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Circulation of Brucellaceae,Anaplasma and Ehrlichia *** borderline of Iran,Azerbaijan,and Armenia

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Asian Pacific Journal of Tropical Medicine 2021年第5期14卷 223-230页

作者： Rahimeh Abdoli Hasan Bakhshi Sedigheh Kheirandish faezeh Faghihi Asadollah Hosseini-Chegeni Mohammad Ali Oshaghi Zakkyeh Telmadarraiy Mohammad Mehdi Sedaghat Department of Medical Entomology and Vector Control School of Public HealthTehran University of Medical SciencesTehranIran Department of Oral and Maxillofacial Pathology School of DentistryBushehr University of Medical SciencesBushehrIran Cellular and Molecular Research Center Iran University of Medical SciencesTehranIran Department of Plant Protection Faculty of AgricultureLorestan UniversityKhorramabadIran Rahyan Novin Danesh(RND)Private University SariMazandaranIran

Objective:To estimate the infection of ticks to Anaplasma,Ehrlichia,Babesia,Theileria,and Brucellaceae using molecular methods in borderline of Iran,Azerbaijan,and ***:Totally,2022 ticks were collected from different ***,species were diagnosed under stereomicroscope according to valid morphological *** DNA was extracted followed by PCR to detect Anaplasma,Ehrlichia,Theileria,Babesia and Brucellaceae infection in ***:A total of 498 males[24.62%(95%CI 22.76%-26.57%)],741 females[36.64%(95%CI 34.54%-38.79%)],782 nymphs[38.67%(95%CI 36.55%-40.84%)]and 1 larva[0.04%(95%CI 0.00%-0.28%)]were *** identified samples,we found four genera including Hyalomma,Rhipicephalus,Haemaphysalis,and *** assay revealed that the prevalence of ticks to Anaplasma or Ehrlichia,and Brucellaceae was 22.02%(95%CI 16.01%-29.06%)and 15.03%(95%CI 9.43%-22.26%),*** analysis showed that the identified Anaplasma *** the most similarity with Anaplasma centrale,Anaplasma platys,Anaplasma camelii,and Anaplasma phagocytophilum,submitted in ***,the detected Ehrlichia *** Brucellaceae bacterium had the most similarity with Ehrlichia ruminantium and Mycoplana peli,***,no sign of the presence of Theileria and Babesia *** seen in the studied ***:Anaplasmosis,ehrlichiosis and brucellosis should be considered as important health threats in northwestern Iran and consistent monitoring on infection of ticks and livestock should be performed regularly.

关键词： Tick Anaplasma Ehrlichia Brucellaceae PCR

Cytotoxicity and Apoptosis Assay of Novel Cyclomyrsinol Diterpenes Against Breast Cancer Cell Lines

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World Journal of Traditional Chinese Medicine 2022年第2期8卷 273-277页

作者： faezeh Rabbani Zeinab Yazdiniapour Mustafa Ghanadian Behzad Zolfaghari Melika Maleki Fatemeh Shafiee Pharmacy Student’s Research Committee School of PharmacyIsfahan University of Medical Sciences Department of Pharmacognosy School of Pharmacy and Pharmaceutical SciencesIsfahan University of Medical Sciences Department of Pharmaceutical Biotechnology School of Pharmacy and Pharmaceutical SciencesIsfahan University of Medical SciencesIsfahanIran

Background:Cyclomyrsinane diterpenes especially those extracted from various Euphorbia species have shown interesting biological properties in recent *** of the high prevalence of breast cancer and the challenges ahead in its treatment,the use of these compounds as potential anti cancer agents seem ***:The aim of the present study was to evaluate the cytotoxic effects of some myrsinane type diterpenoids extracted from Euphorbia sogdiana Popov and determine their induced cell death ***:MTT assay was used to determine the cytotoxicity of six various myrsinane compounds on MCF 7 and 4 T1 breast cancer cell *** umbilical vein endothelial cells were used as the normal cell line *** apoptotic effects of the structure with the most cytotoxic effects were determined using flow cytometry assay in IC50 concentration for 24 h of ***:Compound(6)showed the most cytotoxic effects with IC50 of about 8±4 and 24±4μg/mL for MCF 7 and 4 T1 cell lines,***,the cells treated with 5 and 10μg/mL of compound(6)for 24 h,showed 37 and 55%of apoptotic ***:These surveyed compounds have the potential to be considered as useful anti-breast cancer agents due to the great cytotoxicity and apoptotic effects against these cancer cells and the fact that there was no significant cytotoxicity on normal cells.

关键词： Apoptosis breast cancer cyclomyrsinol diterpenoids cytotoxicity Euphorbia sogdiana Popov

Oncologic Trogocytosis Protects Tumour Stromal Cells from γδ Cell Cytotoxicity

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Journal of Life Sciences 2011年第12期5卷 986-995页

作者： Emilie Decaup Pej man mirshahi Arash Rafii Massoud mirshahi Jean-Jacques Foumie Mary Poupot INSERM UMR1037-Cancer Research Center of Toulouse CNRS ERL CHU Purpan Toulouse 31024 France University of Toulouse 3 Toulouse 31000 France UMRS 872 INSERA/L University of Pierre et Marie Curie-Paris 6 and University of Paris Descartes Team 18 CRC 15 Rue del ＇Ecole de Mddecine Paris Cedex 06 75270 France Department of Genetic Medecine and Obstetrics and Gynecology WCMC-Qatar Doha Qatar

Tumours progressively develop chemoresistance and immunoescape abilities thanks to support from their stromal microenvironment. In ovarian carcinomas, for instance, tumour-associated mesenchymal stem cells （TAMC） can transfer multi-drug-resistant proteins to develop metastases. However, since the microenvironment of such carcinomas is frequently infiltrated by both TAMC and γδ T lymphocytes, the consequences of interactions between these cell types were unclear. Here, we report that whilst γδ T lymphocytes were not activated when co-incubated in vitro with TAMC, their cell membranes were trogocytosed by the TAMC. Since TAMC constitutively express a low level of HLA class I, which is increased by trogocytosis of γδ cell-derived HLA class I, the interaction increased the expression of HLA class-I molecules on TAMC. In addition, γδ T lymphocytes are HLA-unrestricted cytolytic cells and their activity is regulated by inhibitory receptors （KIR） for self-HLA class I. Hence, although the lytic activity of γδ T lymphocytes for unrelated target cells was unaffected by trogocytosis, it spared the TAMC. Therefore, interactions between TAMC and cytolytic γδ T cells avoided the killing of these stromal cells due to an active transfer of their protective HLA class-I molecules. These results suggest that trogocytosis contributes to the maintenance of cancer-associated stromal cells.

关键词： Membrane transfer tumour microenvironment stromal cells HLA-class I molecules

Facile Synthesis and Characterization of Nanoporous NiO with Folic Acid as Photodegredation Catalyst for Congo Red

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Materials Sciences and Applications 2012年第10期3卷 697-703页

作者： faezeh Farzaneh Sara Haghshenas Department of Chemistry University of Alzahra Vanak P.O.Box *** Vanak Tehran Iran

In this study nanoporous NiO was prepared using Ni(CH3COO)2,4H2O, folic acid and water as starting material, template and solvent respectively, by sol gel method followed by calcination at 400℃. The solid product was characterized by X-ray diffraction (XRD), nitrogen adsorption-desorption, scanning electron microscopy (SEM), transmission electron microscopy (TEM) Fourier transform infrared (FT-IR) and photoluminescence (PL) techniques. The particle size of the nanoparticles estimated by XRD was in good agreement with the particle size obtained by TEM analysis (4-5nm). It was also found that the prepared nanoporous NiO show very good activity for photodegredation of dye organic pollutants such as Congo red (91%) during 1.5 hours.

关键词： Nanoporous NiO Photodegredation Congo Red Folic Acid

酞咪哌啶酮对多发性骨髓瘤细胞系血管新生抑制作用的研究

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中华血液学杂志 2002年第10期23卷 520-523页

作者：陈文明朱嘉芷 F mirshahi J Soria M mirshahi C Soria 首都医科大学附属北京朝阳医院 100020 LabortoireDIFEMA UFRdeMedecineetPhamaciedeRouenfrance76183 INSREMEMI9912 HopitaldeHotelDieufrance75181

目的　研究多发性骨髓瘤 (MM)细胞系培养上清液对人骨髓来源的内皮细胞系(HBMEC)的增殖、迁移、血管新生的促进作用及酞咪哌啶酮对其抑制作用。方法　用MM细胞系 (IM9、XG1、U2 6 6和MOLP 5 )培养上清液培养HBMEC ,检测其对HBMEC的增殖... 详细信息

目的　研究多发性骨髓瘤 (MM)细胞系培养上清液对人骨髓来源的内皮细胞系(HBMEC)的增殖、迁移、血管新生的促进作用及酞咪哌啶酮对其抑制作用。方法　用MM细胞系 (IM9、XG1、U2 6 6和MOLP 5 )培养上清液培养HBMEC ,检测其对HBMEC的增殖、迁移作用。在纤维蛋白胶及基质胶 (matrigel)中观察此上清液对血管新生的影响 ,并研究酞咪哌啶酮对这些作用的抑制。用酶联免疫吸附实验 (ELISA)测定此上清液中血管内皮生长因子 (VEGF)含量。结果　MM培养上清液明显促进HBMEC的增殖及迁移。在纤维蛋白胶及基质胶 (matrigel)中 ,促进微血管的生长。这些作用均可被酞咪哌啶酮抑制。所有这些作用与MM细胞系产生的VEGF无相关性。结论　MM细胞系通过分泌VEGF或其他某些细胞因子促进HBMEC的增殖、迁移及微血管形成 ;酞咪哌啶酮可抑制这些作用。

关键词：多发性骨髓瘤血管新生血管内皮生长因子酞咪哌啶酮治疗

Investigating the Relationship between Responsibility-Taking and Identity Crisis among One-Child Students

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Open Journal of Psychiatry 2018年第1期8卷 61-72页

作者： Ebrahim Namani Samaneh Firouzian faezeh Pardakhti Department of Educational Sciences Faculty of Literature and Humanities Hakim Sabzevari University Sabzevar Iran Department of Psychology Faculty of Humanities Islamic Azad University Neyshabur Branch Neyshabur Iran

The present study has investigated the relationship between responsibility-taking and identity crisis among one-child students. This research is a descriptive-correlational study and the target population comprised all one-child female students of Mashhad secondary schools in the academic year 2014-2015. In this study, multistage cluster sampling method was applied and finally, Region 4, 6 and 7 were randomly selected and 150 students were also randomly chosen according to Morgan table. The research data was collected through California Psychological Inventory (CPI) and Ahmadi identity crisis questionnaire. The obtained information was analyzed by Pearson correlation test and regression. The achieved results indicated that the relationship between responsibility-taking and identity crisis among students is statistically reverse and significant at the level of p < 0.01. In other words, with reducing the identity crisis in students, their responsibility-taking increases. As a result, the main research hypothesis indicating the relationship between responsibility-taking and identity crisis among one-child students of Mashhad secondary schools was confirmed.

关键词： Responsibility-Taking Identity Crisis One-Child

Reduced Graphene Oxide-TiO<sub>2</sub>Nanocomposite Facilitated Visible Light Photodegradation of Gaseous Toluene

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Journal of Environmental Protection 2017年第5期8卷 591-602页

作者： Reza Ahmadkhaniha faezeh Izadpanah Noushin Rastkari Department of Human Ecology School of Public Health Tehran University of Medical Sciences Tehran Iran Center for Air Pollution Research (CAPR) Institute for Environmental Research (IER) Tehran University of Medical Sciences Tehran Iran

The photocatalytic degradation of gaseous toluene was investigated on TiO2 nanoparticles coated on reduced graphene oxide. Reduced graphene oxide-TiO2 composite (RGO-TiO2) was synthesized via two step processes. The prepared RGO-TiO2 composite was characterized using SEM, XRD, and UV-visible spectra. A significant increase in light absorption to visible light was observed by RGO-TiO2 compared with that of pure TiO2 nano particles. The photocatalytic degradation efficiency of the RGO-TiO2 composite was much higher than that of the P25 TiO2, 95% and 40% respectively. In our investigated conditions, the initial concentration, flow rate and relative humidity had significant influences on the photocatalytic degradation of gaseous toluene. The most efficiency was recorded at the 0.3 ppm concentration, 1L/min flow rate and 30% relative humidity. We believe that this TiO2 based composite material can be effectively used as a highly active and stable photocatalyst to remove various indoor air pollutants especially gaseous toluene. The photocatalytic degradation efficiencies of toluene increased slowly below 20% relative humidity and then decreased as the relative humidity increased further. The main reason of enhanced photocatalytic property might be the strong electron transfer ability, and the increased adsorption capacity of RGO sheets in the composites as well as the retarded charge recombination rate contributed by the energy level of the two materials. We believe that this TiO2 based composite material can be effectively used as a highly active and stable photocatalyst to remove various gaseous pollutants.

关键词： Photocatalytic RGO-TiO2 Nano Particles

Progress in the development of vaccines for hepatitis C virus infection

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World Journal of Gastroenterology 2015年第42期21卷 11984-12002页

作者： faezeh Ghasemi Sina Rostami Zahra Meshkat Department of New Sciences and Technology Faculty of Medicine Mashhad University of Medical Sciences Department of Biology Faculty of Sciences Ferdowsi University of Mashhad The Influenza Centre Department of Clinical Science University of Bergen Antimicrobial Resistance Research Center Faculty of Medicine Mashhad University of Medical Sciences

The hepatitis C virus(HCV), first described in 1989, is now a leading cause of liver cirrhosis and hepatocellular carcinoma. With more than 170 million people infected globally, this virus is a major public health issue. The current standard therapy is based on interferon in combination with ribavirin. This costly therapy often fails to completely clear the infection and is associated with adverse side effects. Recent anti-HCV therapies are interferon-free direct-acting antiviral(DAA) regimens for HCV, including simeprevir, sofosbuvir, and ledipasvir, which have effects on non-structural proteins. DAA regimens have several advantages, such as specifically targeting HCV viral replication, accompanied by very high sustained virological response rates and lower side effects like flu-like syndrome. These facts plus the fact that most HCV cases progress to chronic infection suggest the potential need for an efficient HCV vaccine. Different innovative methods, including methods based on peptide, recombinant protein, DNA, vector-based, and virus-like particles, have been introduced for the development of HCV vaccines. An extensive number of studies have been published on these vaccines, and some vaccines were even tested in clinical trials. In the current review, progress in the development of preventive and therapeutic vaccines against the HCV is reviewed in the context of peptide vaccines, recombinant protein vaccines, HCV-like particle, DNA vaccines and viral vectors expressing HCV genes.

关键词： Preventive vaccine Therapeutic vaccine Hepatitis C

Surgical Outcomes and Local Recurrence Following Total or Subtotal Gastrectomy for Early Adenocarcinoma of Antrum

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Chinese Journal of Cancer Research 2008年第4期20卷 279-285页

作者： Mehrdad Moghimi Seyed Ali Marashi Taghi Salehian Habibollah Peirovi faezeh Sodagari Taleghani Hospital Shahid Beheshti University of Medical Sciences Iran University of Medical Sciences

Objective： The choice between total gastrectomy （TG） and subtotal gastrectomy （STG） for early adenocarcinoma of the lower third of the stomach is still a matter of debate and controversy amongst surgeons. The aim of this study was to compare the surgical outcomes, quality of life （QoL）, and local recurrence rates as well as other results of curative resection of early distal adenocarcinoma of the stomach using TG or STG performed in Iran. Methods： Hospital records of 66 patients with early distal adenocarcinoma of stomach that underwent even total or subtotal gastrectomy with perigastric （D2） lymphadenectomy between October 2001 and February 2006 in Taleghani Hospital, Iran were reviewed retrospectively. Demographic data as well as clinicopathological factors including number of involved lymph nodes, tumor grading, depth of invation, tumor size, and tumor type were recorded. Post-operative outcomes including mortality and morbidity, tumor recurrence and quality of life were assessed. Univariate analyses using Fisher＇s exact test, the Student t-test, and the Pearson χ^2 test were used. Results： Local recurrence of tumor was found in 8 （23%） TG group patients and in 19 （61%） patients of STG group, the Pearson χ^2 test showed a significant higher recurrence rate in STG （P value=0.002, Relative Risk=2.68, Confidence Interval： 1.37-5.24）.The mean time interval between gastrectomy and tumor recurrence was not different between TG and STG. （19.75±5.1 vs. 18.0±7.8 respectively; P value=0.507） Tumor size 〉5 cm （P value=0.004）, diffuse type （P value=0.034）, poor differentiation （P value=0.000） and serosal invasion （P value=0.012） were found to be significantly related to tumor recurrence in patients undergone gastrectomy. In none of the QoL measures a significant difference was found between TG and STG Conclusion： Our results show that subtotal and total gastrectomy methods with perigastric lymphadenectomy have a similar postoperative complication rate and surgical outcomes a

关键词： Gastrectomy Adenocarcinoma Recurrence rate