪毛剂的综述

中国畜牧兽医 1985年第1期 63-63页

作者：郭年藩 Mohamed h.fahmy

人们由一些治癌药物能使病人暂时脱发得到启示,从1969年起经多种药物试验,最后确认环磷酰胺比较适合.近年来由于剪毛工钱上涨而羊毛落价,化学剪毛法又引起了人们的兴趣.其机制是暂时改变细胞功能,引起生发细胞的细胞质变性,最后脱下.可... 详细信息

人们由一些治癌药物能使病人暂时脱发得到启示,从1969年起经多种药物试验,最后确认环磷酰胺比较适合.近年来由于剪毛工钱上涨而羊毛落价,化学剪毛法又引起了人们的兴趣.其机制是暂时改变细胞功能,引起生发细胞的细胞质变性,最后脱下.可采用注射及口服方法给药,口服、肌注较适用于生产.口服

关键词：高剂量环磷酞胺剪毛

三维深度卷积神经网络用于肥厚性心肌病的自动心肌瘢痕定量：一个多中心多供应商研究

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国际医学放射学杂志 2020年第2期 232-232页

作者： A.S.fahmy U.Neisius R.h.Chan E.J.Rowin W.J.Manning M.S.Maron 朱羽苑 Department of Medicine Beth Israel Deaconess Medical Center and harvard Medical School

心肌MRI钆延迟强化(LGE)瘢痕体积是预测肥厚型心肌病(hCM)病人预后的重要标志,但由于缺乏测量标准,其临床应用受到限制。目的开发和评估基于三维(3D)卷

关键词：心肌瘢痕肥厚性心肌病多供应商深度卷积神经网络