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Disease clearance in ulcerative colitis:A new therapeutic target for the future

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World Journal of Gastroenterology 2024年第13期30卷 1801-1809页

作者： Syed Adeel Hassan Neeraj Kapur fahad Sheikh Anam fahad Somia Jamal Division of Digestive Disease and Nutrition University of KentuckyLexingtonKY 40536United States Department of Pathology and Laboratory Medicine Montefiore Medical CenterAlbert Einstein College of MedicineNew YorkNY 10461United States Division of Primary Care Essen HealthcareNew YorkNY 10457United States Department of Internal Medicine Karachi Medical and Dental CollegeKarachi 74700SindhPakistan

Advancements in murine modeling systems for ulcerative colitis have diversified our understanding of the pathophysiological factors involved in disease onset and *** has fueled the identification of molecular targets,resulting in a rapidly expanding therapeutic ***,management strategies have evolved from symptomatic resolution to well-defined objective endpoints,including clinical remission,endoscopic remission and mucosal *** the incorporation of these assessment modalities has permitted targeted intervention in the context of a natural disease history and the prevention of complications,studies have consistently depicted discrepancies associated with ascertaining disease status through clinical and endoscopic *** recommendations lack consideration of histological *** simultaneous achievement of clinical,endoscopic,and histologic remission has not been fully *** has laid the groundwork for a novel therapeutic outcome termed disease clearance(DC).This article summarizes the concept of DC and its current evidence.

关键词： Inflammatory bowel disease Ulcerative colitis Clinical remission Endoscopic remission Histological remission Mucosal healing Disease clearance

An Intelligent Model for Online Recruitment Fraud Detection

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Deciphering the role of rGO in tuning dielectric properties of Er_(2)O_(3)/ZnO/rGO nanocomposites synthesized via facile approach

Journal of Information Security（信息安全） 2019年第3期

作者： Bandar Alghamdi fahad alharby

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Journal of Rare Earths 2024年第3期42卷 578-585,I0006页

作者： Saiqa Hafeez Saima Perveen Muhammad Zarrar Khan Awab Hashmi fahad Azad School of Natural Sciences(SNS) National University of Sciences and Technology(NUST)IslamabadPakistan Electronic and Magnetic Materials Laboratory School of Chemical and Materials Engineering(SCME)National University of Sciences and Technology(NUST)IslamabadPakistan

The present research investigated the effect of reduced graphene oxide(rGO) integration with assynthesized Er_(2)O_(3)/ZnO nanocomposites on dielectric properties. The samples were characterized by Xray diffraction(XRD), Fourier transform infrared spectroscopy(FTIR), scanning electron microscopy(SEM), diffuse reflectance spectroscopy(DRS), and energy dispersive spectroscopy(EDS). Complex impedance spectroscopy was utilized to characterize dielectric relaxation phenomena in Er_(2)O_(3)/ZnO and Er_(2)O_(3)/ZnO/rGO nanocomposites. All the samples exhibit single relaxation phenomena which are ascribed to grain boundaries. The addition of rGO to Er_(2)O_(3)/ZnO nanocomposite results in the enhancement of dielectric response due to increased local field intensity caused by the formation of conductinginsulating interfaces. Furthermore, the AC conductivity of the Er_(2)O_(3)/ZnO/rGO is increased at higher frequencies due to the presence of free charge carriers in rGO. At higher frequencies, Er_(2)O_(3)/ZnO/rGO nanocomposite with increased concentration of ZnO exhibits a more stable dielectric constant with extremely low dielectric loss. Hence, the inclusion of rGO in Er_(2)O_(3)/ZnO nanocomposites makes it a novel prospective candidate in the field of energy storage devices.

关键词： Erbium oxide(Er_(2)O_(3)) Rare earths Stable dielectric constant Impedance Polarization Grain boundaries

Medical management of urolithiasis: Great efforts and limited progress

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Asian Journal of Urology 2024年第2期11卷 149-155页

作者： Victoria Jahrreiss Christian Seitz fahad Quhal Department of Urology Comprehensive Cancer CenterMedical University of ViennaViennaAustria Department of Urology King Fahad Specialist HospitalDammamSaudi Arabia

Objective:To provide a comprehensive review on the existing literature on medical management of ***:A thorough literature review was performed using Medline,PubMed/PMC,Embase,and the Cochrane Database of Systematic Reviews up to December 2022 to identify publications on the medical management of *** that assessed dietary and pharmacologic management of urolithiasis were reviewed;studies on medical expulsive therapy were not included in this ***:Medical management of urolithiasis ranges from the prophylactic management of kidney stone disease to dissolution *** most treatment concepts have been long established,large randomized controlled trials are *** modification and increased fluid intake remain cornerstones in the conservative management of urolithiasis.A major limitation for medical management of urolithiasis is poor patient ***:Medical management of urolithiasis is more important in patients with recurrent urolithiasis and patients with metabolic abnormalities putting them at higher risk of developing *** medical management can be effective in limiting stone recurrence,medical interventions often fail due to poor compliance.

关键词： Medicalmanagement Medical therapy Urolithiasis Kidneystonedisease

A Novel Approach to Energy Optimization:Efficient Path Selection in Wireless Sensor Networks with Hybrid ANN

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Computers, Materials & Continua 2024年第5期79卷 2945-2970页

作者： Muhammad Salman Qamar Ihsan ulHaq Amil Daraz Atif MAlamri Salman A.AlQahtani Muhammad fahad Munir Department of Electrical and Computer Engineering International Islamic UniversityIslamabad44000Pakistan School of Information Science and Engineering NingboTech UniversityNingbo315100China Software Engineering Department College of Computer and Information SciencesKing Saud UniversityRiyadh11495Saudi Arabia Computer Engineering Department College of Computer and Information SciencesKing Saud UniversityRiyadh11495Saudi Arabia

In pursuit of enhancing the Wireless Sensor Networks(WSNs)energy efficiency and operational lifespan,this paper delves into the domain of energy-efficient routing ***,the limited energy resources of Sensor Nodes(SNs)are a big challenge for ensuring their efficient and reliable *** data gathering involves the utilization of a mobile sink(MS)to mitigate the energy consumption problem through periodic network *** mobile sink(MS)strategy minimizes energy consumption and latency by visiting the fewest nodes or predetermined locations called rendezvous points(RPs)instead of all cluster heads(CHs).CHs subsequently transmit packets to neighboring *** unique determination of this study is the shortest path to reach *** the mobile sink(MS)concept has emerged as a promising solution to the energy consumption problem in WSNs,caused by multi-hop data collection with static *** this study,we proposed two novel hybrid algorithms,namely“ Reduced k-means based on Artificial Neural Network”(RkM-ANN)and“Delay Bound Reduced kmeans with ANN”(DBRkM-ANN)for designing a fast,efficient,and most proficient MS path depending upon rendezvous points(RPs).The first algorithm optimizes the MS’s latency,while the second considers the designing of delay-bound paths,also defined as the number of paths with delay over bound for the *** methods use a weight function and k-means clustering to choose RPs in a way that maximizes efficiency and guarantees network-wide *** addition,a method of using MS scheduling for efficient data collection is *** simulations and comparisons to several existing algorithms have shown the effectiveness of the suggested methodologies over a wide range of performance indicators.

关键词： Wireless Sensor Networks(WSNs) mobile sink(MS) rendezvous point(RP) machine learning Artificial Neural Networks(ANNs)

Betalains protect various body organs through antioxidant and anti-inflammatory pathways

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Food Science and Human Wellness 2024年第3期13卷 1109-1117页

作者： Nilesh Prakash Nirmal Seema Medhe Merina Dahal Pankaj Koirala Siriwan Nirmal fahad Al-Asmari Baojun Xu Institute of Nutrition Mahidol UniversityNakhon Pathom 73170Thailand Department of Nutrition and Dietetics Central Campus of TechnologyTribhuvan UniversityKathmandu 46000Nepal Department of Adult Nursing Faculty of NursingBurapha UniversityChonburi 20131Thailand Department of Food Science and Nutrition College of Agriculture and Food SciencesKing Faisal UniversityAl-Ahsa 31982Saudi Arabia Food Science and Technology Program Department of Life SciencesBNU-HKBU United International CollegeZhuhai 519088China

Betalains are natural coloring pigments with betalamic acid as the core structure of all *** their coloring properties,betalains exhibit various biological activities,including antioxidant and anti-inflammatory properties,which are highly *** in-vivo studies reported that betalains protect various body organs,leading to health *** organs,including the heart,liver,kidney,lung,etc.,are important for a healthy ***,these organs can be affected or damaged by various stress factors,toxicants,and harmful *** studies have claimed that betalains could protect all vital organs of the body through antioxidant and anti-inflammatory *** review article described the in-vivo antioxidant and anti-inflammatory activities of betalains in various cell-line or animal models.A comprehensive discussion has been provided on the mechanism of action of betalains in protecting various body organs,including cardio-protective effect,hepato-protective ability,renal protection capacity,repro-protective ability,neuro-protective effect,lung protection,and gut protection ***,future research directions and conclusions have been outlined.

关键词： Betalains Antioxidant Anti-inflammatory Bioactivities Ogans-protection

Enhanced Topic-Aware Summarization Using Statistical Graph Neural Networks

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Computers, Materials & Continua 2024年第8期80卷 3221-3242页

作者： Ayesha Khaliq Salman Afsar Awan fahad Ahmad Muhammad Azam Zia Muhammad Zafar Iqbal Department of Computer Science University of Agriculture FaisalabadFaisalabadPunjab37300Pakistan School of Computing Faculty of TechnologyUniversity of PortsmouthSouthseaPortsmouthPO12UPUK Department of Mathematics and Statistics University of Agriculture FaisalabadFaisalabadPunjab37300Pakistan

The rapid expansion of online content and big data has precipitated an urgent need for efficient summarization techniques to swiftly comprehend vast textual documents without compromising their original *** approaches in Extractive Text Summarization(ETS)leverage the modeling of inter-sentence relationships,a task of paramount importance in producing coherent *** study introduces an innovative model that integrates Graph Attention Networks(GATs)with Transformer-based Bidirectional Encoder Representa-tions from Transformers(BERT)and Latent Dirichlet Allocation(LDA),further enhanced by Term Frequency-Inverse Document Frequency(TF-IDF)values,to improve sentence selection by capturing comprehensive topical *** approach constructs a graph with nodes representing sentences,words,and topics,thereby elevating the interconnectivity and enabling a more refined understanding of text *** model is stretched to Multi-Document Summarization(MDS)from Single-Document Summarization,offering significant improvements over existing models such as THGS-GMM and Topic-GraphSum,as demonstrated by empirical evaluations on benchmark news datasets like Cable News Network(CNN)/Daily Mail(DM)and *** results consistently demonstrate superior performance,showcasing the model’s robustness in handling complex summarization tasks across single and multi-document *** research not only advances the integration of BERT and LDA within a GATs but also emphasizes our model’s capacity to effectively manage global information and adapt to diverse summarization challenges.

关键词： Summarization graph attention network bidirectional encoder representations from transformers Latent Dirichlet Allocation term frequency-inverse document frequency

Using Flowable Composite as Gingival Retraction Cord in Prosthodontics Dentistry: Two Case Reports: A Dental Technique

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Open Journal of Stomatology 2024年第2期14卷 118-131页

作者： fahad Hussain Alqahtani Saudi Boards in Restorative Dentistry Center of Advanced Consultants in Healthcare Education and Training Riyadh Saudi Arabia

One of the most challenging factors affecting impression quality and good marginal fit is the gingival retraction method, which aims to separate the gingiva from the tooth to expose the finishing line of the prepared tooth. Bleeding and contamination from the crevicular fluid may compete for space with the impression material within the sulcus, leading to indistinct preparations and a lack of detail at the margin. In addition, such procedures might damage the PDL and cause permanent recession. Flowable composite cable, as opposed to traditional retraction cords, offers the proper marginal seal and visibility during the impression record because of its lower viscosity, improved adaptability, and elastic properties. The aim of this report is to present a brand-new, innovative method for controlling gingival hemorrhage in addition to the gingival retraction in restorative and prosthodontic treatment by utilizing a flowable composite during the final impression record procedure. In these case reports, the flowable composite cord technique is used instead of traditional gingival cords to modify and refine the gingival tissue before taking the traditional final impression or digital scan. Two cases were done for patients undergoing fixed prosthodontics and veneer treatment within a 2-year follow-up period. In addition, the flowable composite cord was used as temporary restoration before the final prosthetic cementation or under the provisional crowns. As a result, clean and healthy gingival tissues render cementation of the final prosthesis quicker and easier to perform. The patients in both cases claimed that their prosthodontic treatments, which involved the application of a flowable composite cord to temporarily retraction the gingiva, had produced good outcomes at the yearlong follow-up. In conclusion, the flowable composite cord technique is found to be a useful tool to improve the quality of impressions in fixed prosthodontics by providing excellent access for impre

关键词： Flowable Composite Gingival Retraction Methods Impression Material Marginal Integrity Final Cementation

Retrograde cricopharyngeal dysfunction(R-CPD):What do we know so far?

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第3期10卷 231-236页

作者： fahad Z.Alotaibi Department of Otolaryngology–Head and Neck Surgery Imam Mohammad Ibn Saud Islamic UniversityRiyadhSaudi Arabia

Objective:This comprehensive review aims to explain the disease pathophysiology,clinical presentation,and management ***:A review was carried out in the following databases:Medline,Scopus,Web of Science,and *** following terms were used alone and combined:Retrograde,Cricopharyngeus muscle,Dysfunction,Abelchia,and inability to ***:A total of 68 articles were identified,and only 11 were found to be relevant and included in writing this *** cricopharyngeal dysfunction(R-CPD)is a relatively new disease entity that has recently been described in clinical *** is caused by the inability of the cricopharyngeus muscle to *** cricopharyngeal dysfunction(CPD),which is well-known and characterized by dysphagia,R-CPD is characterized by the inability to belch in almost all patients,which is considered diagnostic for the ***:High-resolution manometry(HRM)is the definitive diagnostic *** patients reported in the literature responded well to treatment with botulinum toxin injection.

关键词： botulinum toxin cricopharyngeal dysfunction pharyngoesophageal segment R-CPD retrograde