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Post-COVID-19 cholangiopathy:Current understanding and management options

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World Journal of Gastrointestinal Surgery 2023年第5期15卷 788-798页

作者： fadl h veerankutty Kushan Sengupta Mukul Vij Ashwin Rammohan Dinesh Jothimani Ananthavadivelu Murali Mohamed Rela Institute of Liver Disease and Transplantation Dr.Rela Institute and Research CentreChennai 600044India Institute of Liver Disease and Transplantation Dr.Rela Institute and Medical CentreChennai 600044India Department of Pathology Institute of Liver Disease and TransplantationChennai 600044India Gastroenterology and hepatology Clinician’s PointChennai 600014Tamil NaduIndia

Post-coronavirus disease 2019(COVID-19)cholangiopathy(PCC)is a rare but lifethreatening complication of COVID-19 *** typically presents when patients recovering from the contagion and manifests as cholestasis in patients with no history of pre-existing liver *** pathogenesis of PCC is little *** injury in PCC could be mediated by the predilection of severe acute respiratory syndrome coronavirus 2 for *** PCC shows some resemblance to secondary sclerosing cholangitis in critically ill patients,it is considered as a separate and unique entity in the *** treatment options like ursodeoxycholic acid,steroids,plasmapheresis,and endoscopic retrograde cholangiopancreatography guided interventions have been tried but with limited *** have noticed significant improvement in liver function with antiplatelet therapy in a couple of *** can progress to end-stage liver disease necessitating liver *** this article,we discuss the current knowledge of PCC focusing on its pathophysiology,clinical manifestations,and management strategies.

关键词： COVID-19 Liver Post-COVID-19 syndrome Long haulers Cholangiopathy Cholestasis

Artificial Intelligence in hepatology,liver surgery and transplantation:Emerging applications and frontiers of research

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World Journal of hepatology 2021年第12期13卷 1977-1990页

作者： fadl h veerankutty Govind Jayan Manish Kumar Yadav Krishnan Sarojam Manoj Abhishek Yadav Sindhu Radha Sadasivan Nair T U Shabeerali Varghese Yeldho Madhu Sasidharan Shiraz Ahmad Rather Comprehensive Liver Care VPS Lakeshore HospitalCochin 682040KeralaIndia hepatobiliary Pancreatic and Liver Transplant Surgery Kerala Institute of Medical SciencesTrivandrum 695029KeralaIndia Department of Radiodiagnosis Kerala Institute of Medical SciencesTrivandrum 695029KeralaIndia Gastroenterology and hepatology Kerala Institute of Medical SciencesThiruvananthapuram 695029India

The integration of artificial intelligence(AI)and augmented realities into the medical field is being attempted by various researchers across the *** a matter of fact,most of the advanced technologies utilized by medical providers today have been borrowed and extrapolated from other *** introduction of AI into the field of hepatology and liver surgery is relatively a recent *** purpose of this narrative review is to highlight the different AI concepts which are currently being tried to improve the care of patients with liver *** end with summarizing emerging trends and major challenges in the future development of AI in hepatology and liver surgery.

关键词： Liver disease Machine learning Deep learning Artificial neural networks Transplantation hepatectomy

Use of testicular sperm in couples with SCSA-defined high sperm DNA fragmentation and failed intracytoplasmic sperm injection using ejaculated sperm

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Asian Journal of Andrology 2020年第4期22卷 348-353页

作者： Mohannad Alharbi fadl hamouche Simon Phillips Jacques Isaac Kadoch Armand Zini Division of Urology Department of SurgeryMcGill UniversityMontreal H4A3J1Canada Department of Urology College of MedicineQassim UniversityQassim 1162Saudi Arabia OVO Fertility Clinic Montreal H4P2S4Canada Department of Obstetrics and Gynecology University of MontrealMontreal H3C3J7Canada

Sperm DNA fragmentation(SDF)has been linked with male infertility,and previous studies suggest that SDF can have negative influence on pregnancy outcomes with assisted *** performed a retrospective review of consecutive couples with a high SDF level that had intracytoplasmic sperm injection(ICSI)using testicular sperm(T-ICSI).We compared the T-ICSI outcomes to that of two control groups:87 couples with failed first ICSI cycle and who had a second ICSI cycle using ejaculated sperm(Ej-ICSI),and 48 consecutive couples with high sperm chromatin structure assay(SCSA)-defined SDF(>15%)that underwent an ICSI cycle using ejaculated sperm after one or more failed ICSI cycles(Ej-ICSI-high SDF).The mean number of oocytes that were retrieved and the total number of embryos were not different among the three *** mean number of transferred embryos in the T-ICSI group was higher than the Ej-ICSI group but not significantly different than the Ej-ICSI-high SDF group(1.4,1.2,and 1.3,respectively,Phe T-ICSI group was not significantly different than the Ej-ICSI and Ej-ICSI-high SDF groups(48.6%,48.2%,and 38.7%,respectively,P>0.05).No significant difference was found in live birth rate when comparing T-ICSI to Ej-ICSI and Ej-ICSI-high SDF *** results suggest that pregnancy outcomes and live birth rates with T-ICSI are not significantly superior to Ej-ICSI in patients with an elevated SCSA-defined sperm DNA fragmentation and prior ICSI failure(s).

关键词： intracytoplasmic sperm injection male infertility sperm chromatin structure assay sperm DNA fragmentation sperm retrieval testicular sperm

INRA82 extender enhances semen quality in ram under cooled and cryopreserved stages

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Asian pacific Journal of Reproduction 2022年第2期11卷 100-104页

作者： Aya M.fadl Elshymaa A.Abdelnaby hossam R.El-Sherbiny Theriogenology Department Faculty of Veterinary MedicineCairo UniversityEgypt

Objective:To investigate the effect of INRA82 extender on ram semen quality preserved in cooled and frozen conditions in comparison with Tris-based extenders and to select the suitable extender for ram semen ***:Semen samples were collected and pooled from Awassi rams(n=5)and divided into three *** aliquot was diluted with one of the following extenders:(1)Tris-citrate glucose,(2)Triscitrate fructose,and (3)*** liquid storage,diluted samples were kept at 5℃ for 72 *** motility was measured at 0,24,48 and 72 h after ***,viability,morphology,membrane,acrosome and DNA integrities were evaluated at 24 h *** cryopreservation,diluted samples were cooled,equilibrated,loaded and frozen in liquid *** samples were evaluated in the same manner as cooled ***:Seminal characteristics were improved after cooling and thawing in samples diluted with INRA-82 compared to those diluted with Tris-citrate glucose or Tris-citrate fructose(Ph INRA-82 improves semen ***,INRA-82,as a stimulating diluent,can be successfully used to reserve viability and sustainability of cooled and cryopreserved ram semen.

关键词： Cryopreservation Dilution INRA-82 Ram Tris-citrate glucose Tris-citrate fructose