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Liver stiffness as a predictor of hepatocellular carcinoma behavior in patients with hepatitis C related liver cirrhosis

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hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 22-28页

作者： Sameh A Lashen Mohamed M Elshafei fahmy h hablass Eman A Alsayed Asmaa A hassan Department of Internal Medicine Faculty of MedicineUniversity of AlexandriaAlexandriaEgypt Department of Radiology Faculty of MedicineUniversity of AlexandriaAlexandriaEgypt Department of Biomedical Informatics and Medical Statistics Medical Research InstituteUniversity of AlexandriaAlexandriaEgypt

Background: Risk strati cation and prognostication of hepatocellular carcinoma (hCC) help to improve patient outcome. herein we investigated the role of liver stiffness measurement (LSM) in the prediction of hCC behavior. Methods: Totally 121 na ve patients with hCC were included. hCC radiological evaluation and staging were done. LSM was measured using virtual touch quanti cation. Patients were divided into early to intermediate hCC (BCLC-0, A and B) and late hCC (BCLCC and D). hCC was treated according to the BCLC stage. hCC recurrence-free interval was estimated. Results: The mean LSM inside the tumor was signi cantly lower than the peri-tumoral area and the cirrhotic non-cancerous liver parts (PhCCs stage, the mean LSM inside the tumor and in the peri-tumoral tissue was lower than the corresponding values in the early to intermediate hCCs stage (Phe tumor and in the peri-tumoral tissue negatively correlated with serum AFP, tumor vascular invasion, and stage (Phe recurrence-free interval was directly correlated to LSM inside the tumor and inversely to LSM in cirrhotic non tumorous liver part. Kaplan-Meier analysis showed that the recurrence-free interval was signi cantly longer in patients with LSM inside the tumor of ≥1.25m/s compared to those with LSM inside the tumor ofhCC clinical behavior and the recurrence-free interval following loco-regional treatments.

关键词： Fibrosis hepatitis C hepatocellular carcinoma Point shear wave Liver cirrhosis

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Relationship between vitamin D and IL-23,IL-17 and macrophage chemoattractant protein-1 as markers of fibrosis in hepatitis C virus Egyptians

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World Journal of hepatology 2012年第8期4卷 242-247页

作者： Noha M El husseiny hala M fahmy Waleed A Mohamed hisham h Amin Internal Medicine Department Faculty of MedicineCairo UniversityCairo 11111Egypt Internal Medicine Department Faculty of MedicineCairo University Cairo 11111Egypt Department of Chemistry Cairo UniversityCairo 12534Egypt Clinical Pathology Department Faculty of Medicine AL Azhar UniversityCairo 15533Egypt

AIM: To assess vitamin D in hepatitis C patients and its relationship to interleukin (IL)-23, IL-17, and macrophage chemoattractant protein-1 (MCP-1). METhODS: The study was conducted on 50 Egyptian hepatitis C virus (hCV) genotype number IV-infected patients and 25 age- and gender-matched healthy subjects. Venous blood samples were obtained. Samples were allowed to clot and sera were separated by centrifugation and stored at -20?°C. A 25 hydroxy vitamin D assay was carried out using solid phase RIA. A 1,25 dihydroxy vitamin D assay was carried out using a commercial kit purchased from Incstar Corporation. IL-17 and -23 and MCP-1 were assayed by an enzyme immunoassay. Quantitative and qualitative polymerase chain reaction for hCV virus were done by TaqMan technology. Only hCV genotype IV-infected subjects were included in the study. The mean ± SD were determined, a t-test for comparison of means of different parameters was used. Correlation analysis was done using Pearson’s correlation. Differences among different groups were determined using the Kruskal-Wallis test. RESULTS: The mean vitamin D level in hCV patients (group?I) was 15 ± 5.2 ng/mL while in control (group II) was 39.7 ± 10.8. For active vitamin D in group?I?as 16.6 ± 4.8 ng/mL while in group II was 41.9 ± 7.9. IL-23 was 154 ± 97.8 in group?I?and 6.7 ± 2.17 in group II. IL-17 was 70.7 ± 72.5 in cases and 1.2 ± 0.4 in control. MCP-1 was 1582 ± 794.4 in group?I?and 216.1 ± 5.38 in group II. Vitamin D deficiency affected 72% of hCV-infected patients and 0% of the control group. Vitamin D insufficiency existed in 28% of hCV-infected patients and 12% of the control group. One hundred percent of the cirrhotic patients and 40% of non cirrhotic hCV-infected patients had vitamin D deficiency. IL-23, IL-17, and MCP-1 were markedly increased in hCV-infected patients in comparison to controls.A significant negative correlation between vitamin D and IL-17 and -23 and MCP-1 was detected. hCV-infected males and females

关键词： Vitamin D Macrophage chemoattractant protin-1 Liver cirrhosis Interleukin-23 Interleukin-17 Liver cirrhosis

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Circulating Levels of hypoxia-regulating MicroRNAs in Systemic Lupus Erythematosus Patients with hemolytic Anemia

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Current Medical Science 2022年第6期42卷 1231-1239页

作者： Amira M.Gamal-Eldeen Cinderella A.fahmy Bassem M.Raafat Fayez Althobaiti Iman h.Bassyouni Roba M.Talaat Clinical Laboratory Sciences Department College of Applied Medical SciencesTaif UniversityTaif21944Saudi Arabia high Altitude Research Center Prince Sultan Medical ComplexAl-HawiyahTaif UniversityTaif21944Saudi Arabia Cancer Biology and Genetics Laboratory Centre of Excellence for Advanced SciencesNational Research CentreCairo12622Egypt Biochemistry Department National Research CentreCairo12622Egypt Radiological Sciences Department College of Applied Medical SciencesTaif UniversityTaif21944Saudi Arabia Biotechnology Department Faculty of ScienceTaif UniversityTaif21944Saudi Arabia Department of Rheumatology and Rehabilitation Faculty of MedicineCairo UniversityEl-Kasr El-Aini HospitalCairo12613Egypt Molecular Biology Department Genetic Engineering and Biotechnology Research Institute(GEBRI)Sadat City UniversitySadat City32897Egypt

Objective MicroRNAs are fine regulators for gene expression during the post-transcriptional stage in many autoimmune ***(miR-210 and miR-21)play an important role in hypoxia and in inflammation-associated *** lupus erythematosus(SLE)is a chronic systemic autoimmune disease that would potentiate many pathological complications,including hemolytic *** study aimed to investigate the role of hypoxamiRs in SLE/hemolytic anemia *** This work was designed to analyze the circulating levels of↱the miR-210 and miR-21 expressions and hypoxia-inducible factor-1α(hIF-α)in SLE/hemolytic anemia *** activity was evaluated for all patients by SLE Disease Activity Index(SLEDAI).Clinical manifestations/complications and serological/hematological investigations were ***-αconcentration was assayed by ELISA and expression of miR-21 and miR-210 was analyzed by *** The results indicated that the fold change of the miR-210/miR-21 expressions in plasma was significantly elevated in SLE/hemolytic anemia patients.A strong positive correlation between the miR-210 and miR-21 expression levels was also *** the associated-disease complications,hypertension,arthritis,oral ulcers,and serositis were associated with a high circulating miR-210 expression,while the occurrence of renal disorders was associated with the increased miR-21 ***,the hIF-αlevel was remarkably elevated in SLE/hemolytic anemia patients.A high positive correlation was recorded between the hIF-αconcentration and miR-210/miR-21 expression *** occurrence of oral ulcers,arthritis,and hypertension was associated with the increased hIF-α*** the other hand,SLEDAI and white blood cell count were positively correlated with miR-21/*** erythrocyte sedimentation rate was positively correlated with *** The dysregulation of the circulating miR-210/miR-210/hIF-1αlevels in SLE/hemolytic anemia pat

关键词： circulating hypoxamiRs miR-210 and miR-21 hypoxia-inducing factor-1α hemolytic anemia systemic lupus erythematosus

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Biosynthesis of raw starch degradingβ-cyclodextrin glycosyltransferase by immobilized cells of Bacillus licheniformis using potato wastewater

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BIOCELL 2021年第6期45卷 1661-1672页

作者： YASSER S.MOSTAFA SAAD A.ALAMRI SULIMAN A.ALRUMMAN TAREK h.TAhA MOhAMED hAShEM MAhMOUD MOUSTAFA LAMIAA I.fahmy Department of Biology College of ScienceKing Khalid UniversityAbha9004Saudi Arabia Prince Sultan Bin Abdulaziz Center for Environmental and Tourism Research and Studies King Khalid UniversityAbha9004Saudi Arabia Environmental Biotechnology Department Genetic Engineering and Biotechnology Research InstituteCity of Scientific Research&Technological ApplicationsNew Borg El-Arab City21934Egypt Department of Botany and Microbiology Faculty of ScienceAssiut UniversityAssiut71515Egypt Department of Botany and Microbiology Faculty of ScienceSouth Valley UniversityQena83523Egypt Department of Microbiology and Immunology Faculty of PharmacyOctober University for Modern Science and ArtGiza12451Egypta

The study was sought to enhance the synthesis of thermal stableβ-cyclodextrin glycosyltransferase(β-CGTase)using potato wastewater as a low-cost medium and assess the degree to which it is efficient for industrial production ofβ-cyclodextrin(β-CD)from raw potato *** bacteria producingβ-CGTase was isolated from Saudi Arabia and the promising strain was identified as Bacillus licheniformis using phylogenetic analysis of the 16S rRNA ***-encapsulated cultures exhibited twice-fold ofβ-CGTase production more than free *** electron microscopy(SEM)of polymeric capsules indicated the potential for a longer shelf-life,which promotes the restoration of activity in bacterial cells across semi-continuous fermentation ofβ-CGTase production for 252 *** optimal conditions forβ-CGTase synthesis using potato wastewater medium were at 36 h,ph of 8.0,and 50°C with 0.4%potato starch and 0.6%yeast extract as carbon and nitrogen sources,*** purified enzyme showed a specific activity of 63.90 U/mg with a molecular weight of∼84.6 kDa as determined by SDS-PAGE *** high enzyme activity was observed up to 60°C,and complete stability was achieved at 75°*** levels of activity and stability were shown at ph 8.0,and the ph range from 7.0–10.0,*** enzyme has an appreciable affinity for raw potato starch with a Km of 5.7×10−6 M and a Vmax of 87.71μmoL/mL/min.β-CD production was effective against 25 U/g of raw potato *** outcomes demonstrated its feasibility to develop a fermentation process by integrating the cost-effective production ofβ-CGTase having distinctive properties forβ-CD production with ecofriendly utilization of potato wastewater.

关键词： Potato wastewater Bacillus licheniformis β-CGTase 16S rDNA gene Semi-continuous fermentation β-cyclodextrin

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Nondestructive evaluation of mechanical properties of nanostructured Al-Cu alloy at room and elevated temperatures

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Transactions of Nonferrous Metals Society of China 2019年第12期29卷 2472-2482页

作者： hany R.AMMAR fahmy MhAGGAG Mechanical Engineering Department College of EngineeringQassim UniversitySaudi Arabia Metallurgical and Materials Engineering Department Faculty of Petroleum and Mining EngineeringSuez UniversitySuezEgypt ABI Services LLC115 Clemson DriveOak RidgeTennessee 37830USA

The influence of processing variables on the mechanical properties of a nanostructured Al-10 wt.%Cu alloy was ***-strain microprobe®system(SSM)and its automated ball indentation®(ABI®)test were used for evaluating the mechanical properties of this *** tests were conducted at 21℃ on the bulk samples that were mechanically alloyed for 6 h at two ball-to-powder mass ratios(BPR)of 30:1 and 90:***,the tests were conducted at 200 and 400℃ on the samples that were processed at BPR of 90:*** BPR resulted in raising the final indentation load from(316±26)to(631±9)N and reducing the final indentation depth from 111 to 103μ*** the samples that were processed at BPR of 90:1,increasing the test temperature from 21 to 400℃ resulted in decreasing the final load from(631±9)to(125±1)N and increasing the final depth from 103 to(116±1)μ*** sample processed at BPR of 90:1 and tested at 21℃ revealed the highest strength and the least deformability while the sample processed at BPR of 90:1 and tested at 400℃ exhibited the lowest strength and the greatest deformability,as compared to all samples under study.

关键词： Al-Cu alloy ball milling automated ball indentation®(ABI®) mechanical properties test temperature

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Positional effect of mutations in 5'UTR of hepatitis C virus 4a on patients' response to therapy

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World Journal of Gastroenterology 2009年第12期15卷 1480-1486页

作者： Mostafa K El Awady hassan M Azzazy Ahmed M fahmy Sherif M Shawky Noha G Badreldin Samar S Yossef Moataza h Omran Abdel Rahman N Zekri Said A Goueli Department of Biomedical Technology National Research CenterDokkiCairo 12622Egypt Department of Chemistry and Yousef Jameel Science and Technology Research Center the American University in CairoCairo 11511Egypt Structural biology department Free University of AmsterdamDe Boelelaan 10851081 HV AmsterdamThe Netherlands National Cancer Institute Cairo 11796Egypt Department of Pathology and Laboratory Medicine University of WisconsinMadisonWI 53711United States

AIM： To investigate the effects of mutations in domain Ⅲ of the hepatitis C virus （hCV） internal ribosome entry sequences （IRES） on the response of chronic hCV genotype 4a patients to interferon therapy.METhODS： hCV RNA was extracted from 19 chronic hCV 4a patients receiving interferon/ribavirin therapy who showed dramatic differences in their response to combination therapy after initial viral clearance. IRES domain Ⅲ was cloned and 15 clones for each patient were sequenced. The obtained sequences were aligned with genotype 4a prototype using the ClustaIW program and mutations scored. Prediction of stem-loop secondary structure and thermodynamic stability of the major quasispecies in each patient was performed using the MFOLD 3.2 program with Turner energies and selected constraints on base pairing.RESULTS： Analysis of RNA secondary structure revealed that insertions in domain Ⅲ altered WatsonCrick base pairing of stems and reduced molecular stability of RNA, which may ultimately reduce binding affinity to ribosomal proteins. Insertion mutations in domain - were statistically more prevalent in sustained viral response patients （SVR, n = 14） as compared to breakthrough （BT, n = 5） patients.CONCLUSION： The influence of mutations within domain Ⅲ on the response of hCV patients to combination therapy depends primarily on the position, but not the frequency, of these mutations within IRES domain Ⅲ.

关键词： hepatitis C virus Internal ribosome entrysequences Domain Ⅲ Genotype 4a Ribosomal sub-unit Interferon therapy RNA folding

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Does Caffeine Citrate Administration Decrease Risk of Acute Kidney Injury in hospitalized Preterm Neonates?

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Open Journal of Pediatrics 2021年第3期11卷 532-542页

作者： Fatma h. Mohamed Saneya A. fahmy Amal G. Mohamed Department of Pediatrics Faculty of Medicine for Girls Al-Azhar University Cairo Egypt

Background: Acute kidney injury (AKI) is a life threatening condition with still high mortality rate in neonates. Early recognition of the risk factors and the rapid effective treatment of the contributing conditions will reduce AKI in the neonatal period. Aim of the Work: To determine association between early caffeine citrate administration and risk of acute kidney injury in hospitalized preterm neonates. Patients and Methods: This study was a prospective study that was conducted at the NICU of El Galaa Teaching Hospital. This study included 100 preterm neonates who were born alive from 32 weeks to 35 weeks of gestation. Results: There was highly statistically significant occurrence of apneaic episode in preterm babies who don’t receive caffeine citrate and consequently decreased incidence of AKI in those babies. Conclusion:

关键词： Caffeine Citrate Acute Kidney Injury Neonates

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Using Environmentally Friendly hydrogels to Alleviate the Negative Impact of Drought on Plant

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Open Journal of Applied Sciences 2022年第1期12卷 111-133页

作者： Gehan h. Abd El-Aziz Ahmed S. Ibrahim Ashraf h. fahmy Soils Water and Environment Research Institute Agricultural Research Center Giza Egypt Cairo University-Plant Biotechnology Research Laboratories (CU-PBRL) Scientific Center of Excellence in Plant Biotechnolo-gy Plant Physiology Division Department of Agricultural Botany Faculty of Agriculture Cairo University Cairo Egypt Agriculture Genetic Engineering Research Institute Agricultural Research Center Giza Egypt

The use of natural hydrogels in agriculture provides solutions to many problems without threatening the environment. This study aims to evaluate the potential impact of environmentally friendly hydrogels (pectin, starch and pectin + starch) in reducing the negative effects of drought stress on tomato yield and quality. Two different peels (orange peel and banana peel) are used to prepare environmentally friendly hydrogels. The water retention efficiency of hydrogels has been studied. Greenhouse experiment for tomato under drought stress was conducted during 2019. These hydrogels were used under several level of irrigation (100%, 75%, and 50% FC), soil without hydrogel was used as a control. The results showed that the eco-friendly hydrogels (starch, pectin, and pectin + starch) had capacity retention of water for a long time. The obtained data from the greenhouse experiment showed that the eco-friendly hydrogel showed a positive effect on retention of water and increase the soil moisture content compared to control. The highest increase was observed at pectin + starch treatment. This increase reached to 2.8-, 2.4- and 2.0-fold for 100%, 75% and 50% FC compared to the control. Eco- friendly hydrogel application under different drought conditions led to improve yield and quality of tomato fruits. Moreover, conversion of agricultural wastes to hydrogels and the use of these eco-friendly materials instead of synthetic hydrogels are necessary to utilize the limited natural resources and decrease the harmful impact of agricultural wastes on the environment and pave the way for the transition to a sustainable agriculture system.

关键词： Eco-Friendly hydrogel Pectin Starch Tomato Soil Drought

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Solar Thermal Aquaculture System Controller Based on Artificial Neural Network

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Engineering（科研） 2011年第8期3卷 815-822页

作者： Doaa M Atia Faten h fahmy Ninet M Ahmed hassen T Dorrah 不详

Temperature is one of the most principle factors affects aquaculture system. The water temperature is very important parameter for shrimp growth. It can cause stress and mortality or superior environment for growth and reproduction. The required temperature for optimal growth is 34oC, if temperature increase up to 38oC it causes death of the shrimp, so it is important to control water temperature. Solar thermal water heating system is designed to supply an aquaculture pond with the required hot water in Mersa Matruh in Egypt as presented in this paper. This paper introduces a complete mathematical modeling and MATLAB SIMULINK model for the solar thermal aquaculture system. Moreover the paper presents the control of pond water temperature using artificial intelligence technique. Neural networks are massively parallel processors that have the ability to learn patterns through a training experience. Because of this feature, they are often well suited for modeling complex and non-linear processes such as those commonly found in the heating system. They have been used to solve complicated practical problems. The simulation results indicate that, the control unit success in keeping water temperature constant at the desired temperature by controlling the hot water flow rate.

关键词： Aquaculture Forced Circulation hot Water System Artificial Neural Networks

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Positive and Negative Environmental Effect of Using Zinc Oxide Nanoparticles on Wheat under Drought Stress

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Open Journal of Applied Sciences 2022年第6期12卷 1026-1044页

作者： Gehan h. Abd El-Aziz Shreen S. Ahmed Khaled h. Radwan Ashraf h. fahmy Soils Water and Environment Research Institute ARC Giza Egypt Microbial Molecular Biology Department Agricultural Genetic Engineering Research Institute ARC Giza Egypt National Biotechnology Network of Expertise ASRT Cairo Egypt Plant Genetic Transformation Department Agricultural Genetic Engineering Research Institute ARC Giza Egypt

Nanoscience is a development concept in the field of agriculture. Water scarcity is one of the most serious stresses that restrict growth of plant. This search was done to value the positive and negative influence of ZnO nanoparticles on wheat plant growth under drought stress. A green synthesis technique was used to produce pollutant-free nano structures. A field experiment was carried out during successive season (2019/2020). NP-Zn-O was applied either by seed-soaking, foliar spraying, or both together applications. The dose of ZnO NPs was 100 mg/l. Data showed that drought stress reduced the grain and shoot wheat yield. The use of different forms of ZnO improved the grain and shoot wheat yield, these increases reached 1.16-, 1.54-fold that control. In addition, one of the other effects of Zn-O-NPs is to increase the levels of chlorophyll and proline antioxidants in plant tissues, as it is a cofactor for enzymes such as superoxide dismutase and catalase. The data suggest that the role of ZnO NPs is not only to improve plant growth and physiological parameters, but also to improve nutrient uptake and plant nutrient levels. In this regard, the use of zinc in the form of ZnO NPs has a positive effect on reducing the adverse effects of drought conditions and improving the nutritional quality of plants.

关键词： Nanoparticles Zinc Wheat Drought Stress

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