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Analysis of Local Diagnostic Reference Levels for Pediatric Patients Undergoing 18F-FDG PET/CT Imaging for Oncology

Journal of Applied Mathematics and Physics 2023年第7期11卷 2144-2155页

作者： Saad Alqahtani Khaled Soliman Saad Alotaibi Khaled Alnofaie Abdullah Alahmari fahad alyahya Abdullah Albdullah Rashed Alharbi Radiodiagnostic and Medical Imaging Department Prince Sultan Military Medical City Riyadh Saudi Arabia Medical Physics Department Prince Sultan Military Medical City Riyadh Saudi Arabia

Background: The PET/CT imaging studies have two doses components the dose from the PET radiopharmaceutical and the other from the low dose CT used for PET images attenuation correction. We have one PET/CT scanner at our institution a Philips Time of Flight scanner. Our local patient’s radiation protection rules requires continuous assessment of radiation doses delivered to our patients. Purposes: The objectives of this study are to develop a weight- based facility DRLs for paediatric F-18-FDG PET-CT imaging for oncology in a large tertiary hospital and to determine whether the calculated DRLs compares with internationally published DRLs. Materials & Methods: Radiation dose data and patient demographics of two-hundreds and sixteen paediatric PET-CT oncology patients imaging procedures from one large tertiary hospital were selected and analysed in order to establish a facility paediatric DRLs. Statistical analysis was performed. Results: The PET dose reference levels ranged between [62 - 525] MBq of injected activity for a range of pediatric age groups. The CTDIvol values were between 3.5 and 16.5 mGy for all age groups. Comparison with current EANM and SNMMI recommendations of patient’s dose are discussed. Conclusion: Our pediatric PET/CT reference levels are higher than the ones reported internationally with notable variations. .

关键词： Diagnostic Reference Levels PET/CT 18-F-FDG Pediatric Radiation Dose CTDIvol Oncology

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Saudi Consensus for GLP-1 RAs Switching Guidance: Consensus Report

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International Journal of Clinical Medicine 2022年第1期13卷 22-35页

作者： Saud Alsifri Hussein Elbadawi fahad Alsabaan Abdulraouf Almahfouz Khalid alyahya Eman Shesha Laila Abu Esba Meshal Alnais Raed Aldahash Turky Alharbi Saleh Aljaser Emad R. Issak Endocrinology Department Alhada & Taif Armed Forces Hospitals Taif Saudi Arabia My Clinic Medical Center Jeddah Saudi Arabia Endocrinology Department Security Forces Hospital Riyadh Saudi Arabia Section of Endocrinology Department of Medicine The King Faisal Specialist Hospital and Research Centre Riyadh Saudi Arabia Pharmacy Department Prince Sultan Military Medical City Riyadh Saudi Arabia Diabetes Center King Salman Hospital Riyadh Saudi Arabia King Abdulaziz Medical City Riyadh Saudi Arabia Internal Medicine and Diabetes King Khalid Hospital Hail Saudi Arabia Department of Medicine King Abdulaziz Medical City National Guard Riyadh Saudi Arabia Family Medicine Department Prince Sultan Military Medical City Riyadh Saudi Arabia King Saud bin Abdulaziz University for Health Science Riyadh Saudi Arabia Medicine Department Faculty of Medicine Ain-Shams University Cairo Egypt

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) provide adequate glycemic control, weight reduction, low risk of hypoglycemia, and CV risk reduction. Their usage for type 2 DM (T2DM) is recommended mainly when hypoglycemia or weight gain should be considered, also, whenever initial therapy is failed. There are many recent updates in the treatment paradigm of T2DM. There are many types of GLP-1RAs, with a knowledge gap regarding switching between the different types. A Saudi task force gathered to develop an explicit, evidence-based consensus for switching between GLP-1RAs, when, why, and how? This article contains the expert panel’s recommendations as a contribution to complement the knowledge gap in this area from the national perspective. As an alternative to intensifying therapy, switching from one GLP-1RA to another has various advantages. Improvements in glycemic control, weight loss, adherence, and medications with established cardiovascular benefits are among them. Also, switching needs to be individualized upon many discussed factors like the dose of the previous GLP1-RA and gastrointestinal adverse effects. Discussion with patients about the why and how to switch is critical.

关键词： Glucagon-Like Peptide-1 Receptor Agonists Switching Type 2 DM Glycemic Control

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Saudi Consensus for Low-Premixed Insulin Analogues in Type 2 Diabetes: Consensus Report

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International Journal of Clinical Medicine 2021年第4期12卷 165-182页

作者： Abdulrahman Alshaikh Mohammed Aljamal Saud Alsifri Ali Alrumaih Samia Bokhari Mohammed Almuzaini Khalid alyahya Abdulaziz Bin Shaikh Turky Alharbi Rashid Aljuwair fahad Alsabaan Emad R. Issak Medicine Department College of Medicine King Abdulaziz University Jeddah KSA Supply Chain Department King Fahd Armed Forces Hospital Jeddah KSA Endocrinology Department Alhada & Taif Armed Forces Hospitals Taif KSA Endocrinology Department King Fahad Armed Forces Hospital Jeddah KSA Pharmacy Department Prince Sultan Military Medical City Riyadh KSA Family Medicine Department Prince Sultan military Medical City Riyadh KSA Endocrinology Department Dahran Medical Complex Dahran KSA Endocrinology Department Security Forces Hospital Riyadh KSA Medicine Department Faculty of Medicine Ain-Shams University Cairo Egypt

Dear Dr. Martin Hovland, We learned from the literature that premixed insulins are short-acting insulin or rapid-acting insulin analogue mixed with intermediate-acting insulin in a fixed ratio, addressing FBG and PPBG in one injection. There are two categories;high-mix and low-mix premixed insulins. We, a Saudi task force, gathered to develop an explicit, evidence-based consensus for the use of the low-mix premixed insulin for better glycemic control. The treatment with premixed aspart 30 was non-inferior to treatment with premixed insulin lispro 25. In addition, Self-monitored blood glucose levels were comparable. Safety profiles were similar between both treatments, as was the incidence of hypoglycemic episodes. The switch between both products of the low-mix family can be carried out without any problem. Both products of the low-mix premixed insulin analogues aspart 30/70 and premixed insulin lispro 25/75 have comparable efficacy and safety as shown from the medical literature. Therefore, we can change from one to another safely as demonstrated by the US FDA statement. In addition, the ergonomic features of KwikPen’s design and function may offer important advantages for the user during insulin administration.

关键词： Low-Mix Premixed Insulin Lispro 25/75 Aspart 30/70

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The Awareness of Keratoconus among General Population in Saudi Arabia

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Open Journal of Ophthalmology 2021年第1期11卷 49-59页

作者： Rahaf Mohammed Alruwaili Abeer Surihan Alharbi Omar Ali Alghamdi Yahya Abdulrahman alyahya Nouf Mohammed Albalawi Sameer Sohail Alostaz Omar Ahmed Asiri Khalid Alarfaj College of Medicine Jouf University Sakaka Saudi Arabia Ophthalmology Department Ohud Hospital Madina Saudi Arabia Ophthalmology Department King Fahad Hospital Albaha Saudi Arabia Ophthalmology Department Burydah Central Hospital Qassim Saudi Arabia College of Medicine Tabuk University Tabuk Saudi Arabia Batterjee Medical College Jeddah Saudi Arabia Faculty of Medicine Taif University Taif Saudi Arabia Ophthalmology Department Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia

Introduction: Keratoconus (KCN) is one of the degenerative corneal disorders, which causes impairment in normal visual acuity with a higher prevalence in Saudi Arabia. The study aimed to assess the awareness and knowledge regarding KCN, its risk factors, and management among the Saudi population. Materials and Methods: A survey was conducted using a pre-tested and validated questionnaire distributed through online platforms. A mixture of convenience and snowball sampling techniques was adopted for sample collection. Our analysis included a final sample size of 837 participant responses. The questionnaire had items related to sociodemographic characteristics (5 items), knowledge (10 items), and source of information (1 item). The mean knowledge scores were calculated and categorized (good, fair, and poor) to assess each participant’s knowledge. Pearson’s chi-square test was used to determine the statistical association between categorical variables. Results: The mean knowledge score was found to be 4.12 ± 2.6, and 67.5% of the participants showed “poor” scores. There was no statistically significant association of knowledge scores observed with any of the sociodemographic details. It was agreed by 76% and 42.5% that genetic predisposition and chronic eye inflammation could predispose to KCN. Only 38.1% (n = 157) agreed that KCN could be treated with optical glasses or contact lenses in the initial stages. Conclusion: The knowledge regarding KCN was not satisfactory among our study population. There is a need to create an increased level of awareness for KCN. Health awareness programs and community campaigns should be organized to raise awareness regarding KCN and better eye health care utilization.

关键词： Ophthalmology Inflammation Keratoconus Blindness

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