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Understanding the Recovery of the Intervertebral Disc:A Comprehensive Review of In Vivo and In Vitro Studies

Journal of Bionic Engineering 2024年第4期21卷 1919-1948页

作者： Faten Feki Fahmi Zaïri Abderrahman Tamoud Melissa Moulart Rym Taktak Nader Haddar fahed Zaïri Sfax University ENISMaterials Engineering and Environment Laboratory3038SfaxTunisia University of Lille IMT Nord EuropeJUNIAUniversity of ArtoisULR 4515-LGCgELaboratoire de Génie Civil et geo-Environnement59000LilleFrance PrediTwins Lab 59000LilleFrance Japet Medical Device 59000LilleFrance Sfax University ENISLaboratory of Advanced Materials3038SfaxTunisia Ramsay Générale de Santé Hôpital PrivéLe Bois59000LilleFrance

Within the consistent daily rhythm of human life,intervertebral discs endure a variety of complex loads beyond the influences of gravity and muscle forces,leading to significant morphological changes(in terms of volume,area,and height)as well as biomechanical alterations,including an increase in disc stiffness and a decrease in intradiscal ***,the discs demonstrate an ability to regain their original morphological and biomechanical characteristics after a period of nocturnal *** preservation of normal disc function is critically dependent on this recovery phase,which serves to forestall premature disc *** phenomenon of disc recovery has been extensively documented through numerous in vivo studies employing advanced clinical techniques such as Magnetic Resonance Imaging(MRI),stadiometry,and intradiscal pressure ***,the findings from in vitro studies present a more complex picture,with reports varying between full recovery and only partial recuperation of the disc ***,research focusing on degenerated discs in vitro has shed light on the quantifiable impact of degeneration on the disc ability to *** dynamics within the disc are considered a primary factor in recovery,yet the disc intricate multiscale structure and its viscoelastic properties also play key *** elements interact in complex ways to influence the recovery mechanism,particularly in relation to the overall health of the *** objective of this review is to collate,analyze,and critically evaluate the existing body of in vivo and in vitro research on this topic,providing a comprehensive understanding of disc recovery *** understanding offers a blueprint for future advancements in medical treatments and bionic engineering solutions designed to mimic,support,and enhance the natural recovery processes of intervertebral discs.

关键词： Intervertebral disc Recovery In vivo vs.in vitro studies Degeneration Viscoelastic effects Fluid dynamics

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AB090. MOG1, the genetic modifier at 20q13, delays the age-at-onset of glaucoma by 8 to 10 years

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Annals of Eye Science 2018年第1期 496-496页

作者： Vincent Raymond Pascal Belleau Rose Arseneault Stéphane Dubois Jean-Louis Anctil Gilles Côté Marcel Amyot fahed elian Michael AWalter Québec Glaucoma Network Département d’ophtalmologie Centre de rechrechr du CHU de QuébecQuébecQCCanada

Background:Primary open-angle glaucoma(POAG)is a genetically complex disorder caused primarily by gene-gene *** identify these interactions,we studied the CA family,a large French-Canadian pedigree in which the myocilin K423E mutation(MYOCK423E)causes autosomal dominant glaucoma with diagnoses ranging from juvenile-onset OAG(JOAG)to late adult-onset POAG in the heterozygotes(HTZ).To explain this extreme variability,we hypothesized that a second gene,called a modifier,was interacting with MYOC,the primary disease *** goals were(I)to map the modifier on the human genome and;(II)to characterize the symptoms affected genetically by the *** symptoms are called ***:Three hundred seventy-five CA members were studied using four quantitative endophenotypes:age of maximal intra-ocular pressures(IOPmax),IOPs progression,progression of cup to disk ratios and age-at-onset(AAO)defined as age at which ocular hypertension(OHT)was first detected with IOP≥22 ***-wide linkage analysis was performed by genotyping 408 genetic markers in 184 CA *** unbiased pedigree-based algorithm was designed to identify the individuals who were double-mutants,i.e.,these individuals carried one MYOCK423E mutation(i.e.,they were HTZ,affected or not)and they also carry simultaneously a DNA mutation within the ***:Out of the 375 CA family members investigated,156 were HTZ for the MYOCK423E mutation.120 HTZ were affected with OAG or OHT with treatment while the remaining 36 HTZ were *** ranged from 7 to 63 years old;4 individuals over 50 years old were still *** preceded optic nerve damage in>98%of the HTZ carriers,confirming that AAO reflected the true severity of the *** modifier showed strong inherited effects on 2 of the 4 endophenotypes:AAO and *** next mapped with very high confidence the modifier locus for AAO at chromosome *** genotyping with additional markers refined th

关键词： Blindness genomics complex genetic disorder gene-gene interactions biostatistics

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*** dissection of myocilin(MYOC)-induced glaucoma reveals that the modifier of glaucoma 1(MOG1)locus encodes a gene which prevents ocular hypertension

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Annals of Eye Science 2019年第1期 199-199页

作者： Vincent Raymond Pascal Belleau Rose Arseneault Jean-Louis Anctil Gilles Côté Marcel Amyot Patrick Laplante Laurent Lamalice Stéphane Dubois fahed elian Michael A.Walter Québec Glaucoma Network CHUL at CHU de Québec-UniversitéLaval Québec CityQCCanada Molecular Medicine UniversitéLavalQuébec CityQCCanada Cold Spring Harbor Laboratory NYUSA Department of Ophthalmology UniversitéLavalQuébec CityQCCanada Department of Ophthalmology Universitéde MontréalMontréalQCCanada Medical Genetics University of AlbertaEdmontonABCanada Ophthalmologists from Province of Québec QuébecQCCanada

Background:Pathogenic mechanisms leading to open-angle glaucoma(OAG)are genetically *** involve neuroinflammation,elevation of intra-ocular pressures(IOP)and optic nerve hypersensitivity to cellular *** mapped a locus at chromosome 20q13 that contains a modifier gene for glaucoma *** searching for its identity,we named this gene modifier of glaucoma 1(MOG1).The goal of this study is to characterize the mechanism by which MOG1 delays the age of onset of glaucoma when OAG is caused by mutations in the MYOC *** hypothesized that MOG1 mechanism may be linked to a specific endophenotype and thus dissected ocular phenotypes present in a large French-Canadian MYOC glaucoma ***:We studied 375 members of the CA pedigree in which autosomal dominant OAG is caused by the MYOCK423E *** this family,wild-type MOG1(normal form)delays the age-at-onset(AAO)of *** records of MYOCK423E carriers were reviewed to extract the values of four quantitative traits portraying four endophenotypes:(I)age of maximal intra-ocular pressure(IOP max),(II)IOP progression,(III)rate of optic nerve degeneration and,(IV)AAO defined as the age at which IOP≥22 mmHg or age at which optic disk degeneration was first *** were tested for their heritability.A three-stage algorithm was designed to detect double mutants who carry the MYOCK423E mutation and putative MOG1 *** traits values of double-mutants were then ***:We found 156 individuals who were heterozygotes(HTZ)for *** hundred and twenty of these were classified affected as they were OAG or had treatment for ocular hypertension(OHT)with IOP≥22 *** other 36 HTZ were *** two endophenotypes,AAO and IOP max,showed significant *** was the 1st symptom detected in 99%of the affecteds;it always preceded optic nerve *** of the affecteds ranged from 7 to 63 years old while rates of optic nerve degenera

关键词： Blindness glaucoma genetics modifier myocilin

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石墨烯增强功能梯度多孔梁材料不确定性对热机械过屈曲行为的影响

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Acta Mechanica Sinica 2023年第4期39卷 21-43页

作者： fahed Mohd Mohammad Talha Computational Design Lab School of Mechanical and Materials EngineeringIndian Institute of Technology MandiMandi175075India

本文旨在研究石墨烯片增强功能梯度多孔梁材料不确定性对在热环境下的过屈曲行为的影响.通过采用随机有限元方法,已经完成了全面的确定性和随机性研究.考虑了温度依赖性(TD)和温度无关性(TID)的材料特性.使用Halpin-Tsai微力学模型估计... 详细信息

本文旨在研究石墨烯片增强功能梯度多孔梁材料不确定性对在热环境下的过屈曲行为的影响.通过采用随机有限元方法,已经完成了全面的确定性和随机性研究.考虑了温度依赖性(TD)和温度无关性(TID)的材料特性.使用Halpin-Tsai微力学模型估计了杨氏模量等均质化有效材料性质,通过Voigt混合法则估计了密度和热膨胀系数.假设均质化的材料特性沿厚度方向以功能渐变的方式变化.所开发的公式基于高阶剪切变形理论,结合冯-卡门型几何非线性进行过屈曲分析.开发C^(0)有限元模型求解非线性控制方程组,使用直接迭代过程进行数值求解.所开发方法的收敛和验证研究也通过独立的蒙特卡罗模拟进行,以确保方法的准确性.分别讨论了材料设计参数如孔隙率含量、纳米填料量和材料特性(即杨氏模量、金属基体密度和纳米填料)的低变异性(随机性)等材料不确定性对FGGPLRC多孔梁热机械过屈曲行为的影响.结果表明,材料性能的不确定性会显著影响FG-GPLRC多孔梁的过屈曲响应.

关键词：杨氏模量功能梯度蒙特卡罗模拟纳米填料温度依赖性热膨胀系数材料特性直接迭代

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Types of Irrigation Water and Soil Amendment Affect the Growth and Flowering of Petunia x alkinsiana ‘Bravo Pinc’

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Phyton-International Journal of Experimental Botany 2023年第2期92卷 487-499页

作者： Abdullah M.Algahtani fahed A.Al-Mana Khalid M.Elhindi Department of Plant Production College of Food and Agriculture SciencesKing Saud UniversityRiyadh11671Saudi Arabia Department of Vegetable and Floriculture Faculty of AgricultureMansoura UniversityMansoura35516Egypt

Water insufficiency is the hampering feature of crop sustainability,especially in arid and semi-arid ***,the effectual usage of all water resources especially underground brackish water represents the core priority in Saudi *** present study aimed to recognize the influence of different types of water irrigation(tap water as a control,salinized well water,and magnetized salinized well water)with or without soil amendments(soil without any amendment as a control,peat-moss,ferrous sulfate,and peat-moss plus ferrous sulfate)on petunia plant growth and flowering as well as ion *** Petunia plants with saline well water adversely affected growth and flowering as compared to tap water and magnetized saline well ***,plants irrigated with magnetized water showed a significant enhancement in all the studied vegetative and flowering growth parameters as compared to those irrigated with salinized well ***,mineral contents and survival of Petunia plants irrigated with magnetized well water were higher than those irrigated with tap *** with magnetized well water significantly reduced levels of Na+and Cl−ions in leaves of Petunia plants indicating the role of magnetization in alleviating harmful effects of *** conclusion,we recommend the utilization of magnetized saline well water for irrigating Petunia plants either alone or in combination with soil amendments(peat moss plus ferrous sulfate).

关键词： Flowering magnetization petunia saline water soil amendment

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Predicting long-term outcomes in acute intracerebral haemorrhage using delayed prognostication scores

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Stroke & Vascular Neurology 2021年第4期6卷 536-541,I0013-I0025页

作者： Ronda Lun Vignan Yogendrakumar Tim Ramsay Michel Shamy Robert fahed Magdy H Selim Dar Dowlatshahi Department of Medicine Division of NeurologyStroke ProgramOttawa HospitalOttawaOntarioCanada Clinical Epidemiology Program School of EpidemiologyPublic Health and Preventative MedicineOttawa Hospital Research InstituteOttawa UniversityOttawaOntarioCanada Ottawa Hospital Research Institute OttawaOntarioCanada Interventional Neuroradiology Rothschild FoundationParisÎle-de FranceFrance Department of Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA

Objective The concept of the‘self-fulfilling prophecy’is well established in intracerebral haemorrhage(ICH).The ability to improve prognostication and prediction of long-term outcomes during the first days of hospitalisation is important in guiding conversations around goals of *** previously demonstrated that incorporating delayed imaging into various prognostication scores for ICH improves the predictive accuracy of 90-day ***,delayed prognostication scores have not been used to predict long-term functional outcomes beyond 90 ***,setting and participants We analysed data from the ICH Deferoxamine trial to see if delaying the use of prognostication scores to 96 hours after ICH onset will improve performance to predict outcomes at 180 days.276 patients were *** and measurements We calculated the original ICH score(oICH),modified-ICH score(MICH),max-ICH score and the FUNC score on presentation(baseline),and on day 4(delayed).Outcomes assessed were mortality and poor functional outcome in survivors(defined as modified Rankin Scale of 4-5)at 180 *** generated receiver operating characteristic curves,and measured the area under the curve values(AUC)for mortality and functional *** compared baseline and delayed AUCs with non-parametric *** At 180 days,21 of 276(7.6%)*** of the survivors,54 of 255 had poor functional outcome(21.2%).The oICH,MICH and max-ICH performed significantly better at predicting 180-day mortality when calculated 4 days later compared with their baseline equivalents((0.74 vs 0.83,p=0.005),(0.73 vs 0.80,p=0.036),(0.74 vs 0.83,p=0.008),respectively).The delayed calculation of these scores did not significantly improve our accuracy for predicting poor functional *** Delaying the calculation of prognostication scores in acute ICH until day 4 improved prediction of 6-month mortality but not functional *** registration number *** Registry(NCT0

关键词： acute delayed score

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Human Detection by Robotic Urban Search and Rescue Using Image Processing and Neural Networks

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International Journal of Intelligence Science 2014年第2期4卷 39-53页

作者： fahed Awad Rufaida Shamroukh Depatment of Computer Engineering Jordan University of Science & Technology Irbid Jordan Depatment of Network Engineering & Security Jordan University of Science & Technology Irbid Jordan

This paper proposes a new approach for detecting human survivors in destructed environments using an autonomous robot. The proposed system uses a passive infrared sensor to detect the existence of living humans and a low-cost camera to acquire snapshots of the scene. The images are fed into a feed-forward neural network, trained to detect the existence of a human body or part of it within an obstructed environment. This approach requires a relatively small number of images to be acquired and processed during the rescue operation, which considerably reduces the cost of image processing, data transmission, and power consumption. The results of the conducted experiments demonstrated that this system has the potential to achieve high performance in detecting living humans in obstructed environments relatively quickly and cost-effectively. The detection accuracy ranged between 79% and 91% depending on a number of factors such as the body position, the light intensity, and the relative color matching between the body and the surrounding environment.

关键词： Urban Search and Rescue Human-Robot Interaction Autonomous Systems Intelligent Interface Neural Networks

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Effect of Spraying with GA<sub>3</sub>on the Quality and Oil Content of Syrian Okra Seeds <i>Abelmoschus esculentus</i>(L.)

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American Journal of Plant Sciences 2022年第1期13卷 83-90页

作者： Dima Zolfikar Khrmashow Miteadi Bouras fahed Sahuni Department of Horticulture Faculty of Agriculture Tishreen University Lattakia Syria Department of Horticulture Second College of Agriculture Aleppo University Aleppo Syria

This study aimed to estimate the effect of spraying of okra plants, Abelmoschus esculentus (L.) with GA3 on the quality and oil content of the seeds. For this, the local okra variety was selected and used, which was growing widespread in the coastal region of Syria. This study was carried out in Al-Haffa area, Lattakia governorate, Syria (with 105 MSL elevation) for two seasons 2019-2020. The results showed that the effect of spraying with GA3 was more evident in the quality of the seeds as well as oil content at 75 ppm concentration with 68.7 g weight of 1000 seeds and 5.31% seed oil percentage. This study also showed that oil of local okra variety seed was rich in the essential fatty acids namely, linoleic, palmitic, oleic, stearic and linolenic, treatment with 75 ppm concentration of GA3 was more effective in the seed content of essential fatty acids with 42.30%, 32.55%, 9.20%, 6.73% and 5.72%, respectively. Finally, our results were indicated that treatment of okra plants at 75 ppm of GA3 enhanced the quality and oil content of seeds compared to the other concentrations.

关键词： Oil Content GA3 Fatty Acids Linoleic Palmitic Okra

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Energy-Efficient and Coverage-Aware Clustering in Wireless Sensor Networks

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Wireless Engineering and Technology 2012年第3期3卷 142-151页

作者： fahed Awad Eyad Taqieddin Asmaa Seyam Department of Computer Engineering Jordan University of Science and Technology Irbid Jordan Department of Network Engineering and Security Jordan University of Science and Technology Irbid Jordan

Energy efficiency and sensing coverage are essential metrics for enhancing the lifetime and the utilization of wireless sensor networks. Many protocols have been developed to address these issues, among which, clustering is considered a key technique in minimizing the consumed energy. However, few clustering protocols address the sensing coverage metric. This paper proposes a general framework that addresses both metrics for clustering algorithms in wireless sensor networks. The proposed framework is based on applying the principles of Virtual Field Force on each cluster within the network in order to move the sensor nodes towards proper locations that maximize the sensing coverage and minimize the transmitted energy. Two types of virtual forces are used: an attractive force that moves the nodes towards the cluster head in order to reduce the energy used for communication and a repulsive force that moves the overlapping nodes away from each other such that their sensing coverage is maximized. The performance of the proposed mechanism was evaluated by applying it to the well-known LEACH clustering algorithm. The simulation results demonstrate that the proposed mechanism improves the performance of the LEACH protocol considerably in terms of the achieved sensing coverage, and the network lifetime.

关键词： WSN Clustering LEACH Virtual Field Force Lifetime Sensing Coverage

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Diagnosis and management challenges of in-stent restenosis in coronary arteries

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World Journal of Cardiology 2017年第8期9卷 640-651页

作者： M Chadi Alraies fahed Darmoch Ramyashree Tummala Ron Waksman Heart and Vascular Institute Department of Interventional CardiologyGeorgetown University/Med Star Washington Hospital Center Internal Medicine Department St Vincent Charity Medical Center/Case Western Reserve University

Over the course of the 3 decades, percutaneous coronary intervention(PCI) with stent implantation transformed the practice of cardiology. PCI with stenting is currently the most widely performed procedure for the treatment of symptomatic coronary disease. In large trials, drugeluting stents(DES) have led to a significant reduction in in-stent restenosis(ISR) rates, one of the major limitations of bare-metal stents. Due to these favorable findings, DES was rapidly and widely adopted enabling more complex coronary interventions. Nevertheless, ISR remains a serious concern as late stent complications. ISR mainly results from aggressive neointimal proliferation and neoatherosclerosis. DES-ISR treatment continues to be challenging complications for interventional cardiologists.

关键词： Stent In-stent Restenosis Percutaneous coronary intervention

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